145P Identification of next generation sequencing (NGS)-based genomic signature predicting resistance to immunotherapy (IO) in patients (pts) with metastatic non-small cell lung cancer (mNSCLC): A single-center cohort study Article Swipe
Antonio Vitale
,
Luca Mastrantoni
,
Francesco Maria Guida
,
Emanuele Vita
,
Alessandro Di Stefani
,
P. Troisi
,
F. Monaca
,
G. Horn
,
G. Trovato
,
J. Russo
,
D. Barone
,
I. Sparagna
,
Mariantonietta Di Salvatore
,
Ettore D’Argento
,
Alessandra Cancellieri
,
Angelo Minucci
,
Giovanni Scambia
,
Rocco Trisolini
,
Giampaolo Tortora
,
Emilio Bria
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1016/j.esmoop.2023.101995
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1016/j.esmoop.2023.101995
IO ± chemotherapy (CT) is first-line therapy for mNSCLC without actionable mutations. We aimed to identify a genomic signature potentially predicting resistance to IO using NGS. Pts with mNSCLC who received IO or CT/IO were eligible. NGS was performed by TSO500HT® assay (DNA [522 genes], RNA [55 genes], Tumor Mutational Burden, Microsatellite Instability) or Oncomine Focus Assay® (DNA, 35 genes) plus Archer's FusionPlex Lung Panel® (RNA, 17 genes), according to quality/quantity cellularity. A least absolute shrinkage and selection operator (LASSO) Cox regression was conducted to choose genes. The correlation between LASSO-selected genes and progression-free survival (PFS) was evaluated by univariable Cox regression. A risk score was derived using regression coefficients of significant genes in the multivariable analysis. Pts were divided into two groups based on the median risk score (0 vs >0). The risk score was evaluated in a multivariable model including clinical features. 56 pts were retrospectively included. 32 (57%) received CT/IO and 23 (43%) IO. Median follow-up was 10.4 months. Among 346 genes, 15 resulted potentially predictive of PFS. At univariable analysis, 6 genes were significantly correlated to PFS: AKT3 (HR 40.39, 95% IC 5.58-292.30, p<0.001), ARID5B (HR 4.98, 95% IC 1.11-22.24, p=0.04), CD276 (HR 14.33, 95% IC 2.60-78.99, p=0.002), PAX8 (HR 8.33, 95% IC 1.78-38.95, p=0.007), PDGFRB (HR 4.88, 95% IC 1.42-16.75, p=0.01) and RICTOR (HR 3.82, 95% IC 1.08-13.57, p=0.04). In the multivariable analysis PAX8 was excluded and a genomic signature with 5 genes was considered. PFS was significantly different in the two risk groups: HR 13.56, 95% IC 5.30-34.67, p<0.001, with a median PFS of 1.64 (95% IC 0.76-NA) vs 13.25 months. (95% IC 10.88-NA). The genomic signature remained prognostic in a multivariable model including age, smoke, histology and regimen (HR 15.71; 95% IC 5.19-47.52, p<0.001). A genomic signature including AKT3, ARID5B, CD276, PDGFRB and RICTOR alterations was significantly associated with shorter PFS in pts receiving IO. Validation in external cohort is ongoing.
Related Topics
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.esmoop.2023.101995
- http://www.esmoopen.com/article/S2059702923012358/pdf
- OA Status
- gold
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4387402150
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4387402150Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1016/j.esmoop.2023.101995Digital Object Identifier
- Title
-
145P Identification of next generation sequencing (NGS)-based genomic signature predicting resistance to immunotherapy (IO) in patients (pts) with metastatic non-small cell lung cancer (mNSCLC): A single-center cohort studyWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-10-01Full publication date if available
- Authors
-
Antonio Vitale, Luca Mastrantoni, Francesco Maria Guida, Emanuele Vita, Alessandro Di Stefani, P. Troisi, F. Monaca, G. Horn, G. Trovato, J. Russo, D. Barone, I. Sparagna, Mariantonietta Di Salvatore, Ettore D’Argento, Alessandra Cancellieri, Angelo Minucci, Giovanni Scambia, Rocco Trisolini, Giampaolo Tortora, Emilio BriaList of authors in order
- Landing page
-
https://doi.org/10.1016/j.esmoop.2023.101995Publisher landing page
- PDF URL
-
https://www.esmoopen.com/article/S2059702923012358/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.esmoopen.com/article/S2059702923012358/pdfDirect OA link when available
- Concepts
-
Medicine, Oncology, Internal medicine, Proportional hazards model, Lung cancerTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4387402150 |
|---|---|
| doi | https://doi.org/10.1016/j.esmoop.2023.101995 |
| ids.doi | https://doi.org/10.1016/j.esmoop.2023.101995 |
| ids.openalex | https://openalex.org/W4387402150 |
| fwci | 0.0 |
| type | article |
| title | 145P Identification of next generation sequencing (NGS)-based genomic signature predicting resistance to immunotherapy (IO) in patients (pts) with metastatic non-small cell lung cancer (mNSCLC): A single-center cohort study |
| biblio.issue | 1 |
| biblio.volume | 8 |
| biblio.last_page | 101995 |
| biblio.first_page | 101995 |
| topics[0].id | https://openalex.org/T11287 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.9803000092506409 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1306 |
| topics[0].subfield.display_name | Cancer Research |
| topics[0].display_name | Cancer Genomics and Diagnostics |
| topics[1].id | https://openalex.org/T10158 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.977400004863739 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2730 |
| topics[1].subfield.display_name | Oncology |
| topics[1].display_name | Cancer Immunotherapy and Biomarkers |
| topics[2].id | https://openalex.org/T10417 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9749000072479248 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2740 |
| topics[2].subfield.display_name | Pulmonary and Respiratory Medicine |
| topics[2].display_name | Lung Cancer Treatments and Mutations |
| is_xpac | False |
| apc_list.value | 2750 |
| apc_list.currency | EUR |
| apc_list.value_usd | 2965 |
| apc_paid.value | 2750 |
| apc_paid.currency | EUR |
| apc_paid.value_usd | 2965 |
| concepts[0].id | https://openalex.org/C71924100 |
| concepts[0].level | 0 |
| concepts[0].score | 0.6727368235588074 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[0].display_name | Medicine |
| concepts[1].id | https://openalex.org/C143998085 |
| concepts[1].level | 1 |
| concepts[1].score | 0.6581310629844666 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q162555 |
| concepts[1].display_name | Oncology |
| concepts[2].id | https://openalex.org/C126322002 |
| concepts[2].level | 1 |
| concepts[2].score | 0.6561828851699829 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[2].display_name | Internal medicine |
| concepts[3].id | https://openalex.org/C50382708 |
| concepts[3].level | 2 |
| concepts[3].score | 0.6232666969299316 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q223218 |
| concepts[3].display_name | Proportional hazards model |
| concepts[4].id | https://openalex.org/C2776256026 |
| concepts[4].level | 2 |
| concepts[4].score | 0.5011425018310547 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q47912 |
| concepts[4].display_name | Lung cancer |
| keywords[0].id | https://openalex.org/keywords/medicine |
| keywords[0].score | 0.6727368235588074 |
| keywords[0].display_name | Medicine |
| keywords[1].id | https://openalex.org/keywords/oncology |
| keywords[1].score | 0.6581310629844666 |
| keywords[1].display_name | Oncology |
| keywords[2].id | https://openalex.org/keywords/internal-medicine |
| keywords[2].score | 0.6561828851699829 |
| keywords[2].display_name | Internal medicine |
| keywords[3].id | https://openalex.org/keywords/proportional-hazards-model |
| keywords[3].score | 0.6232666969299316 |
| keywords[3].display_name | Proportional hazards model |
| keywords[4].id | https://openalex.org/keywords/lung-cancer |
| keywords[4].score | 0.5011425018310547 |
| keywords[4].display_name | Lung cancer |
| language | en |
| locations[0].id | doi:10.1016/j.esmoop.2023.101995 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S4210217024 |
| locations[0].source.issn | 2059-7029 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2059-7029 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | ESMO Open |
| locations[0].source.host_organization | https://openalex.org/P4310320990 |
| locations[0].source.host_organization_name | Elsevier BV |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320990 |
| locations[0].license | cc-by-nc-nd |
| locations[0].pdf_url | http://www.esmoopen.com/article/S2059702923012358/pdf |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by-nc-nd |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | ESMO Open |
| locations[0].landing_page_url | https://doi.org/10.1016/j.esmoop.2023.101995 |
| indexed_in | crossref, doaj |
| authorships[0].author.id | https://openalex.org/A5015139202 |
| authorships[0].author.orcid | https://orcid.org/0000-0003-1582-8006 |
| authorships[0].author.display_name | Antonio Vitale |
| authorships[0].countries | IT |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I2802557943 |
| authorships[0].affiliations[0].raw_affiliation_string | Medical Oncology Department, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy |
| authorships[0].institutions[0].id | https://openalex.org/I2802557943 |
| authorships[0].institutions[0].ror | https://ror.org/00rg70c39 |
| authorships[0].institutions[0].type | healthcare |
| authorships[0].institutions[0].lineage | https://openalex.org/I2802557943 |
| authorships[0].institutions[0].country_code | IT |
| authorships[0].institutions[0].display_name | Agostino Gemelli University Polyclinic |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | A. Vitale |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Medical Oncology Department, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy |
| authorships[1].author.id | https://openalex.org/A5043737382 |
| authorships[1].author.orcid | https://orcid.org/0000-0003-1853-4927 |
| authorships[1].author.display_name | Luca Mastrantoni |
| authorships[1].countries | IT |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I2802557943 |
| authorships[1].affiliations[0].raw_affiliation_string | Medical Oncology Department, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy |
| authorships[1].institutions[0].id | https://openalex.org/I2802557943 |
| authorships[1].institutions[0].ror | https://ror.org/00rg70c39 |
| authorships[1].institutions[0].type | healthcare |
| authorships[1].institutions[0].lineage | https://openalex.org/I2802557943 |
| authorships[1].institutions[0].country_code | IT |
| authorships[1].institutions[0].display_name | Agostino Gemelli University Polyclinic |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | L. Mastrantoni |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Medical Oncology Department, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy |
| authorships[2].author.id | https://openalex.org/A5028861602 |
| authorships[2].author.orcid | https://orcid.org/0000-0003-1794-2064 |
| authorships[2].author.display_name | Francesco Maria Guida |
| authorships[2].countries | IT |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I2802557943 |
| authorships[2].affiliations[0].raw_affiliation_string | Medical Oncology Department, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy |
| authorships[2].institutions[0].id | https://openalex.org/I2802557943 |
| authorships[2].institutions[0].ror | https://ror.org/00rg70c39 |
| authorships[2].institutions[0].type | healthcare |
| authorships[2].institutions[0].lineage | https://openalex.org/I2802557943 |
| authorships[2].institutions[0].country_code | IT |
| authorships[2].institutions[0].display_name | Agostino Gemelli University Polyclinic |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | F. Guida |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Medical Oncology Department, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy |
| authorships[3].author.id | https://openalex.org/A5037537100 |
| authorships[3].author.orcid | https://orcid.org/0000-0003-4546-547X |
| authorships[3].author.display_name | Emanuele Vita |
| authorships[3].countries | IT |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I2802557943 |
| authorships[3].affiliations[0].raw_affiliation_string | Medical Oncology Department, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy |
| authorships[3].institutions[0].id | https://openalex.org/I2802557943 |
| authorships[3].institutions[0].ror | https://ror.org/00rg70c39 |
| authorships[3].institutions[0].type | healthcare |
| authorships[3].institutions[0].lineage | https://openalex.org/I2802557943 |
| authorships[3].institutions[0].country_code | IT |
| authorships[3].institutions[0].display_name | Agostino Gemelli University Polyclinic |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | E. Vita |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Medical Oncology Department, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy |
| authorships[4].author.id | https://openalex.org/A5026402818 |
| authorships[4].author.orcid | https://orcid.org/0000-0001-8283-2633 |
| authorships[4].author.display_name | Alessandro Di Stefani |
| authorships[4].countries | IT |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I2802557943 |
| authorships[4].affiliations[0].raw_affiliation_string | Medical Oncology Department, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy |
| authorships[4].institutions[0].id | https://openalex.org/I2802557943 |
| authorships[4].institutions[0].ror | https://ror.org/00rg70c39 |
| authorships[4].institutions[0].type | healthcare |
| authorships[4].institutions[0].lineage | https://openalex.org/I2802557943 |
| authorships[4].institutions[0].country_code | IT |
| authorships[4].institutions[0].display_name | Agostino Gemelli University Polyclinic |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | A. Stefani |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Medical Oncology Department, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy |
| authorships[5].author.id | https://openalex.org/A5109223195 |
| authorships[5].author.orcid | |
| authorships[5].author.display_name | P. Troisi |
| authorships[5].countries | IT |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I2802557943 |
| authorships[5].affiliations[0].raw_affiliation_string | Medical Oncology Department, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy |
| authorships[5].institutions[0].id | https://openalex.org/I2802557943 |
| authorships[5].institutions[0].ror | https://ror.org/00rg70c39 |
| authorships[5].institutions[0].type | healthcare |
| authorships[5].institutions[0].lineage | https://openalex.org/I2802557943 |
| authorships[5].institutions[0].country_code | IT |
| authorships[5].institutions[0].display_name | Agostino Gemelli University Polyclinic |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | P. Troisi |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Medical Oncology Department, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy |
| authorships[6].author.id | https://openalex.org/A5019265626 |
| authorships[6].author.orcid | |
| authorships[6].author.display_name | F. Monaca |
| authorships[6].countries | IT |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I2802557943 |
| authorships[6].affiliations[0].raw_affiliation_string | Medical Oncology Department, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy |
| authorships[6].institutions[0].id | https://openalex.org/I2802557943 |
| authorships[6].institutions[0].ror | https://ror.org/00rg70c39 |
| authorships[6].institutions[0].type | healthcare |
| authorships[6].institutions[0].lineage | https://openalex.org/I2802557943 |
| authorships[6].institutions[0].country_code | IT |
| authorships[6].institutions[0].display_name | Agostino Gemelli University Polyclinic |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | F. Monaca |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Medical Oncology Department, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy |
| authorships[7].author.id | https://openalex.org/A5111586234 |
| authorships[7].author.orcid | |
| authorships[7].author.display_name | G. Horn |
| authorships[7].countries | IT |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I2802557943 |
| authorships[7].affiliations[0].raw_affiliation_string | Medical Oncology Department, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy |
| authorships[7].institutions[0].id | https://openalex.org/I2802557943 |
| authorships[7].institutions[0].ror | https://ror.org/00rg70c39 |
| authorships[7].institutions[0].type | healthcare |
| authorships[7].institutions[0].lineage | https://openalex.org/I2802557943 |
| authorships[7].institutions[0].country_code | IT |
| authorships[7].institutions[0].display_name | Agostino Gemelli University Polyclinic |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | G. Horn |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Medical Oncology Department, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy |
| authorships[8].author.id | https://openalex.org/A5078101595 |
| authorships[8].author.orcid | https://orcid.org/0009-0004-9526-0725 |
| authorships[8].author.display_name | G. Trovato |
| authorships[8].countries | IT |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I2802557943 |
| authorships[8].affiliations[0].raw_affiliation_string | Medical Oncology Department, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy |
| authorships[8].institutions[0].id | https://openalex.org/I2802557943 |
| authorships[8].institutions[0].ror | https://ror.org/00rg70c39 |
| authorships[8].institutions[0].type | healthcare |
| authorships[8].institutions[0].lineage | https://openalex.org/I2802557943 |
| authorships[8].institutions[0].country_code | IT |
| authorships[8].institutions[0].display_name | Agostino Gemelli University Polyclinic |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | G. Trovato |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Medical Oncology Department, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy |
| authorships[9].author.id | https://openalex.org/A5108321824 |
| authorships[9].author.orcid | |
| authorships[9].author.display_name | J. Russo |
| authorships[9].countries | IT |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I2802557943 |
| authorships[9].affiliations[0].raw_affiliation_string | Medical Oncology Department, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy |
| authorships[9].institutions[0].id | https://openalex.org/I2802557943 |
| authorships[9].institutions[0].ror | https://ror.org/00rg70c39 |
| authorships[9].institutions[0].type | healthcare |
| authorships[9].institutions[0].lineage | https://openalex.org/I2802557943 |
| authorships[9].institutions[0].country_code | IT |
| authorships[9].institutions[0].display_name | Agostino Gemelli University Polyclinic |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | J. Russo |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Medical Oncology Department, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy |
| authorships[10].author.id | https://openalex.org/A5031854502 |
| authorships[10].author.orcid | |
| authorships[10].author.display_name | D. Barone |
| authorships[10].countries | IT |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I2802557943 |
| authorships[10].affiliations[0].raw_affiliation_string | Medical Oncology Department, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy |
| authorships[10].institutions[0].id | https://openalex.org/I2802557943 |
| authorships[10].institutions[0].ror | https://ror.org/00rg70c39 |
| authorships[10].institutions[0].type | healthcare |
| authorships[10].institutions[0].lineage | https://openalex.org/I2802557943 |
| authorships[10].institutions[0].country_code | IT |
| authorships[10].institutions[0].display_name | Agostino Gemelli University Polyclinic |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | D. Barone |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Medical Oncology Department, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy |
| authorships[11].author.id | https://openalex.org/A5031266549 |
| authorships[11].author.orcid | |
| authorships[11].author.display_name | I. Sparagna |
| authorships[11].countries | IT |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I2802557943 |
| authorships[11].affiliations[0].raw_affiliation_string | Medical Oncology Department, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy |
| authorships[11].institutions[0].id | https://openalex.org/I2802557943 |
| authorships[11].institutions[0].ror | https://ror.org/00rg70c39 |
| authorships[11].institutions[0].type | healthcare |
| authorships[11].institutions[0].lineage | https://openalex.org/I2802557943 |
| authorships[11].institutions[0].country_code | IT |
| authorships[11].institutions[0].display_name | Agostino Gemelli University Polyclinic |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | I. Sparagna |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | Medical Oncology Department, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy |
| authorships[12].author.id | https://openalex.org/A5066923986 |
| authorships[12].author.orcid | |
| authorships[12].author.display_name | Mariantonietta Di Salvatore |
| authorships[12].countries | IT |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I2802557943 |
| authorships[12].affiliations[0].raw_affiliation_string | Medical Oncology Department, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy |
| authorships[12].institutions[0].id | https://openalex.org/I2802557943 |
| authorships[12].institutions[0].ror | https://ror.org/00rg70c39 |
| authorships[12].institutions[0].type | healthcare |
| authorships[12].institutions[0].lineage | https://openalex.org/I2802557943 |
| authorships[12].institutions[0].country_code | IT |
| authorships[12].institutions[0].display_name | Agostino Gemelli University Polyclinic |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | M. Di Salvatore |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | Medical Oncology Department, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy |
| authorships[13].author.id | https://openalex.org/A5011458340 |
| authorships[13].author.orcid | https://orcid.org/0000-0001-8802-9876 |
| authorships[13].author.display_name | Ettore D’Argento |
| authorships[13].countries | IT |
| authorships[13].affiliations[0].institution_ids | https://openalex.org/I2802557943 |
| authorships[13].affiliations[0].raw_affiliation_string | Medical Oncology Department, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy |
| authorships[13].institutions[0].id | https://openalex.org/I2802557943 |
| authorships[13].institutions[0].ror | https://ror.org/00rg70c39 |
| authorships[13].institutions[0].type | healthcare |
| authorships[13].institutions[0].lineage | https://openalex.org/I2802557943 |
| authorships[13].institutions[0].country_code | IT |
| authorships[13].institutions[0].display_name | Agostino Gemelli University Polyclinic |
| authorships[13].author_position | middle |
| authorships[13].raw_author_name | E. D'Argento |
| authorships[13].is_corresponding | False |
| authorships[13].raw_affiliation_strings | Medical Oncology Department, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy |
| authorships[14].author.id | https://openalex.org/A5061423439 |
| authorships[14].author.orcid | |
| authorships[14].author.display_name | Alessandra Cancellieri |
| authorships[14].countries | IT |
| authorships[14].affiliations[0].institution_ids | https://openalex.org/I2802557943, https://openalex.org/I4210153126 |
| authorships[14].affiliations[0].raw_affiliation_string | Institute of Pathology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy |
| authorships[14].institutions[0].id | https://openalex.org/I2802557943 |
| authorships[14].institutions[0].ror | https://ror.org/00rg70c39 |
| authorships[14].institutions[0].type | healthcare |
| authorships[14].institutions[0].lineage | https://openalex.org/I2802557943 |
| authorships[14].institutions[0].country_code | IT |
| authorships[14].institutions[0].display_name | Agostino Gemelli University Polyclinic |
| authorships[14].institutions[1].id | https://openalex.org/I4210153126 |
| authorships[14].institutions[1].ror | https://ror.org/04tfzc498 |
| authorships[14].institutions[1].type | healthcare |
| authorships[14].institutions[1].lineage | https://openalex.org/I4210153126 |
| authorships[14].institutions[1].country_code | IT |
| authorships[14].institutions[1].display_name | Istituti di Ricovero e Cura a Carattere Scientifico |
| authorships[14].author_position | middle |
| authorships[14].raw_author_name | A. Cancellieri |
| authorships[14].is_corresponding | False |
| authorships[14].raw_affiliation_strings | Institute of Pathology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy |
| authorships[15].author.id | https://openalex.org/A5079985047 |
| authorships[15].author.orcid | https://orcid.org/0000-0002-0833-4334 |
| authorships[15].author.display_name | Angelo Minucci |
| authorships[15].countries | IT |
| authorships[15].affiliations[0].institution_ids | https://openalex.org/I2802557943 |
| authorships[15].affiliations[0].raw_affiliation_string | Laboratory of Clinical Molecular and Personalized Diagnostics, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy |
| authorships[15].institutions[0].id | https://openalex.org/I2802557943 |
| authorships[15].institutions[0].ror | https://ror.org/00rg70c39 |
| authorships[15].institutions[0].type | healthcare |
| authorships[15].institutions[0].lineage | https://openalex.org/I2802557943 |
| authorships[15].institutions[0].country_code | IT |
| authorships[15].institutions[0].display_name | Agostino Gemelli University Polyclinic |
| authorships[15].author_position | middle |
| authorships[15].raw_author_name | A. Minucci |
| authorships[15].is_corresponding | False |
| authorships[15].raw_affiliation_strings | Laboratory of Clinical Molecular and Personalized Diagnostics, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy |
| authorships[16].author.id | https://openalex.org/A5026048739 |
| authorships[16].author.orcid | https://orcid.org/0000-0002-9503-9041 |
| authorships[16].author.display_name | Giovanni Scambia |
| authorships[16].countries | IT |
| authorships[16].affiliations[0].institution_ids | https://openalex.org/I2802557943 |
| authorships[16].affiliations[0].raw_affiliation_string | Women, Children and Public Health Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy |
| authorships[16].institutions[0].id | https://openalex.org/I2802557943 |
| authorships[16].institutions[0].ror | https://ror.org/00rg70c39 |
| authorships[16].institutions[0].type | healthcare |
| authorships[16].institutions[0].lineage | https://openalex.org/I2802557943 |
| authorships[16].institutions[0].country_code | IT |
| authorships[16].institutions[0].display_name | Agostino Gemelli University Polyclinic |
| authorships[16].author_position | middle |
| authorships[16].raw_author_name | G. Scambia |
| authorships[16].is_corresponding | False |
| authorships[16].raw_affiliation_strings | Women, Children and Public Health Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy |
| authorships[17].author.id | https://openalex.org/A5019176149 |
| authorships[17].author.orcid | https://orcid.org/0000-0002-1067-4696 |
| authorships[17].author.display_name | Rocco Trisolini |
| authorships[17].countries | IT |
| authorships[17].affiliations[0].institution_ids | https://openalex.org/I2802557943 |
| authorships[17].affiliations[0].raw_affiliation_string | Interventional Pulmonology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy |
| authorships[17].institutions[0].id | https://openalex.org/I2802557943 |
| authorships[17].institutions[0].ror | https://ror.org/00rg70c39 |
| authorships[17].institutions[0].type | healthcare |
| authorships[17].institutions[0].lineage | https://openalex.org/I2802557943 |
| authorships[17].institutions[0].country_code | IT |
| authorships[17].institutions[0].display_name | Agostino Gemelli University Polyclinic |
| authorships[17].author_position | middle |
| authorships[17].raw_author_name | R. Trisolini |
| authorships[17].is_corresponding | False |
| authorships[17].raw_affiliation_strings | Interventional Pulmonology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy |
| authorships[18].author.id | https://openalex.org/A5050215401 |
| authorships[18].author.orcid | https://orcid.org/0000-0002-1378-4962 |
| authorships[18].author.display_name | Giampaolo Tortora |
| authorships[18].countries | IT |
| authorships[18].affiliations[0].institution_ids | https://openalex.org/I2802557943 |
| authorships[18].affiliations[0].raw_affiliation_string | Medical Oncology Department, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy |
| authorships[18].institutions[0].id | https://openalex.org/I2802557943 |
| authorships[18].institutions[0].ror | https://ror.org/00rg70c39 |
| authorships[18].institutions[0].type | healthcare |
| authorships[18].institutions[0].lineage | https://openalex.org/I2802557943 |
| authorships[18].institutions[0].country_code | IT |
| authorships[18].institutions[0].display_name | Agostino Gemelli University Polyclinic |
| authorships[18].author_position | middle |
| authorships[18].raw_author_name | G. Tortora |
| authorships[18].is_corresponding | False |
| authorships[18].raw_affiliation_strings | Medical Oncology Department, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy |
| authorships[19].author.id | https://openalex.org/A5030465858 |
| authorships[19].author.orcid | https://orcid.org/0000-0002-2333-704X |
| authorships[19].author.display_name | Emilio Bria |
| authorships[19].countries | IT |
| authorships[19].affiliations[0].institution_ids | https://openalex.org/I2802557943 |
| authorships[19].affiliations[0].raw_affiliation_string | Medical Oncology Department, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy |
| authorships[19].institutions[0].id | https://openalex.org/I2802557943 |
| authorships[19].institutions[0].ror | https://ror.org/00rg70c39 |
| authorships[19].institutions[0].type | healthcare |
| authorships[19].institutions[0].lineage | https://openalex.org/I2802557943 |
| authorships[19].institutions[0].country_code | IT |
| authorships[19].institutions[0].display_name | Agostino Gemelli University Polyclinic |
| authorships[19].author_position | last |
| authorships[19].raw_author_name | E. Bria |
| authorships[19].is_corresponding | False |
| authorships[19].raw_affiliation_strings | Medical Oncology Department, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | http://www.esmoopen.com/article/S2059702923012358/pdf |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | 145P Identification of next generation sequencing (NGS)-based genomic signature predicting resistance to immunotherapy (IO) in patients (pts) with metastatic non-small cell lung cancer (mNSCLC): A single-center cohort study |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11287 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.9803000092506409 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1306 |
| primary_topic.subfield.display_name | Cancer Research |
| primary_topic.display_name | Cancer Genomics and Diagnostics |
| related_works | https://openalex.org/W2748952813, https://openalex.org/W3031052312, https://openalex.org/W4389568370, https://openalex.org/W3032375762, https://openalex.org/W1995515455, https://openalex.org/W2080531066, https://openalex.org/W2586801360, https://openalex.org/W3108674512, https://openalex.org/W1506200166, https://openalex.org/W1489783725 |
| cited_by_count | 0 |
| locations_count | 1 |
| best_oa_location.id | doi:10.1016/j.esmoop.2023.101995 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4210217024 |
| best_oa_location.source.issn | 2059-7029 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2059-7029 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | ESMO Open |
| best_oa_location.source.host_organization | https://openalex.org/P4310320990 |
| best_oa_location.source.host_organization_name | Elsevier BV |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320990 |
| best_oa_location.license | cc-by-nc-nd |
| best_oa_location.pdf_url | http://www.esmoopen.com/article/S2059702923012358/pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by-nc-nd |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | ESMO Open |
| best_oa_location.landing_page_url | https://doi.org/10.1016/j.esmoop.2023.101995 |
| primary_location.id | doi:10.1016/j.esmoop.2023.101995 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S4210217024 |
| primary_location.source.issn | 2059-7029 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2059-7029 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | ESMO Open |
| primary_location.source.host_organization | https://openalex.org/P4310320990 |
| primary_location.source.host_organization_name | Elsevier BV |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320990 |
| primary_location.license | cc-by-nc-nd |
| primary_location.pdf_url | http://www.esmoopen.com/article/S2059702923012358/pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by-nc-nd |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | ESMO Open |
| primary_location.landing_page_url | https://doi.org/10.1016/j.esmoop.2023.101995 |
| publication_date | 2023-10-01 |
| publication_year | 2023 |
| referenced_works_count | 0 |
| abstract_inverted_index.5 | 236 |
| abstract_inverted_index.6 | 174 |
| abstract_inverted_index.A | 72, 102, 291 |
| abstract_inverted_index.a | 16, 138, 232, 256, 276 |
| abstract_inverted_index.(0 | 129 |
| abstract_inverted_index.15 | 165 |
| abstract_inverted_index.17 | 66 |
| abstract_inverted_index.23 | 154 |
| abstract_inverted_index.32 | 149 |
| abstract_inverted_index.35 | 58 |
| abstract_inverted_index.56 | 144 |
| abstract_inverted_index.At | 171 |
| abstract_inverted_index.HR | 249 |
| abstract_inverted_index.IC | 185, 192, 199, 206, 213, 221, 252, 262, 268, 288 |
| abstract_inverted_index.IO | 0, 23, 31 |
| abstract_inverted_index.In | 224 |
| abstract_inverted_index.We | 12 |
| abstract_inverted_index.by | 39, 98 |
| abstract_inverted_index.in | 113, 137, 244, 275, 308, 313 |
| abstract_inverted_index.is | 4, 316 |
| abstract_inverted_index.of | 110, 169, 259 |
| abstract_inverted_index.on | 124 |
| abstract_inverted_index.or | 32, 53 |
| abstract_inverted_index.to | 14, 22, 69, 84, 179 |
| abstract_inverted_index.vs | 130, 264 |
| abstract_inverted_index.± | 1 |
| abstract_inverted_index.(HR | 182, 189, 196, 203, 210, 218, 285 |
| abstract_inverted_index.346 | 163 |
| abstract_inverted_index.95% | 184, 191, 198, 205, 212, 220, 251, 287 |
| abstract_inverted_index.Cox | 80, 100 |
| abstract_inverted_index.IO. | 156, 311 |
| abstract_inverted_index.NGS | 36 |
| abstract_inverted_index.PFS | 240, 258, 307 |
| abstract_inverted_index.Pts | 26, 117 |
| abstract_inverted_index.RNA | 45 |
| abstract_inverted_index.The | 87, 132, 270 |
| abstract_inverted_index.[55 | 46 |
| abstract_inverted_index.and | 76, 92, 153, 216, 231, 283, 299 |
| abstract_inverted_index.for | 7 |
| abstract_inverted_index.pts | 145, 309 |
| abstract_inverted_index.the | 114, 125, 225, 245 |
| abstract_inverted_index.two | 121, 246 |
| abstract_inverted_index.was | 37, 82, 96, 105, 135, 159, 229, 238, 241, 302 |
| abstract_inverted_index.who | 29 |
| abstract_inverted_index.(95% | 261, 267 |
| abstract_inverted_index.(CT) | 3 |
| abstract_inverted_index.(DNA | 42 |
| abstract_inverted_index.1.64 | 260 |
| abstract_inverted_index.10.4 | 160 |
| abstract_inverted_index.>0). | 131 |
| abstract_inverted_index.AKT3 | 181 |
| abstract_inverted_index.Lung | 63 |
| abstract_inverted_index.NGS. | 25 |
| abstract_inverted_index.PAX8 | 202, 228 |
| abstract_inverted_index.PFS. | 170 |
| abstract_inverted_index.PFS: | 180 |
| abstract_inverted_index.[522 | 43 |
| abstract_inverted_index.age, | 280 |
| abstract_inverted_index.into | 120 |
| abstract_inverted_index.plus | 60 |
| abstract_inverted_index.risk | 103, 127, 133, 247 |
| abstract_inverted_index.were | 34, 118, 146, 176 |
| abstract_inverted_index.with | 27, 235, 255, 305 |
| abstract_inverted_index.(43%) | 155 |
| abstract_inverted_index.(57%) | 150 |
| abstract_inverted_index.(DNA, | 57 |
| abstract_inverted_index.(PFS) | 95 |
| abstract_inverted_index.(RNA, | 65 |
| abstract_inverted_index.13.25 | 265 |
| abstract_inverted_index.3.82, | 219 |
| abstract_inverted_index.4.88, | 211 |
| abstract_inverted_index.4.98, | 190 |
| abstract_inverted_index.8.33, | 204 |
| abstract_inverted_index.AKT3, | 295 |
| abstract_inverted_index.Among | 162 |
| abstract_inverted_index.CD276 | 195 |
| abstract_inverted_index.CT/IO | 33, 152 |
| abstract_inverted_index.Focus | 55 |
| abstract_inverted_index.Tumor | 48 |
| abstract_inverted_index.aimed | 13 |
| abstract_inverted_index.assay | 41 |
| abstract_inverted_index.based | 123 |
| abstract_inverted_index.genes | 91, 112, 175, 237 |
| abstract_inverted_index.least | 73 |
| abstract_inverted_index.model | 140, 278 |
| abstract_inverted_index.score | 104, 128, 134 |
| abstract_inverted_index.using | 24, 107 |
| abstract_inverted_index.13.56, | 250 |
| abstract_inverted_index.14.33, | 197 |
| abstract_inverted_index.15.71; | 286 |
| abstract_inverted_index.40.39, | 183 |
| abstract_inverted_index.ARID5B | 188 |
| abstract_inverted_index.CD276, | 297 |
| abstract_inverted_index.Median | 157 |
| abstract_inverted_index.PDGFRB | 209, 298 |
| abstract_inverted_index.RICTOR | 217, 300 |
| abstract_inverted_index.choose | 85 |
| abstract_inverted_index.cohort | 315 |
| abstract_inverted_index.genes) | 59 |
| abstract_inverted_index.genes, | 164 |
| abstract_inverted_index.genes. | 86 |
| abstract_inverted_index.groups | 122 |
| abstract_inverted_index.mNSCLC | 8, 28 |
| abstract_inverted_index.median | 126, 257 |
| abstract_inverted_index.smoke, | 281 |
| abstract_inverted_index.(LASSO) | 79 |
| abstract_inverted_index.ARID5B, | 296 |
| abstract_inverted_index.Assay® | 56 |
| abstract_inverted_index.Burden, | 50 |
| abstract_inverted_index.Panel® | 64 |
| abstract_inverted_index.between | 89 |
| abstract_inverted_index.derived | 106 |
| abstract_inverted_index.divided | 119 |
| abstract_inverted_index.genes), | 67 |
| abstract_inverted_index.genes], | 44, 47 |
| abstract_inverted_index.genomic | 17, 233, 271, 292 |
| abstract_inverted_index.groups: | 248 |
| abstract_inverted_index.months. | 161, 266 |
| abstract_inverted_index.p=0.01) | 215 |
| abstract_inverted_index.regimen | 284 |
| abstract_inverted_index.shorter | 306 |
| abstract_inverted_index.therapy | 6 |
| abstract_inverted_index.without | 9 |
| abstract_inverted_index.0.76-NA) | 263 |
| abstract_inverted_index.Archer's | 61 |
| abstract_inverted_index.Oncomine | 54 |
| abstract_inverted_index.absolute | 74 |
| abstract_inverted_index.analysis | 227 |
| abstract_inverted_index.clinical | 142 |
| abstract_inverted_index.excluded | 230 |
| abstract_inverted_index.external | 314 |
| abstract_inverted_index.identify | 15 |
| abstract_inverted_index.ongoing. | 317 |
| abstract_inverted_index.operator | 78 |
| abstract_inverted_index.p<0.001, | 254 |
| abstract_inverted_index.p=0.04), | 194 |
| abstract_inverted_index.p=0.04). | 223 |
| abstract_inverted_index.received | 30, 151 |
| abstract_inverted_index.remained | 273 |
| abstract_inverted_index.resulted | 166 |
| abstract_inverted_index.survival | 94 |
| abstract_inverted_index.according | 68 |
| abstract_inverted_index.analysis, | 173 |
| abstract_inverted_index.analysis. | 116 |
| abstract_inverted_index.conducted | 83 |
| abstract_inverted_index.different | 243 |
| abstract_inverted_index.eligible. | 35 |
| abstract_inverted_index.evaluated | 97, 136 |
| abstract_inverted_index.features. | 143 |
| abstract_inverted_index.follow-up | 158 |
| abstract_inverted_index.histology | 282 |
| abstract_inverted_index.included. | 148 |
| abstract_inverted_index.including | 141, 279, 294 |
| abstract_inverted_index.p<0.001), | 187 |
| abstract_inverted_index.p<0.001). | 290 |
| abstract_inverted_index.p=0.002), | 201 |
| abstract_inverted_index.p=0.007), | 208 |
| abstract_inverted_index.performed | 38 |
| abstract_inverted_index.receiving | 310 |
| abstract_inverted_index.selection | 77 |
| abstract_inverted_index.shrinkage | 75 |
| abstract_inverted_index.signature | 18, 234, 272, 293 |
| abstract_inverted_index.10.88-NA). | 269 |
| abstract_inverted_index.FusionPlex | 62 |
| abstract_inverted_index.Mutational | 49 |
| abstract_inverted_index.TSO500HT® | 40 |
| abstract_inverted_index.Validation | 312 |
| abstract_inverted_index.actionable | 10 |
| abstract_inverted_index.associated | 304 |
| abstract_inverted_index.correlated | 178 |
| abstract_inverted_index.first-line | 5 |
| abstract_inverted_index.mutations. | 11 |
| abstract_inverted_index.predicting | 20 |
| abstract_inverted_index.predictive | 168 |
| abstract_inverted_index.prognostic | 274 |
| abstract_inverted_index.regression | 81, 108 |
| abstract_inverted_index.resistance | 21 |
| abstract_inverted_index.1.08-13.57, | 222 |
| abstract_inverted_index.1.11-22.24, | 193 |
| abstract_inverted_index.1.42-16.75, | 214 |
| abstract_inverted_index.1.78-38.95, | 207 |
| abstract_inverted_index.2.60-78.99, | 200 |
| abstract_inverted_index.5.19-47.52, | 289 |
| abstract_inverted_index.5.30-34.67, | 253 |
| abstract_inverted_index.alterations | 301 |
| abstract_inverted_index.considered. | 239 |
| abstract_inverted_index.correlation | 88 |
| abstract_inverted_index.potentially | 19, 167 |
| abstract_inverted_index.regression. | 101 |
| abstract_inverted_index.significant | 111 |
| abstract_inverted_index.univariable | 99, 172 |
| abstract_inverted_index.5.58-292.30, | 186 |
| abstract_inverted_index.Instability) | 52 |
| abstract_inverted_index.cellularity. | 71 |
| abstract_inverted_index.chemotherapy | 2 |
| abstract_inverted_index.coefficients | 109 |
| abstract_inverted_index.multivariable | 115, 139, 226, 277 |
| abstract_inverted_index.significantly | 177, 242, 303 |
| abstract_inverted_index.LASSO-selected | 90 |
| abstract_inverted_index.Microsatellite | 51 |
| abstract_inverted_index.retrospectively | 147 |
| abstract_inverted_index.progression-free | 93 |
| abstract_inverted_index.quality/quantity | 70 |
| cited_by_percentile_year | |
| countries_distinct_count | 1 |
| institutions_distinct_count | 20 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.6299999952316284 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.50032309 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |