3-Methoxy Carbazole Impedes the Growth of Human Breast Cancer Cells by Suppressing NF-κB Signaling Pathway Article Swipe
Jowaher Alanazi
,
Aziz Unnisa
,
Muteb Alanazi
,
Tareq Nafea Alharby
,
Afrasim Moin
,
Syed Mohd Danish Rizvi
,
Talib Hussain
,
Amir Mahgoub Awadelkareem
,
AbdElmoneim O. Elkhalifa
,
Syed Shah Mohammed Faiyaz
,
Mohammad Khalid
,
D. V. Gowda
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/ph15111410
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/ph15111410
Breast cancer represents the most frequently occurring cancer globally among women. As per the recent report of the World Health Organization (WHO), it was documented that by the end of the year 2020, approximately 7.8 million females were positively diagnosed with breast cancer and in 2020 alone, 685,000 casualties were documented due to breast cancer. The use of standard chemotherapeutics includes the frontline treatment option for patients; however, the concomitant side effects represent a major obstacle for their usage. Carbazole alkaloids are one such group of naturally-occurring bioactive compounds belonging to the Rutaceae family. Among the various carbazole alkaloids, 3-Methoxy carbazole or C13H11NO (MHC) is obtained from Clausena heptaphylla as well as from Clausena indica. In this study, MHC was investigated for its anti-breast cancer activity based on molecular interactions with specific proteins related to breast cancer, where the MHC had predicted binding affinities for NF-κB with −8.3 kcal/mol. Furthermore, to evaluate the biological activity of MHC, we studied its in vitro cytotoxic effects on MCF-7 cells. This alkaloid showed significant inhibitory effects and induced apoptosis, as evidenced by enhanced caspase activities and the cellular generation of ROS. It was observed that a treatment with MHC inhibited the gene expression of NF-kB in MCF-7 breast cancer cells. These results suggest that MHC could be a promising medical plant for breast cancer treatment. Further studies are needed to understand the molecular mechanisms behind the anticancer action of MHC.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/ph15111410
- https://www.mdpi.com/1424-8247/15/11/1410/pdf?version=1669084186
- OA Status
- gold
- Cited By
- 8
- References
- 45
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4309033865
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4309033865Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/ph15111410Digital Object Identifier
- Title
-
3-Methoxy Carbazole Impedes the Growth of Human Breast Cancer Cells by Suppressing NF-κB Signaling PathwayWork title
- Type
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articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-11-14Full publication date if available
- Authors
-
Jowaher Alanazi, Aziz Unnisa, Muteb Alanazi, Tareq Nafea Alharby, Afrasim Moin, Syed Mohd Danish Rizvi, Talib Hussain, Amir Mahgoub Awadelkareem, AbdElmoneim O. Elkhalifa, Syed Shah Mohammed Faiyaz, Mohammad Khalid, D. V. GowdaList of authors in order
- Landing page
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https://doi.org/10.3390/ph15111410Publisher landing page
- PDF URL
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https://www.mdpi.com/1424-8247/15/11/1410/pdf?version=1669084186Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/1424-8247/15/11/1410/pdf?version=1669084186Direct OA link when available
- Concepts
-
Breast cancer, Cancer research, Cancer, Major histocompatibility complex, MHC class I, Apoptosis, MCF-7, Medicine, Cancer cell, Cytotoxic T cell, Pharmacology, Chemistry, Biology, Immunology, Internal medicine, Immune system, In vitro, Biochemistry, Human breastTop concepts (fields/topics) attached by OpenAlex
- Cited by
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8Total citation count in OpenAlex
- Citations by year (recent)
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2025: 3, 2024: 2, 2023: 3Per-year citation counts (last 5 years)
- References (count)
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45Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.affinities | 143 |
| abstract_inverted_index.alkaloids, | 98 |
| abstract_inverted_index.anticancer | 233 |
| abstract_inverted_index.apoptosis, | 175 |
| abstract_inverted_index.biological | 153 |
| abstract_inverted_index.casualties | 48 |
| abstract_inverted_index.documented | 24, 50 |
| abstract_inverted_index.expression | 199 |
| abstract_inverted_index.frequently | 5 |
| abstract_inverted_index.generation | 185 |
| abstract_inverted_index.inhibitory | 171 |
| abstract_inverted_index.mechanisms | 230 |
| abstract_inverted_index.positively | 38 |
| abstract_inverted_index.represents | 2 |
| abstract_inverted_index.treatment. | 221 |
| abstract_inverted_index.understand | 227 |
| abstract_inverted_index.anti-breast | 123 |
| abstract_inverted_index.concomitant | 69 |
| abstract_inverted_index.heptaphylla | 108 |
| abstract_inverted_index.significant | 170 |
| abstract_inverted_index.Furthermore, | 149 |
| abstract_inverted_index.Organization | 20 |
| abstract_inverted_index.interactions | 129 |
| abstract_inverted_index.investigated | 120 |
| abstract_inverted_index.approximately | 33 |
| abstract_inverted_index.chemotherapeutics | 59 |
| abstract_inverted_index.naturally-occurring | 86 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 94 |
| corresponding_author_ids | https://openalex.org/A5087141265, https://openalex.org/A5049046810 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 12 |
| corresponding_institution_ids | https://openalex.org/I4210088963 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8700000047683716 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.69750292 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |