1282 Morning Bright Light Therapy Improves Sleep and Systemic Inflammatory Profiles in Veterans and Non-Veterans with or Without Traumatic Brain Injury Article Swipe
Jessica V. Brewer
,
Jonathan E. Elliott
,
Savanah Sicard
,
Hannah A. Cunningham
,
Andrea Hildebrand
,
Allison Keil
,
Brittany R. Ligman
,
Mohini Bryant‐Ekstrand
,
Jessica Gill
,
Bradley A. Dengler
,
Miranda M. Lim
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1093/sleep/zsaf090.1282
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1093/sleep/zsaf090.1282
Introduction Sleep-wake disturbances frequently present in Veterans with mild traumatic brain injury (mTBI). These TBI-related sleep impairments confer significant burden and commonly exacerbate other functional impairments. Therapies to improve sleep following mTBI are limited and studies in Veterans are even more scarce. In our previous pilot work, morning bright light therapy (MBLT) was found to be a feasible behavioral sleep intervention in Veterans with a history of mTBI; however, this was single-arm, open-label, and non-randomized, and therefore was not intended to establish efficacy. The present study extends this preliminary work as a fully powered, sham-controlled, participant-masked randomized controlled trial. Methods Veterans and non-Veterans with and without TBI were randomized in a 2:1 allocation ratio to: 1) active: MBLT (n=93), and 2) sham: deactivated negative ion generator (n=46); each with identical engagement parameters (60-min duration; within 2-hrs of waking; daily). Participant masking via deception balanced expectancy assumptions across arms. Assessments were completed following a 14-day baseline (pre-intervention), 28-days of device engagement (post-intervention), and 28-days after the post-intervention assessment (follow-up). Outcomes included self-reported sleep (validated questionnaires and a daily sleep diary), objective sleep via wrist-based actigraphy, and peripheral proteomic profiling examining 250 inflammatory and 120 neurodegenerative biomarkers via NUcleic acid Linked Immuno-Sandwich Assay (NULISA) with Next Generation Sequencing. Results MBLT was associated with significant improvements in self-reported sleep (insomnia severity index (14±20%), and increased actigraphy-derived total sleep time (47±65 min). This was associated with increased time in bed (59±67 min), an earlier bedtime (77±125 min) without change in wake time, and corresponding earlier mid-sleep time (37±72 min) consistent with a potential circadian phase advancement. Peripheral plasma assays demonstrate sweeping reductions in ~20 proinflammatory cytokines and several pro-thrombotic clotting factors, as well as relevant neurodegenerative markers (e.g., pTau-217). No changes were observed in the sham arm. Conclusion MBLT improved actigraphy-derived sleep outcomes in Veterans and non-Veterans with and without traumatic brain injury. Objective and subjective sleep, mood, pain management, and blood-based pro-inflammatory cytokines improved post-MBLT intervention. These results lead us to believe that MBLT could be used as a cost-effective and universal support therapy to those with disrupted sleep. Support (if any) Military Traumatic Brain Injury Initiative (309698-7.01-65310), VA (I01RX004822)
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/sleep/zsaf090.1282
- https://academic.oup.com/sleep/article-pdf/48/Supplement_1/A552/63221335/zsaf090.1282.pdf
- OA Status
- bronze
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4410502072
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4410502072Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1093/sleep/zsaf090.1282Digital Object Identifier
- Title
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1282 Morning Bright Light Therapy Improves Sleep and Systemic Inflammatory Profiles in Veterans and Non-Veterans with or Without Traumatic Brain InjuryWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-05-01Full publication date if available
- Authors
-
Jessica V. Brewer, Jonathan E. Elliott, Savanah Sicard, Hannah A. Cunningham, Andrea Hildebrand, Allison Keil, Brittany R. Ligman, Mohini Bryant‐Ekstrand, Jessica Gill, Bradley A. Dengler, Miranda M. LimList of authors in order
- Landing page
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https://doi.org/10.1093/sleep/zsaf090.1282Publisher landing page
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https://academic.oup.com/sleep/article-pdf/48/Supplement_1/A552/63221335/zsaf090.1282.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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bronzeOpen access status per OpenAlex
- OA URL
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https://academic.oup.com/sleep/article-pdf/48/Supplement_1/A552/63221335/zsaf090.1282.pdfDirect OA link when available
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Morning, Medicine, Sleep (system call), Traumatic brain injury, Systemic inflammation, Anesthesia, Internal medicine, Inflammation, Psychiatry, Computer science, Operating systemTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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| display_name | 1282 Morning Bright Light Therapy Improves Sleep and Systemic Inflammatory Profiles in Veterans and Non-Veterans with or Without Traumatic Brain Injury |
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