β2-Adrenergic receptor expression in subchondral bone of patients with varus knee osteoarthritis Article Swipe
Xiaochun Yang
,
Xuegang Liang
,
Haohui Guo
,
Long Ma
,
Jian Li
,
Xin Zhao
,
Jian Wang
,
Lvlin Yang
,
Zhiqiang Meng
,
Qunhua Jin
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1515/med-2022-0498
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1515/med-2022-0498
An important causative factor in osteoarthritis (OA) is the abnormal mechanical stress-induced bone remodeling of the subchondral bone. β2-adrenergic receptor (Adrb2) plays a major role in mechanical stresses that induce bone remodeling. The medial tibial plateau (MTP) and lateral tibial plateau (LTP) of patients with varus Knee osteoarthritis (KO) bear different mechanical stresses. The present study aimed to investigate the expression of Adrb2 in medial tibial plateau subchondral bone (MTPSB) and lateral tibial plateau subchondral bone (LTPSB) in patients with varus KO. A total of 30 tibial plateau samples from patients undergoing total knee arthroplasty for varus KO and MTPSB and LTPSB were studied. Statistical analysis was performed using paired sample t -tests. Safranin O-Fast Green staining and Micro-computed tomography showed significant differences in the bone structure between MTPSB and LTPSB. Tartrate-resistant acid phosphatase (TRAP)-positive cell density in MTPSB was higher than that in LTPSB. Immunohistochemistry, reverse transcription-quantitative polymerase chain reaction, and Western blot analysis revealed that compared to LTPSB, the levels of Adrb2, tyrosine hydroxylase (TH), and osteocalcin increased significantly in MTPSB. Double-labeling immunofluorescence showed Adrb2 was present in the majority of TRAP-positive multinuclear cells of the MTPSB. The expression of Adrb2 and TH was significantly higher in MTPSB than in LTPSB, confirming the involvement of these molecules in the development of OA.
Related Topics
Concepts
Medicine
Osteoarthritis
Bone remodeling
Osteocalcin
Immunohistochemistry
Alkaline phosphatase
Subchondral bone
Receptor
Tibia
Pathology
Anatomy
Internal medicine
Biology
Articular cartilage
Enzyme
Alternative medicine
Biochemistry
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1515/med-2022-0498
- https://www.degruyter.com/document/doi/10.1515/med-2022-0498/pdf
- OA Status
- gold
- Cited By
- 4
- References
- 48
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4285070250
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4285070250Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1515/med-2022-0498Digital Object Identifier
- Title
-
β2-Adrenergic receptor expression in subchondral bone of patients with varus knee osteoarthritisWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-01-01Full publication date if available
- Authors
-
Xiaochun Yang, Xuegang Liang, Haohui Guo, Long Ma, Jian Li, Xin Zhao, Jian Wang, Lvlin Yang, Zhiqiang Meng, Qunhua JinList of authors in order
- Landing page
-
https://doi.org/10.1515/med-2022-0498Publisher landing page
- PDF URL
-
https://www.degruyter.com/document/doi/10.1515/med-2022-0498/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.degruyter.com/document/doi/10.1515/med-2022-0498/pdfDirect OA link when available
- Concepts
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Medicine, Osteoarthritis, Bone remodeling, Osteocalcin, Immunohistochemistry, Alkaline phosphatase, Subchondral bone, Receptor, Tibia, Pathology, Anatomy, Internal medicine, Biology, Articular cartilage, Enzyme, Alternative medicine, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
4Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2, 2024: 1, 2023: 1Per-year citation counts (last 5 years)
- References (count)
-
48Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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