A co-ordinated transcriptional programme in the maternal liver supplies LC-PUFAs to the conceptus using phospholipids Article Swipe
Risha Amarsi
,
Samuel Furse
,
Mary Ann Megan Cleaton
,
Sarah Maurel
,
Alice L. Mitchell
,
Anne C. Ferguson‐Smith
,
Nicolas Cénac
,
Catherine Williamson
,
Albert Koulman
,
Marika Charalambous
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1101/2023.06.23.546226
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1101/2023.06.23.546226
Essential fatty acids (EFAs) and their derivatives, the long and very long chain polyunsaturated fatty acids (LC-PUFAs), are preferentially transported by the mother to the fetus. Failure to supply EFAs is strongly linked with stillbirth, fetal growth restriction, and impaired neurodevelopmental outcomes. However, dietary supplementation during pregnancy is unable to simply reverse these outcomes, suggesting imperfectly understood interactions between dietary EFA intake and the molecular mechanisms of maternal supply. Here we combine untargeted lipidomics with transcriptional profiling of healthy and genetically-manipulated murine models to understand the maternal adaptations required to provide LC-PUFAs to the developing fetus. We discovered a late pregnancy-specific, selective activation of the Liver X Receptor signalling pathway which dramatically increases maternal supply of LC-PUFAs within circulating phospholipids. Crucially, genetic ablation of this pathway in the mother reduced LC-PUFA accumulation by the fetus. Overall our work suggests new molecular strategies for improving maternal-fetal transfer of these important lipids.
Related Topics
Concepts
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2023.06.23.546226
- https://www.biorxiv.org/content/biorxiv/early/2023/06/26/2023.06.23.546226.full.pdf
- OA Status
- green
- Cited By
- 1
- References
- 85
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4382047032
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4382047032Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1101/2023.06.23.546226Digital Object Identifier
- Title
-
A co-ordinated transcriptional programme in the maternal liver supplies LC-PUFAs to the conceptus using phospholipidsWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-06-26Full publication date if available
- Authors
-
Risha Amarsi, Samuel Furse, Mary Ann Megan Cleaton, Sarah Maurel, Alice L. Mitchell, Anne C. Ferguson‐Smith, Nicolas Cénac, Catherine Williamson, Albert Koulman, Marika CharalambousList of authors in order
- Landing page
-
https://doi.org/10.1101/2023.06.23.546226Publisher landing page
- PDF URL
-
https://www.biorxiv.org/content/biorxiv/early/2023/06/26/2023.06.23.546226.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.biorxiv.org/content/biorxiv/early/2023/06/26/2023.06.23.546226.full.pdfDirect OA link when available
- Concepts
-
Conceptus, Polyunsaturated fatty acid, Fetus, Lipidomics, Pregnancy, Biology, Long chain, Endocrinology, Cell biology, Chemistry, Biochemistry, Fatty acid, Genetics, Polymer scienceTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
- Citations by year (recent)
-
2024: 1Per-year citation counts (last 5 years)
- References (count)
-
85Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4382047032 |
|---|---|
| doi | https://doi.org/10.1101/2023.06.23.546226 |
| ids.doi | https://doi.org/10.1101/2023.06.23.546226 |
| ids.openalex | https://openalex.org/W4382047032 |
| fwci | 0.26041532 |
| type | preprint |
| title | A co-ordinated transcriptional programme in the maternal liver supplies LC-PUFAs to the conceptus using phospholipids |
| biblio.issue | |
| biblio.volume | |
| biblio.last_page | |
| biblio.first_page | |
| topics[0].id | https://openalex.org/T10387 |
| topics[0].field.id | https://openalex.org/fields/29 |
| topics[0].field.display_name | Nursing |
| topics[0].score | 0.9994000196456909 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2916 |
| topics[0].subfield.display_name | Nutrition and Dietetics |
| topics[0].display_name | Fatty Acid Research and Health |
| topics[1].id | https://openalex.org/T11629 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9987999796867371 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2735 |
| topics[1].subfield.display_name | Pediatrics, Perinatology and Child Health |
| topics[1].display_name | Birth, Development, and Health |
| topics[2].id | https://openalex.org/T11457 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9948999881744385 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2737 |
| topics[2].subfield.display_name | Physiology |
| topics[2].display_name | Adipose Tissue and Metabolism |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C32253518 |
| concepts[0].level | 4 |
| concepts[0].score | 0.872289776802063 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q5158447 |
| concepts[0].display_name | Conceptus |
| concepts[1].id | https://openalex.org/C19038510 |
| concepts[1].level | 3 |
| concepts[1].score | 0.7616602182388306 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q2005087 |
| concepts[1].display_name | Polyunsaturated fatty acid |
| concepts[2].id | https://openalex.org/C172680121 |
| concepts[2].level | 3 |
| concepts[2].score | 0.6904574036598206 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q26513 |
| concepts[2].display_name | Fetus |
| concepts[3].id | https://openalex.org/C58017582 |
| concepts[3].level | 2 |
| concepts[3].score | 0.6094281077384949 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q6556376 |
| concepts[3].display_name | Lipidomics |
| concepts[4].id | https://openalex.org/C2779234561 |
| concepts[4].level | 2 |
| concepts[4].score | 0.5301286578178406 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q11995 |
| concepts[4].display_name | Pregnancy |
| concepts[5].id | https://openalex.org/C86803240 |
| concepts[5].level | 0 |
| concepts[5].score | 0.4776676595211029 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[5].display_name | Biology |
| concepts[6].id | https://openalex.org/C3020382795 |
| concepts[6].level | 2 |
| concepts[6].score | 0.4152992069721222 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q81163 |
| concepts[6].display_name | Long chain |
| concepts[7].id | https://openalex.org/C134018914 |
| concepts[7].level | 1 |
| concepts[7].score | 0.3362501561641693 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q162606 |
| concepts[7].display_name | Endocrinology |
| concepts[8].id | https://openalex.org/C95444343 |
| concepts[8].level | 1 |
| concepts[8].score | 0.3274313807487488 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q7141 |
| concepts[8].display_name | Cell biology |
| concepts[9].id | https://openalex.org/C185592680 |
| concepts[9].level | 0 |
| concepts[9].score | 0.3131777048110962 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[9].display_name | Chemistry |
| concepts[10].id | https://openalex.org/C55493867 |
| concepts[10].level | 1 |
| concepts[10].score | 0.28570622205734253 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[10].display_name | Biochemistry |
| concepts[11].id | https://openalex.org/C543025807 |
| concepts[11].level | 2 |
| concepts[11].score | 0.2395862638950348 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q61476 |
| concepts[11].display_name | Fatty acid |
| concepts[12].id | https://openalex.org/C54355233 |
| concepts[12].level | 1 |
| concepts[12].score | 0.19039496779441833 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[12].display_name | Genetics |
| concepts[13].id | https://openalex.org/C126348684 |
| concepts[13].level | 1 |
| concepts[13].score | 0.0 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q3456979 |
| concepts[13].display_name | Polymer science |
| keywords[0].id | https://openalex.org/keywords/conceptus |
| keywords[0].score | 0.872289776802063 |
| keywords[0].display_name | Conceptus |
| keywords[1].id | https://openalex.org/keywords/polyunsaturated-fatty-acid |
| keywords[1].score | 0.7616602182388306 |
| keywords[1].display_name | Polyunsaturated fatty acid |
| keywords[2].id | https://openalex.org/keywords/fetus |
| keywords[2].score | 0.6904574036598206 |
| keywords[2].display_name | Fetus |
| keywords[3].id | https://openalex.org/keywords/lipidomics |
| keywords[3].score | 0.6094281077384949 |
| keywords[3].display_name | Lipidomics |
| keywords[4].id | https://openalex.org/keywords/pregnancy |
| keywords[4].score | 0.5301286578178406 |
| keywords[4].display_name | Pregnancy |
| keywords[5].id | https://openalex.org/keywords/biology |
| keywords[5].score | 0.4776676595211029 |
| keywords[5].display_name | Biology |
| keywords[6].id | https://openalex.org/keywords/long-chain |
| keywords[6].score | 0.4152992069721222 |
| keywords[6].display_name | Long chain |
| keywords[7].id | https://openalex.org/keywords/endocrinology |
| keywords[7].score | 0.3362501561641693 |
| keywords[7].display_name | Endocrinology |
| keywords[8].id | https://openalex.org/keywords/cell-biology |
| keywords[8].score | 0.3274313807487488 |
| keywords[8].display_name | Cell biology |
| keywords[9].id | https://openalex.org/keywords/chemistry |
| keywords[9].score | 0.3131777048110962 |
| keywords[9].display_name | Chemistry |
| keywords[10].id | https://openalex.org/keywords/biochemistry |
| keywords[10].score | 0.28570622205734253 |
| keywords[10].display_name | Biochemistry |
| keywords[11].id | https://openalex.org/keywords/fatty-acid |
| keywords[11].score | 0.2395862638950348 |
| keywords[11].display_name | Fatty acid |
| keywords[12].id | https://openalex.org/keywords/genetics |
| keywords[12].score | 0.19039496779441833 |
| keywords[12].display_name | Genetics |
| language | en |
| locations[0].id | doi:10.1101/2023.06.23.546226 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S4306402567 |
