17q21 Variants Disturb Mucosal Host Defense in Childhood Asthma Article Swipe
Constanze A. Jakwerth
,
Markus Weckmann
,
Sabina Illi
,
Helen Charles
,
Ulrich M. Zissler
,
Madlen Oelsner
,
Ferdinand Guerth
,
Jimmy Omony
,
Sai Sneha Priya Nemani
,
Ruth Grychtol
,
Anna‐Maria Dittrich
,
Chrysanthi Skevaki
,
Svenja Foth
,
Stefanie Weber
,
Miguel A. Alejandre Alcázar
,
Silke van Koningsbruggen‐Rietschel
,
Robert W. Brock
,
Samira Blau
,
Gesine Hansen
,
Thomas Bahmer
,
Klaus F. Rabe
,
Folke Brinkmann
,
Matthias Kopp
,
Adam Chaker
,
Bianca Schaub
,
Erika von Mutius
,
Carsten B. Schmidt‐Weber
,
Oliver Fuchs
,
Barbara Roesler
,
Nils Welchering
,
Naschla Kohistani-Greif
,
Johanna Kurz
,
Katja Landgraf‐Rauf
,
Kristina Laubhahn
,
Nicole Maison
,
Claudia Liebl
,
Markus Ege
,
Alexander Hose
,
Esther Zeitlmann
,
Mira Berbig
,
Carola Marzi
,
Christina Schauberger
,
Isabell Ricklefs
,
Gesa Diekmann
,
Lena Liboschik
,
Gesche Voigt
,
Laila Sultansei
,
Gyde Nissen
,
Inke R. König
,
Dominik Thiele
,
Anne‐Marie Kirsten
,
Frauke Pedersen
,
Henrik Watz
,
Benjamin Waschki
,
Christian Herzmann
,
Mustafa Abdo
,
Heike Biller
,
Karoline I. Gaede
,
Xenia Bovermann
,
Alena Steinmetz
,
Berrit Liselotte Husstedt
,
Catharina Nitsche
,
Vera Veith
,
Marlen Szewczyk
,
Christine Happle
,
Malik Aydin
,
Nicolaus Schwerk
,
Christian Dopfer
,
Mareike Price
,
Adan Chari Jirmo
,
Anika Habener
,
David S. DeLuca
,
Svenja Gaedcke
,
Bin Liu
,
Mifflin-Rae Calveron
,
Harald Renz
,
Meike Meyer
,
Tom Schildberg
,
Ernst Rietschel
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1164/rccm.202305-0934oc
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1164/rccm.202305-0934oc
Rationale: The strongest genetic risk factor for childhood-onset asthma, the 17q21 locus, is associated with increased viral susceptibility and disease-promoting processes.Objectives: To identify biological targets underlying the escalated viral susceptibility associated with the clinical phenotype mediated by the 17q21 locus.Methods: Genome-wide transcriptome analysis of nasal brush samples from 261 children (78 healthy, 79 with wheezing at preschool age, 104 asthmatic) within the ALLIANCE (All-Age-Asthma) cohort, with a median age of 10.0 (range, 1.0-20.0) years, was conducted to explore the impact of their 17q21 genotype (SNP rs72163891). Concurrently, nasal secretions from the same patients and visits were collected, and high-sensitivity mesoscale technology was employed to measure IFN protein levels.Measurements and Main Results: This study revealed that the 17q21 risk allele induces a genotype- and asthma/wheeze phenotype-dependent enhancement of mucosal GSDMB expression as the only relevant 17q21-encoded gene in children with preschool wheeze. Increased GSDMB expression correlated with the activation of a type-1 proinflammatory, cell-lytic immune, and natural killer signature, encompassing key genes linked to an IFN type-2-signature (IFNG, CXCL9, CXCL10, KLRC1, CD8A, GZMA). Conversely, there was a reduction in IFN type 1 and type 3 expression signatures at the mRNA and protein levels.Conclusions: This study demonstrates a novel disease-driving mechanism induced by the 17q21 risk allele. Increased mucosal GSDMB expression is associated with a cell-lytic immune response coupled with compromised airway immunocompetence. These findings suggest that GSDMB-related airway cell death and perturbations in the mucosal IFN signature account for the increased vulnerability of 17q21 risk allele carriers to respiratory viral infections during early life, opening new options for future biological interventions.The All-Age-Asthma (ALLIANCE) cohort is registered at www.clinicaltrials.gov (pediatric arm, NCT02496468).
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1164/rccm.202305-0934oc
- OA Status
- green
- Cited By
- 20
- References
- 42
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4389477665
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4389477665Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1164/rccm.202305-0934ocDigital Object Identifier
- Title
-
17q21 Variants Disturb Mucosal Host Defense in Childhood AsthmaWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-12-08Full publication date if available
- Authors
-
Constanze A. Jakwerth, Markus Weckmann, Sabina Illi, Helen Charles, Ulrich M. Zissler, Madlen Oelsner, Ferdinand Guerth, Jimmy Omony, Sai Sneha Priya Nemani, Ruth Grychtol, Anna‐Maria Dittrich, Chrysanthi Skevaki, Svenja Foth, Stefanie Weber, Miguel A. Alejandre Alcázar, Silke van Koningsbruggen‐Rietschel, Robert W. Brock, Samira Blau, Gesine Hansen, Thomas Bahmer, Klaus F. Rabe, Folke Brinkmann, Matthias Kopp, Adam Chaker, Bianca Schaub, Erika von Mutius, Carsten B. Schmidt‐Weber, Oliver Fuchs, Barbara Roesler, Nils Welchering, Naschla Kohistani-Greif, Johanna Kurz, Katja Landgraf‐Rauf, Kristina Laubhahn, Nicole Maison, Claudia Liebl, Markus Ege, Alexander Hose, Esther Zeitlmann, Mira Berbig, Carola Marzi, Christina Schauberger, Isabell Ricklefs, Gesa Diekmann, Lena Liboschik, Gesche Voigt, Laila Sultansei, Gyde Nissen, Inke R. König, Dominik Thiele, Anne‐Marie Kirsten, Frauke Pedersen, Henrik Watz, Benjamin Waschki, Christian Herzmann, Mustafa Abdo, Heike Biller, Karoline I. Gaede, Xenia Bovermann, Alena Steinmetz, Berrit Liselotte Husstedt, Catharina Nitsche, Vera Veith, Marlen Szewczyk, Christine Happle, Malik Aydin, Nicolaus Schwerk, Christian Dopfer, Mareike Price, Adan Chari Jirmo, Anika Habener, David S. DeLuca, Svenja Gaedcke, Bin Liu, Mifflin-Rae Calveron, Harald Renz, Meike Meyer, Tom Schildberg, Ernst RietschelList of authors in order
- Landing page
-
https://doi.org/10.1164/rccm.202305-0934ocPublisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.ncbi.nlm.nih.gov/pmc/articles/11531215Direct OA link when available
- Concepts
-
Immunology, Locus (genetics), Genotype, Allele, Medicine, Asthma, Immune system, Lytic cycle, Biology, Genetics, Gene, VirusTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
20Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 12, 2024: 8Per-year citation counts (last 5 years)
- References (count)
-
42Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4389477665 |
|---|---|
| doi | https://doi.org/10.1164/rccm.202305-0934oc |
| ids.doi | https://doi.org/10.1164/rccm.202305-0934oc |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/38064241 |
| ids.openalex | https://openalex.org/W4389477665 |
| fwci | 5.94995328 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D002675 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Child, Preschool |
| mesh[1].qualifier_ui | |
| mesh[1].descriptor_ui | D002648 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | |
| mesh[1].descriptor_name | Child |
| mesh[2].qualifier_ui | |
| mesh[2].descriptor_ui | D006801 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | |
| mesh[2].descriptor_name | Humans |
| mesh[3].qualifier_ui | |
| mesh[3].descriptor_ui | D007223 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | |
| mesh[3].descriptor_name | Infant |
| mesh[4].qualifier_ui | |
| mesh[4].descriptor_ui | D000293 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | |
| mesh[4].descriptor_name | Adolescent |
| mesh[5].qualifier_ui | |
| mesh[5].descriptor_ui | D055815 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | |
| mesh[5].descriptor_name | Young Adult |
| mesh[6].qualifier_ui | |
| mesh[6].descriptor_ui | D000328 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | |
| mesh[6].descriptor_name | Adult |
| mesh[7].qualifier_ui | |
| mesh[7].descriptor_ui | D000369 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | |
| mesh[7].descriptor_name | Aged, 80 and over |
| mesh[8].qualifier_ui | |
| mesh[8].descriptor_ui | D001249 |
| mesh[8].is_major_topic | True |
| mesh[8].qualifier_name | |
| mesh[8].descriptor_name | Asthma |
| mesh[9].qualifier_ui | |
| mesh[9].descriptor_ui | D005838 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | |
| mesh[9].descriptor_name | Genotype |
| mesh[10].qualifier_ui | |
| mesh[10].descriptor_ui | D010641 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | |
| mesh[10].descriptor_name | Phenotype |
| mesh[11].qualifier_ui | |
| mesh[11].descriptor_ui | D000483 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | |
| mesh[11].descriptor_name | Alleles |
| mesh[12].qualifier_ui | |
| mesh[12].descriptor_ui | D012333 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | |
| mesh[12].descriptor_name | RNA, Messenger |
| mesh[13].qualifier_ui | Q000235 |
| mesh[13].descriptor_ui | D020022 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | genetics |
| mesh[13].descriptor_name | Genetic Predisposition to Disease |
| mesh[14].qualifier_ui | Q000235 |
| mesh[14].descriptor_ui | D020641 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | genetics |
| mesh[14].descriptor_name | Polymorphism, Single Nucleotide |
| mesh[15].qualifier_ui | |
| mesh[15].descriptor_ui | D002675 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | |
| mesh[15].descriptor_name | Child, Preschool |
| mesh[16].qualifier_ui | |
| mesh[16].descriptor_ui | D002648 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | |
| mesh[16].descriptor_name | Child |
| mesh[17].qualifier_ui | |
| mesh[17].descriptor_ui | D006801 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | |
| mesh[17].descriptor_name | Humans |
| mesh[18].qualifier_ui | |
| mesh[18].descriptor_ui | D007223 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | |
| mesh[18].descriptor_name | Infant |
| mesh[19].qualifier_ui | |
| mesh[19].descriptor_ui | D000293 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | |
| mesh[19].descriptor_name | Adolescent |
| mesh[20].qualifier_ui | |
| mesh[20].descriptor_ui | D055815 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | |
| mesh[20].descriptor_name | Young Adult |
| mesh[21].qualifier_ui | |
| mesh[21].descriptor_ui | D000328 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | |
| mesh[21].descriptor_name | Adult |
| mesh[22].qualifier_ui | |
| mesh[22].descriptor_ui | D000369 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | |
| mesh[22].descriptor_name | Aged, 80 and over |
| mesh[23].qualifier_ui | |
| mesh[23].descriptor_ui | D001249 |
| mesh[23].is_major_topic | True |
| mesh[23].qualifier_name | |
| mesh[23].descriptor_name | Asthma |
| mesh[24].qualifier_ui | |
| mesh[24].descriptor_ui | D005838 |
| mesh[24].is_major_topic | False |
| mesh[24].qualifier_name | |
| mesh[24].descriptor_name | Genotype |
| mesh[25].qualifier_ui | |
| mesh[25].descriptor_ui | D010641 |
| mesh[25].is_major_topic | False |
| mesh[25].qualifier_name | |
| mesh[25].descriptor_name | Phenotype |
| mesh[26].qualifier_ui | |
| mesh[26].descriptor_ui | D000483 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | |
| mesh[26].descriptor_name | Alleles |
| mesh[27].qualifier_ui | |
| mesh[27].descriptor_ui | D012333 |
| mesh[27].is_major_topic | False |
| mesh[27].qualifier_name | |
| mesh[27].descriptor_name | RNA, Messenger |
| mesh[28].qualifier_ui | Q000235 |
| mesh[28].descriptor_ui | D020022 |
| mesh[28].is_major_topic | False |
| mesh[28].qualifier_name | genetics |
| mesh[28].descriptor_name | Genetic Predisposition to Disease |
| mesh[29].qualifier_ui | Q000235 |
| mesh[29].descriptor_ui | D020641 |
| mesh[29].is_major_topic | False |
| mesh[29].qualifier_name | genetics |
| mesh[29].descriptor_name | Polymorphism, Single Nucleotide |
| mesh[30].qualifier_ui | |
| mesh[30].descriptor_ui | D002675 |
| mesh[30].is_major_topic | False |
| mesh[30].qualifier_name | |
| mesh[30].descriptor_name | Child, Preschool |
| mesh[31].qualifier_ui | |
| mesh[31].descriptor_ui | D002648 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | |
| mesh[31].descriptor_name | Child |
| mesh[32].qualifier_ui | |
| mesh[32].descriptor_ui | D006801 |
| mesh[32].is_major_topic | False |
| mesh[32].qualifier_name | |
| mesh[32].descriptor_name | Humans |
| mesh[33].qualifier_ui | |
| mesh[33].descriptor_ui | D007223 |
| mesh[33].is_major_topic | False |
| mesh[33].qualifier_name | |
| mesh[33].descriptor_name | Infant |
| mesh[34].qualifier_ui | |
| mesh[34].descriptor_ui | D000293 |
| mesh[34].is_major_topic | False |
| mesh[34].qualifier_name | |
| mesh[34].descriptor_name | Adolescent |
| mesh[35].qualifier_ui | |
| mesh[35].descriptor_ui | D055815 |
| mesh[35].is_major_topic | False |
| mesh[35].qualifier_name | |
| mesh[35].descriptor_name | Young Adult |
| mesh[36].qualifier_ui | |
| mesh[36].descriptor_ui | D000328 |
| mesh[36].is_major_topic | False |
| mesh[36].qualifier_name | |
| mesh[36].descriptor_name | Adult |
| mesh[37].qualifier_ui | |
| mesh[37].descriptor_ui | D000369 |
| mesh[37].is_major_topic | False |
| mesh[37].qualifier_name | |
| mesh[37].descriptor_name | Aged, 80 and over |
| mesh[38].qualifier_ui | |
| mesh[38].descriptor_ui | D001249 |
| mesh[38].is_major_topic | True |
| mesh[38].qualifier_name | |
| mesh[38].descriptor_name | Asthma |
| mesh[39].qualifier_ui | |
| mesh[39].descriptor_ui | D005838 |
| mesh[39].is_major_topic | False |
| mesh[39].qualifier_name | |
| mesh[39].descriptor_name | Genotype |
| mesh[40].qualifier_ui | |
| mesh[40].descriptor_ui | D010641 |
| mesh[40].is_major_topic | False |
| mesh[40].qualifier_name | |
| mesh[40].descriptor_name | Phenotype |
| mesh[41].qualifier_ui | |
| mesh[41].descriptor_ui | D000483 |
| mesh[41].is_major_topic | False |
| mesh[41].qualifier_name | |
| mesh[41].descriptor_name | Alleles |
| mesh[42].qualifier_ui | |
| mesh[42].descriptor_ui | D012333 |
| mesh[42].is_major_topic | False |
| mesh[42].qualifier_name | |
| mesh[42].descriptor_name | RNA, Messenger |
| mesh[43].qualifier_ui | Q000235 |
| mesh[43].descriptor_ui | D020022 |
