3D Bioprinted Bacteriostatic Hyperelastic Bone Scaffold for Damage-Specific Bone Regeneration Article Swipe
YOU?
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· 2021
· Open Access
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· DOI: https://doi.org/10.3390/polym13071099
Current strategies for regeneration of large bone fractures yield limited clinical success mainly due to poor integration and healing. Multidisciplinary approaches in design and development of functional tissue engineered scaffolds are required to overcome these translational challenges. Here, a new generation of hyperelastic bone (HB) implants, loaded with superparamagnetic iron oxide nanoparticles (SPIONs), are 3D bioprinted and their regenerative effect on large non-healing bone fractures is studied. Scaffolds are bioprinted with the geometry that closely correspond to that of the bone defect, using an osteoconductive, highly elastic, surgically friendly bioink mainly composed of hydroxyapatite. Incorporation of SPIONs into HB bioink results in enhanced bacteriostatic properties of bone grafts while exhibiting no cytotoxicity. In vitro culture of mouse embryonic cells and human osteoblast-like cells remain viable and functional up to 14 days on printed HB scaffolds. Implantation of damage-specific bioprinted constructs into a rat model of femoral bone defect demonstrates significant regenerative effect over the 2-week time course. While no infection, immune rejection, or fibrotic encapsulation is observed, HB grafts show rapid integration with host tissue, ossification, and growth of new bone. These results suggest a great translational potential for 3D bioprinted HB scaffolds, laden with functional nanoparticles, for hard tissue engineering applications.
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/polym13071099
- https://www.mdpi.com/2073-4360/13/7/1099/pdf?version=1617938217
- OA Status
- gold
- Cited By
- 37
- References
- 47
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3151432835
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3151432835Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/polym13071099Digital Object Identifier
- Title
-
3D Bioprinted Bacteriostatic Hyperelastic Bone Scaffold for Damage-Specific Bone RegenerationWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-03-30Full publication date if available
- Authors
-
Mohammadreza Shokouhimehr, Andrea S. Theus, Archana Kamalakar, Liqun Ning, Cong Cao, Martin L. Tomov, Jarred Kaiser, Steven L. Goudy, Nick J. Willett, Ho Won Jang, Christopher N. LaRock, Philip Hanna, Aron Lechtig, Mohamed Yousef, Janaina Da Silva Martins, Ara Nazarian, Mitchel B. Harris, Morteza Mahmoudi, Vahid SerpooshanList of authors in order
- Landing page
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https://doi.org/10.3390/polym13071099Publisher landing page
- PDF URL
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https://www.mdpi.com/2073-4360/13/7/1099/pdf?version=1617938217Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.mdpi.com/2073-4360/13/7/1099/pdf?version=1617938217Direct OA link when available
- Concepts
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Scaffold, Biomedical engineering, 3D bioprinting, Regeneration (biology), Bone healing, Tissue engineering, Bone tissue, Materials science, Chemistry, Cell biology, Anatomy, Medicine, BiologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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37Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 7, 2024: 9, 2023: 9, 2022: 8, 2021: 4Per-year citation counts (last 5 years)
- References (count)
-
47Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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