| locations[0].source.issn | |
| locations[0].source.type | repository |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | |
| locations[0].source.is_core | False |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| locations[0].source.host_organization | https://openalex.org/I2750212522 |
| locations[0].source.host_organization_name | Cold Spring Harbor Laboratory |
| locations[0].source.host_organization_lineage | https://openalex.org/I2750212522 |
| locations[0].license | |
| locations[0].pdf_url | https://www.biorxiv.org/content/biorxiv/early/2023/06/26/2023.06.23.546226.full.pdf |
| locations[0].version | acceptedVersion |
| locations[0].raw_type | posted-content |
| locations[0].license_id | |
| locations[0].is_accepted | True |
| locations[0].is_published | False |
| locations[0].raw_source_name | |
| locations[0].landing_page_url | https://doi.org/10.1101/2023.06.23.546226 |
| indexed_in | crossref |
| authorships[0].author.id | https://openalex.org/A5001049479 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-6900-1322 |
| authorships[0].author.display_name | Risha Amarsi |
| authorships[0].countries | GB |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I183935753 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Medical and Molecular Genetics, Faculty of Life Sciences and Medicine, King's College London, London SE9RT, UK |
| authorships[0].institutions[0].id | https://openalex.org/I183935753 |
| authorships[0].institutions[0].ror | https://ror.org/0220mzb33 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I124357947, https://openalex.org/I183935753 |
| authorships[0].institutions[0].country_code | GB |
| authorships[0].institutions[0].display_name | King's College London |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Risha Amarsi |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Medical and Molecular Genetics, Faculty of Life Sciences and Medicine, King's College London, London SE9RT, UK |
| authorships[1].author.id | https://openalex.org/A5046207466 |
| authorships[1].author.orcid | https://orcid.org/0000-0003-4267-2051 |
| authorships[1].author.display_name | Samuel Furse |
| authorships[1].countries | GB |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I2799614521 |
| authorships[1].affiliations[0].raw_affiliation_string | Biological chemistry group, Jodrell laboratory, Royal Botanic Gardens Kew, Kew Road, Richmond, Surrey, TW9 3DS, United Kingdom |
| authorships[1].affiliations[1].institution_ids | https://openalex.org/I241749, https://openalex.org/I4210116691 |
| authorships[1].affiliations[1].raw_affiliation_string | Core Metabolomics and Lipidomics Laboratory, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Addenbrooke’s Treatment Centre, Keith Day Road, Cambridge, CB2 0QQ, United Kingdom |
| authorships[1].institutions[0].id | https://openalex.org/I2799614521 |
| authorships[1].institutions[0].ror | https://ror.org/00ynnr806 |
| authorships[1].institutions[0].type | archive |
| authorships[1].institutions[0].lineage | https://openalex.org/I2799614521 |
| authorships[1].institutions[0].country_code | GB |
| authorships[1].institutions[0].display_name | Royal Botanic Gardens, Kew |
| authorships[1].institutions[1].id | https://openalex.org/I241749 |
| authorships[1].institutions[1].ror | https://ror.org/013meh722 |
| authorships[1].institutions[1].type | education |
| authorships[1].institutions[1].lineage | https://openalex.org/I241749 |
| authorships[1].institutions[1].country_code | GB |
| authorships[1].institutions[1].display_name | University of Cambridge |
| authorships[1].institutions[2].id | https://openalex.org/I4210116691 |
| authorships[1].institutions[2].ror | https://ror.org/0264dxb48 |
| authorships[1].institutions[2].type | facility |
| authorships[1].institutions[2].lineage | https://openalex.org/I241749, https://openalex.org/I2802466933, https://openalex.org/I4210087105, https://openalex.org/I4210116691, https://openalex.org/I87048295, https://openalex.org/I90344618 |
| authorships[1].institutions[2].country_code | GB |
| authorships[1].institutions[2].display_name | Wellcome/MRC Institute of Metabolic Science |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Samuel Furse |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Biological chemistry group, Jodrell laboratory, Royal Botanic Gardens Kew, Kew Road, Richmond, Surrey, TW9 3DS, United Kingdom, Core Metabolomics and Lipidomics Laboratory, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Addenbrooke’s Treatment Centre, Keith Day Road, Cambridge, CB2 0QQ, United Kingdom |
| authorships[2].author.id | https://openalex.org/A5090973695 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-8363-0838 |
| authorships[2].author.display_name | Mary Ann Megan Cleaton |
