A biodegradable, flexible photonic patch for in vivo phototherapy Article Swipe
YOU?
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· 2023
· Open Access
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· DOI: https://doi.org/10.1038/s41467-023-38554-x
Diagnostic and therapeutic illumination on internal organs and tissues with high controllability and adaptability in terms of spectrum, area, depth, and intensity remains a major challenge. Here, we present a flexible, biodegradable photonic device called iCarP with a micrometer scale air gap between a refractive polyester patch and the embedded removable tapered optical fiber. ICarP combines the advantages of light diffraction by the tapered optical fiber, dual refractions in the air gap, and reflection inside the patch to obtain a bulb-like illumination, guiding light towards target tissue. We show that iCarP achieves large area, high intensity, wide spectrum, continuous or pulsatile, deeply penetrating illumination without puncturing the target tissues and demonstrate that it supports phototherapies with different photosensitizers. We find that the photonic device is compatible with thoracoscopy-based minimally invasive implantation onto beating hearts. These initial results show that iCarP could be a safe, precise and widely applicable device suitable for internal organs and tissue illumination and associated diagnosis and therapy.
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s41467-023-38554-x
- https://www.nature.com/articles/s41467-023-38554-x.pdf
- OA Status
- gold
- Cited By
- 28
- References
- 56
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4378530497
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4378530497Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1038/s41467-023-38554-xDigital Object Identifier
- Title
-
A biodegradable, flexible photonic patch for in vivo phototherapyWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-05-27Full publication date if available
- Authors
-
Kaicheng Deng, Yao Tang, Yan Xiao, Danni Zhong, Hua Zhang, Wen Bin Fang, Liyin Shen, Zhaochuang Wang, Jiazhen Pan, Yuwen Lu, Chang‐Ming Chen, Yun Gao, Qiao Jin, Lenan Zhuang, Hao Wan, Liujing Zhuang, Ping Wang, Junfeng Zhai, Tanchen Ren, Qiaoling Hu, Meidong Lang, Yue Zhang, Huanan Wang, Min Zhou, Changyou Gao, Lei Zhang, Yang ZhuList of authors in order
- Landing page
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https://doi.org/10.1038/s41467-023-38554-xPublisher landing page
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https://www.nature.com/articles/s41467-023-38554-x.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.nature.com/articles/s41467-023-38554-x.pdfDirect OA link when available
- Concepts
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In vivo, Photonics, Nanotechnology, Materials science, Optoelectronics, Biology, BiotechnologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
28Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 11, 2024: 14, 2023: 3Per-year citation counts (last 5 years)
- References (count)
-
56Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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