bioRxiv (Cold Spring Harbor Laboratory)
5-aminolevulinic acid-photodynamic therapy ameliorates cutaneous granuloma by killing drug-resistant <i>Mycobacterium marinum</i>
December 2021 • Zhiya Yang, Yahui Feng, Zhiping P. Pang, Dongmei Li, Sisi Wang, Huiqi Chen, Mingze Jiang, Hongxia Yan, Tianhang Li, Hongjun Fu, Hubao Xiong, Dongmei …
Abstract Background Although 5-aminolevulinic acid photodynamic therapy (ALA-PDT) has been extensively used to treat to various skin disease, the application of ALA-PDT on cutaneous infection caused by Mycobacterium marinum ( M. marinum ), especially by drug-resistant M. marinum is still not clear. Objectives We evaluated the therapeutic efficacy of ALA-PDT on M. marinum in a mouse infection model and tested its killing effect on M. marinum in vitro . Finally, we investigated the clinical effect of ALA-PDT in trea…