18F-FDG PET or PET/CT in detecting high-grade transformation of chronic lymphocytic leukaemia and indolent lymphomas: a systematic review and meta-analysis Article Swipe
Osher Ngo Yung Lee
,
John Kuruvilla
,
David Hodgson
,
Patrick Veit‐Haibach
,
Ur Metser
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1093/bjr/tqaf028
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1093/bjr/tqaf028
Objectives To evaluate the diagnostic accuracy of 18F-FDG positron emission tomography (PET) or PET/computed tomography (CT) in detecting histological transformation (HT) of indolent lymphomas. Methods A systematic search of articles up to July 2024 was performed in Embase and Medline. Eligible studies included adults with histologically proven indolent lymphoma, 18F-FDG PET or PET/CT as the index test, and sufficient data to assess diagnostic performance. Summary receiver operating characteristic curves were plotted using a bivariate model to estimate diagnostic accuracy with area under the curve (AUC). Results Fifteen studies with 1307 participants were included. Ten studies assessed PET ability to detect Richter’s transformation, and 5 studies focused on HT in follicular lymphoma and other subtypes. A meta-analysis of the former showed pooled sensitivity of 0.90 (95% CI, 0.84-0.93) and specificity of 0.54 (95% CI, 0.28-0.77) when using a maximum standardized uptake value (SUVmax) threshold of around 5. AUC was 0.89. Pooled sensitivity was 0.74 (95% CI, 0.54-0.87), and specificity was 0.84 (95% CI, 0.67-0.93) when using an SUVmax threshold of around 10. Area under the curve was 0.84. For detecting HT in follicular lymphoma, thresholds were found higher than those for Richter’s transformation. Conclusions 18F-FDG PET or PET/CT demonstrates good diagnostic accuracy to detect Richter’s transformation, best when employing SUVmax ≥ 5. SUVmax thresholds may be limited in discriminating follicular lymphoma from HT, and alternatives should be sought. Advances in knowledge If biopsy is feasible, SUVmax ≥ 5 can guide biopsy in patients with clinically suspicious Richter’s transformation. If biopsy is infeasible, SUVmax ≥ 10 can better identify HT and guide patient management.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1093/bjr/tqaf028
- OA Status
- hybrid
- Cited By
- 2
- References
- 40
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4407368596
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4407368596Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1093/bjr/tqaf028Digital Object Identifier
- Title
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18F-FDG PET or PET/CT in detecting high-grade transformation of chronic lymphocytic leukaemia and indolent lymphomas: a systematic review and meta-analysisWork title
- Type
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reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-02-11Full publication date if available
- Authors
-
Osher Ngo Yung Lee, John Kuruvilla, David Hodgson, Patrick Veit‐Haibach, Ur MetserList of authors in order
- Landing page
-
https://doi.org/10.1093/bjr/tqaf028Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1093/bjr/tqaf028Direct OA link when available
- Concepts
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Medicine, Follicular lymphoma, Receiver operating characteristic, Nuclear medicine, Lymphoma, Biopsy, Meta-analysis, Positron emission tomography, Area under the curve, Radiology, Diagnostic accuracy, Pathology, Internal medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
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2Total citation count in OpenAlex
- Citations by year (recent)
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2025: 2Per-year citation counts (last 5 years)
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40Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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