A Bisphenolic Honokiol Analog Outcompetes Oral Antimicrobial Agent Cetylpyridinium Chloride via a Membrane-Associated Mechanism Article Swipe

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Cetylpyridinium chloride Antimicrobial Honokiol Streptococcus mutans Chemistry Mechanism (biology) Pharmacology Microbiology Biochemistry Bacteria Biology Pulmonary surfactant Organic chemistry Genetics Philosophy Epistemology

Cristian Ochoa , Amy E. Solinski , Marcus Nowlan , Madeline M. Dekarske , William M. Wuest , Marisa C. Kozlowski ·

YOU? · · 2019 · Open Access · · DOI: https://doi.org/10.1021/acsinfecdis.9b00190 · OA: W2982325127

Targeting <i>Streptococcus mutans</i> is the primary focus in reducing dental caries, one of the most common maladies in the world. Previously, our groups discovered a potent bactericidal biaryl compound that was inspired by the natural product honokiol. Herein, a structure activity relationship (SAR) study to ascertain structural motifs key to inhibition is outlined. Furthermore, mechanism studies show that bacterial membrane disruption is central to the bacterial growth inhibition. During this process, it was discovered that analog <b>C2</b> demonstrated a 4-fold better therapeutic index compared to the commercially available antimicrobial cetylpyridinium chloride (CPC) making it a viable alternative for oral care.