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Clinical Chemistry • Vol 71 • No Supplement_1
A-069 Comparison of Three Hemoglobin A1c Methodologies in Variant and Non-Variant Samples
October 2025 • Christopher L. Rosemark, Michael Nicklas, Christine L.H. Snozek, Baumann Nikola, Darci R Block
Abstract Background Hemoglobin A1c is used to assess glycemic control to both diagnose and monitor diabetes mellitus. Several different methodologies are available including high performance liquid chromatography (HPLC), capillary electrophoresis (CE), and immunoassay (IA). These methods are standardized and traceable to the Diabetes Control and Complications Trial (DCCT). The aim of this study was to evaluate the difference in HbA1c results between methods and percent of reportable results in variant samples. Met…
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