A co-culture model of the hippocampal neurogenic niche reveals differential effects of astrocytes, endothelial cells and pericytes on proliferation and differentiation of adult murine precursor cells Article Swipe
Fanny Ehret
,
Steffen Vogler
,
Gerd Kempermann
·
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.1016/j.scr.2015.09.010
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.1016/j.scr.2015.09.010
The niche concept of stem cell biology proposes a functional unit between the precursor cells and their local microenvironment, to which several cell types might contribute by cell-cell contacts, extracellular matrix, and humoral factors. We here established three co-culture models (with cell types separated by membrane) for both adherent monolayers and neurospheres to address the potential influence of different niche cell types in the neurogenic zone of the adult hippocampus of mice. Astrocytes and endothelial cells enhanced precursor cell proliferation and neurosphere formation. Endothelial factors also led to a prolonged increase in proliferation after growth factor withdrawal, which otherwise induces differentiation. All niche cell types enhanced cell survival in monolayer cultures, endothelial cells also stimulated neuronal differentiation. A parallel trend elicited by astrocytes did not reach conventional statistical significance. Pericytes had variable effects here. We did not observe changes in differentiation in neurosphere co-cultures. In summary, our data indicate that in precursor cell culture protocols survival could be improved by adding as yet unknown factors physiologically contributed by astrocytes and endothelial cells. Our findings also underscore the complexity of the niche and the differential impact of factors from the different sources on distinct aspects of neuronal development. With the help of the models presented here, identification of these factors and their specific biological activity can now be initiated.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.scr.2015.09.010
- OA Status
- gold
- Cited By
- 33
- References
- 45
- Related Works
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- OpenAlex ID
- https://openalex.org/W2154390864
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2154390864Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.scr.2015.09.010Digital Object Identifier
- Title
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A co-culture model of the hippocampal neurogenic niche reveals differential effects of astrocytes, endothelial cells and pericytes on proliferation and differentiation of adult murine precursor cellsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2015Year of publication
- Publication date
-
2015-09-26Full publication date if available
- Authors
-
Fanny Ehret, Steffen Vogler, Gerd KempermannList of authors in order
- Landing page
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https://doi.org/10.1016/j.scr.2015.09.010Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1016/j.scr.2015.09.010Direct OA link when available
- Concepts
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Biology, Hippocampal formation, Cell biology, Niche, Precursor cell, Differential (mechanical device), Immunology, Neuroscience, Cell, Biochemistry, Aerospace engineering, EngineeringTop concepts (fields/topics) attached by OpenAlex
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33Total citation count in OpenAlex
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2025: 2, 2024: 1, 2023: 2, 2022: 2, 2021: 4Per-year citation counts (last 5 years)
- References (count)
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45Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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