3D‐Printed Hollow Microneedles Array with Luer Lock Connection for Facile and Painless Intradermal Injection: A Proof of Concept Article Swipe
Amirreza Ghaznavi
,
Jie Xu
,
Christine U. Lee
,
Seth A. Hara
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1002/admt.202400286
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1002/admt.202400286
A 3D‐printed array of hollow microneedles (HMNs) is designed and fabricated using a high‐resolution stereolithography 3D printer and assembled with a 3D‐printed reservoir that incorporates a Luer lock mechanism, ensuring standard and secure connection to syringes. The proof‐of‐concept needle designs consist of half‐eccentric and concentric conical tip shapes, each arrayed with two different interspacing values. After the geometrical features of the devices are characterized, the devices are tested ex vivo in porcine skin to evaluate the impact of tip shape and interspacing on the depth of penetration and the efficacy of the devices in delivering fluids (such as tattoo ink) into the dermis. Overall, the 3D‐printed HMNs can deliver fluids into the target layer of skin. Refinement of the design is ongoing with the ultimate aim to provide alternatives for intradermal drug delivery and diagnostic imaging, such as superficial lymphography.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/admt.202400286
- OA Status
- hybrid
- Cited By
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- References
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- Related Works
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4399707252Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/admt.202400286Digital Object Identifier
- Title
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3D‐Printed Hollow Microneedles Array with Luer Lock Connection for Facile and Painless Intradermal Injection: A Proof of ConceptWork title
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-06-14Full publication date if available
- Authors
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Amirreza Ghaznavi, Jie Xu, Christine U. Lee, Seth A. HaraList of authors in order
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https://doi.org/10.1002/admt.202400286Publisher landing page
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YesWhether a free full text is available
- OA status
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hybridOpen access status per OpenAlex
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https://doi.org/10.1002/admt.202400286Direct OA link when available
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Lock (firearm), Proof of concept, Connection (principal bundle), Biomedical engineering, 3d printed, Computer science, Materials science, Medicine, Engineering, Mechanical engineering, Operating systemTop concepts (fields/topics) attached by OpenAlex
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7Total citation count in OpenAlex
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2025: 6, 2024: 1Per-year citation counts (last 5 years)
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43Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.using | 12 |
| abstract_inverted_index.(HMNs) | 7 |
| abstract_inverted_index.design | 120 |
| abstract_inverted_index.fluids | 96, 110 |
| abstract_inverted_index.hollow | 5 |
| abstract_inverted_index.impact | 77 |
| abstract_inverted_index.needle | 39 |
| abstract_inverted_index.secure | 33 |
| abstract_inverted_index.target | 113 |
| abstract_inverted_index.tattoo | 99 |
| abstract_inverted_index.tested | 68 |
| abstract_inverted_index.arrayed | 50 |
| abstract_inverted_index.conical | 46 |
| abstract_inverted_index.consist | 41 |
| abstract_inverted_index.deliver | 109 |
| abstract_inverted_index.dermis. | 103 |
| abstract_inverted_index.designs | 40 |
| abstract_inverted_index.devices | 62, 66, 93 |
| abstract_inverted_index.ongoing | 122 |
| abstract_inverted_index.porcine | 72 |
| abstract_inverted_index.printer | 17 |
| abstract_inverted_index.provide | 128 |
| abstract_inverted_index.shapes, | 48 |
| abstract_inverted_index.values. | 55 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.Overall, | 104 |
| abstract_inverted_index.delivery | 133 |
| abstract_inverted_index.designed | 9 |
| abstract_inverted_index.efficacy | 90 |
| abstract_inverted_index.ensuring | 30 |
| abstract_inverted_index.evaluate | 75 |
| abstract_inverted_index.features | 59 |
| abstract_inverted_index.imaging, | 136 |
| abstract_inverted_index.standard | 31 |
| abstract_inverted_index.ultimate | 125 |
| abstract_inverted_index.assembled | 19 |
| abstract_inverted_index.different | 53 |
| abstract_inverted_index.reservoir | 23 |
| abstract_inverted_index.syringes. | 36 |
| abstract_inverted_index.Refinement | 117 |
| abstract_inverted_index.concentric | 45 |
| abstract_inverted_index.connection | 34 |
| abstract_inverted_index.delivering | 95 |
| abstract_inverted_index.diagnostic | 135 |
| abstract_inverted_index.fabricated | 11 |
| abstract_inverted_index.mechanism, | 29 |
| abstract_inverted_index.geometrical | 58 |
| abstract_inverted_index.intradermal | 131 |
| abstract_inverted_index.penetration | 87 |
| abstract_inverted_index.superficial | 139 |
| abstract_inverted_index.3D‐printed | 2, 22, 106 |
| abstract_inverted_index.alternatives | 129 |
| abstract_inverted_index.incorporates | 25 |
| abstract_inverted_index.interspacing | 54, 82 |
| abstract_inverted_index.microneedles | 6 |
| abstract_inverted_index.lymphography. | 140 |
| abstract_inverted_index.characterized, | 64 |
| abstract_inverted_index.half‐eccentric | 43 |
| abstract_inverted_index.high‐resolution | 14 |
| abstract_inverted_index.stereolithography | 15 |
| abstract_inverted_index.proof‐of‐concept | 38 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 90 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 4 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8100000023841858 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.84518496 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |