38 OLIG2 MEDIATES A RARE TARGETABLE STEM CELL FATE TRANSITION IN SONIC HEDGEHOG MEDULLOBLASTOMA Article Swipe
Kinjal Desai
,
Siyi Wanggou
,
Erika Luis
,
Heather Whetstone
,
Chunying Yu
,
Robert J. Vanner
,
Hayden Selvadurai
,
Lilian Lee
,
Jinchu Vijay
,
Julia E. Jaramillo
,
Jerry Fan
,
Paul Guilhamon
,
Michelle Kushida
,
Xuejun Li
,
Gregory Stein
,
Santosh Kesari
,
Benjamin D. Simons
,
Xi Huang
,
Peter Dirks
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1093/noajnl/vdaf166.037
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1093/noajnl/vdaf166.037
Functional cellular heterogeneity in tumours often underlies incomplete response to therapy and relapse. Previously, we demonstrated that the growth of the paediatric brain malignancy, sonic hedgehog subgroup medulloblastoma, is rooted in a dysregulated developmental hierarchy, the apex of which is defined by characteristically quiescent SOX2+ stem-like cells. Integrating gene expression and chromatin accessibility patterns in distinct cellular compartments, we identify the transcription factor Olig2 as regulating the stem cell fate transition from quiescence to activation, driving the generation of downstream neoplastic progenitors. Inactivation of Olig2 blocks stem cell activation and tumour output. Targeting this rare OLIG2-driven proliferative programme with a small molecule inhibitor, CT-179, dramatically attenuates early tumour formation and tumour regrowth post-therapy, and significantly increases median survival in vivo. We demonstrate that targeting transition from quiescence to proliferation at the level of the tumorigenic cell could be a pivotal medulloblastoma treatment strategy.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/noajnl/vdaf166.037
- https://academic.oup.com/noa/article-pdf/7/Supplement_3/iii9/64169026/vdaf166.037.pdf
- OA Status
- gold
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4413856551
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4413856551Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1093/noajnl/vdaf166.037Digital Object Identifier
- Title
-
38 OLIG2 MEDIATES A RARE TARGETABLE STEM CELL FATE TRANSITION IN SONIC HEDGEHOG MEDULLOBLASTOMAWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-08-01Full publication date if available
- Authors
-
Kinjal Desai, Siyi Wanggou, Erika Luis, Heather Whetstone, Chunying Yu, Robert J. Vanner, Hayden Selvadurai, Lilian Lee, Jinchu Vijay, Julia E. Jaramillo, Jerry Fan, Paul Guilhamon, Michelle Kushida, Xuejun Li, Gregory Stein, Santosh Kesari, Benjamin D. Simons, Xi Huang, Peter DirksList of authors in order
- Landing page
-
https://doi.org/10.1093/noajnl/vdaf166.037Publisher landing page
- PDF URL
-
https://academic.oup.com/noa/article-pdf/7/Supplement_3/iii9/64169026/vdaf166.037.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://academic.oup.com/noa/article-pdf/7/Supplement_3/iii9/64169026/vdaf166.037.pdfDirect OA link when available
- Concepts
-
Sonic hedgehog, Medulloblastoma, OLIG2, Hedgehog signaling pathway, Stem cell, Cancer research, Hedgehog, Medicine, Biology, Internal medicine, Cell biology, Signal transduction, Central nervous system, Myelin, OligodendrocyteTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4413856551 |
|---|---|
| doi | https://doi.org/10.1093/noajnl/vdaf166.037 |
| ids.doi | https://doi.org/10.1093/noajnl/vdaf166.037 |
| ids.openalex | https://openalex.org/W4413856551 |
| fwci | 0.0 |
| type | article |
| title | 38 OLIG2 MEDIATES A RARE TARGETABLE STEM CELL FATE TRANSITION IN SONIC HEDGEHOG MEDULLOBLASTOMA |
| biblio.issue | Supplement_3 |
| biblio.volume | 7 |
| biblio.last_page | iii9 |
| biblio.first_page | iii9 |
| topics[0].id | https://openalex.org/T12009 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.9907000064849854 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1312 |
| topics[0].subfield.display_name | Molecular Biology |
| topics[0].display_name | Hedgehog Signaling Pathway Studies |
| topics[1].id | https://openalex.org/T10492 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.9190000295639038 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1307 |
| topics[1].subfield.display_name | Cell Biology |
| topics[1].display_name | Microtubule and mitosis dynamics |
| is_xpac | False |
| apc_list.value | 1622 |
| apc_list.currency | GBP |
| apc_list.value_usd | 1989 |
| apc_paid.value | 1622 |
| apc_paid.currency | GBP |
| apc_paid.value_usd | 1989 |
| concepts[0].id | https://openalex.org/C2776637008 |
| concepts[0].level | 3 |
| concepts[0].score | 0.8420103192329407 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q14860072 |
| concepts[0].display_name | Sonic hedgehog |
| concepts[1].id | https://openalex.org/C2780789225 |
| concepts[1].level | 2 |
| concepts[1].score | 0.8240081071853638 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q1333608 |
| concepts[1].display_name | Medulloblastoma |
| concepts[2].id | https://openalex.org/C2779055221 |
| concepts[2].level | 5 |
| concepts[2].score | 0.6643989086151123 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q18035130 |
| concepts[2].display_name | OLIG2 |
| concepts[3].id | https://openalex.org/C88498014 |
| concepts[3].level | 3 |
| concepts[3].score | 0.5196972489356995 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q14859918 |
| concepts[3].display_name | Hedgehog signaling pathway |
| concepts[4].id | https://openalex.org/C28328180 |
| concepts[4].level | 2 |
| concepts[4].score | 0.4963412880897522 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q48196 |
| concepts[4].display_name | Stem cell |
| concepts[5].id | https://openalex.org/C502942594 |
| concepts[5].level | 1 |
| concepts[5].score | 0.4691939055919647 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q3421914 |
| concepts[5].display_name | Cancer research |
| concepts[6].id | https://openalex.org/C2778539099 |
| concepts[6].level | 3 |
| concepts[6].score | 0.4191925525665283 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q6120 |
| concepts[6].display_name | Hedgehog |
| concepts[7].id | https://openalex.org/C71924100 |
| concepts[7].level | 0 |
| concepts[7].score | 0.30422818660736084 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[7].display_name | Medicine |
| concepts[8].id | https://openalex.org/C86803240 |
| concepts[8].level | 0 |
| concepts[8].score | 0.2940599322319031 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[8].display_name | Biology |
| concepts[9].id | https://openalex.org/C126322002 |
| concepts[9].level | 1 |
| concepts[9].score | 0.217905193567276 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[9].display_name | Internal medicine |
| concepts[10].id | https://openalex.org/C95444343 |
| concepts[10].level | 1 |
| concepts[10].score | 0.17975947260856628 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q7141 |
| concepts[10].display_name | Cell biology |
| concepts[11].id | https://openalex.org/C62478195 |
| concepts[11].level | 2 |
| concepts[11].score | 0.0542866587638855 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q828130 |
| concepts[11].display_name | Signal transduction |
| concepts[12].id | https://openalex.org/C529278444 |
| concepts[12].level | 2 |
| concepts[12].score | 0.037698447704315186 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q47273 |
| concepts[12].display_name | Central nervous system |
| concepts[13].id | https://openalex.org/C2778609137 |
| concepts[13].level | 3 |
| concepts[13].score | 0.0 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q105790271 |
| concepts[13].display_name | Myelin |
| concepts[14].id | https://openalex.org/C2776985911 |
| concepts[14].level | 4 |
| concepts[14].score | 0.0 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q916698 |
| concepts[14].display_name | Oligodendrocyte |
| keywords[0].id | https://openalex.org/keywords/sonic-hedgehog |
| keywords[0].score | 0.8420103192329407 |
| keywords[0].display_name | Sonic hedgehog |
| keywords[1].id | https://openalex.org/keywords/medulloblastoma |
| keywords[1].score | 0.8240081071853638 |
| keywords[1].display_name | Medulloblastoma |
| keywords[2].id | https://openalex.org/keywords/olig2 |
| keywords[2].score | 0.6643989086151123 |
| keywords[2].display_name | OLIG2 |
| keywords[3].id | https://openalex.org/keywords/hedgehog-signaling-pathway |
| keywords[3].score | 0.5196972489356995 |
| keywords[3].display_name | Hedgehog signaling pathway |
| keywords[4].id | https://openalex.org/keywords/stem-cell |
| keywords[4].score | 0.4963412880897522 |
| keywords[4].display_name | Stem cell |
| keywords[5].id | https://openalex.org/keywords/cancer-research |
| keywords[5].score | 0.4691939055919647 |
| keywords[5].display_name | Cancer research |
| keywords[6].id | https://openalex.org/keywords/hedgehog |
| keywords[6].score | 0.4191925525665283 |
| keywords[6].display_name | Hedgehog |
| keywords[7].id | https://openalex.org/keywords/medicine |
| keywords[7].score | 0.30422818660736084 |
| keywords[7].display_name | Medicine |
| keywords[8].id | https://openalex.org/keywords/biology |
| keywords[8].score | 0.2940599322319031 |
| keywords[8].display_name | Biology |
| keywords[9].id | https://openalex.org/keywords/internal-medicine |
| keywords[9].score | 0.217905193567276 |
| keywords[9].display_name | Internal medicine |
| keywords[10].id | https://openalex.org/keywords/cell-biology |
| keywords[10].score | 0.17975947260856628 |
| keywords[10].display_name | Cell biology |
| keywords[11].id | https://openalex.org/keywords/signal-transduction |
| keywords[11].score | 0.0542866587638855 |
| keywords[11].display_name | Signal transduction |
| keywords[12].id | https://openalex.org/keywords/central-nervous-system |
| keywords[12].score | 0.037698447704315186 |
| keywords[12].display_name | Central nervous system |
| language | en |
| locations[0].id | doi:10.1093/noajnl/vdaf166.037 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S4210237914 |
| locations[0].source.issn | 2632-2498 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2632-2498 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Neuro-Oncology Advances |
| locations[0].source.host_organization | https://openalex.org/P4310311648 |
| locations[0].source.host_organization_name | Oxford University Press |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310311648 |
| locations[0].license | cc-by-nc |
| locations[0].pdf_url | https://academic.oup.com/noa/article-pdf/7/Supplement_3/iii9/64169026/vdaf166.037.pdf |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by-nc |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Neuro-Oncology Advances |
| locations[0].landing_page_url | https://doi.org/10.1093/noajnl/vdaf166.037 |
| locations[1].id | pmh:oai:europepmc.org:11209465 |
| locations[1].is_oa | True |
| locations[1].source.id | https://openalex.org/S4306400806 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | Europe PMC (PubMed Central) |
| locations[1].source.host_organization | https://openalex.org/I1303153112 |
| locations[1].source.host_organization_name | European Bioinformatics Institute |
| locations[1].source.host_organization_lineage | https://openalex.org/I1303153112 |
| locations[1].license | other-oa |
| locations[1].pdf_url | |
| locations[1].version | submittedVersion |
| locations[1].raw_type | Text |
| locations[1].license_id | https://openalex.org/licenses/other-oa |
| locations[1].is_accepted | False |
| locations[1].is_published | False |
| locations[1].raw_source_name | |
| locations[1].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/12398765 |
| indexed_in | crossref, doaj |
| authorships[0].author.id | https://openalex.org/A5071071258 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-3941-9584 |
| authorships[0].author.display_name | Kinjal Desai |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Kinjal Desai |
| authorships[0].is_corresponding | False |
| authorships[1].author.id | https://openalex.org/A5072615424 |
| authorships[1].author.orcid | https://orcid.org/0000-0001-9031-9338 |
| authorships[1].author.display_name | Siyi Wanggou |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Siyi Wanggou |
| authorships[1].is_corresponding | False |
| authorships[2].author.id | https://openalex.org/A5025663014 |
| authorships[2].author.orcid | |
| authorships[2].author.display_name | Erika Luis |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Erika Luis |
| authorships[2].is_corresponding | False |
| authorships[3].author.id | https://openalex.org/A5090212899 |
| authorships[3].author.orcid | |
| authorships[3].author.display_name | Heather Whetstone |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Heather Whetstone |
| authorships[3].is_corresponding | False |
| authorships[4].author.id | https://openalex.org/A5068165502 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-7320-7876 |
| authorships[4].author.display_name | Chunying Yu |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Chunying Yu |
| authorships[4].is_corresponding | False |
| authorships[5].author.id | https://openalex.org/A5005300416 |
| authorships[5].author.orcid | https://orcid.org/0000-0003-1169-1778 |
| authorships[5].author.display_name | Robert J. Vanner |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Robert J Vanner |
| authorships[5].is_corresponding | False |
| authorships[6].author.id | https://openalex.org/A5083923643 |
| authorships[6].author.orcid | |
| authorships[6].author.display_name | Hayden Selvadurai |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Hayden J Selvadurai |
| authorships[6].is_corresponding | False |
| authorships[7].author.id | https://openalex.org/A5056690377 |
| authorships[7].author.orcid | |
| authorships[7].author.display_name | Lilian Lee |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Lilian Lee |
| authorships[7].is_corresponding | False |
| authorships[8].author.id | https://openalex.org/A5084516688 |
| authorships[8].author.orcid | https://orcid.org/0000-0002-7311-475X |
| authorships[8].author.display_name | Jinchu Vijay |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Jinchu Vijay |
| authorships[8].is_corresponding | False |
| authorships[9].author.id | https://openalex.org/A5053667455 |
| authorships[9].author.orcid | |
| authorships[9].author.display_name | Julia E. Jaramillo |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Julia E Jaramillo |
| authorships[9].is_corresponding | False |
| authorships[10].author.id | https://openalex.org/A5049451190 |
| authorships[10].author.orcid | https://orcid.org/0000-0002-2381-5427 |
| authorships[10].author.display_name | Jerry Fan |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Jerry Fan |
| authorships[10].is_corresponding | False |
| authorships[11].author.id | https://openalex.org/A5035384039 |
| authorships[11].author.orcid | https://orcid.org/0000-0001-8276-5987 |
| authorships[11].author.display_name | Paul Guilhamon |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Paul Guilhamon |
| authorships[11].is_corresponding | False |
| authorships[12].author.id | https://openalex.org/A5045575377 |
| authorships[12].author.orcid | |
| authorships[12].author.display_name | Michelle Kushida |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | Michelle Kushida |
| authorships[12].is_corresponding | False |
| authorships[13].author.id | https://openalex.org/A5100759317 |
| authorships[13].author.orcid | https://orcid.org/0000-0001-6406-4423 |
| authorships[13].author.display_name | Xuejun Li |
| authorships[13].author_position | middle |
| authorships[13].raw_author_name | Xuejun Li |
| authorships[13].is_corresponding | False |
| authorships[14].author.id | https://openalex.org/A5039003649 |
| authorships[14].author.orcid | https://orcid.org/0000-0002-3588-8834 |
| authorships[14].author.display_name | Gregory Stein |
| authorships[14].author_position | middle |
| authorships[14].raw_author_name | Gregory Stein |
| authorships[14].is_corresponding | False |
| authorships[15].author.id | https://openalex.org/A5063863193 |
| authorships[15].author.orcid | https://orcid.org/0000-0003-3772-6000 |
| authorships[15].author.display_name | Santosh Kesari |
| authorships[15].author_position | middle |
| authorships[15].raw_author_name | Santosh Kesari |
| authorships[15].is_corresponding | False |
| authorships[16].author.id | https://openalex.org/A5032141728 |
| authorships[16].author.orcid | https://orcid.org/0000-0002-3875-7071 |
| authorships[16].author.display_name | Benjamin D. Simons |
| authorships[16].author_position | middle |
| authorships[16].raw_author_name | Benjamin D Simons |
| authorships[16].is_corresponding | False |
| authorships[17].author.id | https://openalex.org/A5073054729 |
| authorships[17].author.orcid | https://orcid.org/0000-0002-7177-7525 |
| authorships[17].author.display_name | Xi Huang |
| authorships[17].author_position | middle |
| authorships[17].raw_author_name | Xi Huang |
| authorships[17].is_corresponding | False |
| authorships[18].author.id | https://openalex.org/A5112729971 |
| authorships[18].author.orcid | |
| authorships[18].author.display_name | Peter Dirks |
| authorships[18].author_position | last |
| authorships[18].raw_author_name | Peter B Dirks |
| authorships[18].is_corresponding | False |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://academic.oup.com/noa/article-pdf/7/Supplement_3/iii9/64169026/vdaf166.037.pdf |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | 38 OLIG2 MEDIATES A RARE TARGETABLE STEM CELL FATE TRANSITION IN SONIC HEDGEHOG MEDULLOBLASTOMA |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T12009 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.9907000064849854 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1312 |
| primary_topic.subfield.display_name | Molecular Biology |
| primary_topic.display_name | Hedgehog Signaling Pathway Studies |
| related_works | https://openalex.org/W2095724755, https://openalex.org/W4234251015, https://openalex.org/W2948584774, https://openalex.org/W1971412744, https://openalex.org/W2512208268, https://openalex.org/W2060505600, https://openalex.org/W3008016544, https://openalex.org/W2378829050, https://openalex.org/W2380748750, https://openalex.org/W1978833015 |
| cited_by_count | 0 |
| locations_count | 2 |
| best_oa_location.id | doi:10.1093/noajnl/vdaf166.037 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4210237914 |
| best_oa_location.source.issn | 2632-2498 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2632-2498 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Neuro-Oncology Advances |
| best_oa_location.source.host_organization | https://openalex.org/P4310311648 |
| best_oa_location.source.host_organization_name | Oxford University Press |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310311648 |
| best_oa_location.license | cc-by-nc |
| best_oa_location.pdf_url | https://academic.oup.com/noa/article-pdf/7/Supplement_3/iii9/64169026/vdaf166.037.pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by-nc |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Neuro-Oncology Advances |
| best_oa_location.landing_page_url | https://doi.org/10.1093/noajnl/vdaf166.037 |
| primary_location.id | doi:10.1093/noajnl/vdaf166.037 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S4210237914 |
| primary_location.source.issn | 2632-2498 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2632-2498 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Neuro-Oncology Advances |
| primary_location.source.host_organization | https://openalex.org/P4310311648 |
| primary_location.source.host_organization_name | Oxford University Press |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310311648 |
| primary_location.license | cc-by-nc |
| primary_location.pdf_url | https://academic.oup.com/noa/article-pdf/7/Supplement_3/iii9/64169026/vdaf166.037.pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by-nc |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Neuro-Oncology Advances |
| primary_location.landing_page_url | https://doi.org/10.1093/noajnl/vdaf166.037 |
| publication_date | 2025-08-01 |
| publication_year | 2025 |
| referenced_works_count | 0 |
| abstract_inverted_index.a | 32, 100, 139 |
| abstract_inverted_index.We | 121 |
| abstract_inverted_index.as | 65 |
| abstract_inverted_index.at | 130 |
| abstract_inverted_index.be | 138 |
| abstract_inverted_index.by | 42 |
| abstract_inverted_index.in | 4, 31, 55, 119 |
| abstract_inverted_index.is | 29, 40 |
| abstract_inverted_index.of | 20, 38, 79, 84, 133 |
| abstract_inverted_index.to | 10, 74, 128 |
| abstract_inverted_index.we | 15, 59 |
| abstract_inverted_index.and | 12, 51, 90, 110, 114 |
| abstract_inverted_index.the | 18, 21, 36, 61, 67, 77, 131, 134 |
| abstract_inverted_index.apex | 37 |
| abstract_inverted_index.cell | 69, 88, 136 |
| abstract_inverted_index.fate | 70 |
| abstract_inverted_index.from | 72, 126 |
| abstract_inverted_index.gene | 49 |
| abstract_inverted_index.rare | 95 |
| abstract_inverted_index.stem | 68, 87 |
| abstract_inverted_index.that | 17, 123 |
| abstract_inverted_index.this | 94 |
| abstract_inverted_index.with | 99 |
| abstract_inverted_index.Olig2 | 64, 85 |
| abstract_inverted_index.SOX2+ | 45 |
| abstract_inverted_index.brain | 23 |
| abstract_inverted_index.could | 137 |
| abstract_inverted_index.early | 107 |
| abstract_inverted_index.level | 132 |
| abstract_inverted_index.often | 6 |
| abstract_inverted_index.small | 101 |
| abstract_inverted_index.sonic | 25 |
| abstract_inverted_index.vivo. | 120 |
| abstract_inverted_index.which | 39 |
| abstract_inverted_index.blocks | 86 |
| abstract_inverted_index.cells. | 47 |
| abstract_inverted_index.factor | 63 |
| abstract_inverted_index.growth | 19 |
| abstract_inverted_index.median | 117 |
| abstract_inverted_index.rooted | 30 |
| abstract_inverted_index.tumour | 91, 108, 111 |
| abstract_inverted_index.CT-179, | 104 |
| abstract_inverted_index.defined | 41 |
| abstract_inverted_index.driving | 76 |
| abstract_inverted_index.output. | 92 |
| abstract_inverted_index.pivotal | 140 |
| abstract_inverted_index.therapy | 11 |
| abstract_inverted_index.tumours | 5 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.cellular | 2, 57 |
| abstract_inverted_index.distinct | 56 |
| abstract_inverted_index.hedgehog | 26 |
| abstract_inverted_index.identify | 60 |
| abstract_inverted_index.molecule | 102 |
| abstract_inverted_index.patterns | 54 |
| abstract_inverted_index.regrowth | 112 |
| abstract_inverted_index.relapse. | 13 |
| abstract_inverted_index.response | 9 |
| abstract_inverted_index.subgroup | 27 |
| abstract_inverted_index.survival | 118 |
| abstract_inverted_index.Targeting | 93 |
| abstract_inverted_index.chromatin | 52 |
| abstract_inverted_index.formation | 109 |
| abstract_inverted_index.increases | 116 |
| abstract_inverted_index.programme | 98 |
| abstract_inverted_index.quiescent | 44 |
| abstract_inverted_index.stem-like | 46 |
| abstract_inverted_index.strategy. | 143 |
| abstract_inverted_index.targeting | 124 |
| abstract_inverted_index.treatment | 142 |
| abstract_inverted_index.underlies | 7 |
| abstract_inverted_index.Functional | 1 |
| abstract_inverted_index.activation | 89 |
| abstract_inverted_index.attenuates | 106 |
| abstract_inverted_index.downstream | 80 |
| abstract_inverted_index.expression | 50 |
| abstract_inverted_index.generation | 78 |
| abstract_inverted_index.hierarchy, | 35 |
| abstract_inverted_index.incomplete | 8 |
| abstract_inverted_index.inhibitor, | 103 |
| abstract_inverted_index.neoplastic | 81 |
| abstract_inverted_index.paediatric | 22 |
| abstract_inverted_index.quiescence | 73, 127 |
| abstract_inverted_index.regulating | 66 |
| abstract_inverted_index.transition | 71, 125 |
| abstract_inverted_index.Integrating | 48 |
| abstract_inverted_index.Previously, | 14 |
| abstract_inverted_index.activation, | 75 |
| abstract_inverted_index.demonstrate | 122 |
| abstract_inverted_index.malignancy, | 24 |
| abstract_inverted_index.tumorigenic | 135 |
| abstract_inverted_index.Inactivation | 83 |
| abstract_inverted_index.OLIG2-driven | 96 |
| abstract_inverted_index.demonstrated | 16 |
| abstract_inverted_index.dramatically | 105 |
| abstract_inverted_index.dysregulated | 33 |
| abstract_inverted_index.progenitors. | 82 |
| abstract_inverted_index.accessibility | 53 |
| abstract_inverted_index.compartments, | 58 |
| abstract_inverted_index.developmental | 34 |
| abstract_inverted_index.heterogeneity | 3 |
| abstract_inverted_index.post-therapy, | 113 |
| abstract_inverted_index.proliferation | 129 |
| abstract_inverted_index.proliferative | 97 |
| abstract_inverted_index.significantly | 115 |
| abstract_inverted_index.transcription | 62 |
| abstract_inverted_index.medulloblastoma | 141 |
| abstract_inverted_index.medulloblastoma, | 28 |
| abstract_inverted_index.characteristically | 43 |
| cited_by_percentile_year | |
| countries_distinct_count | 0 |
| institutions_distinct_count | 19 |
| citation_normalized_percentile.value | 0.37400468 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |