A bioinformatic analysis of the role of TP53 status on the infiltration of CD8+ T cells into the tumor microenvironment Article Swipe
Amr Ahmed El‐Arabey
,
Hala E. Abdel‐Hamied
,
Maaweya Awadalla
,
Bandar Alosaimi
,
Taghreed N. Almanaa
,
Samia T. Al‐Shouli
,
Yosra A. Modafer
,
Heba W. Alhamdi
,
Mohnad Abdalla
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1590/1414-431x2023e12970
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1590/1414-431x2023e12970
CD8+ T cells play basic roles in the immune system in a tumor microenvironment (TME) to fight cancer. Several reports have suggested signs of the involvement of tumor protein p53 (TP53) in a complex immune system network. Moreover, our previous research indicated that TP53 orchestrates the polarization and infiltration of macrophages into the TME. In the present study, the clinical function of TP53 status (wild/mutant) in CD8+ T cell infiltration was assessed using more than 10,000 The Cancer Genome Atlas (TCGA) samples from 30 cancer types through Tumor Immune Estimation (TIMER). Our investigation revealed that CD8+ T cell infiltration was higher in head and neck squamous cell carcinoma (HNSC) and uterine corpus endometrial carcinoma (UCEC) patients with wild-type TP53 than in those with mutant TP53. Wild-type TP53 conferred a good prognosis for HNSC and UCEC (P<0.05). In contrast, CD8+ T cell infiltration in lung adenocarcinoma (LUAD) patients with wild-type TP53 was much lower than in those with mutant TP53. Notably, clinical outcomes for LUAD with wild-type TP53 were poor (P<0.05). This study was the first to provide insights into the novel association of TP53 with CD8+ T cells infiltration in the TME in patients with HNSC, LUAD, and UCEC. Therefore, TP53 status acts as a prognostic marker, and this can be used as a basis to further study the effect of targeting TP53 in these patients. Furthermore, our study found that TP53 status was a reliable predictive factor and therapeutic target in patients with HNSC and UCEC.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1590/1414-431x2023e12970
- https://www.scielo.br/j/bjmbr/a/RngK6HkGTYKmsJQy3q8DSpN/?lang=en&format=pdf
- OA Status
- gold
- Cited By
- 4
- References
- 34
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4387831177
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4387831177Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1590/1414-431x2023e12970Digital Object Identifier
- Title
-
A bioinformatic analysis of the role of TP53 status on the infiltration of CD8+ T cells into the tumor microenvironmentWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-01-01Full publication date if available
- Authors
-
Amr Ahmed El‐Arabey, Hala E. Abdel‐Hamied, Maaweya Awadalla, Bandar Alosaimi, Taghreed N. Almanaa, Samia T. Al‐Shouli, Yosra A. Modafer, Heba W. Alhamdi, Mohnad AbdallaList of authors in order
- Landing page
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https://doi.org/10.1590/1414-431x2023e12970Publisher landing page
- PDF URL
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https://www.scielo.br/j/bjmbr/a/RngK6HkGTYKmsJQy3q8DSpN/?lang=en&format=pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.scielo.br/j/bjmbr/a/RngK6HkGTYKmsJQy3q8DSpN/?lang=en&format=pdfDirect OA link when available
- Concepts
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Immune system, CD8, Tumor microenvironment, Infiltration (HVAC), Cancer research, Biology, Wild type, Cytotoxic T cell, Adenocarcinoma, Medicine, Mutant, Immunology, Gene, Cancer, Genetics, Physics, Thermodynamics, In vitroTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
4Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2024: 3Per-year citation counts (last 5 years)
- References (count)
-
34Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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