706 An Audit of Antibiotic Prescribing in Acute Pancreatitis and Introduction of a Patient Safety and Cost Saving Diagnostic Tool Article Swipe
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1093/bjs/znad258.364
Background In managing acute pancreatitis it is challenging to distinguish systemic inflammatory response syndrome (SIRS) from bacterial infection, contributing to inappropriate use of antibiotics, which are only recommended in cases of infected pancreatitis. Over prescribing of broad-spectrum antibiotics is associated with C. difficile, adverse reactions and antibiotic resistance, and has a cost implication. Procalcitonin (PCT) is sensitive (93%) and specific (79%) for diagnosing infected pancreatitis and recommended to guide antibiotic therapy. Method We performed a retrospective audit of the care received by 88 acute pancreatitis patients over 12-months. Results 19/52 (36.5%) with uncomplicated pancreatitis were prescribed antibiotics. 22/36 (61.1%) with infected pancreatitis or a secondary infection source received antibiotics. 36/41 (87.8%) were prescribed broad-spectrum IV antibiotics. Seven days of IV co-amoxiclav costs £15.80, excluding consumables or nursing staff/pharmacy time. A single PCT costs £9.64. Conclusions These results suggest inappropriate prescribing of antibiotics in managing acute pancreatitis. Where diagnostic uncertainty lies between acute uncomplicated pancreatitis with SIRS versus infected pancreatitis, PCT is a useful diagnostic tool to help guide antibiotic therapy, therefore improving patient safety and antibiotic stewardship, with cost benefits. Following this audit, our trust has approved PCT for use in acute pancreatitis, and future audits will assess ongoing antibiotic prescribing in this cohort.
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/bjs/znad258.364
- https://academic.oup.com/bjs/article-pdf/110/Supplement_7/znad258.364/51297302/znad258.364.pdf
- OA Status
- bronze
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4386292366
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4386292366Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1093/bjs/znad258.364Digital Object Identifier
- Title
-
706 An Audit of Antibiotic Prescribing in Acute Pancreatitis and Introduction of a Patient Safety and Cost Saving Diagnostic ToolWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
-
2023-08-30Full publication date if available
- Authors
-
Lee F. Allen, Douglas Pearman, Owen A. O’Connor, M BagnallList of authors in order
- Landing page
-
https://doi.org/10.1093/bjs/znad258.364Publisher landing page
- PDF URL
-
https://academic.oup.com/bjs/article-pdf/110/Supplement_7/znad258.364/51297302/znad258.364.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
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https://academic.oup.com/bjs/article-pdf/110/Supplement_7/znad258.364/51297302/znad258.364.pdfDirect OA link when available
- Concepts
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Medicine, Acute pancreatitis, Antibiotics, Pancreatitis, Intensive care medicine, Audit, Procalcitonin, Antimicrobial stewardship, Internal medicine, Antibiotic resistance, Sepsis, Economics, Biology, Microbiology, ManagementTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.adverse | 44 |
| abstract_inverted_index.between | 151 |
| abstract_inverted_index.cohort. | 204 |
| abstract_inverted_index.nursing | 127 |
| abstract_inverted_index.ongoing | 199 |
| abstract_inverted_index.patient | 173 |
| abstract_inverted_index.results | 137 |
| abstract_inverted_index.suggest | 138 |
| abstract_inverted_index.£9.64. | 134 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.approved | 187 |
| abstract_inverted_index.infected | 32, 64, 101, 158 |
| abstract_inverted_index.managing | 3, 144 |
| abstract_inverted_index.patients | 86 |
| abstract_inverted_index.received | 81, 108 |
| abstract_inverted_index.response | 13 |
| abstract_inverted_index.specific | 60 |
| abstract_inverted_index.syndrome | 14 |
| abstract_inverted_index.systemic | 11 |
| abstract_inverted_index.therapy, | 170 |
| abstract_inverted_index.therapy. | 71 |
| abstract_inverted_index.£15.80, | 123 |
| abstract_inverted_index.Following | 181 |
| abstract_inverted_index.bacterial | 17 |
| abstract_inverted_index.benefits. | 180 |
| abstract_inverted_index.excluding | 124 |
| abstract_inverted_index.improving | 172 |
| abstract_inverted_index.infection | 106 |
| abstract_inverted_index.performed | 74 |
| abstract_inverted_index.reactions | 45 |
| abstract_inverted_index.secondary | 105 |
| abstract_inverted_index.sensitive | 57 |
| abstract_inverted_index.therefore | 171 |
| abstract_inverted_index.12-months. | 88 |
| abstract_inverted_index.Background | 1 |
| abstract_inverted_index.antibiotic | 47, 70, 169, 176, 200 |
| abstract_inverted_index.associated | 40 |
| abstract_inverted_index.diagnosing | 63 |
| abstract_inverted_index.diagnostic | 148, 164 |
| abstract_inverted_index.difficile, | 43 |
| abstract_inverted_index.infection, | 18 |
| abstract_inverted_index.prescribed | 96, 113 |
| abstract_inverted_index.Conclusions | 135 |
| abstract_inverted_index.antibiotics | 38, 142 |
| abstract_inverted_index.challenging | 8 |
| abstract_inverted_index.consumables | 125 |
| abstract_inverted_index.distinguish | 10 |
| abstract_inverted_index.prescribing | 35, 140, 201 |
| abstract_inverted_index.recommended | 28, 67 |
| abstract_inverted_index.resistance, | 48 |
| abstract_inverted_index.uncertainty | 149 |
| abstract_inverted_index.antibiotics, | 24 |
| abstract_inverted_index.antibiotics. | 97, 109, 116 |
| abstract_inverted_index.co-amoxiclav | 121 |
| abstract_inverted_index.contributing | 19 |
| abstract_inverted_index.implication. | 53 |
| abstract_inverted_index.inflammatory | 12 |
| abstract_inverted_index.pancreatitis | 5, 65, 85, 94, 102, 154 |
| abstract_inverted_index.stewardship, | 177 |
| abstract_inverted_index.Procalcitonin | 54 |
| abstract_inverted_index.inappropriate | 21, 139 |
| abstract_inverted_index.pancreatitis, | 159, 193 |
| abstract_inverted_index.pancreatitis. | 33, 146 |
| abstract_inverted_index.retrospective | 76 |
| abstract_inverted_index.uncomplicated | 93, 153 |
| abstract_inverted_index.broad-spectrum | 37, 114 |
| abstract_inverted_index.staff/pharmacy | 128 |
| cited_by_percentile_year | |
| countries_distinct_count | 1 |
| institutions_distinct_count | 4 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.6899999976158142 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.26791931 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |