2,4-Diaminothieno[3,2-d]pyrimidines, a new class of anthelmintic with activity against adult and egg stages of whipworm Article Swipe
Frederick A. Partridge
,
Ruth Forman
,
Nicky J. Willis
,
Carole J. R. Bataille
,
Emma Murphy
,
Anwen E. Brown
,
Narinder Heyer-Chauhan
,
Bruno Marinič
,
Daniel J. C. Sowood
,
Graham M. Wynne
,
Kathryn J. Else
,
Angela J. Russell
,
David B. Sattelle
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pntd.0006487
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pntd.0006487
The human whipworm Trichuris trichiura is a parasite that infects around 500 million people globally, with consequences including damage to physical growth and educational performance. Current drugs such as mebendazole have a notable lack of efficacy against whipworm, compared to other soil-transmitted helminths. Mass drug administration programs are therefore unlikely to achieve eradication and new treatments for trichuriasis are desperately needed. All current drug control strategies focus on post-infection eradication, targeting the parasite in vivo. Here we propose developing novel anthelmintics which target the egg stage of the parasite in the soil as an adjunct environmental strategy. As evidence in support of such an approach we describe the actions of a new class of anthelmintic compounds, the 2,4-diaminothieno[3,2-d]pyrimidines (DATPs). This compound class has found broad utility in medicinal chemistry, but has not previously been described as having anthelmintic activity. Importantly, these compounds show efficacy against not only the adult parasite, but also both the embryonated and unembryonated egg stages and thereby may enable a break in the parasite lifecycle.
Related Topics
Concepts
Trichuris trichiura
Embryonated
Trichuriasis
Anthelmintic
Mebendazole
Trichuris
Parasite hosting
Biology
Helminths
Helminthiasis
Pharmacology
Immunology
Ascariasis
Zoology
Ascaris lumbricoides
Inoculation
Computer science
World Wide Web
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1371/journal.pntd.0006487
- https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0006487&type=printable
- OA Status
- gold
- Cited By
- 30
- References
- 50
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2952203084
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2952203084Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1371/journal.pntd.0006487Digital Object Identifier
- Title
-
2,4-Diaminothieno[3,2-d]pyrimidines, a new class of anthelmintic with activity against adult and egg stages of whipwormWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2018Year of publication
- Publication date
-
2018-07-11Full publication date if available
- Authors
-
Frederick A. Partridge, Ruth Forman, Nicky J. Willis, Carole J. R. Bataille, Emma Murphy, Anwen E. Brown, Narinder Heyer-Chauhan, Bruno Marinič, Daniel J. C. Sowood, Graham M. Wynne, Kathryn J. Else, Angela J. Russell, David B. SattelleList of authors in order
- Landing page
-
https://doi.org/10.1371/journal.pntd.0006487Publisher landing page
- PDF URL
-
https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0006487&type=printableDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0006487&type=printableDirect OA link when available
- Concepts
-
Trichuris trichiura, Embryonated, Trichuriasis, Anthelmintic, Mebendazole, Trichuris, Parasite hosting, Biology, Helminths, Helminthiasis, Pharmacology, Immunology, Ascariasis, Zoology, Ascaris lumbricoides, Inoculation, Computer science, World Wide WebTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
30Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2022: 6, 2021: 11, 2020: 8, 2019: 4Per-year citation counts (last 5 years)
- References (count)
-
50Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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