10235-TB-9 TRANSLATIONAL RESEARCH OF BORON NEUTRON CAPTURE THERAPY FOR SPINAL CORD AND SPINE TUMOR IN ANIMAL MODELS Article Swipe

PDF

Yoshiki Fujikawa , Shinji Kawabata , Ryo Kayama , Kohei Tsujino , Hideki Kashiwagi , Yusuke Fukuo , Ryo Hiramatsu , Takushi Takata , Hiroki Tanaka , Minoru Suzuki , Naonori Hu , Shin‐Ichi Miyatake , Toshihiro Takami , Masahiko Wanibuchi ·

YOU? · · 2023 · Open Access · · DOI: https://doi.org/10.1093/noajnl/vdad141.090

BACKGROUND Boron Neutron Capture Therapy (BNCT) is a particle beam therapy that can target at the cellular level. This study evaluated the effectiveness of BNCT on spinal cord gliomas using animal models. METHODS F98 rat glioma or 9L rat gliosarcoma cell lines were implanted in rats' spinal cords to create a model. BPA, a boron compound, was administered and the biodistribution compared. Neutron irradiation was performed post-BPA injection, and the effectiveness was evaluated by survival period and hindlimb muscle strength using the Basso-Bresnahan-Beattie (BBB) score. RESULTS Significant boron accumulation was observed in tumors. In irradiation experiments, the BNCT group showed suppressed BBB score decrease and a significantly extended survival period compared to other groups. No cases of death or lower limb function decline were observed in the sham-BNCT group. CONCLUSION BNCT for spinal cord gliomas was shown to be safe and effective. The spinal cord is an organ at risk in irradiation for spinal cord and spine tumors. As it has a history of being a safety evaluation organ when applying BNCT to the central nervous system, BNCT may be applicable to cases such as recurrence after radiation therapy.

Related Topics

Concepts

Spinal cord Medicine Nuclear medicine Glioma Hindlimb Animal model Radiation therapy Radiology Internal medicine Cancer research Psychiatry

Metadata

Type: article
Language: en
Landing Page: https://doi.org/10.1093/noajnl/vdad141.090
PDF: https://academic.oup.com/noa/article-pdf/5/Supplement_5/v22/54205100/vdad141.090.pdf
OA Status: gold
Related Works: 10
OpenAlex ID: https://openalex.org/W4389515890

All OpenAlex metadata

Raw OpenAlex JSON

OpenAlex ID: https://openalex.org/W4389515890

Canonical identifier for this work in OpenAlex
DOI: https://doi.org/10.1093/noajnl/vdad141.090

Digital Object Identifier
Title: 10235-TB-9 TRANSLATIONAL RESEARCH OF BORON NEUTRON CAPTURE THERAPY FOR SPINAL CORD AND SPINE TUMOR IN ANIMAL MODELS

Work title
Type: article

OpenAlex work type
Language: en

Primary language
Publication year: 2023

Year of publication
Publication date: 2023-12-01

Full publication date if available
Authors: Yoshiki Fujikawa, Shinji Kawabata, Ryo Kayama, Kohei Tsujino, Hideki Kashiwagi, Yusuke Fukuo, Ryo Hiramatsu, Takushi Takata, Hiroki Tanaka, Minoru Suzuki, Naonori Hu, Shin‐Ichi Miyatake, Toshihiro Takami, Masahiko Wanibuchi

List of authors in order
Landing page: https://doi.org/10.1093/noajnl/vdad141.090

Publisher landing page
PDF URL: https://academic.oup.com/noa/article-pdf/5/Supplement_5/v22/54205100/vdad141.090.pdf

Direct link to full text PDF
Open access: Yes

Whether a free full text is available
OA status: gold

Open access status per OpenAlex
OA URL: https://academic.oup.com/noa/article-pdf/5/Supplement_5/v22/54205100/vdad141.090.pdf

Direct OA link when available
Concepts: Spinal cord, Medicine, Nuclear medicine, Glioma, Hindlimb, Animal model, Radiation therapy, Radiology, Internal medicine, Cancer research, Psychiatry

Top concepts (fields/topics) attached by OpenAlex
Cited by: 0

Total citation count in OpenAlex
Related works (count): 10

Other works algorithmically related by OpenAlex

Full payload

id	https://openalex.org/W4389515890
doi	https://doi.org/10.1093/noajnl/vdad141.090
ids.doi	https://doi.org/10.1093/noajnl/vdad141.090
ids.openalex	https://openalex.org/W4389515890
fwci	0.0
type	article
title	10235-TB-9 TRANSLATIONAL RESEARCH OF BORON NEUTRON CAPTURE THERAPY FOR SPINAL CORD AND SPINE TUMOR IN ANIMAL MODELS
biblio.issue	Supplement_5
biblio.volume	5
biblio.last_page	v23
biblio.first_page	v22
topics[0].id	https://openalex.org/T12055
topics[0].field.id	https://openalex.org/fields/27
topics[0].field.display_name	Medicine
topics[0].score	0.9994000196456909
topics[0].domain.id	https://openalex.org/domains/4
topics[0].domain.display_name	Health Sciences
topics[0].subfield.id	https://openalex.org/subfields/2741
topics[0].subfield.display_name	Radiology, Nuclear Medicine and Imaging
topics[0].display_name	Boron Compounds in Chemistry
topics[1].id	https://openalex.org/T11949
topics[1].field.id	https://openalex.org/fields/31
topics[1].field.display_name	Physics and Astronomy
topics[1].score	0.9575999975204468
topics[1].domain.id	https://openalex.org/domains/3
topics[1].domain.display_name	Physical Sciences
topics[1].subfield.id	https://openalex.org/subfields/3108
topics[1].subfield.display_name	Radiation
topics[1].display_name	Nuclear Physics and Applications
is_xpac	False
apc_list.value	1622
apc_list.currency	GBP
apc_list.value_usd	1989
apc_paid.value	1622
apc_paid.currency	GBP
apc_paid.value_usd	1989
concepts[0].id	https://openalex.org/C2780775167
concepts[0].level	2
concepts[0].score	0.8234409093856812
concepts[0].wikidata	https://www.wikidata.org/wiki/Q9606
concepts[0].display_name	Spinal cord
concepts[1].id	https://openalex.org/C71924100
concepts[1].level	0
concepts[1].score	0.7560439109802246
concepts[1].wikidata	https://www.wikidata.org/wiki/Q11190
concepts[1].display_name	Medicine
concepts[2].id	https://openalex.org/C2989005
concepts[2].level	1
concepts[2].score	0.5320203304290771
concepts[2].wikidata	https://www.wikidata.org/wiki/Q214963
concepts[2].display_name	Nuclear medicine
concepts[3].id	https://openalex.org/C2778227246
concepts[3].level	2
concepts[3].score	0.5186078548431396
concepts[3].wikidata	https://www.wikidata.org/wiki/Q1365309
concepts[3].display_name	Glioma
concepts[4].id	https://openalex.org/C51738704
concepts[4].level	2
concepts[4].score	0.5070157051086426
concepts[4].wikidata	https://www.wikidata.org/wiki/Q5766112
concepts[4].display_name	Hindlimb
concepts[5].id	https://openalex.org/C2778117688
concepts[5].level	2
concepts[5].score	0.5045062303543091
concepts[5].wikidata	https://www.wikidata.org/wiki/Q264024
concepts[5].display_name	Animal model
concepts[6].id	https://openalex.org/C509974204
concepts[6].level	2
concepts[6].score	0.49978160858154297
concepts[6].wikidata	https://www.wikidata.org/wiki/Q180507
concepts[6].display_name	Radiation therapy
concepts[7].id	https://openalex.org/C126838900
concepts[7].level	1
concepts[7].score	0.23049986362457275
concepts[7].wikidata	https://www.wikidata.org/wiki/Q77604
concepts[7].display_name	Radiology
concepts[8].id	https://openalex.org/C126322002
concepts[8].level	1
concepts[8].score	0.15470632910728455
concepts[8].wikidata	https://www.wikidata.org/wiki/Q11180
concepts[8].display_name	Internal medicine
concepts[9].id	https://openalex.org/C502942594
concepts[9].level	1
concepts[9].score	0.1388566792011261
concepts[9].wikidata	https://www.wikidata.org/wiki/Q3421914
concepts[9].display_name	Cancer research
concepts[10].id	https://openalex.org/C118552586
concepts[10].level	1
concepts[10].score	0.0
concepts[10].wikidata	https://www.wikidata.org/wiki/Q7867
concepts[10].display_name	Psychiatry
keywords[0].id	https://openalex.org/keywords/spinal-cord
keywords[0].score	0.8234409093856812
keywords[0].display_name	Spinal cord
keywords[1].id	https://openalex.org/keywords/medicine
keywords[1].score	0.7560439109802246
keywords[1].display_name	Medicine
keywords[2].id	https://openalex.org/keywords/nuclear-medicine
keywords[2].score	0.5320203304290771
keywords[2].display_name	Nuclear medicine
keywords[3].id	https://openalex.org/keywords/glioma
keywords[3].score	0.5186078548431396
keywords[3].display_name	Glioma
keywords[4].id	https://openalex.org/keywords/hindlimb
keywords[4].score	0.5070157051086426
keywords[4].display_name	Hindlimb
keywords[5].id	https://openalex.org/keywords/animal-model
keywords[5].score	0.5045062303543091
keywords[5].display_name	Animal model
keywords[6].id	https://openalex.org/keywords/radiation-therapy
keywords[6].score	0.49978160858154297
keywords[6].display_name	Radiation therapy
keywords[7].id	https://openalex.org/keywords/radiology
keywords[7].score	0.23049986362457275
keywords[7].display_name	Radiology
keywords[8].id	https://openalex.org/keywords/internal-medicine
keywords[8].score	0.15470632910728455
keywords[8].display_name	Internal medicine
keywords[9].id	https://openalex.org/keywords/cancer-research
keywords[9].score	0.1388566792011261
keywords[9].display_name	Cancer research
language	en
locations[0].id	doi:10.1093/noajnl/vdad141.090
locations[0].is_oa	True
locations[0].source.id	https://openalex.org/S4210237914
locations[0].source.issn	2632-2498
locations[0].source.type	journal
locations[0].source.is_oa	True
locations[0].source.issn_l	2632-2498
locations[0].source.is_core	True
locations[0].source.is_in_doaj	True
locations[0].source.display_name	Neuro-Oncology Advances
locations[0].source.host_organization	https://openalex.org/P4310311648
locations[0].source.host_organization_name	Oxford University Press
locations[0].source.host_organization_lineage	https://openalex.org/P4310311648
locations[0].license	cc-by-nc
locations[0].pdf_url	https://academic.oup.com/noa/article-pdf/5/Supplement_5/v22/54205100/vdad141.090.pdf
locations[0].version	publishedVersion
locations[0].raw_type	journal-article
locations[0].license_id	https://openalex.org/licenses/cc-by-nc
locations[0].is_accepted	True
locations[0].is_published	True
locations[0].raw_source_name	Neuro-Oncology Advances
locations[0].landing_page_url	https://doi.org/10.1093/noajnl/vdad141.090
locations[1].id	pmh:oai:pubmedcentral.nih.gov:10710614
locations[1].is_oa	True
locations[1].source.id	https://openalex.org/S2764455111
locations[1].source.issn
locations[1].source.type	repository
locations[1].source.is_oa	False
locations[1].source.issn_l
locations[1].source.is_core	False
locations[1].source.is_in_doaj	False
locations[1].source.display_name	PubMed Central
locations[1].source.host_organization	https://openalex.org/I1299303238
locations[1].source.host_organization_name	National Institutes of Health
locations[1].source.host_organization_lineage	https://openalex.org/I1299303238
locations[1].license	cc-by-nc
locations[1].pdf_url	https://pmc.ncbi.nlm.nih.gov/articles/PMC10710614/pdf/vdad141.090.pdf
locations[1].version	submittedVersion
locations[1].raw_type	Text
locations[1].license_id	https://openalex.org/licenses/cc-by-nc
locations[1].is_accepted	False
locations[1].is_published	False
locations[1].raw_source_name	Neurooncol Adv
locations[1].landing_page_url	https://www.ncbi.nlm.nih.gov/pmc/articles/10710614
indexed_in	crossref, doaj
authorships[0].author.id	https://openalex.org/A5040178553
authorships[0].author.orcid	https://orcid.org/0000-0002-7672-9266
authorships[0].author.display_name	Yoshiki Fujikawa
authorships[0].countries	JP
authorships[0].affiliations[0].institution_ids	https://openalex.org/I90237989
authorships[0].affiliations[0].raw_affiliation_string	Department of Neurosurgery, Osaka Medical and Pharmaceutical University , Osaka , Japan
authorships[0].institutions[0].id	https://openalex.org/I90237989
authorships[0].institutions[0].ror	https://ror.org/029yaft79
authorships[0].institutions[0].type	education
authorships[0].institutions[0].lineage	https://openalex.org/I90237989
authorships[0].institutions[0].country_code	JP
authorships[0].institutions[0].display_name	Osaka University of Pharmaceutical Sciences
authorships[0].author_position	first
authorships[0].raw_author_name	Yoshiki Fujikawa
authorships[0].is_corresponding	False
authorships[0].raw_affiliation_strings	Department of Neurosurgery, Osaka Medical and Pharmaceutical University , Osaka , Japan
authorships[1].author.id	https://openalex.org/A5008787851
authorships[1].author.orcid	https://orcid.org/0000-0001-5007-5279
authorships[1].author.display_name	Shinji Kawabata
authorships[1].countries	JP
authorships[1].affiliations[0].institution_ids	https://openalex.org/I90237989
authorships[1].affiliations[0].raw_affiliation_string	Department of Neurosurgery, Osaka Medical and Pharmaceutical University , Osaka , Japan
authorships[1].institutions[0].id	https://openalex.org/I90237989
authorships[1].institutions[0].ror	https://ror.org/029yaft79
authorships[1].institutions[0].type	education
authorships[1].institutions[0].lineage	https://openalex.org/I90237989
authorships[1].institutions[0].country_code	JP
authorships[1].institutions[0].display_name	Osaka University of Pharmaceutical Sciences
authorships[1].author_position	middle
authorships[1].raw_author_name	Shinji Kawabata
authorships[1].is_corresponding	False
authorships[1].raw_affiliation_strings	Department of Neurosurgery, Osaka Medical and Pharmaceutical University , Osaka , Japan
authorships[2].author.id	https://openalex.org/A5060486354
authorships[2].author.orcid
authorships[2].author.display_name	Ryo Kayama
authorships[2].countries	JP
authorships[2].affiliations[0].institution_ids	https://openalex.org/I90237989
authorships[2].affiliations[0].raw_affiliation_string	Department of Neurosurgery, Osaka Medical and Pharmaceutical University , Osaka , Japan
authorships[2].institutions[0].id	https://openalex.org/I90237989
authorships[2].institutions[0].ror	https://ror.org/029yaft79
authorships[2].institutions[0].type	education
authorships[2].institutions[0].lineage	https://openalex.org/I90237989
authorships[2].institutions[0].country_code	JP
authorships[2].institutions[0].display_name	Osaka University of Pharmaceutical Sciences
authorships[2].author_position	middle
authorships[2].raw_author_name	Ryo Kayama
authorships[2].is_corresponding	False
authorships[2].raw_affiliation_strings	Department of Neurosurgery, Osaka Medical and Pharmaceutical University , Osaka , Japan
authorships[3].author.id	https://openalex.org/A5086446276
authorships[3].author.orcid	https://orcid.org/0000-0002-2274-3214
authorships[3].author.display_name	Kohei Tsujino
authorships[3].countries	JP
authorships[3].affiliations[0].institution_ids	https://openalex.org/I90237989
authorships[3].affiliations[0].raw_affiliation_string	Department of Neurosurgery, Osaka Medical and Pharmaceutical University , Osaka , Japan
authorships[3].institutions[0].id	https://openalex.org/I90237989
authorships[3].institutions[0].ror	https://ror.org/029yaft79
authorships[3].institutions[0].type	education
authorships[3].institutions[0].lineage	https://openalex.org/I90237989
authorships[3].institutions[0].country_code	JP
authorships[3].institutions[0].display_name	Osaka University of Pharmaceutical Sciences
authorships[3].author_position	middle
authorships[3].raw_author_name	Kohei Tsujino
authorships[3].is_corresponding	False
authorships[3].raw_affiliation_strings	Department of Neurosurgery, Osaka Medical and Pharmaceutical University , Osaka , Japan
authorships[4].author.id	https://openalex.org/A5061169656
authorships[4].author.orcid	https://orcid.org/0000-0003-3192-4065
authorships[4].author.display_name	Hideki Kashiwagi
authorships[4].countries	JP
authorships[4].affiliations[0].institution_ids	https://openalex.org/I90237989
authorships[4].affiliations[0].raw_affiliation_string	Department of Neurosurgery, Osaka Medical and Pharmaceutical University , Osaka , Japan
authorships[4].institutions[0].id	https://openalex.org/I90237989
authorships[4].institutions[0].ror	https://ror.org/029yaft79
authorships[4].institutions[0].type	education
authorships[4].institutions[0].lineage	https://openalex.org/I90237989
authorships[4].institutions[0].country_code	JP
authorships[4].institutions[0].display_name	Osaka University of Pharmaceutical Sciences
authorships[4].author_position	middle
authorships[4].raw_author_name	Hideki Kashiwagi
authorships[4].is_corresponding	False
authorships[4].raw_affiliation_strings	Department of Neurosurgery, Osaka Medical and Pharmaceutical University , Osaka , Japan
authorships[5].author.id	https://openalex.org/A5044786418
authorships[5].author.orcid	https://orcid.org/0000-0002-6395-2215
authorships[5].author.display_name	Yusuke Fukuo
authorships[5].countries	JP
authorships[5].affiliations[0].institution_ids	https://openalex.org/I90237989
authorships[5].affiliations[0].raw_affiliation_string	Department of Neurosurgery, Osaka Medical and Pharmaceutical University , Osaka , Japan
authorships[5].institutions[0].id	https://openalex.org/I90237989
authorships[5].institutions[0].ror	https://ror.org/029yaft79
authorships[5].institutions[0].type	education
authorships[5].institutions[0].lineage	https://openalex.org/I90237989
authorships[5].institutions[0].country_code	JP
authorships[5].institutions[0].display_name	Osaka University of Pharmaceutical Sciences
authorships[5].author_position	middle
authorships[5].raw_author_name	Yusuke Fukuo
authorships[5].is_corresponding	False
authorships[5].raw_affiliation_strings	Department of Neurosurgery, Osaka Medical and Pharmaceutical University , Osaka , Japan
authorships[6].author.id	https://openalex.org/A5067212232
authorships[6].author.orcid	https://orcid.org/0000-0002-5581-5472
authorships[6].author.display_name	Ryo Hiramatsu
authorships[6].countries	JP
authorships[6].affiliations[0].institution_ids	https://openalex.org/I90237989
authorships[6].affiliations[0].raw_affiliation_string	Department of Neurosurgery, Osaka Medical and Pharmaceutical University , Osaka , Japan
authorships[6].institutions[0].id	https://openalex.org/I90237989
authorships[6].institutions[0].ror	https://ror.org/029yaft79
authorships[6].institutions[0].type	education
authorships[6].institutions[0].lineage	https://openalex.org/I90237989
authorships[6].institutions[0].country_code	JP
authorships[6].institutions[0].display_name	Osaka University of Pharmaceutical Sciences
authorships[6].author_position	middle
authorships[6].raw_author_name	Ryo Hiramatsu
authorships[6].is_corresponding	False
authorships[6].raw_affiliation_strings	Department of Neurosurgery, Osaka Medical and Pharmaceutical University , Osaka , Japan
authorships[7].author.id	https://openalex.org/A5101875690
authorships[7].author.orcid	https://orcid.org/0000-0001-6436-6130
authorships[7].author.display_name	Takushi Takata
authorships[7].countries	JP
authorships[7].affiliations[0].institution_ids	https://openalex.org/I22299242
authorships[7].affiliations[0].raw_affiliation_string	Institute for Integrated Radiation and Nuclear Science, Kyoto University , Osaka , Japan
authorships[7].institutions[0].id	https://openalex.org/I22299242
authorships[7].institutions[0].ror	https://ror.org/02kpeqv85
authorships[7].institutions[0].type	education
authorships[7].institutions[0].lineage	https://openalex.org/I22299242
authorships[7].institutions[0].country_code	JP
authorships[7].institutions[0].display_name	Kyoto University
authorships[7].author_position	middle
authorships[7].raw_author_name	Takushi Takata
authorships[7].is_corresponding	False
authorships[7].raw_affiliation_strings	Institute for Integrated Radiation and Nuclear Science, Kyoto University , Osaka , Japan
authorships[8].author.id	https://openalex.org/A5075497120
authorships[8].author.orcid	https://orcid.org/0000-0002-6195-3177
authorships[8].author.display_name	Hiroki Tanaka
authorships[8].countries	JP
authorships[8].affiliations[0].institution_ids	https://openalex.org/I22299242
authorships[8].affiliations[0].raw_affiliation_string	Institute for Integrated Radiation and Nuclear Science, Kyoto University , Osaka , Japan
authorships[8].institutions[0].id	https://openalex.org/I22299242
authorships[8].institutions[0].ror	https://ror.org/02kpeqv85
authorships[8].institutions[0].type	education
authorships[8].institutions[0].lineage	https://openalex.org/I22299242
authorships[8].institutions[0].country_code	JP
authorships[8].institutions[0].display_name	Kyoto University
authorships[8].author_position	middle
authorships[8].raw_author_name	Hiroki Tanaka
authorships[8].is_corresponding	False
authorships[8].raw_affiliation_strings	Institute for Integrated Radiation and Nuclear Science, Kyoto University , Osaka , Japan
authorships[9].author.id	https://openalex.org/A5077846797
authorships[9].author.orcid	https://orcid.org/0000-0002-5421-9417
authorships[9].author.display_name	Minoru Suzuki
authorships[9].countries	JP
authorships[9].affiliations[0].institution_ids	https://openalex.org/I22299242
authorships[9].affiliations[0].raw_affiliation_string	Institute for Integrated Radiation and Nuclear Science, Kyoto University , Osaka , Japan
authorships[9].institutions[0].id	https://openalex.org/I22299242
authorships[9].institutions[0].ror	https://ror.org/02kpeqv85
authorships[9].institutions[0].type	education
authorships[9].institutions[0].lineage	https://openalex.org/I22299242
authorships[9].institutions[0].country_code	JP
authorships[9].institutions[0].display_name	Kyoto University
authorships[9].author_position	middle
authorships[9].raw_author_name	Minoru Suzuki
authorships[9].is_corresponding	False
authorships[9].raw_affiliation_strings	Institute for Integrated Radiation and Nuclear Science, Kyoto University , Osaka , Japan
authorships[10].author.id	https://openalex.org/A5008733751
authorships[10].author.orcid	https://orcid.org/0000-0003-2702-3344
authorships[10].author.display_name	Naonori Hu
authorships[10].countries	JP
authorships[10].affiliations[0].institution_ids	https://openalex.org/I90237989
authorships[10].affiliations[0].raw_affiliation_string	Kansai BNCT Medical Center, Osaka Medical and Pharmaceutical University , Osaka , Japan
authorships[10].institutions[0].id	https://openalex.org/I90237989
authorships[10].institutions[0].ror	https://ror.org/029yaft79
authorships[10].institutions[0].type	education
authorships[10].institutions[0].lineage	https://openalex.org/I90237989
authorships[10].institutions[0].country_code	JP
authorships[10].institutions[0].display_name	Osaka University of Pharmaceutical Sciences
authorships[10].author_position	middle
authorships[10].raw_author_name	Naonori Hu
authorships[10].is_corresponding	False
authorships[10].raw_affiliation_strings	Kansai BNCT Medical Center, Osaka Medical and Pharmaceutical University , Osaka , Japan
authorships[11].author.id	https://openalex.org/A5089261199
authorships[11].author.orcid	https://orcid.org/0000-0001-8056-1016
authorships[11].author.display_name	Shin‐Ichi Miyatake
authorships[11].countries	JP
authorships[11].affiliations[0].institution_ids	https://openalex.org/I90237989
authorships[11].affiliations[0].raw_affiliation_string	Kansai BNCT Medical Center, Osaka Medical and Pharmaceutical University , Osaka , Japan
authorships[11].institutions[0].id	https://openalex.org/I90237989
authorships[11].institutions[0].ror	https://ror.org/029yaft79
authorships[11].institutions[0].type	education
authorships[11].institutions[0].lineage	https://openalex.org/I90237989
authorships[11].institutions[0].country_code	JP
authorships[11].institutions[0].display_name	Osaka University of Pharmaceutical Sciences
authorships[11].author_position	middle
authorships[11].raw_author_name	Shin-Ichi Miyatake
authorships[11].is_corresponding	False
authorships[11].raw_affiliation_strings	Kansai BNCT Medical Center, Osaka Medical and Pharmaceutical University , Osaka , Japan
authorships[12].author.id	https://openalex.org/A5082441413
authorships[12].author.orcid	https://orcid.org/0000-0002-1816-2724
authorships[12].author.display_name	Toshihiro Takami
authorships[12].countries	JP
authorships[12].affiliations[0].institution_ids	https://openalex.org/I90237989
authorships[12].affiliations[0].raw_affiliation_string	Department of Neurosurgery, Osaka Medical and Pharmaceutical University , Osaka , Japan
authorships[12].institutions[0].id	https://openalex.org/I90237989
authorships[12].institutions[0].ror	https://ror.org/029yaft79
authorships[12].institutions[0].type	education
authorships[12].institutions[0].lineage	https://openalex.org/I90237989
authorships[12].institutions[0].country_code	JP
authorships[12].institutions[0].display_name	Osaka University of Pharmaceutical Sciences
authorships[12].author_position	middle
authorships[12].raw_author_name	Toshihiro Takami
authorships[12].is_corresponding	False
authorships[12].raw_affiliation_strings	Department of Neurosurgery, Osaka Medical and Pharmaceutical University , Osaka , Japan
authorships[13].author.id	https://openalex.org/A5069059367
authorships[13].author.orcid	https://orcid.org/0000-0002-1856-7123
authorships[13].author.display_name	Masahiko Wanibuchi
authorships[13].countries	JP
authorships[13].affiliations[0].institution_ids	https://openalex.org/I90237989
authorships[13].affiliations[0].raw_affiliation_string	Department of Neurosurgery, Osaka Medical and Pharmaceutical University , Osaka , Japan
authorships[13].institutions[0].id	https://openalex.org/I90237989
authorships[13].institutions[0].ror	https://ror.org/029yaft79
authorships[13].institutions[0].type	education
authorships[13].institutions[0].lineage	https://openalex.org/I90237989
authorships[13].institutions[0].country_code	JP
authorships[13].institutions[0].display_name	Osaka University of Pharmaceutical Sciences
authorships[13].author_position	last
authorships[13].raw_author_name	Masahiko Wanibuchi
authorships[13].is_corresponding	False
authorships[13].raw_affiliation_strings	Department of Neurosurgery, Osaka Medical and Pharmaceutical University , Osaka , Japan
has_content.pdf	True
has_content.grobid_xml	True
is_paratext	False
open_access.is_oa	True
open_access.oa_url	https://academic.oup.com/noa/article-pdf/5/Supplement_5/v22/54205100/vdad141.090.pdf
open_access.oa_status	gold
open_access.any_repository_has_fulltext	False
created_date	2025-10-10T00:00:00
display_name	10235-TB-9 TRANSLATIONAL RESEARCH OF BORON NEUTRON CAPTURE THERAPY FOR SPINAL CORD AND SPINE TUMOR IN ANIMAL MODELS
has_fulltext	True
is_retracted	False
updated_date	2025-11-06T03:46:38.306776
primary_topic.id	https://openalex.org/T12055
primary_topic.field.id	https://openalex.org/fields/27
primary_topic.field.display_name	Medicine
primary_topic.score	0.9994000196456909
primary_topic.domain.id	https://openalex.org/domains/4
primary_topic.domain.display_name	Health Sciences
primary_topic.subfield.id	https://openalex.org/subfields/2741
primary_topic.subfield.display_name	Radiology, Nuclear Medicine and Imaging
primary_topic.display_name	Boron Compounds in Chemistry
related_works	https://openalex.org/W2234322404, https://openalex.org/W3208778134, https://openalex.org/W3005931108, https://openalex.org/W2063133063, https://openalex.org/W2087719526, https://openalex.org/W4386951147, https://openalex.org/W4223451915, https://openalex.org/W2887359201, https://openalex.org/W4308767530, https://openalex.org/W4220833452
cited_by_count	0
locations_count	2
best_oa_location.id	doi:10.1093/noajnl/vdad141.090
best_oa_location.is_oa	True
best_oa_location.source.id	https://openalex.org/S4210237914
best_oa_location.source.issn	2632-2498
best_oa_location.source.type	journal
best_oa_location.source.is_oa	True
best_oa_location.source.issn_l	2632-2498
best_oa_location.source.is_core	True
best_oa_location.source.is_in_doaj	True
best_oa_location.source.display_name	Neuro-Oncology Advances
best_oa_location.source.host_organization	https://openalex.org/P4310311648
best_oa_location.source.host_organization_name	Oxford University Press
best_oa_location.source.host_organization_lineage	https://openalex.org/P4310311648
best_oa_location.license	cc-by-nc
best_oa_location.pdf_url	https://academic.oup.com/noa/article-pdf/5/Supplement_5/v22/54205100/vdad141.090.pdf
best_oa_location.version	publishedVersion
best_oa_location.raw_type	journal-article
best_oa_location.license_id	https://openalex.org/licenses/cc-by-nc
best_oa_location.is_accepted	True
best_oa_location.is_published	True
best_oa_location.raw_source_name	Neuro-Oncology Advances
best_oa_location.landing_page_url	https://doi.org/10.1093/noajnl/vdad141.090
primary_location.id	doi:10.1093/noajnl/vdad141.090
primary_location.is_oa	True
primary_location.source.id	https://openalex.org/S4210237914
primary_location.source.issn	2632-2498
primary_location.source.type	journal
primary_location.source.is_oa	True
primary_location.source.issn_l	2632-2498
primary_location.source.is_core	True
primary_location.source.is_in_doaj	True
primary_location.source.display_name	Neuro-Oncology Advances
primary_location.source.host_organization	https://openalex.org/P4310311648
primary_location.source.host_organization_name	Oxford University Press
primary_location.source.host_organization_lineage	https://openalex.org/P4310311648
primary_location.license	cc-by-nc
primary_location.pdf_url	https://academic.oup.com/noa/article-pdf/5/Supplement_5/v22/54205100/vdad141.090.pdf
primary_location.version	publishedVersion
primary_location.raw_type	journal-article
primary_location.license_id	https://openalex.org/licenses/cc-by-nc
primary_location.is_accepted	True
primary_location.is_published	True
primary_location.raw_source_name	Neuro-Oncology Advances
primary_location.landing_page_url	https://doi.org/10.1093/noajnl/vdad141.090
publication_date	2023-12-01
publication_year	2023
referenced_works_count	0
abstract_inverted_index.a	8, 51, 54, 106, 162, 166
abstract_inverted_index.9L	38
abstract_inverted_index.As	159
abstract_inverted_index.In	94
abstract_inverted_index.No	115
abstract_inverted_index.an	147
abstract_inverted_index.as	185
abstract_inverted_index.at	15, 149
abstract_inverted_index.be	139, 180
abstract_inverted_index.by	74
abstract_inverted_index.in	45, 92, 126, 151
abstract_inverted_index.is	7, 146
abstract_inverted_index.it	160
abstract_inverted_index.of	24, 117, 164
abstract_inverted_index.on	26
abstract_inverted_index.or	37, 119
abstract_inverted_index.to	49, 112, 138, 173, 182
abstract_inverted_index.BBB	102
abstract_inverted_index.F98	34
abstract_inverted_index.The	143
abstract_inverted_index.and	59, 69, 77, 105, 141, 156
abstract_inverted_index.can	13
abstract_inverted_index.for	132, 153
abstract_inverted_index.has	161
abstract_inverted_index.may	179
abstract_inverted_index.rat	35, 39
abstract_inverted_index.the	16, 22, 60, 70, 82, 97, 127, 174
abstract_inverted_index.was	57, 65, 72, 90, 136
abstract_inverted_index.BNCT	25, 98, 131, 172, 178
abstract_inverted_index.BPA,	53
abstract_inverted_index.This	19
abstract_inverted_index.beam	10
abstract_inverted_index.cell	41
abstract_inverted_index.cord	28, 134, 145, 155
abstract_inverted_index.limb	121
abstract_inverted_index.risk	150
abstract_inverted_index.safe	140
abstract_inverted_index.such	184
abstract_inverted_index.that	12
abstract_inverted_index.were	43, 124
abstract_inverted_index.when	170
abstract_inverted_index.(BBB)	84
abstract_inverted_index.Boron	2
abstract_inverted_index.after	187
abstract_inverted_index.being	165
abstract_inverted_index.boron	55, 88
abstract_inverted_index.cases	116, 183
abstract_inverted_index.cords	48
abstract_inverted_index.death	118
abstract_inverted_index.group	99
abstract_inverted_index.lines	42
abstract_inverted_index.lower	120
abstract_inverted_index.organ	148, 169
abstract_inverted_index.other	113
abstract_inverted_index.rats'	46
abstract_inverted_index.score	103
abstract_inverted_index.shown	137
abstract_inverted_index.spine	157
abstract_inverted_index.study	20
abstract_inverted_index.using	30, 81
abstract_inverted_index.(BNCT)	6
abstract_inverted_index.animal	31
abstract_inverted_index.create	50
abstract_inverted_index.glioma	36
abstract_inverted_index.group.	129
abstract_inverted_index.level.	18
abstract_inverted_index.model.	52
abstract_inverted_index.muscle	79
abstract_inverted_index.period	76, 110
abstract_inverted_index.safety	167
abstract_inverted_index.score.	85
abstract_inverted_index.showed	100
abstract_inverted_index.spinal	27, 47, 133, 144, 154
abstract_inverted_index.target	14
abstract_inverted_index.Capture	4
abstract_inverted_index.METHODS	33
abstract_inverted_index.Neutron	3, 63
abstract_inverted_index.RESULTS	86
abstract_inverted_index.Therapy	5
abstract_inverted_index.central	175
abstract_inverted_index.decline	123
abstract_inverted_index.gliomas	29, 135
abstract_inverted_index.groups.	114
abstract_inverted_index.history	163
abstract_inverted_index.models.	32
abstract_inverted_index.nervous	176
abstract_inverted_index.system,	177
abstract_inverted_index.therapy	11
abstract_inverted_index.tumors.	93, 158
abstract_inverted_index.Abstract	0
abstract_inverted_index.applying	171
abstract_inverted_index.cellular	17
abstract_inverted_index.compared	111
abstract_inverted_index.decrease	104
abstract_inverted_index.extended	108
abstract_inverted_index.function	122
abstract_inverted_index.hindlimb	78
abstract_inverted_index.observed	91, 125
abstract_inverted_index.particle	9
abstract_inverted_index.post-BPA	67
abstract_inverted_index.strength	80
abstract_inverted_index.survival	75, 109
abstract_inverted_index.therapy.	189
abstract_inverted_index.compared.	62
abstract_inverted_index.compound,	56
abstract_inverted_index.evaluated	21, 73
abstract_inverted_index.implanted	44
abstract_inverted_index.performed	66
abstract_inverted_index.radiation	188
abstract_inverted_index.sham-BNCT	128
abstract_inverted_index.BACKGROUND	1
abstract_inverted_index.CONCLUSION	130
abstract_inverted_index.applicable	181
abstract_inverted_index.effective.	142
abstract_inverted_index.evaluation	168
abstract_inverted_index.injection,	68
abstract_inverted_index.recurrence	186
abstract_inverted_index.suppressed	101
abstract_inverted_index.Significant	87
abstract_inverted_index.gliosarcoma	40
abstract_inverted_index.irradiation	64, 95, 152
abstract_inverted_index.accumulation	89
abstract_inverted_index.administered	58
abstract_inverted_index.experiments,	96
abstract_inverted_index.effectiveness	23, 71
abstract_inverted_index.significantly	107
abstract_inverted_index.biodistribution	61
abstract_inverted_index.Basso-Bresnahan-Beattie	83
cited_by_percentile_year
countries_distinct_count	1
institutions_distinct_count	14
sustainable_development_goals[0].id	https://metadata.un.org/sdg/3
sustainable_development_goals[0].score	0.800000011920929
sustainable_development_goals[0].display_name	Good health and well-being
citation_normalized_percentile.value	0.38909228
citation_normalized_percentile.is_in_top_1_percent	False
citation_normalized_percentile.is_in_top_10_percent	False