A 3D Bioprinted in vitro Model of Neuroblastoma Recapitulates Dynamic Tumor‐Endothelial Cell Interactions Contributing to Solid Tumor Aggressive Behavior Article Swipe
Liqun Ning
,
Jenny Shim
,
Martin L. Tomov
,
Rui Liu
,
Riya Mehta
,
Andrew Mingee
,
Boeun Hwang
,
Linqi Jin
,
Athanasios Mantalaris
,
Chunhui Xu
,
Morteza Mahmoudi
,
Kelly C. Goldsmith
,
Vahid Serpooshan
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1002/advs.202200244
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1002/advs.202200244
Neuroblastoma (NB) is the most common extracranial tumor in children resulting in substantial morbidity and mortality. A deeper understanding of the NB tumor microenvironment (TME) remains an area of active research but there is a lack of reliable and biomimetic experimental models. This study utilizes a 3D bioprinting approach, in combination with NB spheroids, to create an in vitro vascular model of NB for exploring the tumor function within an endothelialized microenvironment. A gelatin methacryloyl (gelMA) bioink is used to create multi‐channel cubic tumor analogues with high printing fidelity and mechanical tunability. Human‐derived NB spheroids and human umbilical vein endothelial cells (HUVECs) are incorporated into the biomanufactured gelMA and cocultured under static versus dynamic conditions, demonstrating high levels of survival and growth. Quantification of NB‐EC integration and tumor cell migration suggested an increased aggressive behavior of NB when cultured in bioprinted endothelialized models, when cocultured with HUVECs, and also as a result of dynamic culture. This model also allowed for the assessment of metabolic, cytokine, and gene expression profiles of NB spheroids under varying TME conditions. These results establish a high throughput research enabling platform to study the TME‐mediated cellular‐molecular mechanisms of tumor growth, aggression, and response to therapy.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/advs.202200244
- OA Status
- gold
- Cited By
- 55
- References
- 148
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4281979575
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4281979575Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1002/advs.202200244Digital Object Identifier
- Title
-
A 3D Bioprinted in vitro Model of Neuroblastoma Recapitulates Dynamic Tumor‐Endothelial Cell Interactions Contributing to Solid Tumor Aggressive BehaviorWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-05-29Full publication date if available
- Authors
-
Liqun Ning, Jenny Shim, Martin L. Tomov, Rui Liu, Riya Mehta, Andrew Mingee, Boeun Hwang, Linqi Jin, Athanasios Mantalaris, Chunhui Xu, Morteza Mahmoudi, Kelly C. Goldsmith, Vahid SerpooshanList of authors in order
- Landing page
-
https://doi.org/10.1002/advs.202200244Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1002/advs.202200244Direct OA link when available
- Concepts
-
Solid tumor, In vitro, Neuroblastoma, Cell biology, Tumor cells, Cancer research, Chemistry, Nanotechnology, Materials science, Biology, Cell culture, Cancer, Biochemistry, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
55Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 10, 2024: 26, 2023: 15, 2022: 4Per-year citation counts (last 5 years)
- References (count)
-
148Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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