| authorships[2].countries | GB |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I241749 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Genetics, Downing Street, University of Cambridge, Cambridge CB2 3EH, UK |
| authorships[2].institutions[0].id | https://openalex.org/I241749 |
| authorships[2].institutions[0].ror | https://ror.org/013meh722 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I241749 |
| authorships[2].institutions[0].country_code | GB |
| authorships[2].institutions[0].display_name | University of Cambridge |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Mary AM Cleaton |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Genetics, Downing Street, University of Cambridge, Cambridge CB2 3EH, UK |
| authorships[3].author.id | https://openalex.org/A5041856681 |
| authorships[3].author.orcid | |
| authorships[3].author.display_name | Sarah Maurel |
| authorships[3].countries | FR |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I134560555, https://openalex.org/I154526488, https://openalex.org/I176063091, https://openalex.org/I17866349, https://openalex.org/I4210122796 |
| authorships[3].affiliations[0].raw_affiliation_string | IRSD, Université de Toulouse-Paul Sabatier, INSERM, INRAe, ENVT, UPS, Toulouse, France |
| authorships[3].institutions[0].id | https://openalex.org/I4210122796 |
| authorships[3].institutions[0].ror | https://ror.org/034nb0f30 |
| authorships[3].institutions[0].type | facility |
| authorships[3].institutions[0].lineage | https://openalex.org/I134560555, https://openalex.org/I154526488, https://openalex.org/I176063091, https://openalex.org/I4210088668, https://openalex.org/I4210117091, https://openalex.org/I4210121065, https://openalex.org/I4210122796, https://openalex.org/I4210145734, https://openalex.org/I4412460029 |
| authorships[3].institutions[0].country_code | FR |
| authorships[3].institutions[0].display_name | Digestive Health Research Institute |
| authorships[3].institutions[1].id | https://openalex.org/I154526488 |
| authorships[3].institutions[1].ror | https://ror.org/02vjkv261 |
| authorships[3].institutions[1].type | government |
| authorships[3].institutions[1].lineage | https://openalex.org/I154526488 |
| authorships[3].institutions[1].country_code | FR |
| authorships[3].institutions[1].display_name | Inserm |
| authorships[3].institutions[2].id | https://openalex.org/I17866349 |
| authorships[3].institutions[2].ror | https://ror.org/004raaa70 |
| authorships[3].institutions[2].type | education |
| authorships[3].institutions[2].lineage | https://openalex.org/I17866349 |
| authorships[3].institutions[2].country_code | FR |
| authorships[3].institutions[2].display_name | Université Fédérale de Toulouse Midi-Pyrénées |
| authorships[3].institutions[3].id | https://openalex.org/I134560555 |
| authorships[3].institutions[3].ror | https://ror.org/02v6kpv12 |
| authorships[3].institutions[3].type | education |
| authorships[3].institutions[3].lineage | https://openalex.org/I134560555, https://openalex.org/I4412460029 |
| authorships[3].institutions[3].country_code | FR |
| authorships[3].institutions[3].display_name | Université Toulouse III - Paul Sabatier |
| authorships[3].institutions[4].id | https://openalex.org/I176063091 |
| authorships[3].institutions[4].ror | https://ror.org/03m3gzv89 |
| authorships[3].institutions[4].type | education |
| authorships[3].institutions[4].lineage | https://openalex.org/I176063091, https://openalex.org/I4210117091, https://openalex.org/I4412460029 |
| authorships[3].institutions[4].country_code | FR |
| authorships[3].institutions[4].display_name | École Nationale Vétérinaire de Toulouse |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Sarah Maurel |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | IRSD, Université de Toulouse-Paul Sabatier, INSERM, INRAe, ENVT, UPS, Toulouse, France |
| authorships[4].author.id | https://openalex.org/A5009958466 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-6861-5779 |
| authorships[4].author.display_name | Alice L. Mitchell |
| authorships[4].countries | GB |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I183935753 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Women and Children's Health, King's College London, Guy's Campus, London, UK |
| authorships[4].institutions[0].id | https://openalex.org/I183935753 |
| authorships[4].institutions[0].ror | https://ror.org/0220mzb33 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I124357947, https://openalex.org/I183935753 |
| authorships[4].institutions[0].country_code | GB |
| authorships[4].institutions[0].display_name | King's College London |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Alice L Mitchell |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Women and Children's Health, King's College London, Guy's Campus, London, UK |
| authorships[5].author.id | https://openalex.org/A5086644518 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-7608-5894 |
| authorships[5].author.display_name | Anne C. Ferguson‐Smith |
| authorships[5].countries | GB |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I241749 |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Genetics, Downing Street, University of Cambridge, Cambridge CB2 3EH, UK |
| authorships[5].institutions[0].id | https://openalex.org/I241749 |
| authorships[5].institutions[0].ror | https://ror.org/013meh722 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I241749 |
| authorships[5].institutions[0].country_code | GB |
| authorships[5].institutions[0].display_name | University of Cambridge |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Anne C. Ferguson-Smith |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Genetics, Downing Street, University of Cambridge, Cambridge CB2 3EH, UK |
| authorships[6].author.id | https://openalex.org/A5008410004 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-1552-7812 |
| authorships[6].author.display_name | Nicolas Cénac |
| authorships[6].countries | FR |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I134560555, https://openalex.org/I154526488, https://openalex.org/I176063091, https://openalex.org/I17866349, https://openalex.org/I4210122796 |
| authorships[6].affiliations[0].raw_affiliation_string | IRSD, Université de Toulouse-Paul Sabatier, INSERM, INRAe, ENVT, UPS, Toulouse, France |
| authorships[6].institutions[0].id | https://openalex.org/I4210122796 |
| authorships[6].institutions[0].ror | https://ror.org/034nb0f30 |
| authorships[6].institutions[0].type | facility |
| authorships[6].institutions[0].lineage | https://openalex.org/I134560555, https://openalex.org/I154526488, https://openalex.org/I176063091, https://openalex.org/I4210088668, https://openalex.org/I4210117091, https://openalex.org/I4210121065, https://openalex.org/I4210122796, https://openalex.org/I4210145734, https://openalex.org/I4412460029 |
| authorships[6].institutions[0].country_code | FR |
| authorships[6].institutions[0].display_name | Digestive Health Research Institute |
| authorships[6].institutions[1].id | https://openalex.org/I154526488 |
| authorships[6].institutions[1].ror | https://ror.org/02vjkv261 |
| authorships[6].institutions[1].type | government |
| authorships[6].institutions[1].lineage | https://openalex.org/I154526488 |
| authorships[6].institutions[1].country_code | FR |
| authorships[6].institutions[1].display_name | Inserm |
| authorships[6].institutions[2].id | https://openalex.org/I17866349 |
| authorships[6].institutions[2].ror | https://ror.org/004raaa70 |
| authorships[6].institutions[2].type | education |
| authorships[6].institutions[2].lineage | https://openalex.org/I17866349 |
| authorships[6].institutions[2].country_code | FR |
| authorships[6].institutions[2].display_name | Université Fédérale de Toulouse Midi-Pyrénées |
| authorships[6].institutions[3].id | https://openalex.org/I134560555 |
| authorships[6].institutions[3].ror | https://ror.org/02v6kpv12 |
| authorships[6].institutions[3].type | education |
| authorships[6].institutions[3].lineage | https://openalex.org/I134560555, https://openalex.org/I4412460029 |
| authorships[6].institutions[3].country_code | FR |
| authorships[6].institutions[3].display_name | Université Toulouse III - Paul Sabatier |
| authorships[6].institutions[4].id | https://openalex.org/I176063091 |
| authorships[6].institutions[4].ror | https://ror.org/03m3gzv89 |
| authorships[6].institutions[4].type | education |
| authorships[6].institutions[4].lineage | https://openalex.org/I176063091, https://openalex.org/I4210117091, https://openalex.org/I4412460029 |
| authorships[6].institutions[4].country_code | FR |
| authorships[6].institutions[4].display_name | École Nationale Vétérinaire de Toulouse |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Nicolas Cenac |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | IRSD, Université de Toulouse-Paul Sabatier, INSERM, INRAe, ENVT, UPS, Toulouse, France |
| authorships[7].author.id | https://openalex.org/A5052297121 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-6226-7611 |
| authorships[7].author.display_name | Catherine Williamson |
| authorships[7].countries | GB |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I183935753 |
| authorships[7].affiliations[0].raw_affiliation_string | Department of Women and Children's Health, King's College London, Guy's Campus, London, UK |
| authorships[7].institutions[0].id | https://openalex.org/I183935753 |
| authorships[7].institutions[0].ror | https://ror.org/0220mzb33 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I124357947, https://openalex.org/I183935753 |
| authorships[7].institutions[0].country_code | GB |
| authorships[7].institutions[0].display_name | King's College London |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Catherine Williamson |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Department of Women and Children's Health, King's College London, Guy's Campus, London, UK |
| authorships[8].author.id | https://openalex.org/A5012520344 |
| authorships[8].author.orcid | https://orcid.org/0000-0001-9998-051X |
| authorships[8].author.display_name | Albert Koulman |
| authorships[8].countries | GB |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I241749, https://openalex.org/I4210116691 |
| authorships[8].affiliations[0].raw_affiliation_string | Core Metabolomics and Lipidomics Laboratory, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Addenbrooke’s Treatment Centre, Keith Day Road, Cambridge, CB2 0QQ, United Kingdom |
| authorships[8].institutions[0].id | https://openalex.org/I241749 |
| authorships[8].institutions[0].ror | https://ror.org/013meh722 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I241749 |
| authorships[8].institutions[0].country_code | GB |
| authorships[8].institutions[0].display_name | University of Cambridge |
| authorships[8].institutions[1].id | https://openalex.org/I4210116691 |
| authorships[8].institutions[1].ror | https://ror.org/0264dxb48 |
| authorships[8].institutions[1].type | facility |
| authorships[8].institutions[1].lineage | https://openalex.org/I241749, https://openalex.org/I2802466933, https://openalex.org/I4210087105, https://openalex.org/I4210116691, https://openalex.org/I87048295, https://openalex.org/I90344618 |
| authorships[8].institutions[1].country_code | GB |
| authorships[8].institutions[1].display_name | Wellcome/MRC Institute of Metabolic Science |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Albert Koulman |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Core Metabolomics and Lipidomics Laboratory, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Addenbrooke’s Treatment Centre, Keith Day Road, Cambridge, CB2 0QQ, United Kingdom |
| authorships[9].author.id | https://openalex.org/A5061727484 |
| authorships[9].author.orcid | https://orcid.org/0000-0002-1684-5783 |
| authorships[9].author.display_name | Marika Charalambous |
| authorships[9].countries | GB |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I183935753 |
| authorships[9].affiliations[0].raw_affiliation_string | Department of Medical and Molecular Genetics, Faculty of Life Sciences and Medicine, King's College London, London SE9RT, UK |
| authorships[9].institutions[0].id | https://openalex.org/I183935753 |
| authorships[9].institutions[0].ror | https://ror.org/0220mzb33 |
| authorships[9].institutions[0].type | education |
| authorships[9].institutions[0].lineage | https://openalex.org/I124357947, https://openalex.org/I183935753 |
| authorships[9].institutions[0].country_code | GB |
| authorships[9].institutions[0].display_name | King's College London |
| authorships[9].author_position | last |
| authorships[9].raw_author_name | Marika Charalambous |
| authorships[9].is_corresponding | True |
| authorships[9].raw_affiliation_strings | Department of Medical and Molecular Genetics, Faculty of Life Sciences and Medicine, King's College London, London SE9RT, UK |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.biorxiv.org/content/biorxiv/early/2023/06/26/2023.06.23.546226.full.pdf |
| open_access.oa_status | green |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | A co-ordinated transcriptional programme in the maternal liver supplies LC-PUFAs to the conceptus using phospholipids |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10387 |
| primary_topic.field.id | https://openalex.org/fields/29 |
| primary_topic.field.display_name | Nursing |
| primary_topic.score | 0.9994000196456909 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2916 |
| primary_topic.subfield.display_name | Nutrition and Dietetics |
| primary_topic.display_name | Fatty Acid Research and Health |
| related_works | https://openalex.org/W4240986578, https://openalex.org/W2043509413, https://openalex.org/W2044789233, https://openalex.org/W2096478635, https://openalex.org/W2168330912, https://openalex.org/W841506460, https://openalex.org/W4250877912, https://openalex.org/W2438648501, https://openalex.org/W2037456043, https://openalex.org/W2988479009 |
| cited_by_count | 1 |
| counts_by_year[0].year | 2024 |
| counts_by_year[0].cited_by_count | 1 |
| locations_count | 1 |
| best_oa_location.id | doi:10.1101/2023.06.23.546226 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4306402567 |
| best_oa_location.source.issn | |
| best_oa_location.source.type | repository |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | |
| best_oa_location.source.is_core | False |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| best_oa_location.source.host_organization | https://openalex.org/I2750212522 |
| best_oa_location.source.host_organization_name | Cold Spring Harbor Laboratory |
| best_oa_location.source.host_organization_lineage | https://openalex.org/I2750212522 |
