0059 FOXP1 Gene Regulates the Circadian Clock and Its Loss of Function Impairs Sleep Patterns Article Swipe
Bruna Pereira Marquezini
,
Mariana Moysés‐Oliveira
,
Lais A Souza-Cunha
,
Malú Zamariolli
,
Mario Almada
,
Mônica L. Andersen
,
Sérgio Tufik
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1093/sleep/zsaf090.0059
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1093/sleep/zsaf090.0059
Introduction The haploinsufficiency of the FOXP1 protein is associated with a rare genetic disorder of neurodevelopment. Sleep disturbances have already been reported in 45% of patients with pathogenic variants in FOXP1. However, the biological pathways linking sleep traits to the FOXP1-associated syndrome remain unclear. Methods Benefited from recent large-scale genome wide association studies, was manually curated a set of genes associated with sleep traits, including a broad list of sleep disorders and circadian phenotypes. Subsequently, we generated a list of genes directly regulated by FOXP1 by mapping previously described FOXP1 genomic binding sites (data available at the ENCODE database) to gene promoters using Bedtools. We contrasted these 2 gene sets to generate an intersection gene list. A pathway enrichment analysis was performed using this latter gene list of overlapping genes as input. The Benjamini–Hochberg test was used to identify enriched pathways with a significance threshold of adjusted p-value< 0.01. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes terms were considered in the over-representation analysis. Intersect gene lists were used as input on a protein–protein interaction (PPI) analysis via String database, a minimal interaction score of 0.7 enabling physical interactors in the network. Results There were 510 overlapping genes between the gene lists associated with sleep traits (1,062 genes total) and FOXP1 regulatory targets (8,596 genes total). The shared gene set between those two gene lists is greater than expected by chance (p-value=2.6x10-7; OR=1.4), indicating significant genetic overlap. Significantly enriched pathways among these 510 intersect genes are related to neuronal function (Axon Guidance (adjusted p-value=2.29x10-05; OR=5.76)), Circadian Rhythm (adjusted p-value=7.82x10-07; OR=18.5), and Regulation of Insulin Secretion (adjusted p-value=8.66x10-03; OR=5.63). PPI analysis using the sleep versus FOXP1 regulatory targets set as input generated a network with 15 nodes. The network encompasses 3 proteins related to Diabetes Mellitus and 9 proteins related to neurological diseases. Conclusion The set of overlapping genes and biological pathways highlighted by this study may serve as a starting point for new functional investigations of shared molecular mechanisms between sleep disturbances and rare developmental syndromes related to FOXP1 and its regulatory targets. Support (if any) AFIP, FAPESP, CNPq.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/sleep/zsaf090.0059
- https://academic.oup.com/sleep/article-pdf/48/Supplement_1/A26/63223225/zsaf090.0059.pdf
- OA Status
- hybrid
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4410482298
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4410482298Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1093/sleep/zsaf090.0059Digital Object Identifier
- Title
-
0059 FOXP1 Gene Regulates the Circadian Clock and Its Loss of Function Impairs Sleep PatternsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-05-01Full publication date if available
- Authors
-
Bruna Pereira Marquezini, Mariana Moysés‐Oliveira, Lais A Souza-Cunha, Malú Zamariolli, Mario Almada, Mônica L. Andersen, Sérgio TufikList of authors in order
- Landing page
-
https://doi.org/10.1093/sleep/zsaf090.0059Publisher landing page
- PDF URL
-
https://academic.oup.com/sleep/article-pdf/48/Supplement_1/A26/63223225/zsaf090.0059.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://academic.oup.com/sleep/article-pdf/48/Supplement_1/A26/63223225/zsaf090.0059.pdfDirect OA link when available
- Concepts
-
Circadian rhythm, Circadian clock, CLOCK, Sleep (system call), Actigraphy, Neuroscience, Endocrinology, Biology, Internal medicine, Medicine, Computer science, Operating systemTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4410482298 |
|---|---|
| doi | https://doi.org/10.1093/sleep/zsaf090.0059 |