| mesh[43].is_major_topic | False |
| mesh[43].qualifier_name | genetics |
| mesh[43].descriptor_name | Genetic Predisposition to Disease |
| mesh[44].qualifier_ui | Q000235 |
| mesh[44].descriptor_ui | D020641 |
| mesh[44].is_major_topic | False |
| mesh[44].qualifier_name | genetics |
| mesh[44].descriptor_name | Polymorphism, Single Nucleotide |
| mesh[45].qualifier_ui | |
| mesh[45].descriptor_ui | D002675 |
| mesh[45].is_major_topic | False |
| mesh[45].qualifier_name | |
| mesh[45].descriptor_name | Child, Preschool |
| mesh[46].qualifier_ui | |
| mesh[46].descriptor_ui | D002648 |
| mesh[46].is_major_topic | False |
| mesh[46].qualifier_name | |
| mesh[46].descriptor_name | Child |
| mesh[47].qualifier_ui | |
| mesh[47].descriptor_ui | D006801 |
| mesh[47].is_major_topic | False |
| mesh[47].qualifier_name | |
| mesh[47].descriptor_name | Humans |
| mesh[48].qualifier_ui | |
| mesh[48].descriptor_ui | D007223 |
| mesh[48].is_major_topic | False |
| mesh[48].qualifier_name | |
| mesh[48].descriptor_name | Infant |
| mesh[49].qualifier_ui | |
| mesh[49].descriptor_ui | D000293 |
| mesh[49].is_major_topic | False |
| mesh[49].qualifier_name | |
| mesh[49].descriptor_name | Adolescent |
| type | article |
| title | 17q21 Variants Disturb Mucosal Host Defense in Childhood Asthma |
| biblio.issue | 8 |
| biblio.volume | 209 |
| biblio.last_page | 959 |
| biblio.first_page | 947 |
| grants[0].funder | https://openalex.org/F4320320879 |
| grants[0].award_id | |
| grants[0].funder_display_name | Deutsche Forschungsgemeinschaft |
| topics[0].id | https://openalex.org/T10051 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9998000264167786 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2737 |
| topics[0].subfield.display_name | Physiology |
| topics[0].display_name | Asthma and respiratory diseases |
| topics[1].id | https://openalex.org/T12528 |
| topics[1].field.id | https://openalex.org/fields/24 |
| topics[1].field.display_name | Immunology and Microbiology |
| topics[1].score | 0.9991999864578247 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2403 |
| topics[1].subfield.display_name | Immunology |
| topics[1].display_name | IL-33, ST2, and ILC Pathways |
| topics[2].id | https://openalex.org/T10276 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.996399998664856 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2746 |
| topics[2].subfield.display_name | Surgery |
| topics[2].display_name | Helicobacter pylori-related gastroenterology studies |
| funders[0].id | https://openalex.org/F4320320879 |
| funders[0].ror | https://ror.org/018mejw64 |
| funders[0].display_name | Deutsche Forschungsgemeinschaft |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C203014093 |
| concepts[0].level | 1 |
| concepts[0].score | 0.6751840114593506 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q101929 |
| concepts[0].display_name | Immunology |
| concepts[1].id | https://openalex.org/C84597430 |
| concepts[1].level | 3 |
| concepts[1].score | 0.5649035573005676 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q106227 |
| concepts[1].display_name | Locus (genetics) |
| concepts[2].id | https://openalex.org/C135763542 |
| concepts[2].level | 3 |
| concepts[2].score | 0.525821328163147 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q106016 |
| concepts[2].display_name | Genotype |
| concepts[3].id | https://openalex.org/C180754005 |
| concepts[3].level | 3 |
| concepts[3].score | 0.5192444324493408 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q80726 |
| concepts[3].display_name | Allele |
| concepts[4].id | https://openalex.org/C71924100 |
| concepts[4].level | 0 |
| concepts[4].score | 0.4927861988544464 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[4].display_name | Medicine |
| concepts[5].id | https://openalex.org/C2776042228 |
| concepts[5].level | 2 |
| concepts[5].score | 0.4884590208530426 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q35869 |
| concepts[5].display_name | Asthma |
| concepts[6].id | https://openalex.org/C8891405 |
| concepts[6].level | 2 |
| concepts[6].score | 0.47228437662124634 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q1059 |
| concepts[6].display_name | Immune system |
| concepts[7].id | https://openalex.org/C182615771 |
| concepts[7].level | 3 |
| concepts[7].score | 0.41170114278793335 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q1369386 |
| concepts[7].display_name | Lytic cycle |
| concepts[8].id | https://openalex.org/C86803240 |
| concepts[8].level | 0 |
| concepts[8].score | 0.3945804536342621 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[8].display_name | Biology |
| concepts[9].id | https://openalex.org/C54355233 |
| concepts[9].level | 1 |
| concepts[9].score | 0.365530788898468 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[9].display_name | Genetics |
| concepts[10].id | https://openalex.org/C104317684 |
| concepts[10].level | 2 |
| concepts[10].score | 0.32947811484336853 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[10].display_name | Gene |
| concepts[11].id | https://openalex.org/C2522874641 |
| concepts[11].level | 2 |
| concepts[11].score | 0.1255301833152771 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q808 |
| concepts[11].display_name | Virus |
| keywords[0].id | https://openalex.org/keywords/immunology |
| keywords[0].score | 0.6751840114593506 |
| keywords[0].display_name | Immunology |
| keywords[1].id | https://openalex.org/keywords/locus |
| keywords[1].score | 0.5649035573005676 |
| keywords[1].display_name | Locus (genetics) |
| keywords[2].id | https://openalex.org/keywords/genotype |
| keywords[2].score | 0.525821328163147 |
| keywords[2].display_name | Genotype |
| keywords[3].id | https://openalex.org/keywords/allele |
| keywords[3].score | 0.5192444324493408 |
| keywords[3].display_name | Allele |
| keywords[4].id | https://openalex.org/keywords/medicine |
| keywords[4].score | 0.4927861988544464 |
| keywords[4].display_name | Medicine |
| keywords[5].id | https://openalex.org/keywords/asthma |
| keywords[5].score | 0.4884590208530426 |
| keywords[5].display_name | Asthma |
| keywords[6].id | https://openalex.org/keywords/immune-system |
| keywords[6].score | 0.47228437662124634 |
| keywords[6].display_name | Immune system |
| keywords[7].id | https://openalex.org/keywords/lytic-cycle |
| keywords[7].score | 0.41170114278793335 |
| keywords[7].display_name | Lytic cycle |
| keywords[8].id | https://openalex.org/keywords/biology |
| keywords[8].score | 0.3945804536342621 |
| keywords[8].display_name | Biology |
| keywords[9].id | https://openalex.org/keywords/genetics |
| keywords[9].score | 0.365530788898468 |
| keywords[9].display_name | Genetics |
| keywords[10].id | https://openalex.org/keywords/gene |
| keywords[10].score | 0.32947811484336853 |
| keywords[10].display_name | Gene |
| keywords[11].id | https://openalex.org/keywords/virus |
| keywords[11].score | 0.1255301833152771 |
| keywords[11].display_name | Virus |
| language | en |
| locations[0].id | doi:10.1164/rccm.202305-0934oc |
| locations[0].is_oa | False |
| locations[0].source.id | https://openalex.org/S93356601 |
| locations[0].source.issn | 1073-449X, 1535-4970 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 1073-449X |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | American Journal of Respiratory and Critical Care Medicine |
| locations[0].source.host_organization | https://openalex.org/P4310316311 |
| locations[0].source.host_organization_name | American Thoracic Society |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310316311 |
| locations[0].license | |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | American Journal of Respiratory and Critical Care Medicine |
| locations[0].landing_page_url | https://doi.org/10.1164/rccm.202305-0934oc |
| locations[1].id | pmid:38064241 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | American journal of respiratory and critical care medicine |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/38064241 |
| locations[2].id | pmh:oai:mediatum.ub.tum.de:node/1764628 |
| locations[2].is_oa | False |
| locations[2].source.id | https://openalex.org/S4306400453 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) |
| locations[2].source.host_organization | https://openalex.org/I62916508 |
| locations[2].source.host_organization_name | Technical University of Munich |
| locations[2].source.host_organization_lineage | https://openalex.org/I62916508 |
| locations[2].license | |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | article |
| locations[2].license_id | |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | |
| locations[2].landing_page_url | https://mediatum.ub.tum.de/1764628 |
| locations[3].id | pmh:oai:pubmedcentral.nih.gov:11531215 |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S2764455111 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | PubMed Central |
| locations[3].source.host_organization | https://openalex.org/I1299303238 |
| locations[3].source.host_organization_name | National Institutes of Health |
| locations[3].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[3].license | other-oa |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | Text |
| locations[3].license_id | https://openalex.org/licenses/other-oa |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | Am J Respir Crit Care Med |
| locations[3].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/11531215 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5059866489 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-2902-0393 |
| authorships[0].author.display_name | Constanze A. Jakwerth |
| authorships[0].countries | DE |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I3018134672 |
| authorships[0].affiliations[0].raw_affiliation_string | Center of Allergy and Environment (ZAUM), Technical University and Helmholtz Center Munich, Munich, Germany; |
| authorships[0].affiliations[1].institution_ids | https://openalex.org/I4210129183 |
| authorships[0].affiliations[1].raw_affiliation_string | Member of the German Center for Lung Research (DZL), Germany; |
| authorships[0].institutions[0].id | https://openalex.org/I4210129183 |
| authorships[0].institutions[0].ror | https://ror.org/03dx11k66 |
| authorships[0].institutions[0].type | facility |
| authorships[0].institutions[0].lineage | https://openalex.org/I4210129183, https://openalex.org/I4411590659 |
| authorships[0].institutions[0].country_code | DE |
| authorships[0].institutions[0].display_name | German Center for Lung Research |
| authorships[0].institutions[1].id | https://openalex.org/I3018134672 |
| authorships[0].institutions[1].ror | https://ror.org/00cfam450 |
| authorships[0].institutions[1].type | facility |
| authorships[0].institutions[1].lineage | https://openalex.org/I1305996414, https://openalex.org/I3018134672 |
| authorships[0].institutions[1].country_code | DE |
| authorships[0].institutions[1].display_name | Helmholtz Zentrum München |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Constanze A. Jakwerth |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Center of Allergy and Environment (ZAUM), Technical University and Helmholtz Center Munich, Munich, Germany;, Member of the German Center for Lung Research (DZL), Germany; |
| authorships[1].author.id | https://openalex.org/A5062091202 |
| authorships[1].author.orcid | https://orcid.org/0000-0001-5342-979X |
| authorships[1].author.display_name | Markus Weckmann |
| authorships[1].countries | DE |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I4210140903 |
| authorships[1].affiliations[0].raw_affiliation_string | Airway Research Center North, Borstel, Lübeck, Kiel, Grosshansdorf, Germany; |
| authorships[1].affiliations[1].institution_ids | https://openalex.org/I4210112713, https://openalex.org/I9341345 |
| authorships[1].affiliations[1].raw_affiliation_string | Department of Pediatric Pneumology and Allergology, University Medical Center Schleswig-Holstein, Lübeck, Germany; |
| authorships[1].affiliations[2].institution_ids | https://openalex.org/I4210129183 |
| authorships[1].affiliations[2].raw_affiliation_string | Member of the German Center for Lung Research (DZL), Germany; |
| authorships[1].affiliations[3].institution_ids | https://openalex.org/I4210128097 |
| authorships[1].affiliations[3].raw_affiliation_string | Division of Epigenetics in Chronic Lung Disease, Priority Area Chronic Lung Diseases, Research Center Borstel-Leibniz Lung Center, Borstel, Germany; |
| authorships[1].institutions[0].id | https://openalex.org/I4210129183 |
| authorships[1].institutions[0].ror | https://ror.org/03dx11k66 |
| authorships[1].institutions[0].type | facility |
| authorships[1].institutions[0].lineage | https://openalex.org/I4210129183, https://openalex.org/I4411590659 |
| authorships[1].institutions[0].country_code | DE |
| authorships[1].institutions[0].display_name | German Center for Lung Research |
| authorships[1].institutions[1].id | https://openalex.org/I4210140903 |
| authorships[1].institutions[1].ror | https://ror.org/041wfjw90 |
| authorships[1].institutions[1].type | healthcare |
| authorships[1].institutions[1].lineage | https://openalex.org/I4210140903 |
| authorships[1].institutions[1].country_code | DE |
| authorships[1].institutions[1].display_name | LungenClinic Grosshansdorf |
| authorships[1].institutions[2].id | https://openalex.org/I4210128097 |
| authorships[1].institutions[2].ror | https://ror.org/036ragn25 |
| authorships[1].institutions[2].type | facility |
| authorships[1].institutions[2].lineage | https://openalex.org/I315704651, https://openalex.org/I4210128097 |
| authorships[1].institutions[2].country_code | DE |
| authorships[1].institutions[2].display_name | Research Center Borstel - Leibniz Lung Center |
| authorships[1].institutions[3].id | https://openalex.org/I4210112713 |
| authorships[1].institutions[3].ror | https://ror.org/01tvm6f46 |
| authorships[1].institutions[3].type | healthcare |
| authorships[1].institutions[3].lineage | https://openalex.org/I4210112713 |
| authorships[1].institutions[3].country_code | DE |
| authorships[1].institutions[3].display_name | University Hospital Schleswig-Holstein |
| authorships[1].institutions[4].id | https://openalex.org/I9341345 |
| authorships[1].institutions[4].ror | https://ror.org/00t3r8h32 |
| authorships[1].institutions[4].type | education |
| authorships[1].institutions[4].lineage | https://openalex.org/I9341345 |
| authorships[1].institutions[4].country_code | DE |
| authorships[1].institutions[4].display_name | University of Lübeck |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Markus Weckmann |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Airway Research Center North, Borstel, Lübeck, Kiel, Grosshansdorf, Germany;, Department of Pediatric Pneumology and Allergology, University Medical Center Schleswig-Holstein, Lübeck, Germany;, Division of Epigenetics in Chronic Lung Disease, Priority Area Chronic Lung Diseases, Research Center Borstel-Leibniz Lung Center, Borstel, Germany;, Member of the German Center for Lung Research (DZL), Germany; |
| authorships[2].author.id | https://openalex.org/A5058438863 |
| authorships[2].author.orcid | https://orcid.org/0000-0003-4994-7732 |
| authorships[2].author.display_name | Sabina Illi |
| authorships[2].countries | DE |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I3018134672 |
| authorships[2].affiliations[0].raw_affiliation_string | Institute for Asthma and Allergy Prevention, Helmholtz Center Munich, German Research Center for Environmental Health, Munich, Germany; |
| authorships[2].affiliations[1].raw_affiliation_string | Comprehensive Pneumology Center–Munich, Munich, Germany; |
| authorships[2].affiliations[2].institution_ids | https://openalex.org/I4210129183 |
| authorships[2].affiliations[2].raw_affiliation_string | Member of the German Center for Lung Research (DZL), Germany; |
| authorships[2].institutions[0].id | https://openalex.org/I4210129183 |
| authorships[2].institutions[0].ror | https://ror.org/03dx11k66 |
| authorships[2].institutions[0].type | facility |
| authorships[2].institutions[0].lineage | https://openalex.org/I4210129183, https://openalex.org/I4411590659 |
| authorships[2].institutions[0].country_code | DE |
| authorships[2].institutions[0].display_name | German Center for Lung Research |
| authorships[2].institutions[1].id | https://openalex.org/I3018134672 |
| authorships[2].institutions[1].ror | https://ror.org/00cfam450 |
| authorships[2].institutions[1].type | facility |
| authorships[2].institutions[1].lineage | https://openalex.org/I1305996414, https://openalex.org/I3018134672 |
| authorships[2].institutions[1].country_code | DE |
| authorships[2].institutions[1].display_name | Helmholtz Zentrum München |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Sabina Illi |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Comprehensive Pneumology Center–Munich, Munich, Germany;, Institute for Asthma and Allergy Prevention, Helmholtz Center Munich, German Research Center for Environmental Health, Munich, Germany;, Member of the German Center for Lung Research (DZL), Germany; |
| authorships[3].author.id | https://openalex.org/A5108884275 |
| authorships[3].author.orcid | |
| authorships[3].author.display_name | Helen Charles |
| authorships[3].countries | DE |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I4210129183 |
| authorships[3].affiliations[0].raw_affiliation_string | Member of the German Center for Lung Research (DZL), Germany; |
| authorships[3].affiliations[1].institution_ids | https://openalex.org/I3018134672 |
| authorships[3].affiliations[1].raw_affiliation_string | Center of Allergy and Environment (ZAUM), Technical University and Helmholtz Center Munich, Munich, Germany; |
| authorships[3].institutions[0].id | https://openalex.org/I4210129183 |
| authorships[3].institutions[0].ror | https://ror.org/03dx11k66 |
| authorships[3].institutions[0].type | facility |
| authorships[3].institutions[0].lineage | https://openalex.org/I4210129183, https://openalex.org/I4411590659 |
| authorships[3].institutions[0].country_code | DE |
| authorships[3].institutions[0].display_name | German Center for Lung Research |
| authorships[3].institutions[1].id | https://openalex.org/I3018134672 |
| authorships[3].institutions[1].ror | https://ror.org/00cfam450 |
| authorships[3].institutions[1].type | facility |
| authorships[3].institutions[1].lineage | https://openalex.org/I1305996414, https://openalex.org/I3018134672 |
| authorships[3].institutions[1].country_code | DE |
| authorships[3].institutions[1].display_name | Helmholtz Zentrum München |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Helen Charles |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Center of Allergy and Environment (ZAUM), Technical University and Helmholtz Center Munich, Munich, Germany;, Member of the German Center for Lung Research (DZL), Germany; |
| authorships[4].author.id | https://openalex.org/A5053343387 |
| authorships[4].author.orcid | https://orcid.org/0000-0003-4826-3419 |
| authorships[4].author.display_name | Ulrich M. Zissler |
| authorships[4].countries | DE |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I4210129183 |
| authorships[4].affiliations[0].raw_affiliation_string | Member of the German Center for Lung Research (DZL), Germany; |
| authorships[4].affiliations[1].institution_ids | https://openalex.org/I3018134672 |
| authorships[4].affiliations[1].raw_affiliation_string | Center of Allergy and Environment (ZAUM), Technical University and Helmholtz Center Munich, Munich, Germany; |
| authorships[4].institutions[0].id | https://openalex.org/I4210129183 |
| authorships[4].institutions[0].ror | https://ror.org/03dx11k66 |
| authorships[4].institutions[0].type | facility |
| authorships[4].institutions[0].lineage | https://openalex.org/I4210129183, https://openalex.org/I4411590659 |
| authorships[4].institutions[0].country_code | DE |
| authorships[4].institutions[0].display_name | German Center for Lung Research |
| authorships[4].institutions[1].id | https://openalex.org/I3018134672 |
| authorships[4].institutions[1].ror | https://ror.org/00cfam450 |
| authorships[4].institutions[1].type | facility |
| authorships[4].institutions[1].lineage | https://openalex.org/I1305996414, https://openalex.org/I3018134672 |
| authorships[4].institutions[1].country_code | DE |
| authorships[4].institutions[1].display_name | Helmholtz Zentrum München |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Ulrich M. Zissler |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Center of Allergy and Environment (ZAUM), Technical University and Helmholtz Center Munich, Munich, Germany;, Member of the German Center for Lung Research (DZL), Germany; |
| authorships[5].author.id | https://openalex.org/A5112686081 |
| authorships[5].author.orcid | |
| authorships[5].author.display_name | Madlen Oelsner |
| authorships[5].countries | DE |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I4210129183 |
| authorships[5].affiliations[0].raw_affiliation_string | Member of the German Center for Lung Research (DZL), Germany; |
| authorships[5].affiliations[1].institution_ids | https://openalex.org/I3018134672 |
| authorships[5].affiliations[1].raw_affiliation_string | Center of Allergy and Environment (ZAUM), Technical University and Helmholtz Center Munich, Munich, Germany; |
| authorships[5].institutions[0].id | https://openalex.org/I4210129183 |
| authorships[5].institutions[0].ror | https://ror.org/03dx11k66 |
| authorships[5].institutions[0].type | facility |
| authorships[5].institutions[0].lineage | https://openalex.org/I4210129183, https://openalex.org/I4411590659 |
| authorships[5].institutions[0].country_code | DE |
| authorships[5].institutions[0].display_name | German Center for Lung Research |
| authorships[5].institutions[1].id | https://openalex.org/I3018134672 |
| authorships[5].institutions[1].ror | https://ror.org/00cfam450 |
| authorships[5].institutions[1].type | facility |
| authorships[5].institutions[1].lineage | https://openalex.org/I1305996414, https://openalex.org/I3018134672 |
| authorships[5].institutions[1].country_code | DE |
| authorships[5].institutions[1].display_name | Helmholtz Zentrum München |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Madlen Oelsner |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Center of Allergy and Environment (ZAUM), Technical University and Helmholtz Center Munich, Munich, Germany;, Member of the German Center for Lung Research (DZL), Germany; |
| authorships[6].author.id | https://openalex.org/A5015811286 |
| authorships[6].author.orcid | |
| authorships[6].author.display_name | Ferdinand Guerth |
| authorships[6].countries | DE |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I3018134672 |
| authorships[6].affiliations[0].raw_affiliation_string | Center of Allergy and Environment (ZAUM), Technical University and Helmholtz Center Munich, Munich, Germany; |
| authorships[6].affiliations[1].institution_ids | https://openalex.org/I4210129183 |
| authorships[6].affiliations[1].raw_affiliation_string | Member of the German Center for Lung Research (DZL), Germany; |
| authorships[6].institutions[0].id | https://openalex.org/I4210129183 |
| authorships[6].institutions[0].ror | https://ror.org/03dx11k66 |
| authorships[6].institutions[0].type | facility |
| authorships[6].institutions[0].lineage | https://openalex.org/I4210129183, https://openalex.org/I4411590659 |
| authorships[6].institutions[0].country_code | DE |
| authorships[6].institutions[0].display_name | German Center for Lung Research |
| authorships[6].institutions[1].id | https://openalex.org/I3018134672 |
| authorships[6].institutions[1].ror | https://ror.org/00cfam450 |
| authorships[6].institutions[1].type | facility |
| authorships[6].institutions[1].lineage | https://openalex.org/I1305996414, https://openalex.org/I3018134672 |
| authorships[6].institutions[1].country_code | DE |
| authorships[6].institutions[1].display_name | Helmholtz Zentrum München |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Ferdinand Guerth |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Center of Allergy and Environment (ZAUM), Technical University and Helmholtz Center Munich, Munich, Germany;, Member of the German Center for Lung Research (DZL), Germany; |
| authorships[7].author.id | https://openalex.org/A5074429279 |
| authorships[7].author.orcid | https://orcid.org/0000-0001-9983-1039 |
| authorships[7].author.display_name | Jimmy Omony |
| authorships[7].countries | DE |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I3018134672 |
| authorships[7].affiliations[0].raw_affiliation_string | Institute for Asthma and Allergy Prevention, Helmholtz Center Munich, German Research Center for Environmental Health, Munich, Germany; |
| authorships[7].affiliations[1].institution_ids | https://openalex.org/I4210129183 |
| authorships[7].affiliations[1].raw_affiliation_string | Member of the German Center for Lung Research (DZL), Germany; |
| authorships[7].affiliations[2].raw_affiliation_string | Comprehensive Pneumology Center–Munich, Munich, Germany; |
| authorships[7].institutions[0].id | https://openalex.org/I4210129183 |
| authorships[7].institutions[0].ror | https://ror.org/03dx11k66 |
| authorships[7].institutions[0].type | facility |
| authorships[7].institutions[0].lineage | https://openalex.org/I4210129183, https://openalex.org/I4411590659 |
| authorships[7].institutions[0].country_code | DE |
| authorships[7].institutions[0].display_name | German Center for Lung Research |
| authorships[7].institutions[1].id | https://openalex.org/I3018134672 |
| authorships[7].institutions[1].ror | https://ror.org/00cfam450 |
| authorships[7].institutions[1].type | facility |
| authorships[7].institutions[1].lineage | https://openalex.org/I1305996414, https://openalex.org/I3018134672 |
| authorships[7].institutions[1].country_code | DE |
| authorships[7].institutions[1].display_name | Helmholtz Zentrum München |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Jimmy Omony |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Comprehensive Pneumology Center–Munich, Munich, Germany;, Institute for Asthma and Allergy Prevention, Helmholtz Center Munich, German Research Center for Environmental Health, Munich, Germany;, Member of the German Center for Lung Research (DZL), Germany; |
| authorships[8].author.id | https://openalex.org/A5063869084 |
| authorships[8].author.orcid | |
| authorships[8].author.display_name | Sai Sneha Priya Nemani |
| authorships[8].countries | DE |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I4210129183 |
| authorships[8].affiliations[0].raw_affiliation_string | Member of the German Center for Lung Research (DZL), Germany; |
| authorships[8].affiliations[1].institution_ids | https://openalex.org/I4210140903 |
| authorships[8].affiliations[1].raw_affiliation_string | Airway Research Center North, Borstel, Lübeck, Kiel, Grosshansdorf, Germany; |
| authorships[8].affiliations[2].institution_ids | https://openalex.org/I4210112713, https://openalex.org/I9341345 |
| authorships[8].affiliations[2].raw_affiliation_string | Department of Pediatric Pneumology and Allergology, University Medical Center Schleswig-Holstein, Lübeck, Germany; |
| authorships[8].institutions[0].id | https://openalex.org/I4210129183 |
| authorships[8].institutions[0].ror | https://ror.org/03dx11k66 |
| authorships[8].institutions[0].type | facility |
| authorships[8].institutions[0].lineage | https://openalex.org/I4210129183, https://openalex.org/I4411590659 |
| authorships[8].institutions[0].country_code | DE |
| authorships[8].institutions[0].display_name | German Center for Lung Research |
| authorships[8].institutions[1].id | https://openalex.org/I4210140903 |
| authorships[8].institutions[1].ror | https://ror.org/041wfjw90 |
| authorships[8].institutions[1].type | healthcare |
| authorships[8].institutions[1].lineage | https://openalex.org/I4210140903 |
| authorships[8].institutions[1].country_code | DE |
| authorships[8].institutions[1].display_name | LungenClinic Grosshansdorf |
| authorships[8].institutions[2].id | https://openalex.org/I4210112713 |
| authorships[8].institutions[2].ror | https://ror.org/01tvm6f46 |
| authorships[8].institutions[2].type | healthcare |
| authorships[8].institutions[2].lineage | https://openalex.org/I4210112713 |
| authorships[8].institutions[2].country_code | DE |
| authorships[8].institutions[2].display_name | University Hospital Schleswig-Holstein |
| authorships[8].institutions[3].id | https://openalex.org/I9341345 |
| authorships[8].institutions[3].ror | https://ror.org/00t3r8h32 |
| authorships[8].institutions[3].type | education |
| authorships[8].institutions[3].lineage | https://openalex.org/I9341345 |
| authorships[8].institutions[3].country_code | DE |
| authorships[8].institutions[3].display_name | University of Lübeck |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Sai Sneha Priya Nemani |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Airway Research Center North, Borstel, Lübeck, Kiel, Grosshansdorf, Germany;, Department of Pediatric Pneumology and Allergology, University Medical Center Schleswig-Holstein, Lübeck, Germany;, Member of the German Center for Lung Research (DZL), Germany; |
| authorships[9].author.id | https://openalex.org/A5024110218 |
| authorships[9].author.orcid | https://orcid.org/0000-0002-8084-104X |
| authorships[9].author.display_name | Ruth Grychtol |
| authorships[9].countries | DE |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I4210129183 |
| authorships[9].affiliations[0].raw_affiliation_string | Member of the German Center for Lung Research (DZL), Germany; |
| authorships[9].affiliations[1].institution_ids | https://openalex.org/I34809795 |
| authorships[9].affiliations[1].raw_affiliation_string | Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hanover, Germany; |
| authorships[9].affiliations[2].institution_ids | https://openalex.org/I34809795 |
| authorships[9].affiliations[2].raw_affiliation_string | Biomedical Research in Endstage and Obstructive Lung Disease Hannover, Hanover, Germany; |
| authorships[9].institutions[0].id | https://openalex.org/I4210129183 |
| authorships[9].institutions[0].ror | https://ror.org/03dx11k66 |
| authorships[9].institutions[0].type | facility |
| authorships[9].institutions[0].lineage | https://openalex.org/I4210129183, https://openalex.org/I4411590659 |
| authorships[9].institutions[0].country_code | DE |
| authorships[9].institutions[0].display_name | German Center for Lung Research |
| authorships[9].institutions[1].id | https://openalex.org/I34809795 |
| authorships[9].institutions[1].ror | https://ror.org/00f2yqf98 |
| authorships[9].institutions[1].type | education |
| authorships[9].institutions[1].lineage | https://openalex.org/I34809795 |
| authorships[9].institutions[1].country_code | DE |
| authorships[9].institutions[1].display_name | Medizinische Hochschule Hannover |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Ruth Grychtol |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Biomedical Research in Endstage and Obstructive Lung Disease Hannover, Hanover, Germany;, Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hanover, Germany;, Member of the German Center for Lung Research (DZL), Germany; |
| authorships[10].author.id | https://openalex.org/A5039823178 |
| authorships[10].author.orcid | https://orcid.org/0000-0002-9582-1025 |
| authorships[10].author.display_name | Anna‐Maria Dittrich |
| authorships[10].countries | DE |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I34809795 |
| authorships[10].affiliations[0].raw_affiliation_string | Biomedical Research in Endstage and Obstructive Lung Disease Hannover, Hanover, Germany; |
| authorships[10].affiliations[1].institution_ids | https://openalex.org/I4210129183 |
| authorships[10].affiliations[1].raw_affiliation_string | Member of the German Center for Lung Research (DZL), Germany; |
| authorships[10].affiliations[2].institution_ids | https://openalex.org/I34809795 |
| authorships[10].affiliations[2].raw_affiliation_string | Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hanover, Germany; |
| authorships[10].institutions[0].id | https://openalex.org/I4210129183 |
| authorships[10].institutions[0].ror | https://ror.org/03dx11k66 |
| authorships[10].institutions[0].type | facility |
| authorships[10].institutions[0].lineage | https://openalex.org/I4210129183, https://openalex.org/I4411590659 |
| authorships[10].institutions[0].country_code | DE |
| authorships[10].institutions[0].display_name | German Center for Lung Research |
| authorships[10].institutions[1].id | https://openalex.org/I34809795 |
| authorships[10].institutions[1].ror | https://ror.org/00f2yqf98 |
| authorships[10].institutions[1].type | education |
| authorships[10].institutions[1].lineage | https://openalex.org/I34809795 |
| authorships[10].institutions[1].country_code | DE |
| authorships[10].institutions[1].display_name | Medizinische Hochschule Hannover |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Anna-Maria Dittrich |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Biomedical Research in Endstage and Obstructive Lung Disease Hannover, Hanover, Germany;, Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hanover, Germany;, Member of the German Center for Lung Research (DZL), Germany; |
| authorships[11].author.id | https://openalex.org/A5080756715 |
| authorships[11].author.orcid | https://orcid.org/0000-0001-5194-5635 |
| authorships[11].author.display_name | Chrysanthi Skevaki |
| authorships[11].countries | DE, IN |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I4210129183 |
| authorships[11].affiliations[0].raw_affiliation_string | Member of the German Center for Lung Research (DZL), Germany; |
| authorships[11].affiliations[1].institution_ids | https://openalex.org/I4210146488 |
| authorships[11].affiliations[1].raw_affiliation_string | Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics and |
| authorships[11].institutions[0].id | https://openalex.org/I4210129183 |
| authorships[11].institutions[0].ror | https://ror.org/03dx11k66 |
| authorships[11].institutions[0].type | facility |
| authorships[11].institutions[0].lineage | https://openalex.org/I4210129183, https://openalex.org/I4411590659 |
| authorships[11].institutions[0].country_code | DE |
| authorships[11].institutions[0].display_name | German Center for Lung Research |
| authorships[11].institutions[1].id | https://openalex.org/I4210146488 |
| authorships[11].institutions[1].ror | https://ror.org/04eb14s37 |
| authorships[11].institutions[1].type | facility |
| authorships[11].institutions[1].lineage | https://openalex.org/I4210146488 |
| authorships[11].institutions[1].country_code | IN |
| authorships[11].institutions[1].display_name | Institute of Molecular Medicine |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Chrysanthi Skevaki |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics and, Member of the German Center for Lung Research (DZL), Germany; |
| authorships[12].author.id | https://openalex.org/A5011213722 |
| authorships[12].author.orcid | |
| authorships[12].author.display_name | Svenja Foth |
| authorships[12].countries | DE |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I4210131615 |
| authorships[12].affiliations[0].raw_affiliation_string | Universities of Giessen and Marburg Lung Center, Philipps University Marburg and University Children’s Hospital Marburg, University of Marburg, Marburg, Germany; |
| authorships[12].affiliations[1].institution_ids | https://openalex.org/I4210129183 |
| authorships[12].affiliations[1].raw_affiliation_string | Member of the German Center for Lung Research (DZL), Germany; |
| authorships[12].institutions[0].id | https://openalex.org/I4210129183 |
| authorships[12].institutions[0].ror | https://ror.org/03dx11k66 |
| authorships[12].institutions[0].type | facility |
| authorships[12].institutions[0].lineage | https://openalex.org/I4210129183, https://openalex.org/I4411590659 |
| authorships[12].institutions[0].country_code | DE |
| authorships[12].institutions[0].display_name | German Center for Lung Research |
| authorships[12].institutions[1].id | https://openalex.org/I4210131615 |
| authorships[12].institutions[1].ror | https://ror.org/045f0ws19 |
| authorships[12].institutions[1].type | education |
| authorships[12].institutions[1].lineage | https://openalex.org/I4210131615 |
| authorships[12].institutions[1].country_code | DE |
| authorships[12].institutions[1].display_name | Universities of Giessen and Marburg Lung Center |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | Svenja Foth |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | Member of the German Center for Lung Research (DZL), Germany;, Universities of Giessen and Marburg Lung Center, Philipps University Marburg and University Children’s Hospital Marburg, University of Marburg, Marburg, Germany; |
| authorships[13].author.id | https://openalex.org/A5101929042 |
| authorships[13].author.orcid | https://orcid.org/0000-0002-9498-2337 |
| authorships[13].author.display_name | Stefanie Weber |
| authorships[13].countries | DE |
| authorships[13].affiliations[0].institution_ids | https://openalex.org/I4210129183 |
| authorships[13].affiliations[0].raw_affiliation_string | Member of the German Center for Lung Research (DZL), Germany; |
| authorships[13].affiliations[1].institution_ids | https://openalex.org/I4210131615 |
| authorships[13].affiliations[1].raw_affiliation_string | Universities of Giessen and Marburg Lung Center, Philipps University Marburg and University Children’s Hospital Marburg, University of Marburg, Marburg, Germany; |
| authorships[13].institutions[0].id | https://openalex.org/I4210129183 |
| authorships[13].institutions[0].ror | https://ror.org/03dx11k66 |
| authorships[13].institutions[0].type | facility |
| authorships[13].institutions[0].lineage | https://openalex.org/I4210129183, https://openalex.org/I4411590659 |
| authorships[13].institutions[0].country_code | DE |
| authorships[13].institutions[0].display_name | German Center for Lung Research |
| authorships[13].institutions[1].id | https://openalex.org/I4210131615 |
| authorships[13].institutions[1].ror | https://ror.org/045f0ws19 |
| authorships[13].institutions[1].type | education |
| authorships[13].institutions[1].lineage | https://openalex.org/I4210131615 |
| authorships[13].institutions[1].country_code | DE |
| authorships[13].institutions[1].display_name | Universities of Giessen and Marburg Lung Center |
| authorships[13].author_position | middle |
| authorships[13].raw_author_name | Stefanie Weber |
| authorships[13].is_corresponding | False |
| authorships[13].raw_affiliation_strings | Member of the German Center for Lung Research (DZL), Germany;, Universities of Giessen and Marburg Lung Center, Philipps University Marburg and University Children’s Hospital Marburg, University of Marburg, Marburg, Germany; |
| authorships[14].author.id | https://openalex.org/A5062438964 |
| authorships[14].author.orcid | https://orcid.org/0000-0002-3176-0411 |
| authorships[14].author.display_name | Miguel A. Alejandre Alcázar |
| authorships[14].countries | DE, SK |
| authorships[14].affiliations[0].institution_ids | https://openalex.org/I4210131615, https://openalex.org/I4210154233 |
| authorships[14].affiliations[0].raw_affiliation_string | Institute for Lung Health and Cardio-Pulmonary Institute, Universities of Giessen and Marburg Lung Center, Giessen, Germany; |
| authorships[14].affiliations[1].institution_ids | https://openalex.org/I4210104728 |
| authorships[14].affiliations[1].raw_affiliation_string | Translational Experimental Pediatrics, Experimental Pulmonology, Department of Pediatrics, |
| authorships[14].affiliations[2].institution_ids | https://openalex.org/I180923762, https://openalex.org/I4210153755 |
| authorships[14].affiliations[2].raw_affiliation_string | Pediatric Pulmonology and Allergology, Department of Pediatrics, Faculty of Medicine, University of Cologne and University Hospital Cologne, Cologne, Germany; and |
| authorships[14].affiliations[3].institution_ids | https://openalex.org/I4210129183 |
| authorships[14].affiliations[3].raw_affiliation_string | Member of the German Center for Lung Research (DZL), Germany; |
| authorships[14].affiliations[4].institution_ids | https://openalex.org/I4210138270 |
| authorships[14].affiliations[4].raw_affiliation_string | Center for Molecular Medicine Cologne and Cologne Excellence Cluster on Stress Responses in Aging-associated Diseases, and |
| authorships[14].institutions[0].id | https://openalex.org/I4210154233 |
| authorships[14].institutions[0].ror | https://ror.org/04ckbty56 |
| authorships[14].institutions[0].type | facility |
| authorships[14].institutions[0].lineage | https://openalex.org/I114090438, https://openalex.org/I149899117, https://openalex.org/I200763008, https://openalex.org/I4210102801, https://openalex.org/I4210154233 |
