A Buprenorphine depot formulation provides effective sustained post-surgical analgesia for 72h in mouse femoral fracture models Article Swipe
Angelique Wolter
,
Christian H. Bucher
,
Sebastian Kurmies
,
Viktoria Schreiner
,
Frank Konietschke
,
Katharina Hohlbaum
,
Robert Klopfleisch
,
Max Löhning
,
Christa Thöne‐Reineke
,
Frank Buttgereit
,
Jörg Huwyler
,
Paulin Jirkof
,
Anna E. Rapp
,
Annemarie Lang
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1101/2022.07.05.498859
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1101/2022.07.05.498859
Adequate pain management is essential for ethical and scientific reasons in animal experiments and should completely cover the period of expected pain without the need for frequent re-application. However, current depot formulations of Buprenorphine are only available in the USA and have limited duration of action. Recently, a new microparticulate Buprenorphine formulation (BUP-Depot) for sustained release has been developed as an alternative product within Europe. Pharmacokinetics indicate a potential effectiveness for about 72h. Here, we investigated whether the administration of the BUP-Depot ensures continuous and sufficient analgesia in two mouse femoral fracture models and could therefore serve as a potent alternative to the application of Tramadol via drinking water. Both protocols were examined for analgesic effectiveness, side effects on experimental readout, and effects on fracture healing outcomes in male and female C57BL/6N mice. The BUP-Depot provided effective analgesia for 72h, comparable to the effectiveness of Tramadol in drinking water. Fracture healing outcome was not different between analgesic regimes. The availability of a Buprenorphine depot formulation for laboratory animals in Europe would be a beneficial addition for extended pain relief in mice, thereby increasing animal welfare.
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Concepts
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2022.07.05.498859
- https://www.biorxiv.org/content/biorxiv/early/2022/08/06/2022.07.05.498859.full.pdf
- OA Status
- green
- Cited By
- 1
- References
- 73
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4284894795
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4284894795Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1101/2022.07.05.498859Digital Object Identifier
- Title
-
A Buprenorphine depot formulation provides effective sustained post-surgical analgesia for 72h in mouse femoral fracture modelsWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-07-07Full publication date if available
- Authors
-
Angelique Wolter, Christian H. Bucher, Sebastian Kurmies, Viktoria Schreiner, Frank Konietschke, Katharina Hohlbaum, Robert Klopfleisch, Max Löhning, Christa Thöne‐Reineke, Frank Buttgereit, Jörg Huwyler, Paulin Jirkof, Anna E. Rapp, Annemarie LangList of authors in order
- Landing page
-
https://doi.org/10.1101/2022.07.05.498859Publisher landing page
- PDF URL
-
https://www.biorxiv.org/content/biorxiv/early/2022/08/06/2022.07.05.498859.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
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https://www.biorxiv.org/content/biorxiv/early/2022/08/06/2022.07.05.498859.full.pdfDirect OA link when available
- Concepts
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Buprenorphine, Tramadol, Medicine, Analgesic, Depot, Pain relief, Anesthesia, Pharmacokinetics, Pharmacology, Surgery, Opioid, Internal medicine, Archaeology, History, ReceptorTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
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2023: 1Per-year citation counts (last 5 years)
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73Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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