A bioenergetically‐active ploy (glycerol sebacate)‐based multiblock hydrogel improved diabetic wound healing through revitalizing mitochondrial metabolism Article Swipe
Xin Qi
,
Chenjun Liu
,
Jingyi Si
,
Bohao Yin
,
Jingjing Huang
,
Xin Wang
,
Jinghuan Huang
,
Hui Sun
,
Changfeng Zhu
,
Wei Zhang
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1111/cpr.13613
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1111/cpr.13613
Diabetic wounds impose significant burdens on patients' quality of life and healthcare resources due to impaired healing potential. Factors like hyperglycemia, oxidative stress, impaired angiogenesis and excessive inflammation contribute to the delayed healing trajectory. Mounting evidence indicates a close association between impaired mitochondrial function and diabetic complications, including chronic wounds. Mitochondria are critical for providing energy essential to wound healing processes. However, mitochondrial dysfunction exacerbates other pathological factors, creating detrimental cycles that hinder healing. This study conducted correlation analysis using clinical specimens, revealing a positive correlation between mitochondrial dysfunction and oxidative stress, inflammatory response and impaired angiogenesis in diabetic wounds. Restoring mitochondrial function becomes imperative for developing targeted therapies. Herein, we synthesized a biodegradable poly (glycerol sebacate)‐based multiblock hydrogel, named poly (glycerol sebacate)‐co‐poly (ethylene glycol)‐co‐poly (propylene glycol) (PEPGS), which can be degraded in vivo to release glycerol, a crucial component in cellular metabolism, including mitochondrial respiration. We demonstrate the potential of PEPGS‐based hydrogels to improve outcomes in diabetic wound healing by revitalizing mitochondrial metabolism. Furthermore, we investigate the underlying mechanism through proteomics analysis, unravelling the regulation of ATP and nicotinamide adenine dinucleotide metabolic processes, biosynthetic process and generation during mitochondrial metabolism. These findings highlight the therapeutic potential of PEPGS‐based hydrogels as advanced wound dressings for diabetic wound healing.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/cpr.13613
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cpr.13613
- OA Status
- gold
- Cited By
- 9
- References
- 69
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4391817688
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4391817688Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1111/cpr.13613Digital Object Identifier
- Title
-
A bioenergetically‐active ploy (glycerol sebacate)‐based multiblock hydrogel improved diabetic wound healing through revitalizing mitochondrial metabolismWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-02-13Full publication date if available
- Authors
-
Xin Qi, Chenjun Liu, Jingyi Si, Bohao Yin, Jingjing Huang, Xin Wang, Jinghuan Huang, Hui Sun, Changfeng Zhu, Wei ZhangList of authors in order
- Landing page
-
https://doi.org/10.1111/cpr.13613Publisher landing page
- PDF URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cpr.13613Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cpr.13613Direct OA link when available
- Concepts
-
Wound healing, Mitochondrion, Angiogenesis, Oxidative stress, Oxidative phosphorylation, Inflammation, Self-healing hydrogels, Pharmacology, Glycerol, Chemistry, Cell biology, Medicine, Biochemistry, Biology, Cancer research, Surgery, Immunology, Organic chemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
9Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 6, 2024: 3Per-year citation counts (last 5 years)
- References (count)
-
69Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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