| authorships[14].institutions[0].country_code | DE |
| authorships[14].institutions[0].display_name | Cardio-Pulmonary Institute |
| authorships[14].institutions[1].id | https://openalex.org/I4210138270 |
| authorships[14].institutions[1].ror | https://ror.org/04c4bwh63 |
| authorships[14].institutions[1].type | facility |
| authorships[14].institutions[1].lineage | https://openalex.org/I4210138270 |
| authorships[14].institutions[1].country_code | DE |
| authorships[14].institutions[1].display_name | Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases |
| authorships[14].institutions[2].id | https://openalex.org/I4210129183 |
| authorships[14].institutions[2].ror | https://ror.org/03dx11k66 |
| authorships[14].institutions[2].type | facility |
| authorships[14].institutions[2].lineage | https://openalex.org/I4210129183, https://openalex.org/I4411590659 |
| authorships[14].institutions[2].country_code | DE |
| authorships[14].institutions[2].display_name | German Center for Lung Research |
| authorships[14].institutions[3].id | https://openalex.org/I4210131615 |
| authorships[14].institutions[3].ror | https://ror.org/045f0ws19 |
| authorships[14].institutions[3].type | education |
| authorships[14].institutions[3].lineage | https://openalex.org/I4210131615 |
| authorships[14].institutions[3].country_code | DE |
| authorships[14].institutions[3].display_name | Universities of Giessen and Marburg Lung Center |
| authorships[14].institutions[4].id | https://openalex.org/I4210153755 |
| authorships[14].institutions[4].ror | https://ror.org/05mxhda18 |
| authorships[14].institutions[4].type | healthcare |
| authorships[14].institutions[4].lineage | https://openalex.org/I4210153755 |
| authorships[14].institutions[4].country_code | DE |
| authorships[14].institutions[4].display_name | University Hospital Cologne |
| authorships[14].institutions[5].id | https://openalex.org/I180923762 |
| authorships[14].institutions[5].ror | https://ror.org/00rcxh774 |
| authorships[14].institutions[5].type | education |
| authorships[14].institutions[5].lineage | https://openalex.org/I180923762 |
| authorships[14].institutions[5].country_code | DE |
| authorships[14].institutions[5].display_name | University of Cologne |
| authorships[14].institutions[6].id | https://openalex.org/I4210104728 |
| authorships[14].institutions[6].ror | https://ror.org/01a1nz002 |
| authorships[14].institutions[6].type | facility |
| authorships[14].institutions[6].lineage | https://openalex.org/I207624831, https://openalex.org/I4210104728 |
| authorships[14].institutions[6].country_code | SK |
| authorships[14].institutions[6].display_name | Institute of Experimental Endocrinology of the Slovak Academy of Sciences |
| authorships[14].author_position | middle |
| authorships[14].raw_author_name | Miguel A. Alejandre Alcazar |
| authorships[14].is_corresponding | False |
| authorships[14].raw_affiliation_strings | Center for Molecular Medicine Cologne and Cologne Excellence Cluster on Stress Responses in Aging-associated Diseases, and, Institute for Lung Health and Cardio-Pulmonary Institute, Universities of Giessen and Marburg Lung Center, Giessen, Germany;, Member of the German Center for Lung Research (DZL), Germany;, Pediatric Pulmonology and Allergology, Department of Pediatrics, Faculty of Medicine, University of Cologne and University Hospital Cologne, Cologne, Germany; and, Translational Experimental Pediatrics, Experimental Pulmonology, Department of Pediatrics, |
| authorships[15].author.id | https://openalex.org/A5069946496 |
| authorships[15].author.orcid | https://orcid.org/0000-0002-2222-4238 |
| authorships[15].author.display_name | Silke van Koningsbruggen‐Rietschel |
| authorships[15].countries | DE |
| authorships[15].affiliations[0].institution_ids | https://openalex.org/I4210129183 |
| authorships[15].affiliations[0].raw_affiliation_string | Member of the German Center for Lung Research (DZL), Germany; |
| authorships[15].affiliations[1].institution_ids | https://openalex.org/I180923762, https://openalex.org/I4210153755 |
| authorships[15].affiliations[1].raw_affiliation_string | Pediatric Pulmonology and Allergology, Department of Pediatrics, Faculty of Medicine, University of Cologne and University Hospital Cologne, Cologne, Germany; and |
| authorships[15].institutions[0].id | https://openalex.org/I4210129183 |
| authorships[15].institutions[0].ror | https://ror.org/03dx11k66 |
| authorships[15].institutions[0].type | facility |
| authorships[15].institutions[0].lineage | https://openalex.org/I4210129183, https://openalex.org/I4411590659 |
| authorships[15].institutions[0].country_code | DE |
| authorships[15].institutions[0].display_name | German Center for Lung Research |
| authorships[15].institutions[1].id | https://openalex.org/I4210153755 |
| authorships[15].institutions[1].ror | https://ror.org/05mxhda18 |
| authorships[15].institutions[1].type | healthcare |
| authorships[15].institutions[1].lineage | https://openalex.org/I4210153755 |
| authorships[15].institutions[1].country_code | DE |
| authorships[15].institutions[1].display_name | University Hospital Cologne |
| authorships[15].institutions[2].id | https://openalex.org/I180923762 |
| authorships[15].institutions[2].ror | https://ror.org/00rcxh774 |
| authorships[15].institutions[2].type | education |
| authorships[15].institutions[2].lineage | https://openalex.org/I180923762 |
| authorships[15].institutions[2].country_code | DE |
| authorships[15].institutions[2].display_name | University of Cologne |
| authorships[15].author_position | middle |
| authorships[15].raw_author_name | Silke van Koningsbruggen-Rietschel |
| authorships[15].is_corresponding | False |
| authorships[15].raw_affiliation_strings | Member of the German Center for Lung Research (DZL), Germany;, Pediatric Pulmonology and Allergology, Department of Pediatrics, Faculty of Medicine, University of Cologne and University Hospital Cologne, Cologne, Germany; and |
| authorships[16].author.id | https://openalex.org/A5012596372 |
| authorships[16].author.orcid | https://orcid.org/0000-0002-3783-248X |
| authorships[16].author.display_name | Robert W. Brock |
| authorships[16].countries | DE |
| authorships[16].affiliations[0].institution_ids | https://openalex.org/I180923762, https://openalex.org/I4210153755 |
| authorships[16].affiliations[0].raw_affiliation_string | Pediatric Pulmonology and Allergology, Department of Pediatrics, Faculty of Medicine, University of Cologne and University Hospital Cologne, Cologne, Germany; and |
| authorships[16].affiliations[1].institution_ids | https://openalex.org/I4210129183 |
| authorships[16].affiliations[1].raw_affiliation_string | Member of the German Center for Lung Research (DZL), Germany; |
| authorships[16].institutions[0].id | https://openalex.org/I4210129183 |
| authorships[16].institutions[0].ror | https://ror.org/03dx11k66 |
| authorships[16].institutions[0].type | facility |
| authorships[16].institutions[0].lineage | https://openalex.org/I4210129183, https://openalex.org/I4411590659 |
| authorships[16].institutions[0].country_code | DE |
| authorships[16].institutions[0].display_name | German Center for Lung Research |
| authorships[16].institutions[1].id | https://openalex.org/I4210153755 |
| authorships[16].institutions[1].ror | https://ror.org/05mxhda18 |
| authorships[16].institutions[1].type | healthcare |
| authorships[16].institutions[1].lineage | https://openalex.org/I4210153755 |
| authorships[16].institutions[1].country_code | DE |
| authorships[16].institutions[1].display_name | University Hospital Cologne |
| authorships[16].institutions[2].id | https://openalex.org/I180923762 |
| authorships[16].institutions[2].ror | https://ror.org/00rcxh774 |
| authorships[16].institutions[2].type | education |
| authorships[16].institutions[2].lineage | https://openalex.org/I180923762 |
| authorships[16].institutions[2].country_code | DE |
| authorships[16].institutions[2].display_name | University of Cologne |
| authorships[16].author_position | middle |
| authorships[16].raw_author_name | Robert Brock |
| authorships[16].is_corresponding | False |
| authorships[16].raw_affiliation_strings | Member of the German Center for Lung Research (DZL), Germany;, Pediatric Pulmonology and Allergology, Department of Pediatrics, Faculty of Medicine, University of Cologne and University Hospital Cologne, Cologne, Germany; and |
| authorships[17].author.id | https://openalex.org/A5055944439 |
| authorships[17].author.orcid | |
| authorships[17].author.display_name | Samira Blau |
| authorships[17].countries | DE |
| authorships[17].affiliations[0].institution_ids | https://openalex.org/I4210129183 |
| authorships[17].affiliations[0].raw_affiliation_string | Member of the German Center for Lung Research (DZL), Germany; |
| authorships[17].affiliations[1].institution_ids | https://openalex.org/I180923762, https://openalex.org/I4210153755 |
| authorships[17].affiliations[1].raw_affiliation_string | Pediatric Pulmonology and Allergology, Department of Pediatrics, Faculty of Medicine, University of Cologne and University Hospital Cologne, Cologne, Germany; and |
| authorships[17].institutions[0].id | https://openalex.org/I4210129183 |
| authorships[17].institutions[0].ror | https://ror.org/03dx11k66 |
| authorships[17].institutions[0].type | facility |
| authorships[17].institutions[0].lineage | https://openalex.org/I4210129183, https://openalex.org/I4411590659 |
| authorships[17].institutions[0].country_code | DE |
| authorships[17].institutions[0].display_name | German Center for Lung Research |
| authorships[17].institutions[1].id | https://openalex.org/I4210153755 |
| authorships[17].institutions[1].ror | https://ror.org/05mxhda18 |
| authorships[17].institutions[1].type | healthcare |
| authorships[17].institutions[1].lineage | https://openalex.org/I4210153755 |
| authorships[17].institutions[1].country_code | DE |
| authorships[17].institutions[1].display_name | University Hospital Cologne |
| authorships[17].institutions[2].id | https://openalex.org/I180923762 |
| authorships[17].institutions[2].ror | https://ror.org/00rcxh774 |
| authorships[17].institutions[2].type | education |
| authorships[17].institutions[2].lineage | https://openalex.org/I180923762 |
| authorships[17].institutions[2].country_code | DE |
| authorships[17].institutions[2].display_name | University of Cologne |
| authorships[17].author_position | middle |
| authorships[17].raw_author_name | Samira Blau |
| authorships[17].is_corresponding | False |
| authorships[17].raw_affiliation_strings | Member of the German Center for Lung Research (DZL), Germany;, Pediatric Pulmonology and Allergology, Department of Pediatrics, Faculty of Medicine, University of Cologne and University Hospital Cologne, Cologne, Germany; and |
| authorships[18].author.id | https://openalex.org/A5070377988 |
| authorships[18].author.orcid | https://orcid.org/0000-0001-5185-9454 |
| authorships[18].author.display_name | Gesine Hansen |
| authorships[18].countries | DE |
| authorships[18].affiliations[0].institution_ids | https://openalex.org/I34809795 |
| authorships[18].affiliations[0].raw_affiliation_string | Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hanover, Germany; |
| authorships[18].affiliations[1].institution_ids | https://openalex.org/I4210129183 |
| authorships[18].affiliations[1].raw_affiliation_string | Member of the German Center for Lung Research (DZL), Germany; |
| authorships[18].affiliations[2].institution_ids | https://openalex.org/I34809795 |
| authorships[18].affiliations[2].raw_affiliation_string | Cluster of Excellence 2115 (RESIST), Hannover Medical School, Hanover, Germany |
| authorships[18].affiliations[3].institution_ids | https://openalex.org/I34809795 |
| authorships[18].affiliations[3].raw_affiliation_string | Biomedical Research in Endstage and Obstructive Lung Disease Hannover, Hanover, Germany; |
| authorships[18].institutions[0].id | https://openalex.org/I4210129183 |
| authorships[18].institutions[0].ror | https://ror.org/03dx11k66 |
| authorships[18].institutions[0].type | facility |
| authorships[18].institutions[0].lineage | https://openalex.org/I4210129183, https://openalex.org/I4411590659 |
| authorships[18].institutions[0].country_code | DE |
| authorships[18].institutions[0].display_name | German Center for Lung Research |
| authorships[18].institutions[1].id | https://openalex.org/I34809795 |
| authorships[18].institutions[1].ror | https://ror.org/00f2yqf98 |
| authorships[18].institutions[1].type | education |
| authorships[18].institutions[1].lineage | https://openalex.org/I34809795 |
| authorships[18].institutions[1].country_code | DE |
| authorships[18].institutions[1].display_name | Medizinische Hochschule Hannover |
| authorships[18].author_position | middle |
| authorships[18].raw_author_name | Gesine Hansen |
| authorships[18].is_corresponding | False |
| authorships[18].raw_affiliation_strings | Biomedical Research in Endstage and Obstructive Lung Disease Hannover, Hanover, Germany;, Cluster of Excellence 2115 (RESIST), Hannover Medical School, Hanover, Germany, Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hanover, Germany;, Member of the German Center for Lung Research (DZL), Germany; |
| authorships[19].author.id | https://openalex.org/A5007048597 |
| authorships[19].author.orcid | https://orcid.org/0000-0002-7677-7057 |
| authorships[19].author.display_name | Thomas Bahmer |
| authorships[19].countries | DE |
| authorships[19].affiliations[0].institution_ids | https://openalex.org/I4210140903 |
| authorships[19].affiliations[0].raw_affiliation_string | Airway Research Center North, Borstel, Lübeck, Kiel, Grosshansdorf, Germany; |
