0223 Total Sleep Deprivation and Pain Perception during Cold Noxious Stimuli in Older Adults Article Swipe

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Hannah A. Cunningham , Ian M. Greenlund , Ida T. Fonkoue , Carl A. Smoot , Jason R. Carter ·

YOU? · · 2019 · Open Access · · DOI: https://doi.org/10.1093/sleep/zsz067.222

Introduction\nOur laboratory has previously reported an augmented pain response to 24-hour total sleep deprivation (TSD) in young men and women. Because aging is associated with a greater prevalence of chronic pain and diminished sleep quality, we hypothesized TSD would increase pain perception to the cold pressor test (CPT) in older adults. Furthermore, we hypothesized this relationship would be stronger in postmenopausal women compared to age-matched men.\nMethods\nEighteen participants (9 women) between 55 and 75 years were tested once after 24-hour TSD and once after normal sleep (NS) using a randomized, cross-over design. Following a supine baseline, subjects performed a 2-min CPT by immersing their left hand in water (0-3ºC). Perceived pain was recorded every 15 seconds during simultaneous recordings of muscle sympathetic nerve activity (MSNA; microneurography).\nResults\nAge (61±2 vs. 60±1 years) and BMI (26±1 vs. 27±1 kg/m2) were not different between women and men, respectively. CPT elicited a graded increase of perceived pain (time, p0.05). The condition effect was also observed when pain was expressed as mean change from baseline (NS, Δ6.9 ± 2.4 vs. TSD, Δ8.2 ± 2.4 a.u.; p=0.041) and peak change from baseline (NS, Δ8.4 ± 2.7 vs. TSD, Δ9.7 ± 2.5 a.u.; p=0.039). Changes in pain were correlated with changes in MSNA during the initial 30 seconds of CPT during both NS (r=0.513; p =0.025) and TSD (r=0.528; p=0.020).\nConclusion\nTSD significantly augments perceived pain during cold noxious stimuli in older adults. Contrary to our initial hypothesis, this increased pain perception is not significantly different between men and women. Sympathetic reactivity during the initial phase of CPT was associated with changes in pain, but the clinical relevance of this relationship remains unclear. Our findings support the concept of sleep as a cost effective, therapeutic strategy for reducing pain in older men and women.

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Audiology

Perception

Medicine

Physical Medicine And Rehabilitation

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Sleep deprivation Noxious stimulus Audiology Pain perception Sleep (system call) Psychology Perception Medicine Physical medicine and rehabilitation Anesthesia Neuroscience Nociception Circadian rhythm Internal medicine Receptor Computer science Operating system

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Type: article
Language: en
Landing Page: http://doi.org/10.1093/sleep/zsz067.222
PDF: https://academic.oup.com/sleep/article-pdf/42/Supplement_1/A91/28384554/zsz067.222.pdf
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DOI: https://doi.org/10.1093/sleep/zsz067.222

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Title: 0223 Total Sleep Deprivation and Pain Perception during Cold Noxious Stimuli in Older Adults

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Language: en

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Publication year: 2019

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Publication date: 2019-04-01

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Authors: Hannah A. Cunningham, Ian M. Greenlund, Ida T. Fonkoue, Carl A. Smoot, Jason R. Carter

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Landing page: https://doi.org/10.1093/sleep/zsz067.222

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Concepts: Sleep deprivation, Noxious stimulus, Audiology, Pain perception, Sleep (system call), Psychology, Perception, Medicine, Physical medicine and rehabilitation, Anesthesia, Neuroscience, Nociception, Circadian rhythm, Internal medicine, Receptor, Computer science, Operating system

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abstract_inverted_index.as	163, 279
abstract_inverted_index.be	57
abstract_inverted_index.by	100
abstract_inverted_index.in	15, 48, 59, 105, 196, 202, 229, 261, 288
abstract_inverted_index.is	22, 241
abstract_inverted_index.of	28, 118, 148, 209, 255, 267, 277
abstract_inverted_index.to	9, 42, 63, 233
abstract_inverted_index.we	35, 52
abstract_inverted_index.±	170, 175, 186, 191
abstract_inverted_index.2.4	171, 176
abstract_inverted_index.2.5	192
abstract_inverted_index.2.7	187
abstract_inverted_index.BMI	130
abstract_inverted_index.CPT	99, 143, 210, 256
abstract_inverted_index.Our	272
abstract_inverted_index.TSD	37, 79, 218
abstract_inverted_index.The	153
abstract_inverted_index.and	18, 31, 71, 80, 129, 140, 179, 217, 247, 291
abstract_inverted_index.but	263
abstract_inverted_index.for	285
abstract_inverted_index.has	2
abstract_inverted_index.men	17, 246, 290
abstract_inverted_index.not	136, 242
abstract_inverted_index.our	234
abstract_inverted_index.the	43, 205, 252, 264, 275
abstract_inverted_index.vs.	126, 132, 172, 188
abstract_inverted_index.was	110, 156, 161, 257
abstract_inverted_index.(NS)	85
abstract_inverted_index.(NS,	168, 184
abstract_inverted_index.MSNA	203
abstract_inverted_index.TSD,	173, 189
abstract_inverted_index.also	157
abstract_inverted_index.both	212
abstract_inverted_index.cold	44, 226
abstract_inverted_index.cost	281
abstract_inverted_index.from	166, 182
abstract_inverted_index.hand	104
abstract_inverted_index.left	103
abstract_inverted_index.mean	164
abstract_inverted_index.men,	141
abstract_inverted_index.once	76, 81
abstract_inverted_index.pain	7, 30, 40, 109, 150, 160, 197, 224, 239, 287
abstract_inverted_index.peak	180
abstract_inverted_index.test	46
abstract_inverted_index.this	54, 237, 268
abstract_inverted_index.were	74, 135, 198
abstract_inverted_index.when	159
abstract_inverted_index.with	24, 200, 259
abstract_inverted_index.(CPT)	47
abstract_inverted_index.(TSD)	14
abstract_inverted_index.2-min	98
abstract_inverted_index.27±1	133
abstract_inverted_index.60±1	127
abstract_inverted_index.a.u.;	177, 193
abstract_inverted_index.after	77, 82
abstract_inverted_index.aging	21
abstract_inverted_index.every	112
abstract_inverted_index.nerve	121
abstract_inverted_index.older	49, 230, 289
abstract_inverted_index.pain,	262
abstract_inverted_index.phase	254
abstract_inverted_index.sleep	12, 33, 84, 278
abstract_inverted_index.their	102
abstract_inverted_index.total	11
abstract_inverted_index.using	86
abstract_inverted_index.water	106
abstract_inverted_index.women	61, 139
abstract_inverted_index.would	38, 56
abstract_inverted_index.years	73
abstract_inverted_index.young	16
abstract_inverted_index.Δ6.9	169
abstract_inverted_index.Δ8.2	174
abstract_inverted_index.Δ8.4	185
abstract_inverted_index.Δ9.7	190
abstract_inverted_index.(26±1	131
abstract_inverted_index.(61±2	125
abstract_inverted_index.(MSNA;	123
abstract_inverted_index.(time,	151
abstract_inverted_index.change	165, 181
abstract_inverted_index.during	115, 204, 211, 225, 251
abstract_inverted_index.effect	155
abstract_inverted_index.graded	146
abstract_inverted_index.kg/m2)	134
abstract_inverted_index.muscle	119
abstract_inverted_index.normal	83
abstract_inverted_index.supine	93
abstract_inverted_index.tested	75
abstract_inverted_index.women)	68
abstract_inverted_index.women.	19, 248, 292
abstract_inverted_index.years)	128
abstract_inverted_index.24-hour	10, 78
abstract_inverted_index.=0.025)	216
abstract_inverted_index.Because	20
abstract_inverted_index.Changes	195
abstract_inverted_index.adults.	50, 231
abstract_inverted_index.between	69, 138, 245
abstract_inverted_index.changes	201, 260
abstract_inverted_index.chronic	29
abstract_inverted_index.concept	276
abstract_inverted_index.design.	90
abstract_inverted_index.greater	26
abstract_inverted_index.initial	206, 235, 253
abstract_inverted_index.noxious	227
abstract_inverted_index.p0.05).	152
abstract_inverted_index.pressor	45
abstract_inverted_index.remains	270
abstract_inverted_index.seconds	114, 208
abstract_inverted_index.stimuli	228
abstract_inverted_index.support	274
abstract_inverted_index.Contrary	232
abstract_inverted_index.activity	122
abstract_inverted_index.augments	222
abstract_inverted_index.baseline	167, 183
abstract_inverted_index.clinical	265
abstract_inverted_index.compared	62
abstract_inverted_index.elicited	144
abstract_inverted_index.findings	273
abstract_inverted_index.increase	39, 147
abstract_inverted_index.observed	158
abstract_inverted_index.p=0.041)	178
abstract_inverted_index.quality,	34
abstract_inverted_index.recorded	111
abstract_inverted_index.reducing	286
abstract_inverted_index.reported	4
abstract_inverted_index.response	8
abstract_inverted_index.strategy	284
abstract_inverted_index.stronger	58
abstract_inverted_index.subjects	95
abstract_inverted_index.unclear.	271
abstract_inverted_index.(0-3ºC).	107
abstract_inverted_index.(r=0.513;	214
abstract_inverted_index.(r=0.528;	219
abstract_inverted_index.Following	91
abstract_inverted_index.Perceived	108
abstract_inverted_index.augmented	6
abstract_inverted_index.baseline,	94
abstract_inverted_index.condition	154
abstract_inverted_index.different	137, 244
abstract_inverted_index.expressed	162
abstract_inverted_index.immersing	101
abstract_inverted_index.increased	238
abstract_inverted_index.p=0.039).	194
abstract_inverted_index.perceived	149, 223
abstract_inverted_index.performed	96
abstract_inverted_index.relevance	266
abstract_inverted_index.associated	23, 258
abstract_inverted_index.correlated	199
abstract_inverted_index.cross-over	89
abstract_inverted_index.diminished	32
abstract_inverted_index.effective,	282
abstract_inverted_index.laboratory	1
abstract_inverted_index.perception	41, 240
abstract_inverted_index.prevalence	27
abstract_inverted_index.previously	3
abstract_inverted_index.reactivity	250
abstract_inverted_index.recordings	117
abstract_inverted_index.Sympathetic	249
abstract_inverted_index.age-matched	64
abstract_inverted_index.deprivation	13
abstract_inverted_index.hypothesis,	236
abstract_inverted_index.randomized,	88
abstract_inverted_index.sympathetic	120
abstract_inverted_index.therapeutic	283
abstract_inverted_index.Furthermore,	51
abstract_inverted_index.hypothesized	36, 53
abstract_inverted_index.participants	66
abstract_inverted_index.relationship	55, 269
abstract_inverted_index.simultaneous	116
abstract_inverted_index.respectively.	142
abstract_inverted_index.significantly	221, 243
abstract_inverted_index.postmenopausal	60
abstract_inverted_index.Introduction\nOur	0
abstract_inverted_index.men.\nMethods\nEighteen	65
abstract_inverted_index.p=0.020).\nConclusion\nTSD	220
abstract_inverted_index.microneurography).\nResults\nAge	124
cited_by_percentile_year
countries_distinct_count	1
institutions_distinct_count	5
citation_normalized_percentile.value	0.03405312
citation_normalized_percentile.is_in_top_1_percent	False
citation_normalized_percentile.is_in_top_10_percent	False