A Closed-chest Model to Induce Transverse Aortic Constriction in Mice Article Swipe
Lars Eichhorn
,
Christina Weisheit
,
Christopher Gestrich
,
Konrad Peukert
,
Georg Daniel Duerr
,
Muhammad Ajmal Ayub
,
Felix Erdfelder
,
Florian Stöckigt
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.3791/57397
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.3791/57397
Research on cardiac hypertrophy and heart failure is frequently based on pressure overload mouse models induced by TAC. The standard procedure is to perform a partial thoracotomy to visualize the transverse aortic arch. However, the surgical trauma caused by the thoracotomy in open-chest models changes the respiratory physiology as the ribs are dissected and left unattached after chest closure. To prevent this, we established a minimally invasive, closed chest approach via lateral thoracotomy. Herein we approach the aortic arch via the 2nd intercostal space without entering the chest cavities, leaving the mouse with a less traumatic injury to recover from. We perform this operation using standard laboratory settings for open chest TAC procedures with equal survival rates. Apart from maintaining physiological breathing patterns due to the closed chest approach, the mice seem to benefit by showing rapid recovery, as the less invasive technique appears to facilitate a fast healing process and to reduce immune response after trauma.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3791/57397
- https://www.jove.com/pdf/57397/a-closed-chest-model-to-induce-transverse-aortic-constriction-in-mice
- OA Status
- bronze
- Cited By
- 20
- References
- 19
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2795623820
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2795623820Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3791/57397Digital Object Identifier
- Title
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A Closed-chest Model to Induce Transverse Aortic Constriction in MiceWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2018Year of publication
- Publication date
-
2018-04-05Full publication date if available
- Authors
-
Lars Eichhorn, Christina Weisheit, Christopher Gestrich, Konrad Peukert, Georg Daniel Duerr, Muhammad Ajmal Ayub, Felix Erdfelder, Florian StöckigtList of authors in order
- Landing page
-
https://doi.org/10.3791/57397Publisher landing page
- PDF URL
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https://www.jove.com/pdf/57397/a-closed-chest-model-to-induce-transverse-aortic-constriction-in-miceDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
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https://www.jove.com/pdf/57397/a-closed-chest-model-to-induce-transverse-aortic-constriction-in-miceDirect OA link when available
- Concepts
-
Thoracotomy, Medicine, Aortic arch, Pressure overload, Rib cage, Chest injury, Muscle hypertrophy, Aorta, Surgery, Cardiology, Blunt, Anatomy, Cardiac hypertrophyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
20Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 6, 2024: 2, 2023: 2, 2022: 3, 2021: 3Per-year citation counts (last 5 years)
- References (count)
-
19Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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