| authorships[19].affiliations[1].institution_ids | https://openalex.org/I4210112713, https://openalex.org/I9341345 |
| authorships[19].affiliations[1].raw_affiliation_string | Internal Medicine Department I, University Hospital Schleswig-Holstein–Campus Kiel, Kiel, Germany; |
| authorships[19].affiliations[2].institution_ids | https://openalex.org/I4210129183 |
| authorships[19].affiliations[2].raw_affiliation_string | Member of the German Center for Lung Research (DZL), Germany; |
| authorships[19].institutions[0].id | https://openalex.org/I4210129183 |
| authorships[19].institutions[0].ror | https://ror.org/03dx11k66 |
| authorships[19].institutions[0].type | facility |
| authorships[19].institutions[0].lineage | https://openalex.org/I4210129183, https://openalex.org/I4411590659 |
| authorships[19].institutions[0].country_code | DE |
| authorships[19].institutions[0].display_name | German Center for Lung Research |
| authorships[19].institutions[1].id | https://openalex.org/I4210140903 |
| authorships[19].institutions[1].ror | https://ror.org/041wfjw90 |
| authorships[19].institutions[1].type | healthcare |
| authorships[19].institutions[1].lineage | https://openalex.org/I4210140903 |
| authorships[19].institutions[1].country_code | DE |
| authorships[19].institutions[1].display_name | LungenClinic Grosshansdorf |
| authorships[19].institutions[2].id | https://openalex.org/I4210112713 |
| authorships[19].institutions[2].ror | https://ror.org/01tvm6f46 |
| authorships[19].institutions[2].type | healthcare |
| authorships[19].institutions[2].lineage | https://openalex.org/I4210112713 |
| authorships[19].institutions[2].country_code | DE |
| authorships[19].institutions[2].display_name | University Hospital Schleswig-Holstein |
| authorships[19].institutions[3].id | https://openalex.org/I9341345 |
| authorships[19].institutions[3].ror | https://ror.org/00t3r8h32 |
| authorships[19].institutions[3].type | education |
| authorships[19].institutions[3].lineage | https://openalex.org/I9341345 |
| authorships[19].institutions[3].country_code | DE |
| authorships[19].institutions[3].display_name | University of Lübeck |
| authorships[19].author_position | middle |
| authorships[19].raw_author_name | Thomas Bahmer |
| authorships[19].is_corresponding | False |
| authorships[19].raw_affiliation_strings | Airway Research Center North, Borstel, Lübeck, Kiel, Grosshansdorf, Germany;, Internal Medicine Department I, University Hospital Schleswig-Holstein–Campus Kiel, Kiel, Germany;, Member of the German Center for Lung Research (DZL), Germany; |
| authorships[20].author.id | https://openalex.org/A5028265360 |
| authorships[20].author.orcid | https://orcid.org/0000-0002-7020-1401 |
| authorships[20].author.display_name | Klaus F. Rabe |
| authorships[20].countries | DE |
| authorships[20].affiliations[0].institution_ids | https://openalex.org/I4210140903 |
| authorships[20].affiliations[0].raw_affiliation_string | LungenClinic Grosshansdorf GmbH and Medical Clinics, Christian Albrechts University, Kiel, Germany; |
| authorships[20].affiliations[1].institution_ids | https://openalex.org/I4210129183 |
| authorships[20].affiliations[1].raw_affiliation_string | Member of the German Center for Lung Research (DZL), Germany; |
| authorships[20].affiliations[2].institution_ids | https://openalex.org/I4210140903 |
| authorships[20].affiliations[2].raw_affiliation_string | Airway Research Center North, Borstel, Lübeck, Kiel, Grosshansdorf, Germany; |
| authorships[20].institutions[0].id | https://openalex.org/I4210129183 |
| authorships[20].institutions[0].ror | https://ror.org/03dx11k66 |
| authorships[20].institutions[0].type | facility |
| authorships[20].institutions[0].lineage | https://openalex.org/I4210129183, https://openalex.org/I4411590659 |
| authorships[20].institutions[0].country_code | DE |
| authorships[20].institutions[0].display_name | German Center for Lung Research |
| authorships[20].institutions[1].id | https://openalex.org/I4210140903 |
| authorships[20].institutions[1].ror | https://ror.org/041wfjw90 |
| authorships[20].institutions[1].type | healthcare |
| authorships[20].institutions[1].lineage | https://openalex.org/I4210140903 |
| authorships[20].institutions[1].country_code | DE |
| authorships[20].institutions[1].display_name | LungenClinic Grosshansdorf |
| authorships[20].author_position | middle |
| authorships[20].raw_author_name | Klaus F. Rabe |
| authorships[20].is_corresponding | False |
| authorships[20].raw_affiliation_strings | Airway Research Center North, Borstel, Lübeck, Kiel, Grosshansdorf, Germany;, LungenClinic Grosshansdorf GmbH and Medical Clinics, Christian Albrechts University, Kiel, Germany;, Member of the German Center for Lung Research (DZL), Germany; |
| authorships[21].author.id | https://openalex.org/A5012057708 |
| authorships[21].author.orcid | https://orcid.org/0000-0002-4307-4232 |
| authorships[21].author.display_name | Folke Brinkmann |
| authorships[21].countries | DE |
| authorships[21].affiliations[0].institution_ids | https://openalex.org/I4210140903 |
| authorships[21].affiliations[0].raw_affiliation_string | Airway Research Center North, Borstel, Lübeck, Kiel, Grosshansdorf, Germany; |
| authorships[21].affiliations[1].institution_ids | https://openalex.org/I4210112713, https://openalex.org/I9341345 |
| authorships[21].affiliations[1].raw_affiliation_string | Department of Pediatric Pneumology and Allergology, University Medical Center Schleswig-Holstein, Lübeck, Germany; |
| authorships[21].affiliations[2].institution_ids | https://openalex.org/I4210128097 |
| authorships[21].affiliations[2].raw_affiliation_string | Division of Epigenetics in Chronic Lung Disease, Priority Area Chronic Lung Diseases, Research Center Borstel-Leibniz Lung Center, Borstel, Germany; |
| authorships[21].affiliations[3].institution_ids | https://openalex.org/I4210129183 |
| authorships[21].affiliations[3].raw_affiliation_string | Member of the German Center for Lung Research (DZL), Germany; |
| authorships[21].institutions[0].id | https://openalex.org/I4210129183 |
| authorships[21].institutions[0].ror | https://ror.org/03dx11k66 |
| authorships[21].institutions[0].type | facility |
| authorships[21].institutions[0].lineage | https://openalex.org/I4210129183, https://openalex.org/I4411590659 |
| authorships[21].institutions[0].country_code | DE |
| authorships[21].institutions[0].display_name | German Center for Lung Research |
| authorships[21].institutions[1].id | https://openalex.org/I4210140903 |
| authorships[21].institutions[1].ror | https://ror.org/041wfjw90 |
| authorships[21].institutions[1].type | healthcare |
| authorships[21].institutions[1].lineage | https://openalex.org/I4210140903 |
| authorships[21].institutions[1].country_code | DE |
| authorships[21].institutions[1].display_name | LungenClinic Grosshansdorf |
| authorships[21].institutions[2].id | https://openalex.org/I4210128097 |
| authorships[21].institutions[2].ror | https://ror.org/036ragn25 |
| authorships[21].institutions[2].type | facility |
| authorships[21].institutions[2].lineage | https://openalex.org/I315704651, https://openalex.org/I4210128097 |
| authorships[21].institutions[2].country_code | DE |
| authorships[21].institutions[2].display_name | Research Center Borstel - Leibniz Lung Center |
| authorships[21].institutions[3].id | https://openalex.org/I4210112713 |
| authorships[21].institutions[3].ror | https://ror.org/01tvm6f46 |
| authorships[21].institutions[3].type | healthcare |
| authorships[21].institutions[3].lineage | https://openalex.org/I4210112713 |
| authorships[21].institutions[3].country_code | DE |
| authorships[21].institutions[3].display_name | University Hospital Schleswig-Holstein |
| authorships[21].institutions[4].id | https://openalex.org/I9341345 |
| authorships[21].institutions[4].ror | https://ror.org/00t3r8h32 |
| authorships[21].institutions[4].type | education |
| authorships[21].institutions[4].lineage | https://openalex.org/I9341345 |
| authorships[21].institutions[4].country_code | DE |
| authorships[21].institutions[4].display_name | University of Lübeck |
| authorships[21].author_position | middle |
| authorships[21].raw_author_name | Folke Brinkmann |
| authorships[21].is_corresponding | False |
| authorships[21].raw_affiliation_strings | Airway Research Center North, Borstel, Lübeck, Kiel, Grosshansdorf, Germany;, Department of Pediatric Pneumology and Allergology, University Medical Center Schleswig-Holstein, Lübeck, Germany;, Division of Epigenetics in Chronic Lung Disease, Priority Area Chronic Lung Diseases, Research Center Borstel-Leibniz Lung Center, Borstel, Germany;, Member of the German Center for Lung Research (DZL), Germany; |
| authorships[22].author.id | https://openalex.org/A5017550230 |
| authorships[22].author.orcid | https://orcid.org/0000-0003-1989-5492 |
| authorships[22].author.display_name | Matthias Kopp |
| authorships[22].countries | CH, DE |
| authorships[22].affiliations[0].institution_ids | https://openalex.org/I4210140903 |
| authorships[22].affiliations[0].raw_affiliation_string | Airway Research Center North, Borstel, Lübeck, Kiel, Grosshansdorf, Germany; |
| authorships[22].affiliations[1].institution_ids | https://openalex.org/I4210112713, https://openalex.org/I9341345 |
| authorships[22].affiliations[1].raw_affiliation_string | Department of Pediatric Pneumology and Allergology, University Medical Center Schleswig-Holstein, Lübeck, Germany; |
| authorships[22].affiliations[2].institution_ids | https://openalex.org/I118564535, https://openalex.org/I2801112126 |
| authorships[22].affiliations[2].raw_affiliation_string | Pediatric Respiratory Medicine, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; |
| authorships[22].institutions[0].id | https://openalex.org/I2801112126 |
| authorships[22].institutions[0].ror | https://ror.org/01q9sj412 |
| authorships[22].institutions[0].type | healthcare |
| authorships[22].institutions[0].lineage | https://openalex.org/I2801112126 |
| authorships[22].institutions[0].country_code | CH |
| authorships[22].institutions[0].display_name | University Hospital of Bern |
| authorships[22].institutions[1].id | https://openalex.org/I118564535 |
| authorships[22].institutions[1].ror | https://ror.org/02k7v4d05 |
| authorships[22].institutions[1].type | education |
| authorships[22].institutions[1].lineage | https://openalex.org/I118564535 |
| authorships[22].institutions[1].country_code | CH |
| authorships[22].institutions[1].display_name | University of Bern |
| authorships[22].institutions[2].id | https://openalex.org/I4210140903 |
| authorships[22].institutions[2].ror | https://ror.org/041wfjw90 |
| authorships[22].institutions[2].type | healthcare |
| authorships[22].institutions[2].lineage | https://openalex.org/I4210140903 |
| authorships[22].institutions[2].country_code | DE |
| authorships[22].institutions[2].display_name | LungenClinic Grosshansdorf |
| authorships[22].institutions[3].id | https://openalex.org/I4210112713 |
| authorships[22].institutions[3].ror | https://ror.org/01tvm6f46 |
| authorships[22].institutions[3].type | healthcare |
| authorships[22].institutions[3].lineage | https://openalex.org/I4210112713 |
| authorships[22].institutions[3].country_code | DE |
| authorships[22].institutions[3].display_name | University Hospital Schleswig-Holstein |
| authorships[22].institutions[4].id | https://openalex.org/I9341345 |
| authorships[22].institutions[4].ror | https://ror.org/00t3r8h32 |
| authorships[22].institutions[4].type | education |
| authorships[22].institutions[4].lineage | https://openalex.org/I9341345 |
| authorships[22].institutions[4].country_code | DE |
| authorships[22].institutions[4].display_name | University of Lübeck |
| authorships[22].author_position | middle |
| authorships[22].raw_author_name | Matthias Volkmar Kopp |
| authorships[22].is_corresponding | False |
| authorships[22].raw_affiliation_strings | Airway Research Center North, Borstel, Lübeck, Kiel, Grosshansdorf, Germany;, Department of Pediatric Pneumology and Allergology, University Medical Center Schleswig-Holstein, Lübeck, Germany;, Pediatric Respiratory Medicine, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; |
| authorships[23].author.id | https://openalex.org/A5048354088 |
| authorships[23].author.orcid | https://orcid.org/0000-0002-5117-4073 |
| authorships[23].author.display_name | Adam Chaker |
| authorships[23].countries | DE |
| authorships[23].affiliations[0].institution_ids | https://openalex.org/I62916508 |
| authorships[23].affiliations[0].raw_affiliation_string | Department of Otorhinolaryngology and Head and Neck Surgery, Medical School, Technical University of Munich, Munich, Germany; |
| authorships[23].affiliations[1].institution_ids | https://openalex.org/I3018134672 |
| authorships[23].affiliations[1].raw_affiliation_string | Center of Allergy and Environment (ZAUM), Technical University and Helmholtz Center Munich, Munich, Germany; |
| authorships[23].institutions[0].id | https://openalex.org/I3018134672 |
| authorships[23].institutions[0].ror | https://ror.org/00cfam450 |
| authorships[23].institutions[0].type | facility |
| authorships[23].institutions[0].lineage | https://openalex.org/I1305996414, https://openalex.org/I3018134672 |
| authorships[23].institutions[0].country_code | DE |
| authorships[23].institutions[0].display_name | Helmholtz Zentrum München |
| authorships[23].institutions[1].id | https://openalex.org/I62916508 |
| authorships[23].institutions[1].ror | https://ror.org/02kkvpp62 |
| authorships[23].institutions[1].type | education |
| authorships[23].institutions[1].lineage | https://openalex.org/I62916508 |
| authorships[23].institutions[1].country_code | DE |
| authorships[23].institutions[1].display_name | Technical University of Munich |
| authorships[23].author_position | middle |
| authorships[23].raw_author_name | Adam M. Chaker |
| authorships[23].is_corresponding | False |
| authorships[23].raw_affiliation_strings | Center of Allergy and Environment (ZAUM), Technical University and Helmholtz Center Munich, Munich, Germany;, Department of Otorhinolaryngology and Head and Neck Surgery, Medical School, Technical University of Munich, Munich, Germany; |
| authorships[24].author.id | https://openalex.org/A5055164664 |
| authorships[24].author.orcid | https://orcid.org/0000-0003-1652-8873 |
| authorships[24].author.display_name | Bianca Schaub |
| authorships[24].countries | DE |
| authorships[24].affiliations[0].raw_affiliation_string | Comprehensive Pneumology Center–Munich, Munich, Germany; |
| authorships[24].affiliations[1].institution_ids | https://openalex.org/I8204097 |
| authorships[24].affiliations[1].raw_affiliation_string | Dr. von Hauner Children’s Hospital, Ludwig Maximilians University, Munich, Germany; |
| authorships[24].affiliations[2].institution_ids | https://openalex.org/I4210129183 |
| authorships[24].affiliations[2].raw_affiliation_string | Member of the German Center for Lung Research (DZL), Germany; |
| authorships[24].institutions[0].id | https://openalex.org/I4210129183 |
| authorships[24].institutions[0].ror | https://ror.org/03dx11k66 |
| authorships[24].institutions[0].type | facility |
| authorships[24].institutions[0].lineage | https://openalex.org/I4210129183, https://openalex.org/I4411590659 |
| authorships[24].institutions[0].country_code | DE |
| authorships[24].institutions[0].display_name | German Center for Lung Research |
| authorships[24].institutions[1].id | https://openalex.org/I8204097 |
| authorships[24].institutions[1].ror | https://ror.org/05591te55 |
| authorships[24].institutions[1].type | education |
| authorships[24].institutions[1].lineage | https://openalex.org/I8204097 |
| authorships[24].institutions[1].country_code | DE |
| authorships[24].institutions[1].display_name | Ludwig-Maximilians-Universität München |
| authorships[24].author_position | middle |
| authorships[24].raw_author_name | Bianca Schaub |
| authorships[24].is_corresponding | False |
| authorships[24].raw_affiliation_strings | Comprehensive Pneumology Center–Munich, Munich, Germany;, Dr. von Hauner Children’s Hospital, Ludwig Maximilians University, Munich, Germany;, Member of the German Center for Lung Research (DZL), Germany; |
| authorships[25].author.id | https://openalex.org/A5044164531 |
| authorships[25].author.orcid | https://orcid.org/0000-0002-8893-4515 |
| authorships[25].author.display_name | Erika von Mutius |
| authorships[25].countries | DE |
| authorships[25].affiliations[0].institution_ids | https://openalex.org/I4210129183 |
| authorships[25].affiliations[0].raw_affiliation_string | Member of the German Center for Lung Research (DZL), Germany; |
| authorships[25].affiliations[1].institution_ids | https://openalex.org/I3018134672 |
| authorships[25].affiliations[1].raw_affiliation_string | Institute for Asthma and Allergy Prevention, Helmholtz Center Munich, German Research Center for Environmental Health, Munich, Germany; |
| authorships[25].affiliations[2].institution_ids | https://openalex.org/I8204097 |
| authorships[25].affiliations[2].raw_affiliation_string | Dr. von Hauner Children’s Hospital, Ludwig Maximilians University, Munich, Germany; |
| authorships[25].institutions[0].id | https://openalex.org/I4210129183 |
| authorships[25].institutions[0].ror | https://ror.org/03dx11k66 |
| authorships[25].institutions[0].type | facility |
| authorships[25].institutions[0].lineage | https://openalex.org/I4210129183, https://openalex.org/I4411590659 |
| authorships[25].institutions[0].country_code | DE |
| authorships[25].institutions[0].display_name | German Center for Lung Research |
| authorships[25].institutions[1].id | https://openalex.org/I3018134672 |
| authorships[25].institutions[1].ror | https://ror.org/00cfam450 |
| authorships[25].institutions[1].type | facility |
| authorships[25].institutions[1].lineage | https://openalex.org/I1305996414, https://openalex.org/I3018134672 |
| authorships[25].institutions[1].country_code | DE |
| authorships[25].institutions[1].display_name | Helmholtz Zentrum München |
| authorships[25].institutions[2].id | https://openalex.org/I8204097 |
| authorships[25].institutions[2].ror | https://ror.org/05591te55 |
| authorships[25].institutions[2].type | education |
| authorships[25].institutions[2].lineage | https://openalex.org/I8204097 |
| authorships[25].institutions[2].country_code | DE |
| authorships[25].institutions[2].display_name | Ludwig-Maximilians-Universität München |
| authorships[25].author_position | middle |
| authorships[25].raw_author_name | Erika von Mutius |
| authorships[25].is_corresponding | False |
| authorships[25].raw_affiliation_strings | Dr. von Hauner Children’s Hospital, Ludwig Maximilians University, Munich, Germany;, Institute for Asthma and Allergy Prevention, Helmholtz Center Munich, German Research Center for Environmental Health, Munich, Germany;, Member of the German Center for Lung Research (DZL), Germany; |
| authorships[26].author.id | https://openalex.org/A5086064578 |
| authorships[26].author.orcid | https://orcid.org/0000-0002-3203-8084 |
| authorships[26].author.display_name | Carsten B. Schmidt‐Weber |
| authorships[26].countries | DE |
| authorships[26].affiliations[0].institution_ids | https://openalex.org/I4210129183 |
| authorships[26].affiliations[0].raw_affiliation_string | Member of the German Center for Lung Research (DZL), Germany; |
| authorships[26].affiliations[1].institution_ids | https://openalex.org/I3018134672 |
| authorships[26].affiliations[1].raw_affiliation_string | Center of Allergy and Environment (ZAUM), Technical University and Helmholtz Center Munich, Munich, Germany; |
| authorships[26].institutions[0].id | https://openalex.org/I4210129183 |
| authorships[26].institutions[0].ror | https://ror.org/03dx11k66 |
| authorships[26].institutions[0].type | facility |
| authorships[26].institutions[0].lineage | https://openalex.org/I4210129183, https://openalex.org/I4411590659 |
| authorships[26].institutions[0].country_code | DE |
| authorships[26].institutions[0].display_name | German Center for Lung Research |
| authorships[26].institutions[1].id | https://openalex.org/I3018134672 |
| authorships[26].institutions[1].ror | https://ror.org/00cfam450 |
| authorships[26].institutions[1].type | facility |
| authorships[26].institutions[1].lineage | https://openalex.org/I1305996414, https://openalex.org/I3018134672 |
| authorships[26].institutions[1].country_code | DE |
| authorships[26].institutions[1].display_name | Helmholtz Zentrum München |
| authorships[26].author_position | middle |
| authorships[26].raw_author_name | Carsten B. Schmidt-Weber |
| authorships[26].is_corresponding | False |
| authorships[26].raw_affiliation_strings | Center of Allergy and Environment (ZAUM), Technical University and Helmholtz Center Munich, Munich, Germany;, Member of the German Center for Lung Research (DZL), Germany; |
| authorships[27].author.id | https://openalex.org/A5022966140 |
| authorships[27].author.orcid | https://orcid.org/0000-0002-7127-5226 |
| authorships[27].author.display_name | Oliver Fuchs |
| authorships[27].author_position | middle |
| authorships[27].raw_author_name | Oliver Fuchs |
| authorships[27].is_corresponding | False |
| authorships[28].author.id | https://openalex.org/A5057090016 |
| authorships[28].author.orcid | |
| authorships[28].author.display_name | Barbara Roesler |
| authorships[28].author_position | middle |
| authorships[28].raw_author_name | Barbara Roesler |
| authorships[28].is_corresponding | False |
| authorships[29].author.id | https://openalex.org/A5016918594 |
| authorships[29].author.orcid | |
| authorships[29].author.display_name | Nils Welchering |
| authorships[29].author_position | middle |
| authorships[29].raw_author_name | Nils Welchering |
| authorships[29].is_corresponding | False |
| authorships[30].author.id | https://openalex.org/A5013142870 |
| authorships[30].author.orcid | |
| authorships[30].author.display_name | Naschla Kohistani-Greif |
| authorships[30].author_position | middle |
| authorships[30].raw_author_name | Naschla Kohistani-Greif |
| authorships[30].is_corresponding | False |
| authorships[31].author.id | https://openalex.org/A5045482126 |
| authorships[31].author.orcid | https://orcid.org/0000-0001-9912-4377 |
| authorships[31].author.display_name | Johanna Kurz |
| authorships[31].author_position | middle |
| authorships[31].raw_author_name | Johanna Kurz |
| authorships[31].is_corresponding | False |
| authorships[32].author.id | https://openalex.org/A5071501891 |
| authorships[32].author.orcid | |
| authorships[32].author.display_name | Katja Landgraf‐Rauf |
| authorships[32].author_position | middle |
| authorships[32].raw_author_name | Katja Landgraf-Rauf |
| authorships[32].is_corresponding | False |
| authorships[33].author.id | https://openalex.org/A5048337657 |
| authorships[33].author.orcid | https://orcid.org/0000-0002-0785-9964 |
| authorships[33].author.display_name | Kristina Laubhahn |
| authorships[33].author_position | middle |
| authorships[33].raw_author_name | Kristina Laubhahn |
| authorships[33].is_corresponding | False |
| authorships[34].author.id | https://openalex.org/A5030285538 |
| authorships[34].author.orcid | https://orcid.org/0000-0002-8731-4218 |
| authorships[34].author.display_name | Nicole Maison |
| authorships[34].author_position | middle |
| authorships[34].raw_author_name | Nicole Maison |
| authorships[34].is_corresponding | False |
| authorships[35].author.id | https://openalex.org/A5031251647 |
| authorships[35].author.orcid | |
| authorships[35].author.display_name | Claudia Liebl |
| authorships[35].author_position | middle |
| authorships[35].raw_author_name | Claudia Liebl |
| authorships[35].is_corresponding | False |
| authorships[36].author.id | https://openalex.org/A5020597983 |
| authorships[36].author.orcid | https://orcid.org/0000-0001-6643-3923 |
| authorships[36].author.display_name | Markus Ege |
| authorships[36].author_position | middle |
| authorships[36].raw_author_name | Markus Ege |
| authorships[36].is_corresponding | False |
| authorships[37].author.id | https://openalex.org/A5002005063 |
| authorships[37].author.orcid | |
| authorships[37].author.display_name | Alexander Hose |
| authorships[37].author_position | middle |
| authorships[37].raw_author_name | Alexander Hose |
| authorships[37].is_corresponding | False |
| authorships[38].author.id | https://openalex.org/A5001500034 |
| authorships[38].author.orcid | |
| authorships[38].author.display_name | Esther Zeitlmann |
| authorships[38].author_position | middle |
| authorships[38].raw_author_name | Esther Zeitlmann |
| authorships[38].is_corresponding | False |
| authorships[39].author.id | https://openalex.org/A5069523781 |
| authorships[39].author.orcid | |
| authorships[39].author.display_name | Mira Berbig |
| authorships[39].author_position | middle |
| authorships[39].raw_author_name | Mira Berbig |
| authorships[39].is_corresponding | False |
| authorships[40].author.id | https://openalex.org/A5112869585 |
| authorships[40].author.orcid | |
| authorships[40].author.display_name | Carola Marzi |
| authorships[40].author_position | middle |
| authorships[40].raw_author_name | Carola Marzi |
| authorships[40].is_corresponding | False |
| authorships[41].author.id | https://openalex.org/A5020307493 |
| authorships[41].author.orcid | |
| authorships[41].author.display_name | Christina Schauberger |
| authorships[41].author_position | middle |
| authorships[41].raw_author_name | Christina Schauberger |
| authorships[41].is_corresponding | False |
| authorships[42].author.id | https://openalex.org/A5110951337 |
| authorships[42].author.orcid | |
| authorships[42].author.display_name | Isabell Ricklefs |
| authorships[42].author_position | middle |
| authorships[42].raw_author_name | Isabell Ricklefs |
| authorships[42].is_corresponding | False |
| authorships[43].author.id | https://openalex.org/A5072053426 |
| authorships[43].author.orcid | |
| authorships[43].author.display_name | Gesa Diekmann |
| authorships[43].author_position | middle |
| authorships[43].raw_author_name | Gesa Diekmann |
| authorships[43].is_corresponding | False |
| authorships[44].author.id | https://openalex.org/A5042843954 |
| authorships[44].author.orcid | |
| authorships[44].author.display_name | Lena Liboschik |
| authorships[44].author_position | middle |
| authorships[44].raw_author_name | Lena Liboschik |
| authorships[44].is_corresponding | False |
| authorships[45].author.id | https://openalex.org/A5046992055 |
| authorships[45].author.orcid | |
| authorships[45].author.display_name | Gesche Voigt |
| authorships[45].author_position | middle |
| authorships[45].raw_author_name | Gesche Voigt |
| authorships[45].is_corresponding | False |
| authorships[46].author.id | https://openalex.org/A5030039901 |
| authorships[46].author.orcid | |
| authorships[46].author.display_name | Laila Sultansei |
| authorships[46].author_position | middle |
| authorships[46].raw_author_name | Laila Sultansei |
| authorships[46].is_corresponding | False |
| authorships[47].author.id | https://openalex.org/A5108365338 |
| authorships[47].author.orcid | |
| authorships[47].author.display_name | Gyde Nissen |
| authorships[47].author_position | middle |
| authorships[47].raw_author_name | Gyde Nissen |
| authorships[47].is_corresponding | False |
| authorships[48].author.id | https://openalex.org/A5024750728 |
| authorships[48].author.orcid | https://orcid.org/0000-0003-0504-6465 |
| authorships[48].author.display_name | Inke R. König |
| authorships[48].author_position | middle |
| authorships[48].raw_author_name | Inke R. König |
| authorships[48].is_corresponding | False |
| authorships[49].author.id | https://openalex.org/A5039811463 |
| authorships[49].author.orcid | https://orcid.org/0000-0003-1073-0747 |
| authorships[49].author.display_name | Dominik Thiele |
| authorships[49].author_position | middle |
| authorships[49].raw_author_name | Dominik Thiele |
| authorships[49].is_corresponding | False |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.ncbi.nlm.nih.gov/pmc/articles/11531215 |
| open_access.oa_status | green |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | 17q21 Variants Disturb Mucosal Host Defense in Childhood Asthma |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10051 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9998000264167786 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2737 |
| primary_topic.subfield.display_name | Physiology |
| primary_topic.display_name | Asthma and respiratory diseases |
| related_works | https://openalex.org/W2199233783, https://openalex.org/W3104145505, https://openalex.org/W2125344851, https://openalex.org/W2124478268, https://openalex.org/W2413816897, https://openalex.org/W1989502778, https://openalex.org/W2042873259, https://openalex.org/W2361342090, https://openalex.org/W858891458, https://openalex.org/W1956762270 |
| cited_by_count | 20 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 12 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 8 |
| locations_count | 4 |
| best_oa_location.id | pmh:oai:pubmedcentral.nih.gov:11531215 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S2764455111 |
| best_oa_location.source.issn | |
| best_oa_location.source.type | repository |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | |
| best_oa_location.source.is_core | False |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | PubMed Central |
| best_oa_location.source.host_organization | https://openalex.org/I1299303238 |
| best_oa_location.source.host_organization_name | National Institutes of Health |
| best_oa_location.source.host_organization_lineage | https://openalex.org/I1299303238 |
| best_oa_location.license | other-oa |
| best_oa_location.pdf_url | |
| best_oa_location.version | submittedVersion |
| best_oa_location.raw_type | Text |
| best_oa_location.license_id | https://openalex.org/licenses/other-oa |
| best_oa_location.is_accepted | False |
| best_oa_location.is_published | False |
| best_oa_location.raw_source_name | Am J Respir Crit Care Med |
| best_oa_location.landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/11531215 |
| primary_location.id | doi:10.1164/rccm.202305-0934oc |
| primary_location.is_oa | False |
| primary_location.source.id | https://openalex.org/S93356601 |
| primary_location.source.issn | 1073-449X, 1535-4970 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 1073-449X |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | American Journal of Respiratory and Critical Care Medicine |
| primary_location.source.host_organization | https://openalex.org/P4310316311 |
| primary_location.source.host_organization_name | American Thoracic Society |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310316311 |
| primary_location.license | |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | American Journal of Respiratory and Critical Care Medicine |
| primary_location.landing_page_url | https://doi.org/10.1164/rccm.202305-0934oc |
| publication_date | 2023-12-08 |
| publication_year | 2023 |
| referenced_works | https://openalex.org/W2008599922, https://openalex.org/W3023006393, https://openalex.org/W2072063345, https://openalex.org/W2883218164, https://openalex.org/W2152259491, https://openalex.org/W1983043354, https://openalex.org/W2174861227, https://openalex.org/W2012568595, https://openalex.org/W2161915758, https://openalex.org/W2062405350, https://openalex.org/W2165277651, https://openalex.org/W4226030444, https://openalex.org/W3129088312, https://openalex.org/W1964779747, https://openalex.org/W2085312828, https://openalex.org/W2167345828, https://openalex.org/W2055349211, https://openalex.org/W2089627898, https://openalex.org/W3158976928, https://openalex.org/W3026474798, https://openalex.org/W2783654652, https://openalex.org/W2750788866, https://openalex.org/W3128064404, https://openalex.org/W4220987111, https://openalex.org/W3016811071, https://openalex.org/W2897923935, https://openalex.org/W2886753196, https://openalex.org/W2136199835, https://openalex.org/W2888483093, https://openalex.org/W2411100649, https://openalex.org/W2782174691, https://openalex.org/W3108907439, https://openalex.org/W1979977043, https://openalex.org/W2953804070, https://openalex.org/W2174701321, https://openalex.org/W2056107229, https://openalex.org/W1982448036, https://openalex.org/W3087862874, https://openalex.org/W2123543667, https://openalex.org/W4200169120, https://openalex.org/W2160313021, https://openalex.org/W2057672069 |
| referenced_works_count | 42 |
| abstract_inverted_index.1 | 180 |
| abstract_inverted_index.3 | 183 |
| abstract_inverted_index.a | 66, 120, 149, 175, 195, 212 |
| abstract_inverted_index.79 | 52 |
| abstract_inverted_index.To | 21 |
| abstract_inverted_index.an | 163 |
| abstract_inverted_index.as | 130 |
| abstract_inverted_index.at | 55, 186, 265 |
| abstract_inverted_index.by | 36, 200 |
| abstract_inverted_index.in | 136, 177, 231 |
| abstract_inverted_index.is | 12, 209, 263 |
| abstract_inverted_index.of | 43, 69, 80, 126, 148, 241 |
| abstract_inverted_index.to | 76, 103, 162, 246 |
| abstract_inverted_index.(78 | 50 |
| abstract_inverted_index.104 | 58 |
| abstract_inverted_index.261 | 48 |
| abstract_inverted_index.IFN | 105, 164, 178, 234 |
| abstract_inverted_index.The | 1 |
| abstract_inverted_index.age | 68 |
| abstract_inverted_index.and | 18, 93, 97, 108, 122, 154, 181, 189, 229 |
| abstract_inverted_index.for | 6, 237, 256 |
| abstract_inverted_index.key | 159 |
| abstract_inverted_index.new | 254 |
| abstract_inverted_index.the | 9, 26, 32, 37, 61, 78, 90, 115, 131, 146, 187, 201, 232, 238 |
| abstract_inverted_index.was | 74, 101, 174 |
| abstract_inverted_index.(SNP | 84 |
| abstract_inverted_index.10.0 | 70 |
| abstract_inverted_index.Main | 109 |
| abstract_inverted_index.This | 111, 192 |
| abstract_inverted_index.age, | 57 |
| abstract_inverted_index.arm, | 268 |
| abstract_inverted_index.cell | 227 |
| abstract_inverted_index.from | 47, 89 |
| abstract_inverted_index.gene | 135 |
| abstract_inverted_index.mRNA | 188 |
| abstract_inverted_index.only | 132 |
| abstract_inverted_index.risk | 4, 117, 203, 243 |
| abstract_inverted_index.same | 91 |
| abstract_inverted_index.that | 114, 224 |
| abstract_inverted_index.type | 179, 182 |
| abstract_inverted_index.were | 95 |
| abstract_inverted_index.with | 14, 31, 53, 65, 138, 145, 211, 217 |
| abstract_inverted_index.17q21 | 10, 38, 82, 116, 202, 242 |
| abstract_inverted_index.These | 221 |
| abstract_inverted_index.brush | 45 |
| abstract_inverted_index.death | 228 |
| abstract_inverted_index.early | 251 |
| abstract_inverted_index.genes | 160 |
| abstract_inverted_index.life, | 252 |
| abstract_inverted_index.nasal | 44, 87 |
| abstract_inverted_index.novel | 196 |
| abstract_inverted_index.study | 112, 193 |
| abstract_inverted_index.their | 81 |
| abstract_inverted_index.there | 173 |
| abstract_inverted_index.viral | 16, 28, 248 |
| abstract_inverted_index.airway | 219, 226 |
| abstract_inverted_index.allele | 118, 244 |
| abstract_inverted_index.cohort | 262 |
| abstract_inverted_index.during | 250 |
| abstract_inverted_index.factor | 5 |
| abstract_inverted_index.future | 257 |
| abstract_inverted_index.immune | 214 |
| abstract_inverted_index.impact | 79 |
| abstract_inverted_index.killer | 156 |
| abstract_inverted_index.linked | 161 |
| abstract_inverted_index.locus, | 11 |
| abstract_inverted_index.median | 67 |
| abstract_inverted_index.type-1 | 150 |
| abstract_inverted_index.visits | 94 |
| abstract_inverted_index.within | 60 |
| abstract_inverted_index.years, | 73 |
| abstract_inverted_index.(range, | 71 |
| abstract_inverted_index.account | 236 |
| abstract_inverted_index.allele. | 204 |
| abstract_inverted_index.asthma, | 8 |
| abstract_inverted_index.cohort, | 64 |
| abstract_inverted_index.coupled | 216 |
| abstract_inverted_index.explore | 77 |
| abstract_inverted_index.genetic | 3 |
| abstract_inverted_index.immune, | 153 |
| abstract_inverted_index.induced | 199 |
| abstract_inverted_index.induces | 119 |
| abstract_inverted_index.measure | 104 |
| abstract_inverted_index.mucosal | 127, 206, 233 |
| abstract_inverted_index.natural | 155 |
| abstract_inverted_index.opening | 253 |
| abstract_inverted_index.options | 255 |
| abstract_inverted_index.protein | 106, 190 |
| abstract_inverted_index.samples | 46 |
| abstract_inverted_index.suggest | 223 |
| abstract_inverted_index.targets | 24 |
| abstract_inverted_index.wheeze. | 140 |
| abstract_inverted_index.ALLIANCE | 62 |
| abstract_inverted_index.analysis | 42 |
| abstract_inverted_index.carriers | 245 |
| abstract_inverted_index.children | 49, 137 |
| abstract_inverted_index.clinical | 33 |
| abstract_inverted_index.employed | 102 |
| abstract_inverted_index.findings | 222 |
| abstract_inverted_index.genotype | 83 |
| abstract_inverted_index.healthy, | 51 |
| abstract_inverted_index.identify | 22 |
| abstract_inverted_index.mediated | 35 |
| abstract_inverted_index.patients | 92 |
| abstract_inverted_index.relevant | 133 |
| abstract_inverted_index.response | 215 |
| abstract_inverted_index.revealed | 113 |
| abstract_inverted_index.wheezing | 54 |
| abstract_inverted_index.1.0-20.0) | 72 |
| abstract_inverted_index.Increased | 141, 205 |
| abstract_inverted_index.conducted | 75 |
| abstract_inverted_index.escalated | 27 |
| abstract_inverted_index.genotype- | 121 |
| abstract_inverted_index.increased | 15, 239 |
| abstract_inverted_index.mechanism | 198 |
| abstract_inverted_index.mesoscale | 99 |
| abstract_inverted_index.phenotype | 34 |
| abstract_inverted_index.preschool | 56, 139 |
| abstract_inverted_index.reduction | 176 |
| abstract_inverted_index.signature | 235 |
| abstract_inverted_index.strongest | 2 |
| abstract_inverted_index.(ALLIANCE) | 261 |
| abstract_inverted_index.(pediatric | 267 |
| abstract_inverted_index.activation | 147 |
| abstract_inverted_index.associated | 13, 30, 210 |
| abstract_inverted_index.asthmatic) | 59 |
| abstract_inverted_index.biological | 23, 258 |
| abstract_inverted_index.cell-lytic | 152, 213 |
| abstract_inverted_index.collected, | 96 |
| abstract_inverted_index.correlated | 144 |
| abstract_inverted_index.expression | 129, 143, 184, 208 |
| abstract_inverted_index.infections | 249 |
| abstract_inverted_index.registered | 264 |
| abstract_inverted_index.secretions | 88 |
| abstract_inverted_index.signature, | 157 |
| abstract_inverted_index.signatures | 185 |
| abstract_inverted_index.technology | 100 |
| abstract_inverted_index.underlying | 25 |
| abstract_inverted_index.Conversely, | 172 |
| abstract_inverted_index.Genome-wide | 40 |
| abstract_inverted_index.compromised | 218 |
| abstract_inverted_index.enhancement | 125 |
| abstract_inverted_index.respiratory | 247 |
| abstract_inverted_index.<i>CD8A</i>, | 170 |
| abstract_inverted_index.<i>GSDMB</i> | 128, 142, 207 |
| abstract_inverted_index.Results:</b> | 110 |
| abstract_inverted_index.demonstrates | 194 |
| abstract_inverted_index.encompassing | 158 |
| abstract_inverted_index.(<i>IFNG</i>, | 166 |
| abstract_inverted_index.17q21-encoded | 134 |
| abstract_inverted_index.<i>CXCL9</i>, | 167 |
| abstract_inverted_index.<i>GZMA</i>). | 171 |
| abstract_inverted_index.<i>KLRC1</i>, | 169 |
| abstract_inverted_index.Concurrently, | 86 |
| abstract_inverted_index.NCT02496468). | 269 |
| abstract_inverted_index.asthma/wheeze | 123 |
| abstract_inverted_index.perturbations | 230 |
| abstract_inverted_index.transcriptome | 41 |
| abstract_inverted_index.vulnerability | 240 |
| abstract_inverted_index.<i>CXCL10</i>, | 168 |
| abstract_inverted_index.All-Age-Asthma | 260 |
| abstract_inverted_index.susceptibility | 17, 29 |
| abstract_inverted_index.childhood-onset | 7 |
| abstract_inverted_index.disease-driving | 197 |
| abstract_inverted_index.(All-Age-Asthma) | 63 |
| abstract_inverted_index.high-sensitivity | 98 |
| abstract_inverted_index.proinflammatory, | 151 |
| abstract_inverted_index.type-2-signature | 165 |
| abstract_inverted_index.<b>Rationale:</b> | 0 |
| abstract_inverted_index.disease-promoting | 19 |
| abstract_inverted_index.immunocompetence. | 220 |
| abstract_inverted_index.interventions.The | 259 |
| abstract_inverted_index.<i>rs72163891</i>). | 85 |
| abstract_inverted_index.phenotype-dependent | 124 |
| abstract_inverted_index.<i>GSDMB</i>-related | 225 |
| abstract_inverted_index.locus.<b>Methods:</b> | 39 |
| abstract_inverted_index.levels.<b>Measurements | 107 |
| abstract_inverted_index.www.clinicaltrials.gov | 266 |
| abstract_inverted_index.levels.<b>Conclusions:</b> | 191 |
| abstract_inverted_index.processes.<b>Objectives:</b> | 20 |
| cited_by_percentile_year.max | 100 |
| cited_by_percentile_year.min | 99 |
| countries_distinct_count | 4 |
| institutions_distinct_count | 79 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7300000190734863 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.95197526 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |