A Comprehensive Exploration of the Biological Effects of Adipose-Derived Stem Cells in the Treatment of Systemic Sclerosis Article Swipe
Gabriele Storti
,
Riccardo Foti
,
Roberta Foti
,
Marco Palmesano
,
Martina Patacchiola
,
Dalila Incognito
,
G Cervelli
,
Benedetto Longo
,
Maria Giovanna Scioli
,
Elena Fiorelli
,
Sonia Terriaca
,
Andrea Lisa
,
Bong‐Sung Kim
,
Augusto Orlandi
,
Valerio Cervelli
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/cells14060458
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/cells14060458
Systemic sclerosis (SSc) is a complex autoimmune disease characterized by vasculopathy and tissue fibrosis affecting the skin and internal organs. Genetic and environmental factors influence susceptibility, severity, and onset. Current treatments are limited and not always effective, leading researchers to investigate new approaches, such as the use of adipose-derived mesenchymal stem cells (ADSCs) through fat grafting. This review seeks to understand how ADSCs may impact the development and progression of SSc, with a particular focus on how these cells could alter immune responses and reduce fibrosis. ADSCs have been found to affect various immune cells, including T cells, B cells, macrophages, and dendritic cells, by releasing cytokines, chemokines, and growth factors. These interactions generally suppress inflammation and promote a regulatory immune environment. Additionally, ADSCs can influence the extracellular matrix, helping to prevent fibrosis through signaling molecules like exosomes. ADSCs show promise as a treatment for SSc due to their ability to modulate the immune system and reduce fibrosis. Early clinical studies are encouraging, but more research is needed to fully understand how they work and to develop effective treatment protocols.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3390/cells14060458
- https://www.mdpi.com/2073-4409/14/6/458/pdf?version=1742393787
- OA Status
- gold
- Cited By
- 1
- References
- 93
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4408646568
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4408646568Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/cells14060458Digital Object Identifier
- Title
-
A Comprehensive Exploration of the Biological Effects of Adipose-Derived Stem Cells in the Treatment of Systemic SclerosisWork title
- Type
-
reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-03-19Full publication date if available
- Authors
-
Gabriele Storti, Riccardo Foti, Roberta Foti, Marco Palmesano, Martina Patacchiola, Dalila Incognito, G Cervelli, Benedetto Longo, Maria Giovanna Scioli, Elena Fiorelli, Sonia Terriaca, Andrea Lisa, Bong‐Sung Kim, Augusto Orlandi, Valerio CervelliList of authors in order
- Landing page
-
https://doi.org/10.3390/cells14060458Publisher landing page
- PDF URL
-
https://www.mdpi.com/2073-4409/14/6/458/pdf?version=1742393787Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/2073-4409/14/6/458/pdf?version=1742393787Direct OA link when available
- Concepts
-
Immune system, Fibrosis, Microvesicles, Mesenchymal stem cell, Stem cell, Adipose tissue, Chemokine, Immunology, Extracellular matrix, Inflammation, Medicine, Biology, Cell biology, Pathology, Internal medicine, microRNA, Biochemistry, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1Per-year citation counts (last 5 years)
- References (count)
-
93Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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