(246) Age Dependent Effect on Contralateral Testicular Compensation Following Testicular Loss Article Swipe
Daniel E. Nassau
,
Nicholas A. Deebel
,
Eliyahu Kresch
,
J Loloi
,
Ari Bernstein
,
Davis Temple
,
Shathiyah Kulandavelu
,
H Arora
,
Ranjith Ramasamy
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1093/jsxmed/qdae001.236
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1093/jsxmed/qdae001.236
Introduction The human testicle is susceptible to loss from events like torsion, trauma, cancer, or cryptorchidism. Most paired organs are known to undergo compensatory hypertrophy following unilateral organ loss. The testicle is physiologically distinct in that it is thought to undergo a period of quiescence in childhood. Previous work has demonstrated testicular hypertrophy occurs if the loss of the contralateral testis occurs before puberty. However, it is unknown if compensatory physiology and growth differs by age of pre-pubertal loss. Objective This study aimed to investigate compensatory changes in testicular growth and the hormonal axis following unilateral orchiectomy in a neonatal, pre-pubertal and pubertal/adult murine model. Methods C57BL/6 mice were divided into experimental groups: neonatal (days of life 2-4), pre-pubescent (days of life 12-21), and post-pubescent (days of life 42-44) to undergo unilateral orchiectomy. A control group that did not undergo orchiectomy was utilized. Mice were sacrificed at maturity (over 80 days of life), blood samples were drawn, and the remaining testis was removed. Body and testis weight and testicular length in the long axis were measured in blinded fashion. Similarly, testosterone, luteinizing hormone (LH), and Follicle stimulating hormone (FSH) were assessed and expressed as a median and an interquartile range. Results Contralateral testes from neonatal and pre-pubertal mice who underwent orchiectomy weighed more (110.5, 12.2 and 103.0, 7.2 mg respectively. Figure 1.) (p < 0.05) than the control mice (91, 11.9 mg, respectively). There was no difference between post-pubertal group and control group. The degree of compensatory hypertrophy was greater in the neonatal group but not the pre-pubertal group when compared to the post-pubertal group. When examining the ratio of testicular weight to body weight, only the neonatal group was significantly higher than that of the control. Differences in FSH and testosterone were not statistically significant between experimental and control arms (p > 0.05). LH was significantly elevated in all experimental groups as compared to the control (p < 0.05). Conclusions This is the first study to assess testicular compensatory hypertrophy following contralateral testicular loss using a neonatal mouse survival surgery model. Testicular hypertrophy occurs when unilateral loss occurs prior to puberty, but not in adulthood in mice. Earlier testis loss may contribute to a greater degree of growth. Functionally, the unilateral testis can maintain eugonadal testosterone levels, but higher levels of LH are required following hemicastration to sustain eugonadal testosterone levels. Future studies are warranted to identify testicular transcriptomics in this model to evaluate for candidate genes potentially responsible for this phenotypic change. Disclosure No.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/jsxmed/qdae001.236
- https://academic.oup.com/jsm/article-pdf/21/Supplement_1/qdae001.236/56583131/qdae001.236.pdf
- OA Status
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- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4391575174Canonical identifier for this work in OpenAlex
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https://doi.org/10.1093/jsxmed/qdae001.236Digital Object Identifier
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(246) Age Dependent Effect on Contralateral Testicular Compensation Following Testicular LossWork title
- Type
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articleOpenAlex work type
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enPrimary language
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2024Year of publication
- Publication date
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2024-02-01Full publication date if available
- Authors
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Daniel E. Nassau, Nicholas A. Deebel, Eliyahu Kresch, J Loloi, Ari Bernstein, Davis Temple, Shathiyah Kulandavelu, H Arora, Ranjith RamasamyList of authors in order
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https://doi.org/10.1093/jsxmed/qdae001.236Publisher landing page
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https://academic.oup.com/jsm/article-pdf/21/Supplement_1/qdae001.236/56583131/qdae001.236.pdfDirect link to full text PDF
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YesWhether a free full text is available
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bronzeOpen access status per OpenAlex
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https://academic.oup.com/jsm/article-pdf/21/Supplement_1/qdae001.236/56583131/qdae001.236.pdfDirect OA link when available
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Orchiectomy, Internal medicine, Endocrinology, Testicle, Muscle hypertrophy, Testosterone (patch), Medicine, Hormone, Luteinizing hormone, BiologyTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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