β2-Adrenoceptor Deficiency Results in Increased Calcified Cartilage Thickness and Subchondral Bone Remodeling in Murine Experimental Osteoarthritis Article Swipe
Gundula Rösch
,
Dominique Muschter
,
Shahed Taheri
,
Karima El Bagdadi
,
Christoph Dorn
,
Andrea Meurer
,
Frank Zaucke
,
Arndt F. Schilling
,
Susanne Grässel
,
Rainer H. Straub
,
Zsuzsa Jenei‐Lanzl
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3389/fimmu.2021.801505
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3389/fimmu.2021.801505
Purpose Recent studies demonstrated a contribution of adrenoceptors (ARs) to osteoarthritis (OA) pathogenesis. Several AR subtypes are expressed in joint tissues and the β2-AR subtype seems to play a major role during OA progression. However, the importance of β2-AR has not yet been investigated in knee OA. Therefore, we examined the development of knee OA in β2-AR-deficient ( Adrb2 -/- ) mice after surgical OA induction. Methods OA was induced by destabilization of the medial meniscus (DMM) in male wildtype (WT) and Adrb2 -/- mice. Cartilage degeneration and synovial inflammation were evaluated by histological scoring. Subchondral bone remodeling was analyzed using micro-CT. Osteoblast (alkaline phosphatase - ALP) and osteoclast (cathepsin K - CatK) activity were analyzed by immunostainings. To evaluate β2-AR deficiency-associated effects, body weight, sympathetic tone (splenic norepinephrine (NE) via HPLC) and serum leptin levels (ELISA) were determined. Expression of the second major AR, the α2-AR, was analyzed in joint tissues by immunostaining. Results WT and Adrb2 -/- DMM mice developed comparable changes in cartilage degeneration and synovial inflammation. Adrb2 -/- DMM mice displayed elevated calcified cartilage and subchondral bone plate thickness as well as increased epiphyseal BV/TV compared to WTs, while there were no significant differences in Sham animals. In the subchondral bone of Adrb2 -/- mice, osteoblasts activity increased and osteoclast activity deceased. Adrb2 -/- mice had significantly higher body weight and fat mass compared to WT mice. Serum leptin levels increased in Adrb2 -/- DMM compared to WT DMM without any difference between the respective Shams. There was no difference in the development of meniscal ossicles and osteophytes or in the subarticular trabecular microstructure between Adrb2 -/- and WT DMM as well as Adrb2 -/- and WT Sham mice. Number of α2-AR-positive cells was lower in Adrb2 -/- than in WT mice in all analyzed tissues and decreased in both Adrb2 -/- and WT over time. Conclusion We propose that the increased bone mass in Adrb2 -/- DMM mice was not only due to β2-AR deficiency but to a synergistic effect of OA and elevated leptin concentrations. Taken together, β2-AR plays a major role in OA-related subchondral bone remodeling and is thus an attractive target for the exploration of novel therapeutic avenues.
Related Topics
Concepts
Osteoarthritis
Cartilage
Medicine
Internal medicine
Bone remodeling
Osteoclast
Endocrinology
Inflammation
Cathepsin K
Pathogenesis
Osteoblast
Immunostaining
Leptin
Alkaline phosphatase
Pathology
Immunohistochemistry
Chemistry
Anatomy
Receptor
Enzyme
Biochemistry
Alternative medicine
Obesity
In vitro
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fimmu.2021.801505
- OA Status
- gold
- Cited By
- 16
- References
- 74
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4205544831
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4205544831Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/fimmu.2021.801505Digital Object Identifier
- Title
-
β2-Adrenoceptor Deficiency Results in Increased Calcified Cartilage Thickness and Subchondral Bone Remodeling in Murine Experimental OsteoarthritisWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-01-13Full publication date if available
- Authors
-
Gundula Rösch, Dominique Muschter, Shahed Taheri, Karima El Bagdadi, Christoph Dorn, Andrea Meurer, Frank Zaucke, Arndt F. Schilling, Susanne Grässel, Rainer H. Straub, Zsuzsa Jenei‐LanzlList of authors in order
- Landing page
-
https://doi.org/10.3389/fimmu.2021.801505Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.3389/fimmu.2021.801505Direct OA link when available
- Concepts
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Osteoarthritis, Cartilage, Medicine, Internal medicine, Bone remodeling, Osteoclast, Endocrinology, Inflammation, Cathepsin K, Pathogenesis, Osteoblast, Immunostaining, Leptin, Alkaline phosphatase, Pathology, Immunohistochemistry, Chemistry, Anatomy, Receptor, Enzyme, Biochemistry, Alternative medicine, Obesity, In vitroTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
16Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2, 2024: 6, 2023: 7, 2022: 1Per-year citation counts (last 5 years)
- References (count)
-
74Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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