A constitutive active allele of the transcription factor Msn2 mimicking low PKA activity dictates metabolic remodeling in yeast Article Swipe
Vera Pfanzagl
,
Wolfram Görner
,
Martin Radolf
,
Alexandra Parich
,
Rainer Schuhmacher
,
Joseph Strauss
,
Wolfgang Reiter
,
Christoph Schüller
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1091/mbc.e18-06-0389
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1091/mbc.e18-06-0389
In yeast, protein kinase A (PKA) adjusts transcriptional profiles, metabolic rates, and cell growth in accord with carbon source availability. PKA affects gene expression mostly via the transcription factors Msn2 and Msn4, two key regulators of the environmental stress response. Here we analyze the role of the PKA-Msn2 signaling module using an Msn2 allele that harbors serine-to-alanine substitutions at six functionally important PKA motifs (Msn2A6) . Expression of Msn2A6 mimics low PKA activity, entails a transcription profile similar to that of respiring cells, and prevents formation of colonies on glucose-containing medium. Furthermore, Msn2A6 leads to high oxygen consumption and hence high respiratory activity. Substantially increased intracellular concentrations of several carbon metabolites, such as trehalose, point to a metabolic adjustment similar to diauxic shift. This partial metabolic switch is the likely cause for the slow-growth phenotype in the presence of glucose. Consistently, Msn2A6 expression does not interfere with growth on ethanol and tolerated is to a limited degree in deletion mutant strains with a gene expression signature corresponding to nonfermentative growth. We propose that the lethality observed in mutants with hampered PKA activity resides in metabolic reprogramming that is initiated by Msn2 hyperactivity.
Related Topics
Concepts
Biology
Transcription factor
Mutant
Protein kinase A
Biochemistry
Cell biology
Gene expression
Yeast
Saccharomyces cerevisiae
Intracellular
Gene
GATA transcription factor
Phenotype
Kinase
Promoter
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1091/mbc.e18-06-0389
- OA Status
- green
- Cited By
- 27
- References
- 86
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2892757564
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2892757564Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1091/mbc.e18-06-0389Digital Object Identifier
- Title
-
A constitutive active allele of the transcription factor Msn2 mimicking low PKA activity dictates metabolic remodeling in yeastWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2018Year of publication
- Publication date
-
2018-09-26Full publication date if available
- Authors
-
Vera Pfanzagl, Wolfram Görner, Martin Radolf, Alexandra Parich, Rainer Schuhmacher, Joseph Strauss, Wolfgang Reiter, Christoph SchüllerList of authors in order
- Landing page
-
https://doi.org/10.1091/mbc.e18-06-0389Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
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https://www.ncbi.nlm.nih.gov/pmc/articles/6249869Direct OA link when available
- Concepts
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Biology, Transcription factor, Mutant, Protein kinase A, Biochemistry, Cell biology, Gene expression, Yeast, Saccharomyces cerevisiae, Intracellular, Gene, GATA transcription factor, Phenotype, Kinase, PromoterTop concepts (fields/topics) attached by OpenAlex
- Cited by
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27Total citation count in OpenAlex
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2025: 5, 2024: 2, 2023: 3, 2022: 10, 2021: 2Per-year citation counts (last 5 years)
- References (count)
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86Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.via | 25 |
| abstract_inverted_index.Here | 40 |
| abstract_inverted_index.Msn2 | 29, 52, 190 |
| abstract_inverted_index.This | 123 |
| abstract_inverted_index.cell | 12 |
| abstract_inverted_index.does | 143 |
| abstract_inverted_index.gene | 22, 163 |
| abstract_inverted_index.high | 95, 100 |
| abstract_inverted_index.role | 44 |
| abstract_inverted_index.such | 111 |
| abstract_inverted_index.that | 54, 79, 172, 186 |
| abstract_inverted_index.with | 16, 146, 161, 178 |
| abstract_inverted_index.(PKA) | 5 |
| abstract_inverted_index.Msn4, | 31 |
| abstract_inverted_index.cause | 130 |
| abstract_inverted_index.hence | 99 |
| abstract_inverted_index.leads | 93 |
| abstract_inverted_index.point | 114 |
| abstract_inverted_index.using | 50 |
| abstract_inverted_index.Msn2A6 | 68, 92, 141 |
| abstract_inverted_index.accord | 15 |
| abstract_inverted_index.allele | 53 |
| abstract_inverted_index.carbon | 17, 109 |
| abstract_inverted_index.cells, | 82 |
| abstract_inverted_index.degree | 156 |
| abstract_inverted_index.growth | 13, 147 |
| abstract_inverted_index.kinase | 3 |
| abstract_inverted_index.likely | 129 |
| abstract_inverted_index.mimics | 69 |
| abstract_inverted_index.module | 49 |
| abstract_inverted_index.mostly | 24 |
| abstract_inverted_index.motifs | 63 |
| abstract_inverted_index.mutant | 159 |
| abstract_inverted_index.oxygen | 96 |
| abstract_inverted_index.rates, | 10 |
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| abstract_inverted_index.stress | 38 |
| abstract_inverted_index.switch | 126 |
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| abstract_inverted_index.affects | 21 |
| abstract_inverted_index.analyze | 42 |
| abstract_inverted_index.diauxic | 121 |
| abstract_inverted_index.entails | 73 |
| abstract_inverted_index.ethanol | 149 |
| abstract_inverted_index.factors | 28 |
| abstract_inverted_index.growth. | 169 |
| abstract_inverted_index.harbors | 55 |
| abstract_inverted_index.limited | 155 |
| abstract_inverted_index.medium. | 90 |
| abstract_inverted_index.mutants | 177 |
| abstract_inverted_index.partial | 124 |
| abstract_inverted_index.profile | 76 |
| abstract_inverted_index.propose | 171 |
| abstract_inverted_index.protein | 2 |
| abstract_inverted_index.resides | 182 |
| abstract_inverted_index.several | 108 |
| abstract_inverted_index.similar | 77, 119 |
| abstract_inverted_index.strains | 160 |
| abstract_inverted_index.(Msn2A6) | 64 |
| abstract_inverted_index.PKA-Msn2 | 47 |
| abstract_inverted_index.activity | 181 |
| abstract_inverted_index.colonies | 87 |
| abstract_inverted_index.deletion | 158 |
| abstract_inverted_index.glucose. | 139 |
| abstract_inverted_index.hampered | 179 |
| abstract_inverted_index.observed | 175 |
| abstract_inverted_index.presence | 137 |
| abstract_inverted_index.prevents | 84 |
| abstract_inverted_index.activity, | 72 |
| abstract_inverted_index.activity. | 102 |
| abstract_inverted_index.formation | 85 |
| abstract_inverted_index.important | 61 |
| abstract_inverted_index.increased | 104 |
| abstract_inverted_index.initiated | 188 |
| abstract_inverted_index.interfere | 145 |
| abstract_inverted_index.lethality | 174 |
| abstract_inverted_index.metabolic | 9, 117, 125, 184 |
| abstract_inverted_index.phenotype | 134 |
| abstract_inverted_index.profiles, | 8 |
| abstract_inverted_index.respiring | 81 |
| abstract_inverted_index.response. | 39 |
| abstract_inverted_index.signaling | 48 |
| abstract_inverted_index.signature | 165 |
| abstract_inverted_index.tolerated | 151 |
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| abstract_inverted_index.adjustment | 118 |
| abstract_inverted_index.expression | 23, 142, 164 |
| abstract_inverted_index.regulators | 34 |
| abstract_inverted_index.trehalose, | 113 |
| abstract_inverted_index.consumption | 97 |
| abstract_inverted_index.respiratory | 101 |
| abstract_inverted_index.slow-growth | 133 |
| abstract_inverted_index.Furthermore, | 91 |
| abstract_inverted_index.functionally | 60 |
| abstract_inverted_index.metabolites, | 110 |
| abstract_inverted_index.Consistently, | 140 |
| abstract_inverted_index.Substantially | 103 |
| abstract_inverted_index.availability. | 19 |
| abstract_inverted_index.corresponding | 166 |
| abstract_inverted_index.environmental | 37 |
| abstract_inverted_index.intracellular | 105 |
| abstract_inverted_index.reprogramming | 185 |
| abstract_inverted_index.substitutions | 57 |
| abstract_inverted_index.transcription | 27, 75 |
| abstract_inverted_index.concentrations | 106 |
| abstract_inverted_index.hyperactivity. | 191 |
| abstract_inverted_index.nonfermentative | 168 |
| abstract_inverted_index.transcriptional | 7 |
| abstract_inverted_index.serine-to-alanine | 56 |
| abstract_inverted_index.glucose-containing | 89 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 93 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 8 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/6 |
| sustainable_development_goals[0].score | 0.5600000023841858 |
| sustainable_development_goals[0].display_name | Clean water and sanitation |
| citation_normalized_percentile.value | 0.69258026 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |