1,2-Aminosulfonylation of Alkenes via Photoexcited Cu(I)- Sub-strate Complex: A Three-Component Coupling Approach Article Swipe
P. Das
,
Marco A. Henríquez
,
Camilo Verdugo
,
Alan R. Cabrera
,
Oliver Reiser
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.26434/chemrxiv-2025-c8mdb
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.26434/chemrxiv-2025-c8mdb
We report a Cu(I)-photocatalyzed three-component coupling process to achieve the regioselective, vicinal 1,2-aminosulfonylations of alkenes. The critical aspect of this methodology is found in the utilization of in situ generated photoactive Cu(I)-amine substrate com-plexes, which facilitate the formal oxidation of Cu(I) to Cu(III) in a stepwise manner. In this way, the conceivable two-component chlorosulfonylation of alkenes is effectively suppressed, allowing the combination of styrenes, sulfonyl chlorides, and amines. Further-more, this protocol can be used to facilitate late-stage functionalization, thereby enabling the diversification of biomolecules
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- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.26434/chemrxiv-2025-c8mdb
- OA Status
- gold
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4409172769
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Raw OpenAlex JSON
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https://openalex.org/W4409172769Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.26434/chemrxiv-2025-c8mdbDigital Object Identifier
- Title
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1,2-Aminosulfonylation of Alkenes via Photoexcited Cu(I)- Sub-strate Complex: A Three-Component Coupling ApproachWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-04-04Full publication date if available
- Authors
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P. Das, Marco A. Henríquez, Camilo Verdugo, Alan R. Cabrera, Oliver ReiserList of authors in order
- Landing page
-
https://doi.org/10.26434/chemrxiv-2025-c8mdbPublisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.26434/chemrxiv-2025-c8mdbDirect OA link when available
- Concepts
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Component (thermodynamics), Coupling (piping), Chemistry, Physics, Materials science, Quantum mechanics, MetallurgyTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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