5P IDH1 mutation status and overall survival in glioblastoma patients: A meta-analysis Article Swipe
Rana Al-Shimi
,
Ramez M. Odat
,
Zaid Shakhatreh
,
Ahmed M. Abdallah
,
Amer A. Alomari
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.esmoop.2024.102395
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.esmoop.2024.102395
Glioblastoma is the most common and aggressive type of primary brain tumor. The prognosis for patients diagnosed with GBM is unfortunately very poor, with a median overall survival of only 14 months and very limited options for treatment. Several studies have detected a mutation in the isocitrate dehydrogenase 1 (IDH1) gene as a molecular marker associated with improved survival in patients with glioblastoma, but the evidence is inconsistent and inconclusive. We conducted this meta-analysis to investigate the link between IDH1 mutation and overall survival in glioblastoma patients. A thorough literature search of databases (PubMed, Scopus, Cochrane, Embase, and Web of Science databases) yielded five studies involving 541 glioblastoma cases that reported overall survival by IDH1 mutation status. The meta-analysis was conducted using Cochrane review manager V 5.4. Our meta-analysis encompassed five studies, involving a total of 541 patients (480 with IDH1 wild type and 61 with mutant type). Among these, three studies focused on patients with recurrent glioblastoma (GBM), while two studies involved newly diagnosed GBM cases. The treatment modalities varied, with one study employing alkylating agents, two studies utilizing tyrosine kinase inhibitors, one study combining immunotherapy with alkylating agents, and one study not specifying the treatment. The pooled hazard ratio (HR) was 2.37 (95% CI 1.81–3.12; p < 0.001; I2=0%), indicating a significant association between IDH1 mutation and prolonged overall survival in glioblastoma patients, irrespective of the therapeutic intervention. For recurrent GBM, the pooled HR was 2.28 (95% CI 1.72–3.03; p < 0.001; I2=0%). Additionally, in the context of newly diagnosed GBM, the pooled HR was 3.06 (95% CI 0.48–19.63; p < 0.001; I2=39%). This study clearly demonstrates that IDH1 mutation in patients with glioblastoma is a favorable prognostic factor for overall survival, regardless of the treatment modality or disease stage. The findings suggest that IDH1 mutation status should be considered in the clinical management and stratification of glioblastoma patients.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.esmoop.2024.102395
- http://www.esmoopen.com/article/S2059702924001637/pdf
- OA Status
- gold
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4392880902
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4392880902Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.esmoop.2024.102395Digital Object Identifier
- Title
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5P IDH1 mutation status and overall survival in glioblastoma patients: A meta-analysisWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-03-01Full publication date if available
- Authors
-
Rana Al-Shimi, Ramez M. Odat, Zaid Shakhatreh, Ahmed M. Abdallah, Amer A. AlomariList of authors in order
- Landing page
-
https://doi.org/10.1016/j.esmoop.2024.102395Publisher landing page
- PDF URL
-
https://www.esmoopen.com/article/S2059702924001637/pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.esmoopen.com/article/S2059702924001637/pdfDirect OA link when available
- Concepts
-
IDH1, Glioblastoma, Meta-analysis, Oncology, Mutation, Internal medicine, Medicine, Biology, Genetics, Cancer research, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.with | 17, 23, 56, 61, 139, 145, 155, 171, 187, 274 |
| abstract_inverted_index.Among | 148 |
| abstract_inverted_index.brain | 10 |
| abstract_inverted_index.cases | 108 |
| abstract_inverted_index.newly | 163, 250 |
| abstract_inverted_index.poor, | 22 |
| abstract_inverted_index.ratio | 200 |
| abstract_inverted_index.study | 173, 184, 192, 266 |
| abstract_inverted_index.three | 150 |
| abstract_inverted_index.total | 134 |
| abstract_inverted_index.using | 121 |
| abstract_inverted_index.while | 159 |
| abstract_inverted_index.(GBM), | 158 |
| abstract_inverted_index.(IDH1) | 49 |
| abstract_inverted_index.0.001; | 209, 243, 263 |
| abstract_inverted_index.cases. | 166 |
| abstract_inverted_index.common | 4 |
| abstract_inverted_index.factor | 280 |
| abstract_inverted_index.hazard | 199 |
| abstract_inverted_index.kinase | 181 |
| abstract_inverted_index.marker | 54 |
| abstract_inverted_index.median | 25 |
| abstract_inverted_index.months | 31 |
| abstract_inverted_index.mutant | 146 |
| abstract_inverted_index.pooled | 198, 234, 254 |
| abstract_inverted_index.review | 123 |
| abstract_inverted_index.search | 90 |
| abstract_inverted_index.should | 299 |
| abstract_inverted_index.stage. | 291 |
| abstract_inverted_index.status | 298 |
| abstract_inverted_index.these, | 149 |
| abstract_inverted_index.tumor. | 11 |
| abstract_inverted_index.type). | 147 |
| abstract_inverted_index.Embase, | 96 |
| abstract_inverted_index.I2=0%), | 210 |
| abstract_inverted_index.I2=0%). | 244 |
| abstract_inverted_index.Science | 100 |
| abstract_inverted_index.Scopus, | 94 |
| abstract_inverted_index.Several | 38 |
| abstract_inverted_index.agents, | 176, 189 |
| abstract_inverted_index.between | 78, 215 |
| abstract_inverted_index.clearly | 267 |
| abstract_inverted_index.context | 248 |
| abstract_inverted_index.disease | 290 |
| abstract_inverted_index.focused | 152 |
| abstract_inverted_index.limited | 34 |
| abstract_inverted_index.manager | 124 |
| abstract_inverted_index.options | 35 |
| abstract_inverted_index.overall | 26, 82, 111, 220, 282 |
| abstract_inverted_index.primary | 9 |
| abstract_inverted_index.status. | 116 |
| abstract_inverted_index.studies | 39, 104, 151, 161, 178 |
| abstract_inverted_index.suggest | 294 |
| abstract_inverted_index.varied, | 170 |
| abstract_inverted_index.yielded | 102 |
| abstract_inverted_index.(PubMed, | 93 |
| abstract_inverted_index.Cochrane | 122 |
| abstract_inverted_index.I2=39%). | 264 |
| abstract_inverted_index.clinical | 304 |
| abstract_inverted_index.detected | 41 |
| abstract_inverted_index.evidence | 65 |
| abstract_inverted_index.findings | 293 |
| abstract_inverted_index.improved | 57 |
| abstract_inverted_index.involved | 162 |
| abstract_inverted_index.modality | 288 |
| abstract_inverted_index.mutation | 43, 80, 115, 217, 271, 297 |
| abstract_inverted_index.patients | 15, 60, 137, 154, 273 |
| abstract_inverted_index.reported | 110 |
| abstract_inverted_index.studies, | 131 |
| abstract_inverted_index.survival | 27, 58, 83, 112, 221 |
| abstract_inverted_index.thorough | 88 |
| abstract_inverted_index.tyrosine | 180 |
| abstract_inverted_index.Cochrane, | 95 |
| abstract_inverted_index.combining | 185 |
| abstract_inverted_index.conducted | 71, 120 |
| abstract_inverted_index.databases | 92 |
| abstract_inverted_index.diagnosed | 16, 164, 251 |
| abstract_inverted_index.employing | 174 |
| abstract_inverted_index.favorable | 278 |
| abstract_inverted_index.involving | 105, 132 |
| abstract_inverted_index.molecular | 53 |
| abstract_inverted_index.patients, | 224 |
| abstract_inverted_index.patients. | 86, 310 |
| abstract_inverted_index.prognosis | 13 |
| abstract_inverted_index.prolonged | 219 |
| abstract_inverted_index.recurrent | 156, 231 |
| abstract_inverted_index.survival, | 283 |
| abstract_inverted_index.treatment | 168, 287 |
| abstract_inverted_index.utilizing | 179 |
| abstract_inverted_index.aggressive | 6 |
| abstract_inverted_index.alkylating | 175, 188 |
| abstract_inverted_index.associated | 55 |
| abstract_inverted_index.considered | 301 |
| abstract_inverted_index.databases) | 101 |
| abstract_inverted_index.indicating | 211 |
| abstract_inverted_index.isocitrate | 46 |
| abstract_inverted_index.literature | 89 |
| abstract_inverted_index.management | 305 |
| abstract_inverted_index.modalities | 169 |
| abstract_inverted_index.prognostic | 279 |
| abstract_inverted_index.regardless | 284 |
| abstract_inverted_index.specifying | 194 |
| abstract_inverted_index.treatment. | 37, 196 |
| abstract_inverted_index.association | 214 |
| abstract_inverted_index.encompassed | 129 |
| abstract_inverted_index.inhibitors, | 182 |
| abstract_inverted_index.investigate | 75 |
| abstract_inverted_index.significant | 213 |
| abstract_inverted_index.therapeutic | 228 |
| abstract_inverted_index.1.72–3.03; | 240 |
| abstract_inverted_index.1.81–3.12; | 206 |
| abstract_inverted_index.Glioblastoma | 0 |
| abstract_inverted_index.demonstrates | 268 |
| abstract_inverted_index.glioblastoma | 85, 107, 157, 223, 275, 309 |
| abstract_inverted_index.inconsistent | 67 |
| abstract_inverted_index.irrespective | 225 |
| abstract_inverted_index.0.48–19.63; | 260 |
| abstract_inverted_index.Additionally, | 245 |
| abstract_inverted_index.dehydrogenase | 47 |
| abstract_inverted_index.glioblastoma, | 62 |
| abstract_inverted_index.immunotherapy | 186 |
| abstract_inverted_index.inconclusive. | 69 |
| abstract_inverted_index.intervention. | 229 |
| abstract_inverted_index.meta-analysis | 73, 118, 128 |
| abstract_inverted_index.unfortunately | 20 |
| abstract_inverted_index.stratification | 307 |
| cited_by_percentile_year | |
| countries_distinct_count | 1 |
| institutions_distinct_count | 5 |
| citation_normalized_percentile.value | 0.06151092 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |