695. Infective endocarditis in people who inject drugs (PWID) at UK Medical Center Article Swipe
Evelyn Villacorta Cari
,
John T Henderson
,
Donna R. Burgess
,
J. Zachary Porterfield
,
Nicole Leedy
,
Alice Thornton
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1093/ofid/ofaa439.887
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1093/ofid/ofaa439.887
Background The Intravenous Drug Use (IVDU) epidemic has been developing into a public health crisis in the last twenty years. As a result, the incidence of severe bacterial infections such as infective endocarditis (IE) has been rising dramatically. Methods Cross-sectional study, we reviewed records of all admissions to University of Kentucky hospitals with IVDU associated ICD9/10 codes who received an Infectious Diseases consult during 2018 and focused on the cases with a diagnosis of IE. We describe associated epidemiologic, clinical, and microbiological features Results We include 391 patients in this cohort, among those 157 patients were for IE. Patients had a median age of 34 years old (range: 20 - 62); 81 (51.5%) were female, and five (6.1%) were pregnant and 153 (97.4%) identified as white. A previous episode of infective endocarditis was reported in 55 (35%) cases. The most common illicit substances used were heroin 68 (43.3%) and methamphetamine 65 (41.45%). Tobacco abuse was reported in 134 (86.4%) cases. Fever reported in 93 (59.8%) cases, shortness of air in 43 (28.0%) cases, and chest pain in 44 (28.6%) cases were the most common symptoms. Hepatitis C antibody was positive in 115/149 (73.2%) and 3/143 (1.9%) were HIV positive. Right-sided IE was more frequent, the tricuspid valve was involved in 94 (59.8%) patients. Gram-positive pathogens were isolated in 139 (88.5%) patients, Staphylococcus aureus was isolated in 102 (64.9%) patients, of which 67 (65.7%) were methicillin resistant. Gram-negative pathogens were isolated in 18 (11.2%) patients. Eighty-eight (56.4%) patients had an addiction medicine consult during their admission, (22.9%) patients left against medical advice and 20 (12.7%) patients needed to be readmitted within 30 days after discharge. Overall mortality was 12.7% and was significantly associated with infection by gram-negative pathogens (RR: 2.5; CI 95% 1.05 – 6.25, p=0.037). Conclusion Infectious endocarditis is a frequent complication in PWID which carries a high risk of mortality and often involves the tricuspid valve. The most common pathogen isolated was S. aureus, isolation of gram-negative pathogens was associated with increased mortality. Disclosures All Authors: No reported disclosures
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Metadata
- Type
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- Language
- en
- Landing Page
- https://doi.org/10.1093/ofid/ofaa439.887
- https://academic.oup.com/ofid/article-pdf/7/Supplement_1/S399/35337798/ofaa439.887.pdf
- OA Status
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- Related Works
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W3120650848Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1093/ofid/ofaa439.887Digital Object Identifier
- Title
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695. Infective endocarditis in people who inject drugs (PWID) at UK Medical CenterWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
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2020Year of publication
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2020-10-01Full publication date if available
- Authors
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Evelyn Villacorta Cari, John T Henderson, Donna R. Burgess, J. Zachary Porterfield, Nicole Leedy, Alice ThorntonList of authors in order
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https://doi.org/10.1093/ofid/ofaa439.887Publisher landing page
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https://academic.oup.com/ofid/article-pdf/7/Supplement_1/S399/35337798/ofaa439.887.pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://academic.oup.com/ofid/article-pdf/7/Supplement_1/S399/35337798/ofaa439.887.pdfDirect OA link when available
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Medicine, Infective endocarditis, Endocarditis, Incidence (geometry), Internal medicine, Heroin, Emergency department, Pediatrics, Chest pain, Surgery, Drug, Psychiatry, Optics, PhysicsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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