A case of spuriously high CK-MB: Contemplate beyond cardiac Article Swipe
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· 2017
· Open Access
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· DOI: https://doi.org/10.21767/amj.2017.3122
· OA: W2765484431
Creatine kinase-MB (CK-MB) is a widely tested enzyme in cardiac disease and thus has important clinical implications.We relate the scenario of a young patient presenting with chest pain whose CK-MB levels remained inordinately elevated despite a normal total CK level, resolution of symptoms and exclusion of coronary artery disease.Further analysis by electrophoresis revealed the presence of a rare molecular variant of creatine kinase: macro-CK type 1.While this may be a benign finding, there are sparse data demonstrating an association with non-cardiac pathologies such as malignancy, endocrinopathies, connective tissue and autoimmune diseases.Thus, after further exclusion of these associated conditions, the patient was reassured on the likely benign nature of macro-CK in this case.
