A common spectrum underlying brain disorders across lifespan revealed by deep learning on brain networks Article Swipe
Mianxin Liu
,
Jingyang Zhang
,
Yao Wang
,
Yan Zhou
,
Fang Xie
,
Qihao Guo
,
Feng Shi
,
Han Zhang
,
Qian Wang
,
Dinggang Shen
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1016/j.isci.2023.108244
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1016/j.isci.2023.108244
Brain disorders in the early and late life of humans potentially share pathological alterations in brain functions. However, the key neuroimaging evidence remains unrevealed for elucidating such commonness and the relationships among these disorders. To explore this puzzle, we build a restricted single-branch deep learning model, using multi-site functional magnetic resonance imaging data (N = 4,410, 6 sites), for classifying 5 different early- and late-life brain disorders from healthy controls (cognitively unimpaired). Our model achieves 62.6 1.9% overall classification accuracy and thus supports us in detecting a set of commonly affected functional subnetworks, including default mode, executive control, visual, and limbic networks. In the deep-layer representation of data, we observe young and aging patients with disorders are continuously distributed, which is in line with the clinical concept of the "spectrum of disorders." The relationships among brain disorders from the revealed spectrum promote the understanding of disorder comorbidities and time associations in the lifespan.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.isci.2023.108244
- OA Status
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- Cited By
- 4
- References
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- Related Works
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- OpenAlex ID
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Raw OpenAlex JSON
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https://openalex.org/W4387740460Canonical identifier for this work in OpenAlex
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https://doi.org/10.1016/j.isci.2023.108244Digital Object Identifier
- Title
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A common spectrum underlying brain disorders across lifespan revealed by deep learning on brain networksWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-10-18Full publication date if available
- Authors
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Mianxin Liu, Jingyang Zhang, Yao Wang, Yan Zhou, Fang Xie, Qihao Guo, Feng Shi, Han Zhang, Qian Wang, Dinggang ShenList of authors in order
- Landing page
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https://doi.org/10.1016/j.isci.2023.108244Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.1016/j.isci.2023.108244Direct OA link when available
- Concepts
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Neuroimaging, Default mode network, Neuroscience, Functional magnetic resonance imaging, Brain aging, Functional connectivity, Psychology, Medicine, Cognitive psychology, CognitionTop concepts (fields/topics) attached by OpenAlex
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4Total citation count in OpenAlex
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2025: 2, 2024: 2Per-year citation counts (last 5 years)
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80Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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