A 3D Bioprinted Cortical Organoid Platform for Modeling Human Brain Development Article Swipe
Melissa Cadena
,
Anson Sing
,
Kylie M. Taylor
,
Linqi Jin
,
Liqun Ning
,
Mehdi Salar Amoli
,
Yamini Singh
,
Samantha N. Lanjewar
,
Martin L. Tomov
,
Vahid Serpooshan
,
Steven A. Sloan
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1002/adhm.202401603
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1002/adhm.202401603
The ability to promote three‐dimensional (3D) self‐organization of induced pluripotent stem cells into complex tissue structures called organoids presents new opportunities for the field of developmental biology. Brain organoids have been used to investigate principles of neurodevelopment and neuropsychiatric disorders and serve as a drug screening and discovery platform. However, brain organoid cultures are currently limited by a lacking ability to precisely control their extracellular environment. Here, this work employs 3D bioprinting to generate a high‐throughput, tunable, and reproducible scaffold for controlling organoid development and patterning. Additionally, this approach supports the coculture of organoids and vascular cells in a custom architecture containing interconnected endothelialized channels. Printing fidelity and mechanical assessments confirm that fabricated scaffolds closely match intended design features and exhibit stiffness values reflective of the developing human brain. Using organoid growth, viability, cytoarchitecture, proliferation, and transcriptomic benchmarks, this work finds that organoids cultured within the bioprinted scaffold long‐term are healthy and have expected neuroectodermal differentiation. Lastly, this work confirms that the endothelial cells (ECs) in printed channel structures can migrate toward and infiltrate into the embedded organoids. This work demonstrates a tunable 3D culturing platform that can be used to create more complex and accurate models of human brain development and underlying diseases.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/adhm.202401603
- OA Status
- hybrid
- Cited By
- 25
- References
- 122
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4399163047
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4399163047Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1002/adhm.202401603Digital Object Identifier
- Title
-
A 3D Bioprinted Cortical Organoid Platform for Modeling Human Brain DevelopmentWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-05-30Full publication date if available
- Authors
-
Melissa Cadena, Anson Sing, Kylie M. Taylor, Linqi Jin, Liqun Ning, Mehdi Salar Amoli, Yamini Singh, Samantha N. Lanjewar, Martin L. Tomov, Vahid Serpooshan, Steven A. SloanList of authors in order
- Landing page
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https://doi.org/10.1002/adhm.202401603Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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hybridOpen access status per OpenAlex
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https://doi.org/10.1002/adhm.202401603Direct OA link when available
- Concepts
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Organoid, 3D bioprinting, Induced pluripotent stem cell, Scaffold, Cell biology, Neuroscience, Biology, Computer science, Tissue engineering, Computational biology, Biomedical engineering, Embryonic stem cell, Medicine, Gene, Biochemistry, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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25Total citation count in OpenAlex
- Citations by year (recent)
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2025: 21, 2024: 4Per-year citation counts (last 5 years)
- References (count)
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122Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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