A comprehensive antigen-antibody complex database unlocking insights into interaction interface Article Swipe
Yuwei Zhou
,
Wenwen Liu
,
Ziru Huang
,
Yushu Gou
,
Siqi Liu
,
Lixu Jiang
,
Yue Yang
,
Jian Huang
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.7554/elife.104934
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.7554/elife.104934
Antibodies are critical components of the vertebrate immune system and possess a wide array of biomedical applications. Elucidating the complex interactions between antibodies and antigens is an important step in drug development. However, the complex and vast nature of the data presents significant challenges in accurately identifying and comprehending these interactions. To overcome these challenges and deepen our understanding of the antibody-antigen interface, we developed the Antigen-Antibody Complex Database (AACDB). The current version provides a comprehensive collection of 7498 manually processed antigen-antibody complexes, ensuring accuracy and detail. This database provides extensive metadata and rectifies annotation errors found in the PDB database. Furthermore, it integrates data on antibody developability and antigen-drug target relationships, making it valuable for assisting new antibody therapies development. Notably, the database includes comprehensive paratope and epitope annotation information, thereby serving as a valuable benchmark for immunoinformatics research. The AACDB interface is designed to be user-friendly, providing researchers with powerful search and visualization tools that enable effortless querying, manipulation, and visualization of complex data. Researchers can access AACDB completely online at http://i.uestc.edu.cn/AACDB . Regular updates are promised to ensure the timely provision of scientific and valuable information.
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Metadata
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- Language
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- Landing Page
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- OA Status
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- Cited By
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- Related Works
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4406731637Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.7554/elife.104934Digital Object Identifier
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A comprehensive antigen-antibody complex database unlocking insights into interaction interfaceWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-01-22Full publication date if available
- Authors
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Yuwei Zhou, Wenwen Liu, Ziru Huang, Yushu Gou, Siqi Liu, Lixu Jiang, Yue Yang, Jian HuangList of authors in order
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https://doi.org/10.7554/elife.104934Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.7554/elife.104934Direct OA link when available
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Interface (matter), Database, Computer science, Operating system, Bubble, Maximum bubble pressure methodTop concepts (fields/topics) attached by OpenAlex
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3Total citation count in OpenAlex
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2025: 3Per-year citation counts (last 5 years)
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31Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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