5-aminolevulinic acid-photodynamic therapy ameliorates cutaneous granuloma by killing drug-resistant Mycobacterium marinum Article Swipe
Zhiya Yang
,
Yahui Feng
,
Zhiping P. Pang
,
Dongmei Li
,
Sisi Wang
,
Huiqi Chen
,
Mingze Jiang
,
Hongxia Yan
,
Tianhang Li
,
Hongjun Fu
,
Hubao Xiong
,
Dongmei Shi
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1101/2021.12.20.473605
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1101/2021.12.20.473605
Background Although 5-aminolevulinic acid photodynamic therapy (ALA-PDT) has been extensively used to treat to various skin disease, the application of ALA-PDT on cutaneous infection caused by Mycobacterium marinum ( M. marinum ), especially by drug-resistant M. marinum is still not clear. Objectives We evaluated the therapeutic efficacy of ALA-PDT on M. marinum in a mouse infection model and tested its killing effect on M. marinum in vitro . Finally, we investigated the clinical effect of ALA-PDT in treating cutaneous granuloma caused by drug-resistant M. marinum . Materials and methods We isolated total 9 strains of M. marinum from patients and confirmed by morphological and molecular approaches. The strains were identified by anti-mycobacterial susceptibility. Then we evaluated the killing effect of ALA-PDT on M. marinum in vitro and in a mouse model to observe the antimycobacterial effect of ALA-PDT. Therapeutic efficacy was further assessed in patients with cutaneous granuloma caused by drug-resistant M. marinum . Results We demonstrated that the ALA-PDT directly killed M. marinum in vitro . The paws cutaneous lesions of mice caused by M. marinum were fully recovered 2 weeks after ALA-PDT treatment. However, there was no significant difference for immune cells in peripheral blood before and after ALA-PDT therapy. Finally, ALA-PDT proved to be effective in treat two patients with cutaneous infection caused by drug-resistant M. marinum . Conclusions The results suggest that ALA-PDT is effective in treating M. marinum cutaneous infections by killing M. marinum directly, independent of systemic immune responses. The data highlight the ALA-PDT as a promising therapeutic choice for M. marinum infection, especially for drug-resistant strains.
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- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2021.12.20.473605
- https://www.biorxiv.org/content/biorxiv/early/2021/12/22/2021.12.20.473605.full.pdf
- OA Status
- green
- Cited By
- 1
- References
- 45
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4200593715
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4200593715Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1101/2021.12.20.473605Digital Object Identifier
- Title
-
5-aminolevulinic acid-photodynamic therapy ameliorates cutaneous granuloma by killing drug-resistant Mycobacterium marinumWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-12-22Full publication date if available
- Authors
-
Zhiya Yang, Yahui Feng, Zhiping P. Pang, Dongmei Li, Sisi Wang, Huiqi Chen, Mingze Jiang, Hongxia Yan, Tianhang Li, Hongjun Fu, Hubao Xiong, Dongmei ShiList of authors in order
- Landing page
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https://doi.org/10.1101/2021.12.20.473605Publisher landing page
- PDF URL
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https://www.biorxiv.org/content/biorxiv/early/2021/12/22/2021.12.20.473605.full.pdfDirect link to full text PDF
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YesWhether a free full text is available
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-
greenOpen access status per OpenAlex
- OA URL
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https://www.biorxiv.org/content/biorxiv/early/2021/12/22/2021.12.20.473605.full.pdfDirect OA link when available
- Concepts
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Mycobacterium marinum, Photodynamic therapy, Granuloma, Immune system, In vitro, Microbiology, Immunology, Medicine, Biology, Mycobacterium, Pathology, Chemistry, Tuberculosis, Biochemistry, Organic chemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
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2022: 1Per-year citation counts (last 5 years)
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45Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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