| ids.doi | https://doi.org/10.1093/sleep/zsaf090.0059 |
| ids.openalex | https://openalex.org/W4410482298 |
| fwci | 0.0 |
| type | article |
| title | 0059 FOXP1 Gene Regulates the Circadian Clock and Its Loss of Function Impairs Sleep Patterns |
| biblio.issue | Supplement_1 |
| biblio.volume | 48 |
| biblio.last_page | A27 |
| biblio.first_page | A26 |
| topics[0].id | https://openalex.org/T10342 |
| topics[0].field.id | https://openalex.org/fields/28 |
| topics[0].field.display_name | Neuroscience |
| topics[0].score | 0.7684999704360962 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2807 |
| topics[0].subfield.display_name | Endocrine and Autonomic Systems |
| topics[0].display_name | Circadian rhythm and melatonin |
| is_xpac | False |
| apc_list.value | 4018 |
| apc_list.currency | USD |
| apc_list.value_usd | 4018 |
| apc_paid.value | 4018 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 4018 |
| concepts[0].id | https://openalex.org/C121446783 |
| concepts[0].level | 2 |
| concepts[0].score | 0.7409133315086365 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q208353 |
| concepts[0].display_name | Circadian rhythm |
| concepts[1].id | https://openalex.org/C38606739 |
| concepts[1].level | 3 |
| concepts[1].score | 0.6635090112686157 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q5121352 |
| concepts[1].display_name | Circadian clock |
| concepts[2].id | https://openalex.org/C184738001 |
| concepts[2].level | 4 |
| concepts[2].score | 0.6147063970565796 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q14908739 |
| concepts[2].display_name | CLOCK |
| concepts[3].id | https://openalex.org/C2775841894 |
| concepts[3].level | 2 |
| concepts[3].score | 0.5814274549484253 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q4683692 |
| concepts[3].display_name | Sleep (system call) |
| concepts[4].id | https://openalex.org/C2778996325 |
| concepts[4].level | 3 |
| concepts[4].score | 0.4135608673095703 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q422201 |
| concepts[4].display_name | Actigraphy |
| concepts[5].id | https://openalex.org/C169760540 |
| concepts[5].level | 1 |
| concepts[5].score | 0.39394456148147583 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q207011 |
| concepts[5].display_name | Neuroscience |
| concepts[6].id | https://openalex.org/C134018914 |
| concepts[6].level | 1 |
| concepts[6].score | 0.3839830160140991 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q162606 |
| concepts[6].display_name | Endocrinology |
| concepts[7].id | https://openalex.org/C86803240 |
| concepts[7].level | 0 |
| concepts[7].score | 0.37637442350387573 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[7].display_name | Biology |
| concepts[8].id | https://openalex.org/C126322002 |
| concepts[8].level | 1 |
| concepts[8].score | 0.3698588013648987 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[8].display_name | Internal medicine |
| concepts[9].id | https://openalex.org/C71924100 |
| concepts[9].level | 0 |
| concepts[9].score | 0.3666127920150757 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[9].display_name | Medicine |
| concepts[10].id | https://openalex.org/C41008148 |
| concepts[10].level | 0 |
| concepts[10].score | 0.07915836572647095 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q21198 |
| concepts[10].display_name | Computer science |
| concepts[11].id | https://openalex.org/C111919701 |
| concepts[11].level | 1 |
| concepts[11].score | 0.0 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q9135 |
| concepts[11].display_name | Operating system |
| keywords[0].id | https://openalex.org/keywords/circadian-rhythm |
| keywords[0].score | 0.7409133315086365 |
| keywords[0].display_name | Circadian rhythm |
| keywords[1].id | https://openalex.org/keywords/circadian-clock |
| keywords[1].score | 0.6635090112686157 |
| keywords[1].display_name | Circadian clock |
| keywords[2].id | https://openalex.org/keywords/clock |
| keywords[2].score | 0.6147063970565796 |
| keywords[2].display_name | CLOCK |
| keywords[3].id | https://openalex.org/keywords/sleep |
| keywords[3].score | 0.5814274549484253 |
| keywords[3].display_name | Sleep (system call) |
| keywords[4].id | https://openalex.org/keywords/actigraphy |
| keywords[4].score | 0.4135608673095703 |
| keywords[4].display_name | Actigraphy |
| keywords[5].id | https://openalex.org/keywords/neuroscience |
| keywords[5].score | 0.39394456148147583 |
| keywords[5].display_name | Neuroscience |
| keywords[6].id | https://openalex.org/keywords/endocrinology |
| keywords[6].score | 0.3839830160140991 |
| keywords[6].display_name | Endocrinology |
| keywords[7].id | https://openalex.org/keywords/biology |
| keywords[7].score | 0.37637442350387573 |
| keywords[7].display_name | Biology |
| keywords[8].id | https://openalex.org/keywords/internal-medicine |
| keywords[8].score | 0.3698588013648987 |
| keywords[8].display_name | Internal medicine |
| keywords[9].id | https://openalex.org/keywords/medicine |
| keywords[9].score | 0.3666127920150757 |
| keywords[9].display_name | Medicine |
| keywords[10].id | https://openalex.org/keywords/computer-science |
| keywords[10].score | 0.07915836572647095 |
| keywords[10].display_name | Computer science |
| language | en |
| locations[0].id | doi:10.1093/sleep/zsaf090.0059 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S42921845 |
| locations[0].source.issn | 0161-8105, 1550-9109 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 0161-8105 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | SLEEP |
| locations[0].source.host_organization | https://openalex.org/P4310311648 |
| locations[0].source.host_organization_name | Oxford University Press |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310311648 |
| locations[0].license | other-oa |
| locations[0].pdf_url | https://academic.oup.com/sleep/article-pdf/48/Supplement_1/A26/63223225/zsaf090.0059.pdf |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/other-oa |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | SLEEP |
| locations[0].landing_page_url | https://doi.org/10.1093/sleep/zsaf090.0059 |
| indexed_in | crossref |
| authorships[0].author.id | https://openalex.org/A5092843075 |
| authorships[0].author.orcid | https://orcid.org/0009-0009-4852-7462 |
| authorships[0].author.display_name | Bruna Pereira Marquezini |
| authorships[0].countries | BR |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I88273585 |
| authorships[0].affiliations[0].raw_affiliation_string | Departamento de Psicobiologia, Universidade Federal de São Paulo |
| authorships[0].institutions[0].id | https://openalex.org/I88273585 |
| authorships[0].institutions[0].ror | https://ror.org/02k5swt12 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I88273585 |
| authorships[0].institutions[0].country_code | BR |
| authorships[0].institutions[0].display_name | Universidade Federal de São Paulo |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Bruna Marquezini |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Departamento de Psicobiologia, Universidade Federal de São Paulo |
| authorships[1].author.id | https://openalex.org/A5000893407 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-3233-932X |
| authorships[1].author.display_name | Mariana Moysés‐Oliveira |
| authorships[1].countries | BR |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I4210141662 |
| authorships[1].affiliations[0].raw_affiliation_string | Sleep Institute, Associação Fundo de Incentivo à Pesquisa |
| authorships[1].institutions[0].id | https://openalex.org/I4210141662 |
| authorships[1].institutions[0].ror | https://ror.org/040y74d88 |
| authorships[1].institutions[0].type | nonprofit |
| authorships[1].institutions[0].lineage | https://openalex.org/I4210141662 |
| authorships[1].institutions[0].country_code | BR |
| authorships[1].institutions[0].display_name | Associação Fundo de Incentivo à Pesquisa |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Mariana Moyses-oliveira |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Sleep Institute, Associação Fundo de Incentivo à Pesquisa |
| authorships[2].author.id | https://openalex.org/A5077894490 |
| authorships[2].author.orcid | |
| authorships[2].author.display_name | Lais A Souza-Cunha |
| authorships[2].countries | BR |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I88273585 |
| authorships[2].affiliations[0].raw_affiliation_string | Departamento de Psicobiologia, Universidade Federal de São Paulo |
| authorships[2].institutions[0].id | https://openalex.org/I88273585 |
| authorships[2].institutions[0].ror | https://ror.org/02k5swt12 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I88273585 |
| authorships[2].institutions[0].country_code | BR |
| authorships[2].institutions[0].display_name | Universidade Federal de São Paulo |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Lais A Souza-Cunha |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Departamento de Psicobiologia, Universidade Federal de São Paulo |
| authorships[3].author.id | https://openalex.org/A5043976150 |
| authorships[3].author.orcid | https://orcid.org/0000-0003-3125-1948 |
| authorships[3].author.display_name | Malú Zamariolli |
| authorships[3].countries | BR |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I4210141662 |
| authorships[3].affiliations[0].raw_affiliation_string | Sleep Institute, Associação Fundo de Incentivo à Pesquisa |
| authorships[3].institutions[0].id | https://openalex.org/I4210141662 |
| authorships[3].institutions[0].ror | https://ror.org/040y74d88 |
| authorships[3].institutions[0].type | nonprofit |
| authorships[3].institutions[0].lineage | https://openalex.org/I4210141662 |
| authorships[3].institutions[0].country_code | BR |
| authorships[3].institutions[0].display_name | Associação Fundo de Incentivo à Pesquisa |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Malú Zamariolli |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Sleep Institute, Associação Fundo de Incentivo à Pesquisa |
| authorships[4].author.id | https://openalex.org/A5102803355 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-4655-2789 |
| authorships[4].author.display_name | Mario Almada |
| authorships[4].countries | BR |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I4210141662 |
| authorships[4].affiliations[0].raw_affiliation_string | Sleep Institute, Associação Fundo de Incentivo à Pesquisa |
| authorships[4].institutions[0].id | https://openalex.org/I4210141662 |
| authorships[4].institutions[0].ror | https://ror.org/040y74d88 |
| authorships[4].institutions[0].type | nonprofit |
| authorships[4].institutions[0].lineage | https://openalex.org/I4210141662 |
| authorships[4].institutions[0].country_code | BR |
| authorships[4].institutions[0].display_name | Associação Fundo de Incentivo à Pesquisa |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Manuella Almada |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Sleep Institute, Associação Fundo de Incentivo à Pesquisa |
| authorships[5].author.id | https://openalex.org/A5077926189 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-1894-6748 |
| authorships[5].author.display_name | Mônica L. Andersen |
| authorships[5].countries | BR |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I88273585 |
| authorships[5].affiliations[0].raw_affiliation_string | Departamento de Psicobiologia, Universidade Federal de São Paulo |
| authorships[5].institutions[0].id | https://openalex.org/I88273585 |
| authorships[5].institutions[0].ror | https://ror.org/02k5swt12 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I88273585 |
| authorships[5].institutions[0].country_code | BR |
| authorships[5].institutions[0].display_name | Universidade Federal de São Paulo |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Monica Andersen |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Departamento de Psicobiologia, Universidade Federal de São Paulo |
| authorships[6].author.id | https://openalex.org/A5107850275 |
| authorships[6].author.orcid | |
| authorships[6].author.display_name | Sérgio Tufik |
| authorships[6].countries | BR |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I88273585 |
| authorships[6].affiliations[0].raw_affiliation_string | Departamento de Psicobiologia, Universidade Federal de São Paulo |
| authorships[6].institutions[0].id | https://openalex.org/I88273585 |
| authorships[6].institutions[0].ror | https://ror.org/02k5swt12 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I88273585 |
| authorships[6].institutions[0].country_code | BR |
| authorships[6].institutions[0].display_name | Universidade Federal de São Paulo |
| authorships[6].author_position | last |
| authorships[6].raw_author_name | Sergio Tufik |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Departamento de Psicobiologia, Universidade Federal de São Paulo |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://academic.oup.com/sleep/article-pdf/48/Supplement_1/A26/63223225/zsaf090.0059.pdf |
| open_access.oa_status | hybrid |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | 0059 FOXP1 Gene Regulates the Circadian Clock and Its Loss of Function Impairs Sleep Patterns |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10342 |
| primary_topic.field.id | https://openalex.org/fields/28 |
| primary_topic.field.display_name | Neuroscience |
| primary_topic.score | 0.7684999704360962 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2807 |
| primary_topic.subfield.display_name | Endocrine and Autonomic Systems |
| primary_topic.display_name | Circadian rhythm and melatonin |
| related_works | https://openalex.org/W2021051938, https://openalex.org/W2140682486, https://openalex.org/W4285097245, https://openalex.org/W2090209293, https://openalex.org/W3136837454, https://openalex.org/W1973760267, https://openalex.org/W2006785691, https://openalex.org/W2381162521, https://openalex.org/W2068710022, https://openalex.org/W3022220350 |
| cited_by_count | 0 |
| locations_count | 1 |
| best_oa_location.id | doi:10.1093/sleep/zsaf090.0059 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S42921845 |
| best_oa_location.source.issn | 0161-8105, 1550-9109 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | 0161-8105 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | SLEEP |
| best_oa_location.source.host_organization | https://openalex.org/P4310311648 |
| best_oa_location.source.host_organization_name | Oxford University Press |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310311648 |
| best_oa_location.license | other-oa |
| best_oa_location.pdf_url | https://academic.oup.com/sleep/article-pdf/48/Supplement_1/A26/63223225/zsaf090.0059.pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/other-oa |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | SLEEP |
| best_oa_location.landing_page_url | https://doi.org/10.1093/sleep/zsaf090.0059 |
| primary_location.id | doi:10.1093/sleep/zsaf090.0059 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S42921845 |
| primary_location.source.issn | 0161-8105, 1550-9109 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 0161-8105 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | SLEEP |
| primary_location.source.host_organization | https://openalex.org/P4310311648 |
| primary_location.source.host_organization_name | Oxford University Press |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310311648 |
| primary_location.license | other-oa |
| primary_location.pdf_url | https://academic.oup.com/sleep/article-pdf/48/Supplement_1/A26/63223225/zsaf090.0059.pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/other-oa |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | SLEEP |
| primary_location.landing_page_url | https://doi.org/10.1093/sleep/zsaf090.0059 |
| publication_date | 2025-05-01 |
| publication_year | 2025 |
| referenced_works_count | 0 |
| abstract_inverted_index.2 | 108 |
| abstract_inverted_index.3 | 291 |
| abstract_inverted_index.9 | 298 |
| abstract_inverted_index.A | 117 |
| abstract_inverted_index.a | 11, 57, 66, 78, 143, 174, 182, 283, 320 |
| abstract_inverted_index.15 | 286 |
| abstract_inverted_index.We | 105 |
| abstract_inverted_index.an | 113 |
| abstract_inverted_index.as | 131, 171, 280, 319 |
| abstract_inverted_index.at | 96 |
| abstract_inverted_index.by | 84, 86, 231, 314 |
| abstract_inverted_index.in | 23, 30, 162, 191 |
| abstract_inverted_index.is | 8, 227 |
| abstract_inverted_index.of | 4, 15, 25, 59, 69, 80, 128, 146, 155, 186, 264, 307, 327 |
| abstract_inverted_index.on | 173 |
| abstract_inverted_index.to | 39, 100, 111, 138, 249, 294, 301, 339 |
| abstract_inverted_index.we | 76 |
| abstract_inverted_index.(if | 346 |
| abstract_inverted_index.0.7 | 187 |
| abstract_inverted_index.45% | 24 |
| abstract_inverted_index.510 | 197, 244 |
| abstract_inverted_index.PPI | 270 |
| abstract_inverted_index.The | 2, 133, 218, 288, 305 |
| abstract_inverted_index.and | 72, 152, 157, 211, 262, 297, 310, 334, 341 |
| abstract_inverted_index.are | 247 |
| abstract_inverted_index.for | 323 |
| abstract_inverted_index.its | 342 |
| abstract_inverted_index.may | 317 |
| abstract_inverted_index.new | 324 |
| abstract_inverted_index.set | 58, 221, 279, 306 |
| abstract_inverted_index.the | 5, 33, 40, 97, 163, 192, 201, 273 |
| abstract_inverted_index.two | 224 |
| abstract_inverted_index.via | 179 |
| abstract_inverted_index.was | 54, 121, 136 |
| abstract_inverted_index.Gene | 150 |
| abstract_inverted_index.any) | 347 |
| abstract_inverted_index.been | 21 |
| abstract_inverted_index.from | 47 |
| abstract_inverted_index.gene | 101, 109, 115, 126, 167, 202, 220, 225 |
| abstract_inverted_index.have | 19 |
| abstract_inverted_index.list | 68, 79, 127 |
| abstract_inverted_index.rare | 12, 335 |
| abstract_inverted_index.sets | 110 |
| abstract_inverted_index.test | 135 |
| abstract_inverted_index.than | 229 |
| abstract_inverted_index.this | 124, 315 |
| abstract_inverted_index.used | 137, 170 |
| abstract_inverted_index.were | 160, 169, 196 |
| abstract_inverted_index.wide | 51 |
| abstract_inverted_index.with | 10, 27, 62, 142, 205, 285 |
| abstract_inverted_index.(Axon | 252 |
| abstract_inverted_index.(PPI) | 177 |
| abstract_inverted_index.(data | 94 |
| abstract_inverted_index.0.01. | 149 |
| abstract_inverted_index.AFIP, | 348 |
| abstract_inverted_index.CNPq. | 350 |
| abstract_inverted_index.FOXP1 | 6, 85, 90, 212, 276, 340 |
| abstract_inverted_index.Genes | 156 |
| abstract_inverted_index.Kyoto | 153 |
| abstract_inverted_index.Sleep | 17 |
| abstract_inverted_index.There | 195 |
| abstract_inverted_index.among | 242 |
| abstract_inverted_index.broad | 67 |
| abstract_inverted_index.genes | 60, 81, 130, 199, 209, 216, 246, 309 |
| abstract_inverted_index.input | 172, 281 |
| abstract_inverted_index.list. | 116 |
| abstract_inverted_index.lists | 168, 203, 226 |
| abstract_inverted_index.point | 322 |
| abstract_inverted_index.score | 185 |
| abstract_inverted_index.serve | 318 |
| abstract_inverted_index.sites | 93 |
| abstract_inverted_index.sleep | 37, 63, 70, 206, 274, 332 |
| abstract_inverted_index.study | 316 |
| abstract_inverted_index.terms | 159 |
| abstract_inverted_index.these | 107, 243 |
| abstract_inverted_index.those | 223 |
| abstract_inverted_index.using | 103, 123, 272 |
| abstract_inverted_index.(1,062 | 208 |
| abstract_inverted_index.(8,596 | 215 |
| abstract_inverted_index.ENCODE | 98 |
| abstract_inverted_index.FOXP1. | 31 |
| abstract_inverted_index.Rhythm | 258 |
| abstract_inverted_index.String | 180 |
| abstract_inverted_index.chance | 232 |
| abstract_inverted_index.genome | 50 |
| abstract_inverted_index.input. | 132 |
| abstract_inverted_index.latter | 125 |
| abstract_inverted_index.nodes. | 287 |
| abstract_inverted_index.recent | 48 |
| abstract_inverted_index.remain | 43 |
| abstract_inverted_index.shared | 219, 328 |
| abstract_inverted_index.total) | 210 |
| abstract_inverted_index.traits | 38, 207 |
| abstract_inverted_index.versus | 275 |
| abstract_inverted_index.FAPESP, | 349 |
| abstract_inverted_index.Genomes | 158 |
| abstract_inverted_index.Insulin | 265 |
| abstract_inverted_index.Methods | 45 |
| abstract_inverted_index.Results | 194 |
| abstract_inverted_index.Support | 345 |
| abstract_inverted_index.already | 20 |
| abstract_inverted_index.between | 200, 222, 331 |
| abstract_inverted_index.binding | 92 |
| abstract_inverted_index.curated | 56 |
| abstract_inverted_index.genetic | 13, 237 |
| abstract_inverted_index.genomic | 91 |
| abstract_inverted_index.greater | 228 |
| abstract_inverted_index.linking | 36 |
| abstract_inverted_index.mapping | 87 |
| abstract_inverted_index.minimal | 183 |
| abstract_inverted_index.network | 284, 289 |
| abstract_inverted_index.pathway | 118 |
| abstract_inverted_index.protein | 7 |
| abstract_inverted_index.related | 248, 293, 300, 338 |
| abstract_inverted_index.targets | 214, 278 |
| abstract_inverted_index.total). | 217 |
| abstract_inverted_index.traits, | 64 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.Diabetes | 295 |
| abstract_inverted_index.Guidance | 253 |
| abstract_inverted_index.However, | 32 |
| abstract_inverted_index.Mellitus | 296 |
| abstract_inverted_index.OR=1.4), | 234 |
| abstract_inverted_index.Ontology | 151 |
| abstract_inverted_index.adjusted | 147 |
| abstract_inverted_index.analysis | 120, 178, 271 |
| abstract_inverted_index.directly | 82 |
| abstract_inverted_index.disorder | 14 |
| abstract_inverted_index.enabling | 188 |
| abstract_inverted_index.enriched | 140, 240 |
| abstract_inverted_index.expected | 230 |
| abstract_inverted_index.function | 251 |
| abstract_inverted_index.generate | 112 |
| abstract_inverted_index.identify | 139 |
| abstract_inverted_index.manually | 55 |
| abstract_inverted_index.network. | 193 |
| abstract_inverted_index.neuronal | 250 |
| abstract_inverted_index.overlap. | 238 |
| abstract_inverted_index.pathways | 35, 141, 241, 312 |
| abstract_inverted_index.patients | 26 |
| abstract_inverted_index.physical | 189 |
| abstract_inverted_index.proteins | 292, 299 |
| abstract_inverted_index.reported | 22 |
| abstract_inverted_index.starting | 321 |
| abstract_inverted_index.studies, | 53 |
| abstract_inverted_index.syndrome | 42 |
| abstract_inverted_index.targets. | 344 |
| abstract_inverted_index.unclear. | 44 |
| abstract_inverted_index.variants | 29 |
| abstract_inverted_index.(adjusted | 254, 259, 267 |
| abstract_inverted_index.Bedtools. | 104 |
| abstract_inverted_index.Benefited | 46 |
| abstract_inverted_index.Circadian | 257 |
| abstract_inverted_index.Intersect | 166 |
| abstract_inverted_index.OR=18.5), | 261 |
| abstract_inverted_index.OR=5.63). | 269 |
| abstract_inverted_index.Secretion | 266 |
| abstract_inverted_index.analysis. | 165 |
| abstract_inverted_index.available | 95 |
| abstract_inverted_index.circadian | 73 |
| abstract_inverted_index.database) | 99 |
| abstract_inverted_index.database, | 181 |
| abstract_inverted_index.described | 89 |
| abstract_inverted_index.diseases. | 303 |
| abstract_inverted_index.disorders | 71 |
| abstract_inverted_index.generated | 77, 282 |
| abstract_inverted_index.including | 65 |
| abstract_inverted_index.intersect | 245 |
| abstract_inverted_index.molecular | 329 |
| abstract_inverted_index.performed | 122 |
| abstract_inverted_index.promoters | 102 |
| abstract_inverted_index.regulated | 83 |
| abstract_inverted_index.syndromes | 337 |
| abstract_inverted_index.threshold | 145 |
| abstract_inverted_index.Conclusion | 304 |
| abstract_inverted_index.OR=5.76)), | 256 |
| abstract_inverted_index.Regulation | 263 |
| abstract_inverted_index.associated | 9, 61, 204 |
| abstract_inverted_index.biological | 34, 311 |
| abstract_inverted_index.considered | 161 |
| abstract_inverted_index.contrasted | 106 |
| abstract_inverted_index.enrichment | 119 |
| abstract_inverted_index.functional | 325 |
| abstract_inverted_index.indicating | 235 |
| abstract_inverted_index.mechanisms | 330 |
| abstract_inverted_index.pathogenic | 28 |
| abstract_inverted_index.previously | 88 |
| abstract_inverted_index.regulatory | 213, 277, 343 |
| abstract_inverted_index.association | 52 |
| abstract_inverted_index.encompasses | 290 |
| abstract_inverted_index.highlighted | 313 |
| abstract_inverted_index.interaction | 176, 184 |
| abstract_inverted_index.interactors | 190 |
| abstract_inverted_index.large-scale | 49 |
| abstract_inverted_index.overlapping | 129, 198, 308 |
| abstract_inverted_index.phenotypes. | 74 |
| abstract_inverted_index.significant | 236 |
| abstract_inverted_index.Encyclopedia | 154 |
| abstract_inverted_index.Introduction | 1 |
| abstract_inverted_index.disturbances | 18, 333 |
| abstract_inverted_index.intersection | 114 |
| abstract_inverted_index.neurological | 302 |
| abstract_inverted_index.significance | 144 |
| abstract_inverted_index.Significantly | 239 |
| abstract_inverted_index.Subsequently, | 75 |
| abstract_inverted_index.developmental | 336 |
| abstract_inverted_index.investigations | 326 |
| abstract_inverted_index.p-value&lt; | 148 |
| abstract_inverted_index.FOXP1-associated | 41 |
| abstract_inverted_index.neurodevelopment. | 16 |
| abstract_inverted_index.protein–protein | 175 |
| abstract_inverted_index.(p-value=2.6x10-7; | 233 |
| abstract_inverted_index.haploinsufficiency | 3 |
| abstract_inverted_index.over-representation | 164 |
| abstract_inverted_index.p-value=2.29x10-05; | 255 |
| abstract_inverted_index.p-value=7.82x10-07; | 260 |
| abstract_inverted_index.p-value=8.66x10-03; | 268 |
| abstract_inverted_index.Benjamini–Hochberg | 134 |
| cited_by_percentile_year | |
| countries_distinct_count | 1 |
| institutions_distinct_count | 7 |
| citation_normalized_percentile.value | 0.20497312 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |