157 WHOLE HIPPOCAMPAL VOLUMES AND HIPPOCAMPAL SUBFIELD VOLUMES IN MCI-LB AND MCI-ad
Article Swipe
Rory Durcan
,
Sean J. Colloby
,
Paul C. Donaghy
,
Sarah Lawley
,
John‐Paul Taylor
,
John T. O’Brien
,
Alan Thomas
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1093/ageing/afab219.157
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1093/ageing/afab219.157
Background Mild cognitive impairment with Lewy bodies (MCI-LB) is the commonest prodromal phenotype of Dementia with Lewy Bodies (DLB) and may be challenging to differentiate from MCI due to Alzheimer’s disease (MCI-AD). Preservation of medial temporal lobe structures on MRI is recognised as a supportive biomarker consistent with underlying Lewy body disease rather Alzheimer’s disease (AD). We investigated whether whole hippocampal volume and differing hippocampal subfield atrophy patterns, could be used as a surrogate biomarker of underlying ad pathology, allowing for differentiation of MCI-LB from MCI-AD. Methods Participants were recruited to the following groups’: healthy controls (HC), MCI-LB and MCI-ad, all ≥60 years. Alongside detailed clinical, neuropsychological assessments, all participants underwent 3 T MRI, 123I-FP-CIT SPECT and 123I-MIBG myocardial scintigraphy. Using Freesurfer (v.6.0), a fully automated hippocampal subfield segmentation of the MRI data was performed. Results Groups consisted of 31 HC (mean age, 73.7 yrs; mean Mini-Mental state Examination [MMSE] score, 28.4), 34 MCI-LB (mean age, 74.7 yrs; mean MMSE score, 26.6) and 29 MCI-ad (mean age, 75.4 yrs; mean MMSE score, 27.1). There was no significant difference in whole hippocampal volume between MCI-LB and MCI-ad(Mean (SD) in mm3: MCI-LB 6025 (961) vs MCI-ad 5407 (882), p = 0.12) or between MCI-LB and HC (Mean (SD) in mm3: MCI-LB 6025 (961) vs HC 6355 (962), p = 0.11). Whole hippocampal volume was significantly smaller in MCI-ad compared with HC (p < 0.001). Comparison between MCI-LB and MCI-ad, showed absolute hippocampal subfield volumes were all lower in MCI-ad. However, the magnitude of the differences were small and no significant difference in hippocampal subfield volumes were noted between these groups, with the exception of the hippocampal tail being significantly smaller in MCI-ad compared to MCI-LB (p = 0.04). Conclusion In a well-characterised cohort, whole hippocampal and hippocampal subfield volumes were similarly atrophied in MCI-LB and MCI-ad and did not distinguish between the groups.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/ageing/afab219.157
- https://academic.oup.com/ageing/article-pdf/50/Supplement_3/ii9/47364481/afab219.157.pdf
- OA Status
- bronze
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4321639717
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https://openalex.org/W4321639717Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1093/ageing/afab219.157Digital Object Identifier
- Title
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157 WHOLE HIPPOCAMPAL VOLUMES AND HIPPOCAMPAL SUBFIELD VOLUMES IN MCI-LB AND MCI-
ad Work title - Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
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2021-11-01Full publication date if available
- Authors
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Rory Durcan, Sean J. Colloby, Paul C. Donaghy, Sarah Lawley, John‐Paul Taylor, John T. O’Brien, Alan ThomasList of authors in order
- Landing page
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https://doi.org/10.1093/ageing/afab219.157Publisher landing page
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https://academic.oup.com/ageing/article-pdf/50/Supplement_3/ii9/47364481/afab219.157.pdfDirect link to full text PDF
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bronzeOpen access status per OpenAlex
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https://academic.oup.com/ageing/article-pdf/50/Supplement_3/ii9/47364481/afab219.157.pdfDirect OA link when available
- Concepts
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Medicine, Dementia with Lewy bodies, Hippocampal formation, Atrophy, Biomarker, Dementia, Alzheimer's disease, Internal medicine, Cognitive impairment, Neuropsychology, Temporal lobe, Cardiology, Nuclear medicine, Pathology, Disease, Cognition, Psychiatry, Chemistry, Epilepsy, BiochemistryTop concepts (fields/topics) attached by OpenAlex
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10Other works algorithmically related by OpenAlex
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