3D analyses reveal T cells with activated nuclear features in T-cell/histiocyte-rich large B-cell lymphoma Article Swipe
Aresu Sadeghi Shoreh Deli
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.21248/gups.75435
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.21248/gups.75435
The Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) as well as the T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) are rare types of malignant lymphomas. Both NLPHL and THRLBCL are frequently observed in middle-aged men with THRLBCL presenting frequently with an advanced Ann-Arbor stage with B-symptoms and associated with more aggressive courses.3 However, due to the limited number of tumor cells in the tissue of both NLPHL and THRLBCL, limited numbers of studies have been conducted on these lymphomas and current results are mainly based on general molecular genetic studies. In order to obtain a better understanding for these disease forms as well as possible changes in their nuclear and cytoplasmatic sizes, the following study relied on the comparison of the different NLPHL forms and THRLBCL in terms of nuclear size and nuclear volume. This was carried out using both 2D and 3D analysis. During the 2D analysis of nuclear size and nuclear volume no significant differences could be presented between those groups. However, the 3D analysis of NLPHL and THRLBCL pointed out a slightly enlarged nuclear volume in THRLBCL. Furthermore, the analysis indicated a significantly increased cytoplasmatic size of THRLBCL compared to NLPHL forms. Nevertheless, differences occurred not only between the tumor cells of both disease forms, but also the T cells presented a larger nuclear volume in THRLBCL. B cells, which were considered as the control group, did not demonstrate any significant differences between the different groups. The presented results suggest an increased activity of T cells in THRLBCL, which is most likely to be interpreted as a response against the surrounding tumor cells and probably limits the proliferation of the tumor cells. Based on these results, the importance of 3D analysis is also evident due to the fact that it is clearly superior to 2D analysis. For a better understanding of both disease forms, it is therefore recommended to use the 3D technique in combination with molecular genetic analysis in future research.
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Metadata
- Type
- dissertation
- Language
- en
- Landing Page
- https://doi.org/10.21248/gups.75435
- http://publikationen.ub.uni-frankfurt.de/files/75435/Dissertation_SadeghiShorehDeli_Aresu.pdf
- OA Status
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- References
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- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4386607709Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.21248/gups.75435Digital Object Identifier
- Title
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3D analyses reveal T cells with activated nuclear features in T-cell/histiocyte-rich large B-cell lymphomaWork title
- Type
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dissertationOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
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2023-01-01Full publication date if available
- Authors
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Aresu Sadeghi Shoreh DeliList of authors in order
- Landing page
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https://doi.org/10.21248/gups.75435Publisher landing page
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https://publikationen.ub.uni-frankfurt.de/files/75435/Dissertation_SadeghiShorehDeli_Aresu.pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://publikationen.ub.uni-frankfurt.de/files/75435/Dissertation_SadeghiShorehDeli_Aresu.pdfDirect OA link when available
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Histiocyte, Lymphoma, Pathology, Biology, MedicineTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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