2400. Compared Performance Indices of the 2023 Duke-ISCVID, the 2000 Modified Duke, and the 2015 ESC Criteria for the Diagnosis of Infective Endocarditis Article Swipe
François Goehringer
,
Benoît Lalloué
,
Christine Selton‐Suty
,
François Alla
,
Guillaume Baronnet
,
Élisabeth Botelho-Nevers
,
Catherine Chirouze
,
Elodie Curlier
,
Safwane El Hatimi
,
Marie‐Line Erpelding
,
L. Escaut
,
Amandine Gagneux‐Brunon
,
Mesut Gun
,
Benjamin Lefèvre
,
Vincent Le Moing
,
Lionel Piroth
,
Aleyya Radjabaly Mandjee
,
Thibault Sixt
,
Christophe Cellier
,
Noémie Tissot
,
Christophe Tribouilloy
,
Jean‐Marc Virion
,
Nelly Agrinier
,
Xavier Duval
,
Bruno Hoen
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1093/ofid/ofad500.2020
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1093/ofid/ofad500.2020
Background The 2023 Duke-ISCVID criteria for infective endocarditis (IE) were recently proposed to update the diagnostic classification of IE. Using an open prospective multicenter cohort of patients treated for IE (ObservatoireEI, NCT03272724), we evaluated the performance indices of these new criteria, compared with those of the 2000 Modified Duke and the 2015 ESC criteria. Methods Data of patients who developed IE between January 2017 and October 2022, were extracted from the cohort database. Each case was individually adjudicated by 3 IE expert clinicians who met to identify cases they deemed ‘certain IE', which formed the “gold standard” IE group. A case was adjudicated as a ‘certain IE’ only when all 3 experts agreed on certainty of IE. Within each classification, each case was summarized by its criteria and assigned one of the definite, possible, or rejected categories. For each diagnostic classification, sensitivity, specificity, and accuracy and their 95% confidence intervals were computed in the whole case sample and in selected sub-groups (Figure). Case distribution of the 1194 cases by the three sets of criteria Results Cases included 1194 patients (mean age 66.1 years, 71.2% men), of whom 680 (57%) had a previously known pre-existing heart disease (414 prosthetic valves), 284 (23.8%) had a CIED, and 94 (7.9%) had a prior history of IE (see additional characteristics in Table 1). Of the 1194 patients, 946 (79.2%) were adjudicated as certain IE; 978 (81.9%), 997 (83.5%), and 1057 (88.5%) were classified as definite IE in the 2000 modified Duke, the 2015 ESC, and the 2023 Duke-ISCVID criteria, respectively (Figure). In the whole case sample, the sensitivity of each classification was 93.2% [91.6%; 94.8%], 95.0% [93.7%; 96.4%], and 97.6% [ 96.6%; 98.6%], respectively (p< .001 for all 2-by-2 comparisons). Corresponding specificity rates were 61.3% [55.2%; 67.4%], 60.5% [54.4%; 66.6%], and 46.0% [39.8%; 52.2%], respectively. Corresponding accuracy rates were 86.6% [84.7%; 88.5%], 87.9% [86.0%; 89.7%]), and 86.9% [84.9%; 88.8%], respectively. Performance indices on selected subgroups of patients are shown in Table 2. Patients’ Characteristics (Cont'd) Performance indices (% and [95% CI]) of the 2000 modified Duke, 2015 ESC, and 2023 Duke-ISCVID criteria for the diagnosis of IE in the whole study sample and selected subgroups Conclusion Compared to the 2000 Modified Duke and the 2015 ESC criteria, the 2023 Duke-ISCVID criteria had a significantly higher sensitivity and a significantly lower specificity, while accuracy was not significantly different. Disclosures françois Goehringer, n/a, Gilead Sciences: Expert Testimony|Gilead Sciences: Honoraria|GSK: Expert Testimony Christophe Strady, n/a, shionogi: Honoraria
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/ofid/ofad500.2020
- https://academic.oup.com/ofid/article-pdf/10/Supplement_2/ofad500.2020/53768129/ofad500.2020.pdf
- OA Status
- gold
- Cited By
- 3
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4389031393
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Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4389031393Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1093/ofid/ofad500.2020Digital Object Identifier
- Title
-
2400. Compared Performance Indices of the 2023 Duke-ISCVID, the 2000 Modified Duke, and the 2015 ESC Criteria for the Diagnosis of Infective EndocarditisWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-11-27Full publication date if available
- Authors
-
François Goehringer, Benoît Lalloué, Christine Selton‐Suty, François Alla, Guillaume Baronnet, Élisabeth Botelho-Nevers, Catherine Chirouze, Elodie Curlier, Safwane El Hatimi, Marie‐Line Erpelding, L. Escaut, Amandine Gagneux‐Brunon, Mesut Gun, Benjamin Lefèvre, Vincent Le Moing, Lionel Piroth, Aleyya Radjabaly Mandjee, Thibault Sixt, Christophe Cellier, Noémie Tissot, Christophe Tribouilloy, Jean‐Marc Virion, Nelly Agrinier, Xavier Duval, Bruno HoenList of authors in order
- Landing page
-
https://doi.org/10.1093/ofid/ofad500.2020Publisher landing page
- PDF URL
-
https://academic.oup.com/ofid/article-pdf/10/Supplement_2/ofad500.2020/53768129/ofad500.2020.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://academic.oup.com/ofid/article-pdf/10/Supplement_2/ofad500.2020/53768129/ofad500.2020.pdfDirect OA link when available
- Concepts
-
Medicine, Confidence interval, Infective endocarditis, Gold standard (test), Cohort, Internal medicine, Prospective cohort study, Endocarditis, PediatricsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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3Total citation count in OpenAlex
- Citations by year (recent)
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2024: 3Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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