A Brief Review of circRNA Biogenesis, Detection, and Function Article Swipe
Ying Liang
,
Niannian Liu
,
Le Yang
,
Jianjun Tang
,
Yinglong Wang
,
Meng Mei
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.2174/1389202922666210331130722
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.2174/1389202922666210331130722
: Circular RNA (circRNA) is a non-coding molecule produced through alternative splicing of one or more exons of a gene in the presence of an RNA-induced silencing complex (RISC). Its formation depends on complementary intron sequences on both sides of the circularized sequence. CircRNA functions as a sponge for miRNA, playing the role of the transcriptional regulator or potential biomarker. It has an impact on fetal growth and on synaptic facilitation in the brain. In this review, we illustrate biogenesis mechanisms, characteristics, and functions of cirRNAs. We also summarize methods using sequence feature and RNA next-generation sequencing data for circRNA prediction. Finally, we discuss the state of the research on circRNA in diseases, which will bring new contributions to future disease treatments.
Related Topics
Concepts
Circular RNA
Computational biology
Biogenesis
RNA splicing
RNA
Intron
Biology
Exon
microRNA
Gene silencing
Gene
Genetics
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.2174/1389202922666210331130722
- OA Status
- green
- Cited By
- 52
- References
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- Related Works
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- OpenAlex ID
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All OpenAlex metadata
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https://doi.org/10.2174/1389202922666210331130722Digital Object Identifier
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A Brief Review of circRNA Biogenesis, Detection, and FunctionWork title
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reviewOpenAlex work type
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enPrimary language
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2021Year of publication
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2021-04-02Full publication date if available
- Authors
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Ying Liang, Niannian Liu, Le Yang, Jianjun Tang, Yinglong Wang, Meng MeiList of authors in order
- Landing page
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https://doi.org/10.2174/1389202922666210331130722Publisher landing page
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greenOpen access status per OpenAlex
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https://www.ncbi.nlm.nih.gov/pmc/articles/8905635Direct OA link when available
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Circular RNA, Computational biology, Biogenesis, RNA splicing, RNA, Intron, Biology, Exon, microRNA, Gene silencing, Gene, GeneticsTop concepts (fields/topics) attached by OpenAlex
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52Total citation count in OpenAlex
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2025: 20, 2024: 17, 2023: 10, 2022: 4, 2021: 1Per-year citation counts (last 5 years)
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