1774. Surveillance for Emerging and Reemerging Pathogens Using Pathogen Agnostic Metagenomic Sequencing in the United States: A Critical Role for Federal Government Agencies Article Swipe
Diane L Downie
,
Preetika Rao
,
Corinne David‐Ferdon
,
Sean Courtney
,
Justin Lee
,
Claire Quiner
,
Pia D. M. MacDonald
,
Keegan Barnes
,
Shelby Fisher
,
Joanne D. Andreadis
,
Jasmine Chaitram
,
Matthew R. Mauldin
,
Reyolds M Salerno
,
Jarad Schiffer
,
Adi V. Gundlapalli
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1093/ofid/ofad500.1603
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1093/ofid/ofad500.1603
Background The surveillance and identification of emerging, reemerging, and unknown infectious disease pathogens is essential to national public health preparedness and relies on fluidity, coordination, and interconnectivity between public and private surveillance systems and networks. Implementing and sustaining programs to detect emerging and re-emerging pathogens in humans using advanced molecular methods, such as metagenomic sequencing, requires large investments in testing equipment and developing networks of clinicians, laboratory scientists, and bioinformaticians. Methods This study sought to gain an understanding of the role of federal government agencies in supporting such pathogen-agnostic testing of human specimens in the United States. A landscape analysis was conducted of federal agency websites for publicly accessible information on the availability and type of pathogen-agnostic testing and details on flow of clinical specimens and data. The website analysis was supplemented by expert review of results with representatives from the federal agencies. Results Operating divisions within the Department of Health and Human Services and the US Department of Veterans Affairs have developed and sustained extensive clinical and research networks to obtain patient specimens and perform metagenomic sequencing at scale. Metagenomic facilities supported by US agencies were not equally geographically distributed across the US. Although many entities have work dedicated to metagenomics and/or support emerging infectious disease surveillance specimen collection, there was minimal apparent collaboration across agencies. Conclusion Developing a national sentinel surveillance network with existing resources and infrastructure could potentially increase efficiency, accelerate identification of emerging biothreats, and support coordinated intervention strategies that reduce morbidity and mortality. Disclosures All Authors: No reported disclosures
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/ofid/ofad500.1603
- https://academic.oup.com/ofid/article-pdf/10/Supplement_2/ofad500.1603/53758545/ofad500.1603.pdf
- OA Status
- gold
- Cited By
- 1
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4389030892
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4389030892Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1093/ofid/ofad500.1603Digital Object Identifier
- Title
-
1774. Surveillance for Emerging and Reemerging Pathogens Using Pathogen Agnostic Metagenomic Sequencing in the United States: A Critical Role for Federal Government AgenciesWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-11-27Full publication date if available
- Authors
-
Diane L Downie, Preetika Rao, Corinne David‐Ferdon, Sean Courtney, Justin Lee, Claire Quiner, Pia D. M. MacDonald, Keegan Barnes, Shelby Fisher, Joanne D. Andreadis, Jasmine Chaitram, Matthew R. Mauldin, Reyolds M Salerno, Jarad Schiffer, Adi V. GundlapalliList of authors in order
- Landing page
-
https://doi.org/10.1093/ofid/ofad500.1603Publisher landing page
- PDF URL
-
https://academic.oup.com/ofid/article-pdf/10/Supplement_2/ofad500.1603/53758545/ofad500.1603.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://academic.oup.com/ofid/article-pdf/10/Supplement_2/ofad500.1603/53758545/ofad500.1603.pdfDirect OA link when available
- Concepts
-
Metagenomics, Government (linguistics), Preparedness, Identification (biology), Medicine, Disease surveillance, Biodefense, Public health, Infectious disease (medical specialty), Data science, Disease, Computer science, Political science, Biology, Pathology, Biochemistry, Law, Philosophy, Gene, Botany, LinguisticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
- Citations by year (recent)
-
2024: 1Per-year citation counts (last 5 years)
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4389030892 |
|---|---|
| doi | https://doi.org/10.1093/ofid/ofad500.1603 |
| ids.doi | https://doi.org/10.1093/ofid/ofad500.1603 |
| ids.openalex | https://openalex.org/W4389030892 |
| fwci | 0.18567041 |
| type | article |
| title | 1774. Surveillance for Emerging and Reemerging Pathogens Using Pathogen Agnostic Metagenomic Sequencing in the United States: A Critical Role for Federal Government Agencies |
| biblio.issue | Supplement_2 |
| biblio.volume | 10 |
| biblio.last_page | |
| biblio.first_page | |
| topics[0].id | https://openalex.org/T11970 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.9314000010490417 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1312 |
| topics[0].subfield.display_name | Molecular Biology |
