A Comprehensive Self-Management Program With Diet Education Does Not Alter Microbiome Characteristics in Women With Irritable Bowel Syndrome Article Swipe
Kendra Kamp
,
Anna Plantinga
,
Kevin C. Cain
,
Robert L. Burr
,
Pamela Barney
,
Monica Jarrett
,
Ruth Ann Luna
,
Tor Savidge
,
Robert J. Shulman
,
Margaret Heitkemper
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1177/1099800420984543
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1177/1099800420984543
Background and Purpose: Changes in diet and lifestyle factors are frequently recommended for persons with irritable bowel syndrome (IBS). It is unknown whether these recommendations alter the gut microbiome and/or whether baseline microbiome predicts improvement in symptoms and quality of life following treatment. Therefore, the purpose of this study was to explore if baseline gut microbiome composition predicted response to a Comprehensive Self-Management (CSM) intervention and if the intervention resulted in a different gut microbiome composition compared to usual care. Methods: Individuals aged 18–70 years with IBS symptoms ≥6 months were recruited using convenience sampling. Individuals were excluded if medication use or comorbidities would influence symptoms or microbiome. Participants completed a baseline assessment and were randomized into the eight-session CSM intervention which included dietary education and cognitive behavioral therapy versus usual care. Questionnaires included demographics, quality of life, and symptom diaries. Fecal samples were collected at baseline and 3-month post-randomization for 16S rRNA-based microbiome analysis. Results: Within the CSM intervention group (n = 30), Shannon diversity, richness, and beta diversity measures at baseline did not predict benefit from the CSM intervention at 3 months, as measured by change in abdominal pain and quality of life. Based on both alpha and beta diversity, the change from baseline to follow-up microbiome bacterial taxa did not differ between CSM (n = 25) and usual care (n = 25). Conclusions and Inferences: Baseline microbiome does not predict symptom improvement with CSM intervention. We do not find evidence that the CSM intervention influences gut microbiome diversity or composition over the course of 3 months.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1177/1099800420984543
- OA Status
- green
- Cited By
- 4
- References
- 52
- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3120900547Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1177/1099800420984543Digital Object Identifier
- Title
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A Comprehensive Self-Management Program With Diet Education Does Not Alter Microbiome Characteristics in Women With Irritable Bowel SyndromeWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-01-08Full publication date if available
- Authors
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Kendra Kamp, Anna Plantinga, Kevin C. Cain, Robert L. Burr, Pamela Barney, Monica Jarrett, Ruth Ann Luna, Tor Savidge, Robert J. Shulman, Margaret HeitkemperList of authors in order
- Landing page
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https://doi.org/10.1177/1099800420984543Publisher landing page
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YesWhether a free full text is available
- OA status
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greenOpen access status per OpenAlex
- OA URL
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https://www.ncbi.nlm.nih.gov/pmc/articles/8755949Direct OA link when available
- Concepts
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Irritable bowel syndrome, Microbiome, Medicine, Intestinal Microbiome, Internal medicine, Psychology, Intensive care medicine, Bioinformatics, BiologyTop concepts (fields/topics) attached by OpenAlex
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4Total citation count in OpenAlex
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2025: 1, 2024: 1, 2022: 1, 2021: 1Per-year citation counts (last 5 years)
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52Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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