A brainstem integrator for self-localization and positional homeostasis Article Swipe
En Yang
,
Maarten Zwart
,
Mikail Rubinov
,
Benjamin James
,
Ziqiang Wei
,
Sujatha Narayan
,
Nikita Vladimirov
,
Brett D. Mensh
,
James E. Fitzgerald
,
Misha B. Ahrens
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1101/2021.11.26.468907
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1101/2021.11.26.468907
To accurately track self-location, animals need to integrate their movements through space. In amniotes, representations of self-location have been found in regions such as the hippocampus. It is unknown whether more ancient brain regions contain such representations and by which pathways they may drive locomotion. Fish displaced by water currents must prevent uncontrolled drift to potentially dangerous areas. We found that larval zebrafish track such movements and can later swim back to their earlier location. Whole-brain functional imaging revealed the circuit enabling this process of positional homeostasis. Position-encoding brainstem neurons integrate optic flow, then bias future swimming to correct for past displacements by modulating inferior olive and cerebellar activity. Manipulation of position-encoding or olivary neurons abolished positional homeostasis or evoked behavior as if animals had experienced positional shifts. These results reveal a multiregional hindbrain circuit in vertebrates for optic flow integration, memory of self-location, and its neural pathway to behavior.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2021.11.26.468907
- OA Status
- green
- Cited By
- 5
- References
- 112
- Related Works
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- OpenAlex ID
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All OpenAlex metadata
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https://openalex.org/W3215659267Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2021.11.26.468907Digital Object Identifier
- Title
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A brainstem integrator for self-localization and positional homeostasisWork title
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preprintOpenAlex work type
- Language
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enPrimary language
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2021Year of publication
- Publication date
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2021-11-27Full publication date if available
- Authors
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En Yang, Maarten Zwart, Mikail Rubinov, Benjamin James, Ziqiang Wei, Sujatha Narayan, Nikita Vladimirov, Brett D. Mensh, James E. Fitzgerald, Misha B. AhrensList of authors in order
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://doi.org/10.1101/2021.11.26.468907Direct OA link when available
- Concepts
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Brainstem, Hindbrain, Neuroscience, Zebrafish, Hippocampus, Biology, Homeostasis, Central nervous system, Cell biology, Biochemistry, GeneTop concepts (fields/topics) attached by OpenAlex
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5Total citation count in OpenAlex
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2025: 1, 2023: 3, 2022: 1Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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