A complex relation between levels of adult hippocampal neurogenesis and expression of the immature neuron marker doublecortin Article Swipe
Indira Mendez‐David
,
Denis J. David
,
Claudine Deloménie
,
Laurent Tritschler
,
Jean‐Martin Beaulieu
,
Romain Colle
,
Emmanuelle Corruble
,
Alain M. Gardier
,
René Hen
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1002/hipo.23568
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1002/hipo.23568
We investigated the mechanisms underlying the effects of the antidepressant fluoxetine on behavior and adult hippocampal neurogenesis (AHN). After confirming our earlier report that the signaling molecule β‐arrestin‐2 (β‐Arr2) is required for the antidepressant‐like effects of fluoxetine, we found that the effects of fluoxetine on proliferation of neural progenitors and survival of adult‐born granule cells are absent in the β‐Arr2 knockout (KO) mice. To our surprise, fluoxetine induced a dramatic upregulation of the number of doublecortin (DCX)‐expressing cells in the β‐Arr2 KO mice, indicating that this marker can be increased even though AHN is not. We discovered two other conditions where a complex relationship occurs between the number of DCX‐expressing cells compared to levels of AHN: a chronic antidepressant model where DCX is upregulated and an inflammation model where DCX is downregulated. We concluded that assessing the number of DCX‐expressing cells alone to quantify levels of AHN can be complex and that caution should be applied when label retention techniques are unavailable.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/hipo.23568
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hipo.23568
- OA Status
- hybrid
- Cited By
- 12
- References
- 77
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4383621603
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- OpenAlex ID
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https://openalex.org/W4383621603Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1002/hipo.23568Digital Object Identifier
- Title
-
A complex relation between levels of adult hippocampal neurogenesis and expression of the immature neuron marker doublecortinWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-07-08Full publication date if available
- Authors
-
Indira Mendez‐David, Denis J. David, Claudine Deloménie, Laurent Tritschler, Jean‐Martin Beaulieu, Romain Colle, Emmanuelle Corruble, Alain M. Gardier, René HenList of authors in order
- Landing page
-
https://doi.org/10.1002/hipo.23568Publisher landing page
- PDF URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hipo.23568Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hipo.23568Direct OA link when available
- Concepts
-
Doublecortin, Neurogenesis, Hippocampal formation, Fluoxetine, Downregulation and upregulation, Neuroscience, Gene knockdown, Antidepressant, Progenitor cell, Biology, Hippocampus, Cell biology, Dentate gyrus, Internal medicine, Stem cell, Serotonin, Medicine, Cell culture, Receptor, Genetics, Biochemistry, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
12Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 6, 2024: 3, 2021: 1, 2020: 2Per-year citation counts (last 5 years)
- References (count)
-
77Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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