#668 Evaluation of vulvar squamous cell and glandular cell cancers, retrospective multicenter study Article Swipe
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1136/ijgc-2023-esgo.828
· OA: W4387142201
<h3>Introduction/Background</h3> Carcinoma vulva is a rare disease accounting for 1.3% of all gynecological malignancies. The aim of the present study is to analyze the clinicopathological characteristics of women with squamous and glandular cell carcinoma vulva who underwent primary surgical management. <h3>Methodology</h3> A retrospective analysis was conducted on 649 patients who were treated for squamous and glandular cell carcinoma of the vulva at a multicenter in Turkey. <h3>Results</h3> The mean age of patients was 63.2 ± 12.8 years. The most common location for the disease was lateral (55.5%) and then midline (39.6%) and bilateral (0.6%). The surgical treatments for the primary tumor region were radical vulvectomy (80.1%) and simple vulvectomy (19.9%). The surgical margin was negative in 469 (72.3%) patients. The procedure of unilateral or bilateral inguinofemoral lymphadenectomy underwent respectively 77 (11.9%) and 453 (69.8%) patients. The mean number of lymph nodes dissected was 12.8 ± 7.2. The number of patients with lymph node metastasis was 247 (44.5%). Three hundred and eighty-eight cases were in FIGO stage I-II and 234 cases were in stage III. Postoperative adjuvant radiotherapy or chemoradiotherapy were required respectively for 165 (25.4%) and 141 (21.7%) patients. Recurrence developed in one hundred and seventy-three (26.7%) patients. Of these, 100 (15.4%) were local, 54 (8.3%) were inguinal lymph nodes, and 19 (2.9%) were multiple and/or distant. It was determined that the tumor size was larger (P= 0.017) and lymph node involvement was higher (P< 0.001) in those who developed recurrence. Also, it was detected that surgical margin status and histological subtype was effect statistically significant the recurrence rate. <h3>Conclusion</h3> For patients with squamous and glandular cell carcinoma of the vulva, a surgical operation is the primary. Most important factors effecting recurrence are related to surgical quality. <h3>Disclosures</h3> There is no potential conflict of interest (e.g., grant support, consultancy, membership on advisory councils, speaker's bureau) and source of funding.
