2024 Revision of the level of evidence grading system for ESC clinical practice guideline recommendations II: diagnostic tests and prediction models Article Swipe
Emanuele Di Angelantonio
,
Lisa Pennells
,
Magdy Abdelhamid
,
Victor Aboyans
,
Riccardo Asteggiano
,
Jelena Čelutkienė
,
Diederick E. Grobbee
,
Bernard Iung
,
Peter Jüni
,
John W. McEvoy
,
Amina Rakisheva
,
Xavier Rosselló
,
Frank L.J. Visseren
,
Colin Baigent
,
Eva Prescott
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1093/eurheartj/ehaf016
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1093/eurheartj/ehaf016
The level of evidence (LOE) grading system for European Society of Cardiology (ESC) Clinical Practice Guidelines (CPG) classifies the quality of the evidence supporting a recommendation. However, the current taxonomy does not fully consider the optimal study design necessary to establish evidence for different types of recommendations in ESC guidelines. Therefore, two separate task forces of clinical and methodological experts were appointed by the CPG Committee, with the first tasked with updating the LOE grading system for therapy and prevention and the second responsible for developing a LOE grading system for diagnosis and prediction. This report from the second of these Task Forces develops a new system for diagnostic tests and prediction models which maintains the three-level grading structure to classify the quality of the evidence but introduces new definitions specific for diagnosis and prediction. For diagnostic tests, LOE A represents conclusive evidence of adequate diagnostic ability from at least two high-quality studies. Level of evidence B represents suggestive evidence from one high-quality or at least two moderate-quality studies. Level of evidence C represents preliminary evidence not classified as A or B, including evidence from less than two moderate-quality studies, or from expert consensus. For prediction models, LOE A represents conclusive evidence of adequate predictive ability from at least one high-quality derivation and two or more external validation studies of at least moderate quality. Level of evidence B represents suggestive evidence in one or more derivation studies and one or more external validation studies of at least moderate quality. Level of evidence C represents preliminary evidence not classified as A or B, including evidence from a derivation study of at least moderate quality, but with low quality or no external validation, or a derivation study of low quality.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/eurheartj/ehaf016
- https://academic.oup.com/eurheartj/advance-article-pdf/doi/10.1093/eurheartj/ehaf016/62500155/ehaf016.pdf
- OA Status
- bronze
- Cited By
- 4
- References
- 28
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4408745429
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4408745429Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1093/eurheartj/ehaf016Digital Object Identifier
- Title
-
2024 Revision of the level of evidence grading system for ESC clinical practice guideline recommendations II: diagnostic tests and prediction modelsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-03-21Full publication date if available
- Authors
-
Emanuele Di Angelantonio, Lisa Pennells, Magdy Abdelhamid, Victor Aboyans, Riccardo Asteggiano, Jelena Čelutkienė, Diederick E. Grobbee, Bernard Iung, Peter Jüni, John W. McEvoy, Amina Rakisheva, Xavier Rosselló, Frank L.J. Visseren, Colin Baigent, Eva PrescottList of authors in order
- Landing page
-
https://doi.org/10.1093/eurheartj/ehaf016Publisher landing page
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-
https://academic.oup.com/eurheartj/advance-article-pdf/doi/10.1093/eurheartj/ehaf016/62500155/ehaf016.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
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https://academic.oup.com/eurheartj/advance-article-pdf/doi/10.1093/eurheartj/ehaf016/62500155/ehaf016.pdfDirect OA link when available
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Medicine, Evidence-based medicine, Grading (engineering), Guideline, Evidence-based practice, Quality of evidence, Clinical Practice, Quality (philosophy), Medical physics, Family medicine, Meta-analysis, Pathology, Alternative medicine, Epistemology, Civil engineering, Engineering, PhilosophyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
4Total citation count in OpenAlex
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2025: 4Per-year citation counts (last 5 years)
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28Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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