| best_oa_location.license | |
| best_oa_location.pdf_url | https://www.biorxiv.org/content/biorxiv/early/2023/06/26/2023.06.23.546226.full.pdf |
| best_oa_location.version | acceptedVersion |
| best_oa_location.raw_type | posted-content |
| best_oa_location.license_id | |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | False |
| best_oa_location.raw_source_name | |
| best_oa_location.landing_page_url | https://doi.org/10.1101/2023.06.23.546226 |
| primary_location.id | doi:10.1101/2023.06.23.546226 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S4306402567 |
| primary_location.source.issn | |
| primary_location.source.type | repository |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | |
| primary_location.source.is_core | False |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| primary_location.source.host_organization | https://openalex.org/I2750212522 |
| primary_location.source.host_organization_name | Cold Spring Harbor Laboratory |
| primary_location.source.host_organization_lineage | https://openalex.org/I2750212522 |
| primary_location.license | |
| primary_location.pdf_url | https://www.biorxiv.org/content/biorxiv/early/2023/06/26/2023.06.23.546226.full.pdf |
| primary_location.version | acceptedVersion |
| primary_location.raw_type | posted-content |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | False |
| primary_location.raw_source_name | |
| primary_location.landing_page_url | https://doi.org/10.1101/2023.06.23.546226 |
| publication_date | 2023-06-26 |
| publication_year | 2023 |
| referenced_works | https://openalex.org/W2062955339, https://openalex.org/W2055861509, https://openalex.org/W2050546960, https://openalex.org/W2538057510, https://openalex.org/W2125231020, https://openalex.org/W2116032027, https://openalex.org/W2116216619, https://openalex.org/W414781422, https://openalex.org/W2333503488, https://openalex.org/W2024698600, https://openalex.org/W2039819485, https://openalex.org/W2020925755, https://openalex.org/W2080036080, https://openalex.org/W2275280366, https://openalex.org/W3002617563, https://openalex.org/W2972431421, https://openalex.org/W1992789367, https://openalex.org/W1982555544, https://openalex.org/W2769212953, https://openalex.org/W3175383244, https://openalex.org/W3009084246, https://openalex.org/W3183386301, https://openalex.org/W2921045044, https://openalex.org/W2049271632, https://openalex.org/W2029958712, https://openalex.org/W1976336399, https://openalex.org/W2170150986, https://openalex.org/W1966556984, https://openalex.org/W3197559361, https://openalex.org/W2792487685, https://openalex.org/W2345356016, https://openalex.org/W2607111863, https://openalex.org/W2203265731, https://openalex.org/W2164678700, https://openalex.org/W2400784246, https://openalex.org/W2124282499, https://openalex.org/W2170672900, https://openalex.org/W2939784913, https://openalex.org/W3190845296, https://openalex.org/W2903000141, https://openalex.org/W2620664270, https://openalex.org/W2149251767, https://openalex.org/W2103155798, https://openalex.org/W2118528443, https://openalex.org/W2998827413, https://openalex.org/W2017543661, https://openalex.org/W2620565698, https://openalex.org/W3080132584, https://openalex.org/W1493647971, https://openalex.org/W1922312836, https://openalex.org/W2115443997, https://openalex.org/W2107663617, https://openalex.org/W2119194937, https://openalex.org/W2945434279, https://openalex.org/W1974083452, https://openalex.org/W2095777272, https://openalex.org/W2095050768, https://openalex.org/W2100099848, https://openalex.org/W2256067245, https://openalex.org/W2113354535, https://openalex.org/W2092474731, https://openalex.org/W2351934060, https://openalex.org/W3005354871, https://openalex.org/W1766122222, https://openalex.org/W2055422490, https://openalex.org/W2027811513, https://openalex.org/W1912328835, https://openalex.org/W2147354409, https://openalex.org/W3194965264, https://openalex.org/W2003347868, https://openalex.org/W2808548053, https://openalex.org/W2063758999, https://openalex.org/W2011833777, https://openalex.org/W2911836560, https://openalex.org/W3104463060, https://openalex.org/W2018289634, https://openalex.org/W3085140048, https://openalex.org/W3178341171, https://openalex.org/W2924428359, https://openalex.org/W2803664483, https://openalex.org/W1967975652, https://openalex.org/W1982359478, https://openalex.org/W2079264385, https://openalex.org/W2100481760, https://openalex.org/W2159921310 |
| referenced_works_count | 85 |
| abstract_inverted_index.X | 107 |
| abstract_inverted_index.a | 99 |
| abstract_inverted_index.We | 97 |
| abstract_inverted_index.by | 21, 133 |
| abstract_inverted_index.in | 127 |
| abstract_inverted_index.is | 31, 48 |
| abstract_inverted_index.of | 67, 78, 104, 116, 124, 147 |
| abstract_inverted_index.to | 24, 28, 50, 84, 90, 93 |
| abstract_inverted_index.we | 71 |
| abstract_inverted_index.EFA | 61 |
| abstract_inverted_index.and | 5, 10, 39, 63, 80 |
| abstract_inverted_index.are | 18 |
| abstract_inverted_index.for | 143 |
| abstract_inverted_index.new | 140 |
| abstract_inverted_index.our | 137 |
| abstract_inverted_index.the | 8, 22, 25, 64, 86, 94, 105, 128, 134 |
| abstract_inverted_index.EFAs | 30 |
| abstract_inverted_index.Here | 70 |
| abstract_inverted_index.late | 100 |
| abstract_inverted_index.long | 9, 12 |
| abstract_inverted_index.this | 125 |
| abstract_inverted_index.very | 11 |
| abstract_inverted_index.with | 34, 75 |
| abstract_inverted_index.work | 138 |
| abstract_inverted_index.Liver | 106 |
| abstract_inverted_index.acids | 3, 16 |
| abstract_inverted_index.chain | 13 |
| abstract_inverted_index.fatty | 2, 15 |
| abstract_inverted_index.fetal | 36 |
| abstract_inverted_index.their | 6 |
| abstract_inverted_index.these | 53, 148 |
| abstract_inverted_index.which | 111 |
| abstract_inverted_index.(EFAs) | 4 |
| abstract_inverted_index.during | 46 |
| abstract_inverted_index.fetus. | 26, 96, 135 |
| abstract_inverted_index.growth | 37 |
| abstract_inverted_index.intake | 62 |
| abstract_inverted_index.linked | 33 |
| abstract_inverted_index.models | 83 |
| abstract_inverted_index.mother | 23, 129 |
| abstract_inverted_index.murine | 82 |
| abstract_inverted_index.simply | 51 |
| abstract_inverted_index.supply | 29, 115 |
| abstract_inverted_index.unable | 49 |
| abstract_inverted_index.within | 118 |
| abstract_inverted_index.Failure | 27 |
| abstract_inverted_index.LC-PUFA | 131 |
| abstract_inverted_index.Overall | 136 |
| abstract_inverted_index.between | 59 |
| abstract_inverted_index.combine | 72 |
| abstract_inverted_index.dietary | 44, 60 |
| abstract_inverted_index.genetic | 122 |
| abstract_inverted_index.healthy | 79 |
| abstract_inverted_index.lipids. | 150 |
| abstract_inverted_index.pathway | 110, 126 |
| abstract_inverted_index.provide | 91 |
| abstract_inverted_index.reduced | 130 |
| abstract_inverted_index.reverse | 52 |
| abstract_inverted_index.supply. | 69 |
| abstract_inverted_index.ABSTRACT | 0 |
| abstract_inverted_index.However, | 43 |
| abstract_inverted_index.LC-PUFAs | 92, 117 |
| abstract_inverted_index.Receptor | 108 |
| abstract_inverted_index.ablation | 123 |
| abstract_inverted_index.impaired | 40 |
| abstract_inverted_index.maternal | 68, 87, 114 |
| abstract_inverted_index.required | 89 |
| abstract_inverted_index.strongly | 32 |
| abstract_inverted_index.suggests | 139 |
| abstract_inverted_index.transfer | 146 |
| abstract_inverted_index.Essential | 1 |
| abstract_inverted_index.important | 149 |
| abstract_inverted_index.improving | 144 |
| abstract_inverted_index.increases | 113 |
| abstract_inverted_index.molecular | 65, 141 |
| abstract_inverted_index.outcomes, | 54 |
| abstract_inverted_index.outcomes. | 42 |
| abstract_inverted_index.pregnancy | 47 |
| abstract_inverted_index.profiling | 77 |
| abstract_inverted_index.selective | 102 |
| abstract_inverted_index.Crucially, | 121 |
| abstract_inverted_index.activation | 103 |
| abstract_inverted_index.developing | 95 |
| abstract_inverted_index.discovered | 98 |
| abstract_inverted_index.lipidomics | 74 |
| abstract_inverted_index.mechanisms | 66 |
| abstract_inverted_index.signalling | 109 |
| abstract_inverted_index.strategies | 142 |
| abstract_inverted_index.suggesting | 55 |
| abstract_inverted_index.understand | 85 |
| abstract_inverted_index.understood | 57 |
| abstract_inverted_index.untargeted | 73 |
| abstract_inverted_index.(LC-PUFAs), | 17 |
| abstract_inverted_index.adaptations | 88 |
| abstract_inverted_index.circulating | 119 |
| abstract_inverted_index.imperfectly | 56 |
| abstract_inverted_index.stillbirth, | 35 |
| abstract_inverted_index.transported | 20 |
| abstract_inverted_index.accumulation | 132 |
| abstract_inverted_index.derivatives, | 7 |
| abstract_inverted_index.dramatically | 112 |
| abstract_inverted_index.interactions | 58 |
| abstract_inverted_index.restriction, | 38 |
| abstract_inverted_index.maternal-fetal | 145 |
| abstract_inverted_index.phospholipids. | 120 |
| abstract_inverted_index.preferentially | 19 |
| abstract_inverted_index.polyunsaturated | 14 |
| abstract_inverted_index.supplementation | 45 |
| abstract_inverted_index.transcriptional | 76 |
| abstract_inverted_index.neurodevelopmental | 41 |
| abstract_inverted_index.pregnancy-specific, | 101 |
| abstract_inverted_index.genetically-manipulated | 81 |
| cited_by_percentile_year.max | 94 |
| cited_by_percentile_year.min | 90 |
| corresponding_author_ids | https://openalex.org/A5061727484 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 10 |
| corresponding_institution_ids | https://openalex.org/I183935753 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7099999785423279 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.48924192 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |