A Custom Mouthpiece With Lip Bumper for Osteoradionecrosis Risk Reduction After Carbon-Ion Radiation Therapy for Adenoid Cystic Carcinoma of the Lip Article Swipe
Hiroaki Ikawa
,
Masashi Koto
,
Daniel K. Ebner
,
Hirotoshi Takiyama
,
Makoto Shinoto
,
Akihiro Nomoto
,
Shigeru Yamada
,
Hiroshi Tsuji
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1016/j.adro.2022.101114
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1016/j.adro.2022.101114
Purpose A custom mouthpiece with lip bumper for carbon-ion radiotherapy (CIRT) of tumors of the lip was developed with the goal of reducing the incidental exposure of the maxilla. Methods and Materials The mouthpiece was manufactured using a thermoplastic ethylene-vinyl acetate copolymer. This was employed in a patient with primary adenoid cystic carcinoma of the right lip without invasion of the maxilla. To evaluate spacer utility, the volume of maxilla receiving more than 50 Gy (relative biological effectiveness, V50) with and without the spacer was calculated using dose-volume histogram (DVH) analysis in a simulation study and subsequently treated. Results In the simulation study, DVH analysis demonstrated a 46% dose reduction in the high-dose area of the maxilla with mouthpiece usage (V50 = 2.21 mL) compared to non-usage (V50 = 4.11 mL). The mouthpiece was well-tolerated. Eight years after CIRT, no late dermatitis, oral mucositis, or osteoradionecrosis was observed. Conclusions A custom-made mouthpiece with a lip bumper successfully reduced the incidental exposure of the maxilla during CIRT.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.adro.2022.101114
- OA Status
- gold
- Cited By
- 2
- References
- 21
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4307155704
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4307155704Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.adro.2022.101114Digital Object Identifier
- Title
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A Custom Mouthpiece With Lip Bumper for Osteoradionecrosis Risk Reduction After Carbon-Ion Radiation Therapy for Adenoid Cystic Carcinoma of the LipWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
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2022Year of publication
- Publication date
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2022-10-22Full publication date if available
- Authors
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Hiroaki Ikawa, Masashi Koto, Daniel K. Ebner, Hirotoshi Takiyama, Makoto Shinoto, Akihiro Nomoto, Shigeru Yamada, Hiroshi TsujiList of authors in order
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https://doi.org/10.1016/j.adro.2022.101114Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.1016/j.adro.2022.101114Direct OA link when available
- Concepts
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Medicine, Osteoradionecrosis, Adenoid cystic carcinoma, Mouthpiece, Radiation therapy, Reduction (mathematics), Radiology, Carcinoma, Dentistry, Pathology, Mathematics, GeometryTop concepts (fields/topics) attached by OpenAlex
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2Total citation count in OpenAlex
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2025: 1, 2023: 1Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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