664. Therapeutic Effect of Oncolytic Herpes Simplex Virus Type 1 (G47Δ) in Combination with Chemotherapy on Colorectal Cancer Article Swipe

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Shinya Abe , Yasushi Ino , Hiroshi Fukuhara , Miwako Iwai , Toshiaki Watanabe , Tomoki Todo ·

YOU? · · 2016 · Open Access · · DOI: https://doi.org/10.1016/s1525-0016(16)33472-4

One of the reasons for the difficulty of curing unresectable advanced stage colorectal cancer is that cancer cells acquire resistance to anticancer drugs. Oncolytic virus therapy is a potent candidate for developing a new therapeutic approach that counteracts drug resistance, in which an oncolytic virus kills cancer cells in the course of tumor cell specific viral replication. G47Δ is a third-generation oncolytic herpes simplex virus type 1 with triple mutations in the γ34.5, ICP6, and α47 genes.

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Oncolytic virus Colorectal cancer Herpes simplex virus Virology Chemotherapy Medicine Virus Cancer Internal medicine

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Type: article
Language: en
Landing Page: https://doi.org/10.1016/s1525-0016(16)33472-4
PDF: http://www.cell.com/article/S1525001616334724/pdf
OA Status: hybrid
Cited By: 1
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DOI: https://doi.org/10.1016/s1525-0016(16)33472-4

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Title: 664. Therapeutic Effect of Oncolytic Herpes Simplex Virus Type 1 (G47Δ) in Combination with Chemotherapy on Colorectal Cancer

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Type: article

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Language: en

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Publication year: 2016

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Publication date: 2016-05-01

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Authors: Shinya Abe, Yasushi Ino, Hiroshi Fukuhara, Miwako Iwai, Toshiaki Watanabe, Tomoki Todo

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Landing page: https://doi.org/10.1016/s1525-0016(16)33472-4

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OA URL: https://www.cell.com/article/S1525001616334724/pdf

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Concepts: Oncolytic virus, Colorectal cancer, Herpes simplex virus, Virology, Chemotherapy, Medicine, Virus, Cancer, Internal medicine

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Cited by: 1

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