| topics[0].display_name | Molecular Biology Techniques and Applications |
| topics[1].id | https://openalex.org/T10582 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9050999879837036 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2739 |
| topics[1].subfield.display_name | Public Health, Environmental and Occupational Health |
| topics[1].display_name | Ethics in Clinical Research |
| is_xpac | False |
| apc_list.value | 3064 |
| apc_list.currency | USD |
| apc_list.value_usd | 3064 |
| apc_paid.value | 3064 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 3064 |
| concepts[0].id | https://openalex.org/C15151743 |
| concepts[0].level | 3 |
| concepts[0].score | 0.7393535375595093 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q903778 |
| concepts[0].display_name | Metagenomics |
| concepts[1].id | https://openalex.org/C2778137410 |
| concepts[1].level | 2 |
| concepts[1].score | 0.5490055084228516 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q2732820 |
| concepts[1].display_name | Government (linguistics) |
| concepts[2].id | https://openalex.org/C2777042776 |
| concepts[2].level | 2 |
| concepts[2].score | 0.5381897687911987 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q4583103 |
| concepts[2].display_name | Preparedness |
| concepts[3].id | https://openalex.org/C116834253 |
| concepts[3].level | 2 |
| concepts[3].score | 0.5204922556877136 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q2039217 |
| concepts[3].display_name | Identification (biology) |
| concepts[4].id | https://openalex.org/C71924100 |
| concepts[4].level | 0 |
| concepts[4].score | 0.44644758105278015 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[4].display_name | Medicine |
| concepts[5].id | https://openalex.org/C2776480101 |
| concepts[5].level | 3 |
| concepts[5].score | 0.4293109178543091 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q3555250 |
| concepts[5].display_name | Disease surveillance |
| concepts[6].id | https://openalex.org/C2778545548 |
| concepts[6].level | 2 |
| concepts[6].score | 0.42254093289375305 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q4914739 |
| concepts[6].display_name | Biodefense |
| concepts[7].id | https://openalex.org/C138816342 |
| concepts[7].level | 2 |
| concepts[7].score | 0.41192591190338135 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q189603 |
| concepts[7].display_name | Public health |
| concepts[8].id | https://openalex.org/C524204448 |
| concepts[8].level | 3 |
| concepts[8].score | 0.410102516412735 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q788926 |
| concepts[8].display_name | Infectious disease (medical specialty) |
| concepts[9].id | https://openalex.org/C2522767166 |
| concepts[9].level | 1 |
| concepts[9].score | 0.34648019075393677 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q2374463 |
| concepts[9].display_name | Data science |
| concepts[10].id | https://openalex.org/C2779134260 |
| concepts[10].level | 2 |
| concepts[10].score | 0.2387746274471283 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q12136 |
| concepts[10].display_name | Disease |
| concepts[11].id | https://openalex.org/C41008148 |
| concepts[11].level | 0 |
| concepts[11].score | 0.22730597853660583 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q21198 |
| concepts[11].display_name | Computer science |
| concepts[12].id | https://openalex.org/C17744445 |
| concepts[12].level | 0 |
| concepts[12].score | 0.19401055574417114 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q36442 |
| concepts[12].display_name | Political science |
| concepts[13].id | https://openalex.org/C86803240 |
| concepts[13].level | 0 |
| concepts[13].score | 0.14171606302261353 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[13].display_name | Biology |
| concepts[14].id | https://openalex.org/C142724271 |
| concepts[14].level | 1 |
| concepts[14].score | 0.09006530046463013 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q7208 |
| concepts[14].display_name | Pathology |
| concepts[15].id | https://openalex.org/C55493867 |
| concepts[15].level | 1 |
| concepts[15].score | 0.0 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[15].display_name | Biochemistry |
| concepts[16].id | https://openalex.org/C199539241 |
| concepts[16].level | 1 |
| concepts[16].score | 0.0 |
| concepts[16].wikidata | https://www.wikidata.org/wiki/Q7748 |
| concepts[16].display_name | Law |
| concepts[17].id | https://openalex.org/C138885662 |
| concepts[17].level | 0 |
| concepts[17].score | 0.0 |
| concepts[17].wikidata | https://www.wikidata.org/wiki/Q5891 |
| concepts[17].display_name | Philosophy |
| concepts[18].id | https://openalex.org/C104317684 |
| concepts[18].level | 2 |
| concepts[18].score | 0.0 |
| concepts[18].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[18].display_name | Gene |
| concepts[19].id | https://openalex.org/C59822182 |
| concepts[19].level | 1 |
| concepts[19].score | 0.0 |
| concepts[19].wikidata | https://www.wikidata.org/wiki/Q441 |
| concepts[19].display_name | Botany |
| concepts[20].id | https://openalex.org/C41895202 |
| concepts[20].level | 1 |
| concepts[20].score | 0.0 |
| concepts[20].wikidata | https://www.wikidata.org/wiki/Q8162 |
| concepts[20].display_name | Linguistics |
| keywords[0].id | https://openalex.org/keywords/metagenomics |
| keywords[0].score | 0.7393535375595093 |
| keywords[0].display_name | Metagenomics |
| keywords[1].id | https://openalex.org/keywords/government |
| keywords[1].score | 0.5490055084228516 |
| keywords[1].display_name | Government (linguistics) |
| keywords[2].id | https://openalex.org/keywords/preparedness |
| keywords[2].score | 0.5381897687911987 |
| keywords[2].display_name | Preparedness |
| keywords[3].id | https://openalex.org/keywords/identification |
| keywords[3].score | 0.5204922556877136 |
| keywords[3].display_name | Identification (biology) |
| keywords[4].id | https://openalex.org/keywords/medicine |
| keywords[4].score | 0.44644758105278015 |
| keywords[4].display_name | Medicine |
| keywords[5].id | https://openalex.org/keywords/disease-surveillance |
| keywords[5].score | 0.4293109178543091 |
| keywords[5].display_name | Disease surveillance |
| keywords[6].id | https://openalex.org/keywords/biodefense |
| keywords[6].score | 0.42254093289375305 |
| keywords[6].display_name | Biodefense |
| keywords[7].id | https://openalex.org/keywords/public-health |
| keywords[7].score | 0.41192591190338135 |
| keywords[7].display_name | Public health |
| keywords[8].id | https://openalex.org/keywords/infectious-disease |
| keywords[8].score | 0.410102516412735 |
| keywords[8].display_name | Infectious disease (medical specialty) |
| keywords[9].id | https://openalex.org/keywords/data-science |
| keywords[9].score | 0.34648019075393677 |
| keywords[9].display_name | Data science |
| keywords[10].id | https://openalex.org/keywords/disease |
| keywords[10].score | 0.2387746274471283 |
| keywords[10].display_name | Disease |
| keywords[11].id | https://openalex.org/keywords/computer-science |
| keywords[11].score | 0.22730597853660583 |
| keywords[11].display_name | Computer science |
| keywords[12].id | https://openalex.org/keywords/political-science |
| keywords[12].score | 0.19401055574417114 |
| keywords[12].display_name | Political science |
| keywords[13].id | https://openalex.org/keywords/biology |
| keywords[13].score | 0.14171606302261353 |
| keywords[13].display_name | Biology |
| keywords[14].id | https://openalex.org/keywords/pathology |
| keywords[14].score | 0.09006530046463013 |
| keywords[14].display_name | Pathology |
| language | en |
| locations[0].id | doi:10.1093/ofid/ofad500.1603 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S2735126445 |
| locations[0].source.issn | 2328-8957 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2328-8957 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Open Forum Infectious Diseases |
| locations[0].source.host_organization | https://openalex.org/P4310311648 |
| locations[0].source.host_organization_name | Oxford University Press |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310311648, https://openalex.org/P4310311647 |
| locations[0].source.host_organization_lineage_names | Oxford University Press, University of Oxford |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://academic.oup.com/ofid/article-pdf/10/Supplement_2/ofad500.1603/53758545/ofad500.1603.pdf |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Open Forum Infectious Diseases |
| locations[0].landing_page_url | https://doi.org/10.1093/ofid/ofad500.1603 |
| locations[1].id | pmh:oai:pubmedcentral.nih.gov:10676888 |
| locations[1].is_oa | True |
| locations[1].source.id | https://openalex.org/S2764455111 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed Central |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | cc-by |
| locations[1].pdf_url | https://pmc.ncbi.nlm.nih.gov/articles/PMC10676888/pdf/ofad500.1603.pdf |
| locations[1].version | submittedVersion |
| locations[1].raw_type | Text |
| locations[1].license_id | https://openalex.org/licenses/cc-by |
| locations[1].is_accepted | False |
| locations[1].is_published | False |
| locations[1].raw_source_name | Open Forum Infect Dis |
| locations[1].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/10676888 |
| indexed_in | crossref, doaj |
| authorships[0].author.id | https://openalex.org/A5036436148 |
| authorships[0].author.orcid | |
| authorships[0].author.display_name | Diane L Downie |
| authorships[0].countries | US |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I1289490764 |
| authorships[0].affiliations[0].raw_affiliation_string | U.S. Centers for Disease Control and Prevention , Atlanta , Georgia |
| authorships[0].institutions[0].id | https://openalex.org/I1289490764 |
| authorships[0].institutions[0].ror | https://ror.org/042twtr12 |
| authorships[0].institutions[0].type | government |
| authorships[0].institutions[0].lineage | https://openalex.org/I1289490764, https://openalex.org/I1299022934 |
| authorships[0].institutions[0].country_code | US |
| authorships[0].institutions[0].display_name | Centers for Disease Control and Prevention |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Diane L Downie |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | U.S. Centers for Disease Control and Prevention , Atlanta , Georgia |
| authorships[1].author.id | https://openalex.org/A5112875654 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Preetika Rao |
| authorships[1].countries | US |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I1289490764 |
| authorships[1].affiliations[0].raw_affiliation_string | U.S. Centers for Disease Control and Prevention , Atlanta , Georgia |
| authorships[1].institutions[0].id | https://openalex.org/I1289490764 |
| authorships[1].institutions[0].ror | https://ror.org/042twtr12 |
| authorships[1].institutions[0].type | government |
| authorships[1].institutions[0].lineage | https://openalex.org/I1289490764, https://openalex.org/I1299022934 |
| authorships[1].institutions[0].country_code | US |
| authorships[1].institutions[0].display_name | Centers for Disease Control and Prevention |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Preetika Rao |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | U.S. Centers for Disease Control and Prevention , Atlanta , Georgia |
| authorships[2].author.id | https://openalex.org/A5103172080 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-6000-122X |
| authorships[2].author.display_name | Corinne David‐Ferdon |
| authorships[2].countries | US |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I1289490764 |
| authorships[2].affiliations[0].raw_affiliation_string | U.S. Centers for Disease Control and Prevention , Atlanta , Georgia |
| authorships[2].institutions[0].id | https://openalex.org/I1289490764 |
| authorships[2].institutions[0].ror | https://ror.org/042twtr12 |
| authorships[2].institutions[0].type | government |
| authorships[2].institutions[0].lineage | https://openalex.org/I1289490764, https://openalex.org/I1299022934 |
| authorships[2].institutions[0].country_code | US |
| authorships[2].institutions[0].display_name | Centers for Disease Control and Prevention |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Corinne David-Ferdon |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | U.S. Centers for Disease Control and Prevention , Atlanta , Georgia |
| authorships[3].author.id | https://openalex.org/A5039449382 |
| authorships[3].author.orcid | |
| authorships[3].author.display_name | Sean Courtney |
| authorships[3].countries | US |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I1289490764 |
| authorships[3].affiliations[0].raw_affiliation_string | U.S. Centers for Disease Control and Prevention , Atlanta , Georgia |
| authorships[3].institutions[0].id | https://openalex.org/I1289490764 |
| authorships[3].institutions[0].ror | https://ror.org/042twtr12 |
| authorships[3].institutions[0].type | government |
| authorships[3].institutions[0].lineage | https://openalex.org/I1289490764, https://openalex.org/I1299022934 |
| authorships[3].institutions[0].country_code | US |
| authorships[3].institutions[0].display_name | Centers for Disease Control and Prevention |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Sean Courtney |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | U.S. Centers for Disease Control and Prevention , Atlanta , Georgia |
| authorships[4].author.id | https://openalex.org/A5100637872 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-6539-2637 |
| authorships[4].author.display_name | Justin Lee |
| authorships[4].countries | US |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I1289490764 |
| authorships[4].affiliations[0].raw_affiliation_string | U.S. Centers for Disease Control and Prevention , Atlanta , Georgia |
| authorships[4].institutions[0].id | https://openalex.org/I1289490764 |
| authorships[4].institutions[0].ror | https://ror.org/042twtr12 |
| authorships[4].institutions[0].type | government |
| authorships[4].institutions[0].lineage | https://openalex.org/I1289490764, https://openalex.org/I1299022934 |
| authorships[4].institutions[0].country_code | US |
| authorships[4].institutions[0].display_name | Centers for Disease Control and Prevention |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Justin Lee |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | U.S. Centers for Disease Control and Prevention , Atlanta , Georgia |
| authorships[5].author.id | https://openalex.org/A5025140373 |
| authorships[5].author.orcid | https://orcid.org/0000-0003-4419-1542 |
| authorships[5].author.display_name | Claire Quiner |
| authorships[5].countries | US |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I180297670 |
| authorships[5].affiliations[0].raw_affiliation_string | RTI International , Research Triangle Park , North Carolina |
| authorships[5].institutions[0].id | https://openalex.org/I180297670 |
| authorships[5].institutions[0].ror | https://ror.org/052tfza37 |
| authorships[5].institutions[0].type | nonprofit |
| authorships[5].institutions[0].lineage | https://openalex.org/I180297670 |
| authorships[5].institutions[0].country_code | US |
| authorships[5].institutions[0].display_name | RTI International |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Claire Quiner |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | RTI International , Research Triangle Park , North Carolina |
| authorships[6].author.id | https://openalex.org/A5090649670 |
| authorships[6].author.orcid | https://orcid.org/0000-0003-1340-8905 |
| authorships[6].author.display_name | Pia D. M. MacDonald |
| authorships[6].countries | US |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I180297670 |
| authorships[6].affiliations[0].raw_affiliation_string | RTI International , Research Triangle Park , North Carolina |
| authorships[6].institutions[0].id | https://openalex.org/I180297670 |
| authorships[6].institutions[0].ror | https://ror.org/052tfza37 |
| authorships[6].institutions[0].type | nonprofit |
| authorships[6].institutions[0].lineage | https://openalex.org/I180297670 |
| authorships[6].institutions[0].country_code | US |
| authorships[6].institutions[0].display_name | RTI International |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Pia MacDonald |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | RTI International , Research Triangle Park , North Carolina |
| authorships[7].author.id | https://openalex.org/A5048694107 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-7718-6937 |
| authorships[7].author.display_name | Keegan Barnes |
| authorships[7].countries | US |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I180297670 |
| authorships[7].affiliations[0].raw_affiliation_string | RTI International , Research Triangle Park , North Carolina |
| authorships[7].institutions[0].id | https://openalex.org/I180297670 |
| authorships[7].institutions[0].ror | https://ror.org/052tfza37 |
| authorships[7].institutions[0].type | nonprofit |
| authorships[7].institutions[0].lineage | https://openalex.org/I180297670 |
| authorships[7].institutions[0].country_code | US |
| authorships[7].institutions[0].display_name | RTI International |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Keegan Barnes |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | RTI International , Research Triangle Park , North Carolina |
| authorships[8].author.id | https://openalex.org/A5050574848 |
| authorships[8].author.orcid | |
| authorships[8].author.display_name | Shelby Fisher |
| authorships[8].countries | US |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I180297670 |
| authorships[8].affiliations[0].raw_affiliation_string | RTI International , Research Triangle Park , North Carolina |
| authorships[8].institutions[0].id | https://openalex.org/I180297670 |
| authorships[8].institutions[0].ror | https://ror.org/052tfza37 |
| authorships[8].institutions[0].type | nonprofit |
| authorships[8].institutions[0].lineage | https://openalex.org/I180297670 |
| authorships[8].institutions[0].country_code | US |
| authorships[8].institutions[0].display_name | RTI International |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Shelby S Fisher |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | RTI International , Research Triangle Park , North Carolina |
| authorships[9].author.id | https://openalex.org/A5109247515 |
| authorships[9].author.orcid | |
| authorships[9].author.display_name | Joanne D. Andreadis |
| authorships[9].countries | US |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I1289490764 |
| authorships[9].affiliations[0].raw_affiliation_string | U.S. Centers for Disease Control and Prevention , Atlanta , Georgia |
| authorships[9].institutions[0].id | https://openalex.org/I1289490764 |
| authorships[9].institutions[0].ror | https://ror.org/042twtr12 |
| authorships[9].institutions[0].type | government |
| authorships[9].institutions[0].lineage | https://openalex.org/I1289490764, https://openalex.org/I1299022934 |
| authorships[9].institutions[0].country_code | US |
| authorships[9].institutions[0].display_name | Centers for Disease Control and Prevention |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Joanne D Andreadis |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | U.S. Centers for Disease Control and Prevention , Atlanta , Georgia |
| authorships[10].author.id | https://openalex.org/A5052194480 |
| authorships[10].author.orcid | https://orcid.org/0000-0002-0189-0514 |
| authorships[10].author.display_name | Jasmine Chaitram |
| authorships[10].countries | US |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I1289490764 |
| authorships[10].affiliations[0].raw_affiliation_string | U.S. Centers for Disease Control and Prevention , Atlanta , Georgia |
| authorships[10].institutions[0].id | https://openalex.org/I1289490764 |
| authorships[10].institutions[0].ror | https://ror.org/042twtr12 |
| authorships[10].institutions[0].type | government |
| authorships[10].institutions[0].lineage | https://openalex.org/I1289490764, https://openalex.org/I1299022934 |
| authorships[10].institutions[0].country_code | US |
| authorships[10].institutions[0].display_name | Centers for Disease Control and Prevention |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Jasmine Chaitram |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | U.S. Centers for Disease Control and Prevention , Atlanta , Georgia |
| authorships[11].author.id | https://openalex.org/A5055949063 |
| authorships[11].author.orcid | https://orcid.org/0000-0002-3807-2339 |
| authorships[11].author.display_name | Matthew R. Mauldin |
| authorships[11].countries | US |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I1289490764 |
| authorships[11].affiliations[0].raw_affiliation_string | U.S. Centers for Disease Control and Prevention , Atlanta , Georgia |
| authorships[11].institutions[0].id | https://openalex.org/I1289490764 |
| authorships[11].institutions[0].ror | https://ror.org/042twtr12 |
| authorships[11].institutions[0].type | government |
| authorships[11].institutions[0].lineage | https://openalex.org/I1289490764, https://openalex.org/I1299022934 |
| authorships[11].institutions[0].country_code | US |
| authorships[11].institutions[0].display_name | Centers for Disease Control and Prevention |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Matthew R Mauldin |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | U.S. Centers for Disease Control and Prevention , Atlanta , Georgia |
| authorships[12].author.id | https://openalex.org/A5114102882 |
| authorships[12].author.orcid | |
| authorships[12].author.display_name | Reyolds M Salerno |
| authorships[12].countries | US |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I1289490764 |
| authorships[12].affiliations[0].raw_affiliation_string | U.S. Centers for Disease Control and Prevention , Atlanta , Georgia |
| authorships[12].institutions[0].id | https://openalex.org/I1289490764 |
| authorships[12].institutions[0].ror | https://ror.org/042twtr12 |
| authorships[12].institutions[0].type | government |
| authorships[12].institutions[0].lineage | https://openalex.org/I1289490764, https://openalex.org/I1299022934 |
| authorships[12].institutions[0].country_code | US |
| authorships[12].institutions[0].display_name | Centers for Disease Control and Prevention |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | Reyolds M Salerno |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | U.S. Centers for Disease Control and Prevention , Atlanta , Georgia |
| authorships[13].author.id | https://openalex.org/A5009656341 |
| authorships[13].author.orcid | https://orcid.org/0000-0003-3193-2700 |
| authorships[13].author.display_name | Jarad Schiffer |
| authorships[13].countries | US |
| authorships[13].affiliations[0].institution_ids | https://openalex.org/I1289490764 |
| authorships[13].affiliations[0].raw_affiliation_string | Centers for Disease Control and Prevention , Atlanta , Georgia |
| authorships[13].institutions[0].id | https://openalex.org/I1289490764 |
| authorships[13].institutions[0].ror | https://ror.org/042twtr12 |
| authorships[13].institutions[0].type | government |
| authorships[13].institutions[0].lineage | https://openalex.org/I1289490764, https://openalex.org/I1299022934 |
| authorships[13].institutions[0].country_code | US |
| authorships[13].institutions[0].display_name | Centers for Disease Control and Prevention |
| authorships[13].author_position | middle |
| authorships[13].raw_author_name | Jarad Schiffer |
| authorships[13].is_corresponding | False |
| authorships[13].raw_affiliation_strings | Centers for Disease Control and Prevention , Atlanta , Georgia |
| authorships[14].author.id | https://openalex.org/A5005755665 |
| authorships[14].author.orcid | https://orcid.org/0000-0002-7423-7903 |
| authorships[14].author.display_name | Adi V. Gundlapalli |
| authorships[14].countries | US |
| authorships[14].affiliations[0].institution_ids | https://openalex.org/I1289490764 |
| authorships[14].affiliations[0].raw_affiliation_string | U.S. Centers for Disease Control and Prevention , Atlanta , Georgia |
| authorships[14].institutions[0].id | https://openalex.org/I1289490764 |
| authorships[14].institutions[0].ror | https://ror.org/042twtr12 |
| authorships[14].institutions[0].type | government |
| authorships[14].institutions[0].lineage | https://openalex.org/I1289490764, https://openalex.org/I1299022934 |
| authorships[14].institutions[0].country_code | US |
| authorships[14].institutions[0].display_name | Centers for Disease Control and Prevention |
| authorships[14].author_position | last |
| authorships[14].raw_author_name | Adi Gundlapalli |
| authorships[14].is_corresponding | False |
| authorships[14].raw_affiliation_strings | U.S. Centers for Disease Control and Prevention , Atlanta , Georgia |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://academic.oup.com/ofid/article-pdf/10/Supplement_2/ofad500.1603/53758545/ofad500.1603.pdf |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | 1774. Surveillance for Emerging and Reemerging Pathogens Using Pathogen Agnostic Metagenomic Sequencing in the United States: A Critical Role for Federal Government Agencies |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11970 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.9314000010490417 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1312 |
| primary_topic.subfield.display_name | Molecular Biology |
| primary_topic.display_name | Molecular Biology Techniques and Applications |
| related_works | https://openalex.org/W1578967526, https://openalex.org/W2053960705, https://openalex.org/W2631908557, https://openalex.org/W4250544673, https://openalex.org/W2248394722, https://openalex.org/W1510855320, https://openalex.org/W4298085844, https://openalex.org/W2121027067, https://openalex.org/W2354600455, https://openalex.org/W2096325745 |
| cited_by_count | 1 |
| counts_by_year[0].year | 2024 |
| counts_by_year[0].cited_by_count | 1 |
| locations_count | 2 |
| best_oa_location.id | doi:10.1093/ofid/ofad500.1603 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S2735126445 |
| best_oa_location.source.issn | 2328-8957 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2328-8957 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Open Forum Infectious Diseases |
| best_oa_location.source.host_organization | https://openalex.org/P4310311648 |
| best_oa_location.source.host_organization_name | Oxford University Press |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310311648, https://openalex.org/P4310311647 |
| best_oa_location.source.host_organization_lineage_names | Oxford University Press, University of Oxford |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://academic.oup.com/ofid/article-pdf/10/Supplement_2/ofad500.1603/53758545/ofad500.1603.pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Open Forum Infectious Diseases |
| best_oa_location.landing_page_url | https://doi.org/10.1093/ofid/ofad500.1603 |
| primary_location.id | doi:10.1093/ofid/ofad500.1603 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S2735126445 |
| primary_location.source.issn | 2328-8957 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2328-8957 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Open Forum Infectious Diseases |
| primary_location.source.host_organization | https://openalex.org/P4310311648 |
| primary_location.source.host_organization_name | Oxford University Press |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310311648, https://openalex.org/P4310311647 |
| primary_location.source.host_organization_lineage_names | Oxford University Press, University of Oxford |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://academic.oup.com/ofid/article-pdf/10/Supplement_2/ofad500.1603/53758545/ofad500.1603.pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Open Forum Infectious Diseases |
| primary_location.landing_page_url | https://doi.org/10.1093/ofid/ofad500.1603 |
| publication_date | 2023-11-27 |
| publication_year | 2023 |
| referenced_works_count | 0 |
| abstract_inverted_index.A | 98 |
| abstract_inverted_index.a | 220 |
| abstract_inverted_index.No | 252 |
| abstract_inverted_index.US | 157, 185 |
| abstract_inverted_index.an | 77 |
| abstract_inverted_index.as | 53 |
| abstract_inverted_index.at | 179 |
| abstract_inverted_index.by | 133, 184 |
| abstract_inverted_index.in | 46, 59, 86, 94 |
| abstract_inverted_index.is | 14 |
| abstract_inverted_index.of | 6, 65, 79, 82, 91, 103, 116, 123, 136, 150, 159, 236 |
| abstract_inverted_index.on | 23, 111, 121 |
| abstract_inverted_index.to | 16, 40, 75, 171, 201 |
| abstract_inverted_index.All | 250 |
| abstract_inverted_index.The | 2, 128 |
| abstract_inverted_index.US. | 194 |
| abstract_inverted_index.and | 4, 9, 21, 26, 30, 34, 37, 43, 62, 69, 114, 119, 126, 152, 155, 164, 168, 175, 228, 239, 247 |
| abstract_inverted_index.for | 107 |
| abstract_inverted_index.not | 188 |
| abstract_inverted_index.the | 80, 95, 112, 141, 148, 156, 193 |
| abstract_inverted_index.was | 101, 131, 212 |
| abstract_inverted_index.This | 72 |
| abstract_inverted_index.flow | 122 |
| abstract_inverted_index.from | 140 |
| abstract_inverted_index.gain | 76 |
| abstract_inverted_index.have | 162, 198 |
| abstract_inverted_index.many | 196 |
| abstract_inverted_index.role | 81 |
| abstract_inverted_index.such | 52, 88 |
| abstract_inverted_index.that | 244 |
| abstract_inverted_index.type | 115 |
| abstract_inverted_index.were | 187 |
| abstract_inverted_index.with | 138, 225 |
| abstract_inverted_index.work | 199 |
| abstract_inverted_index.Human | 153 |
| abstract_inverted_index.could | 230 |
| abstract_inverted_index.data. | 127 |
| abstract_inverted_index.human | 92 |
| abstract_inverted_index.large | 57 |
| abstract_inverted_index.study | 73 |
| abstract_inverted_index.there | 211 |
| abstract_inverted_index.using | 48 |
| abstract_inverted_index.Health | 151 |
| abstract_inverted_index.United | 96 |
| abstract_inverted_index.across | 192, 216 |
| abstract_inverted_index.agency | 105 |
| abstract_inverted_index.and/or | 203 |
| abstract_inverted_index.detect | 41 |
| abstract_inverted_index.expert | 134 |
| abstract_inverted_index.health | 19 |
| abstract_inverted_index.humans | 47 |
| abstract_inverted_index.obtain | 172 |
| abstract_inverted_index.public | 18, 29 |
| abstract_inverted_index.reduce | 245 |
| abstract_inverted_index.relies | 22 |
| abstract_inverted_index.review | 135 |
| abstract_inverted_index.scale. | 180 |
| abstract_inverted_index.sought | 74 |
| abstract_inverted_index.within | 147 |
| abstract_inverted_index.Affairs | 161 |
| abstract_inverted_index.Methods | 71 |
| abstract_inverted_index.Results | 144 |
| abstract_inverted_index.States. | 97 |
| abstract_inverted_index.between | 28 |
| abstract_inverted_index.details | 120 |
| abstract_inverted_index.disease | 12, 207 |
| abstract_inverted_index.equally | 189 |
| abstract_inverted_index.federal | 83, 104, 142 |
| abstract_inverted_index.minimal | 213 |
| abstract_inverted_index.network | 224 |
| abstract_inverted_index.patient | 173 |
| abstract_inverted_index.perform | 176 |
| abstract_inverted_index.private | 31 |
| abstract_inverted_index.results | 137 |
| abstract_inverted_index.support | 204, 240 |
| abstract_inverted_index.systems | 33 |
| abstract_inverted_index.testing | 60, 90, 118 |
| abstract_inverted_index.unknown | 10 |
| abstract_inverted_index.website | 129 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.Although | 195 |
| abstract_inverted_index.Authors: | 251 |
| abstract_inverted_index.Services | 154 |
| abstract_inverted_index.Veterans | 160 |
| abstract_inverted_index.advanced | 49 |
| abstract_inverted_index.agencies | 85, 186 |
| abstract_inverted_index.analysis | 100, 130 |
| abstract_inverted_index.apparent | 214 |
| abstract_inverted_index.clinical | 124, 167 |
| abstract_inverted_index.emerging | 42, 205, 237 |
| abstract_inverted_index.entities | 197 |
| abstract_inverted_index.existing | 226 |
| abstract_inverted_index.increase | 232 |
| abstract_inverted_index.methods, | 51 |
| abstract_inverted_index.national | 17, 221 |
| abstract_inverted_index.networks | 64, 170 |
| abstract_inverted_index.programs | 39 |
| abstract_inverted_index.publicly | 108 |
| abstract_inverted_index.reported | 253 |
| abstract_inverted_index.requires | 56 |
| abstract_inverted_index.research | 169 |
| abstract_inverted_index.sentinel | 222 |
| abstract_inverted_index.specimen | 209 |
| abstract_inverted_index.websites | 106 |
| abstract_inverted_index.Operating | 145 |
| abstract_inverted_index.agencies. | 143, 217 |
| abstract_inverted_index.conducted | 102 |
| abstract_inverted_index.dedicated | 200 |
| abstract_inverted_index.developed | 163 |
| abstract_inverted_index.divisions | 146 |
| abstract_inverted_index.emerging, | 7 |
| abstract_inverted_index.equipment | 61 |
| abstract_inverted_index.essential | 15 |
| abstract_inverted_index.extensive | 166 |
| abstract_inverted_index.fluidity, | 24 |
| abstract_inverted_index.landscape | 99 |
| abstract_inverted_index.molecular | 50 |
| abstract_inverted_index.morbidity | 246 |
| abstract_inverted_index.networks. | 35 |
| abstract_inverted_index.pathogens | 13, 45 |
| abstract_inverted_index.resources | 227 |
| abstract_inverted_index.specimens | 93, 125, 174 |
| abstract_inverted_index.supported | 183 |
| abstract_inverted_index.sustained | 165 |
| abstract_inverted_index.Background | 1 |
| abstract_inverted_index.Conclusion | 218 |
| abstract_inverted_index.Department | 149, 158 |
| abstract_inverted_index.Developing | 219 |
| abstract_inverted_index.accelerate | 234 |
| abstract_inverted_index.accessible | 109 |
| abstract_inverted_index.developing | 63 |
| abstract_inverted_index.facilities | 182 |
| abstract_inverted_index.government | 84 |
| abstract_inverted_index.infectious | 11, 206 |
| abstract_inverted_index.laboratory | 67 |
| abstract_inverted_index.mortality. | 248 |
| abstract_inverted_index.sequencing | 178 |
| abstract_inverted_index.strategies | 243 |
| abstract_inverted_index.supporting | 87 |
| abstract_inverted_index.sustaining | 38 |
| abstract_inverted_index.Disclosures | 249 |
| abstract_inverted_index.Metagenomic | 181 |
| abstract_inverted_index.biothreats, | 238 |
| abstract_inverted_index.clinicians, | 66 |
| abstract_inverted_index.collection, | 210 |
| abstract_inverted_index.coordinated | 241 |
| abstract_inverted_index.disclosures | 254 |
| abstract_inverted_index.distributed | 191 |
| abstract_inverted_index.efficiency, | 233 |
| abstract_inverted_index.information | 110 |
| abstract_inverted_index.investments | 58 |
| abstract_inverted_index.metagenomic | 54, 177 |
| abstract_inverted_index.potentially | 231 |
| abstract_inverted_index.re-emerging | 44 |
| abstract_inverted_index.reemerging, | 8 |
| abstract_inverted_index.scientists, | 68 |
| abstract_inverted_index.sequencing, | 55 |
| abstract_inverted_index.Implementing | 36 |
| abstract_inverted_index.availability | 113 |
| abstract_inverted_index.intervention | 242 |
| abstract_inverted_index.metagenomics | 202 |
| abstract_inverted_index.preparedness | 20 |
| abstract_inverted_index.supplemented | 132 |
| abstract_inverted_index.surveillance | 3, 32, 208, 223 |
| abstract_inverted_index.collaboration | 215 |
| abstract_inverted_index.coordination, | 25 |
| abstract_inverted_index.understanding | 78 |
| abstract_inverted_index.geographically | 190 |
| abstract_inverted_index.identification | 5, 235 |
| abstract_inverted_index.infrastructure | 229 |
| abstract_inverted_index.representatives | 139 |
| abstract_inverted_index.interconnectivity | 27 |
| abstract_inverted_index.pathogen-agnostic | 89, 117 |
| abstract_inverted_index.bioinformaticians. | 70 |
| cited_by_percentile_year.max | 94 |
| cited_by_percentile_year.min | 90 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 15 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/9 |
| sustainable_development_goals[0].score | 0.44999998807907104 |
| sustainable_development_goals[0].display_name | Industry, innovation and infrastructure |
| sustainable_development_goals[1].id | https://metadata.un.org/sdg/17 |
| sustainable_development_goals[1].score | 0.4300000071525574 |
| sustainable_development_goals[1].display_name | Partnerships for the goals |
| citation_normalized_percentile.value | 0.61752133 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |