A cytoplasmic chemoreceptor and Reactive Oxygen Species mediate bacterial chemotaxis to copper Article Swipe
Gwennaëlle Louis
,
Pauline Cherry
,
Catherine Michaux
,
Sophie Rahuel-Clermont
,
Marc Dieu
,
Françoise Tilquin
,
Laurens Maertens
,
Rob Van Houdt
,
Patricia Renard
,
Éric A. Perpète
,
Jean‐Yves Matroule
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1101/2022.06.29.497744
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1101/2022.06.29.497744
Chemotaxis is a widespread strategy used by unicellular and multicellular living organisms to maintain their fitness in stressful environments. We previously showed that bacteria can trigger a negative chemotactic response to a copper (Cu)-rich environment. Cu ions toxicity on bacterial cell physiology has been mainly linked to mismetallation events and ROS production, although the precise role of Cu-generated ROS remains largely debated. Here, we found that the cytoplasmic Cu ions content mirrors variations of the extracellular Cu ions concentration and triggers a dose-dependent oxidative stress, which can be abrogated by superoxide dismutase and catalase overexpression. The inhibition of ROS production in the cytoplasm not only improves bacterial growth but also impedes Cu-chemotaxis, indicating that ROS derived from cytoplasmic Cu ions mediate the control of bacterial chemotaxis to Cu. We also identified the Cu chemoreceptor McpR, which binds Cu ions with low affinity, suggesting a labile interaction. In addition, we demonstrate that the cysteine 75 and histidine 99 within the McpR sensor domain are key residues in Cu chemotaxis and Cu coordination. Finally, we discovered that in vitro both Cu(I) and Cu(II) ions modulate McpR conformation in a distinct manner. Overall, our study provides mechanistic insights on a redox-based control of Cu chemotaxis, indicating that the cellular redox status can play a key role in bacterial chemotaxis.
Related Topics
Concepts
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2022.06.29.497744
- https://www.biorxiv.org/content/biorxiv/early/2022/09/16/2022.06.29.497744.full.pdf
- OA Status
- green
- References
- 51
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4283729871
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4283729871Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1101/2022.06.29.497744Digital Object Identifier
- Title
-
A cytoplasmic chemoreceptor and Reactive Oxygen Species mediate bacterial chemotaxis to copperWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-06-29Full publication date if available
- Authors
-
Gwennaëlle Louis, Pauline Cherry, Catherine Michaux, Sophie Rahuel-Clermont, Marc Dieu, Françoise Tilquin, Laurens Maertens, Rob Van Houdt, Patricia Renard, Éric A. Perpète, Jean‐Yves MatrouleList of authors in order
- Landing page
-
https://doi.org/10.1101/2022.06.29.497744Publisher landing page
- PDF URL
-
https://www.biorxiv.org/content/biorxiv/early/2022/09/16/2022.06.29.497744.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.biorxiv.org/content/biorxiv/early/2022/09/16/2022.06.29.497744.full.pdfDirect OA link when available
- Concepts
-
Chemotaxis, Cytoplasm, Extracellular, Reactive oxygen species, Biochemistry, Superoxide dismutase, Redox, Cell biology, Catalase, Biophysics, Bacteria, Biology, Copper, Superoxide, Chemoreceptor, Chemistry, Oxidative stress, Receptor, Enzyme, Inorganic chemistry, Genetics, Organic chemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
51Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4283729871 |
|---|---|
| doi | https://doi.org/10.1101/2022.06.29.497744 |
| ids.doi | https://doi.org/10.1101/2022.06.29.497744 |
| ids.openalex | https://openalex.org/W4283729871 |
| fwci | 0.0 |
| type | preprint |
| title | A cytoplasmic chemoreceptor and Reactive Oxygen Species mediate bacterial chemotaxis to copper |
| biblio.issue | |
| biblio.volume | |
| biblio.last_page | |
| biblio.first_page | |
| topics[0].id | https://openalex.org/T10915 |
| topics[0].field.id | https://openalex.org/fields/29 |
| topics[0].field.display_name | Nursing |
| topics[0].score | 0.9976000189781189 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2916 |
| topics[0].subfield.display_name | Nutrition and Dietetics |
| topics[0].display_name | Trace Elements in Health |
| topics[1].id | https://openalex.org/T10593 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.9966999888420105 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1312 |
| topics[1].subfield.display_name | Molecular Biology |
| topics[1].display_name | Bacterial biofilms and quorum sensing |
| topics[2].id | https://openalex.org/T11684 |
| topics[2].field.id | https://openalex.org/fields/13 |
| topics[2].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[2].score | 0.9854999780654907 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1310 |
| topics[2].subfield.display_name | Endocrinology |
| topics[2].display_name | Vibrio bacteria research studies |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C54166955 |
| concepts[0].level | 3 |
| concepts[0].score | 0.9638805389404297 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q658145 |
| concepts[0].display_name | Chemotaxis |
| concepts[1].id | https://openalex.org/C190062978 |
| concepts[1].level | 2 |
| concepts[1].score | 0.6708698272705078 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q79899 |
| concepts[1].display_name | Cytoplasm |
| concepts[2].id | https://openalex.org/C28406088 |
| concepts[2].level | 2 |
| concepts[2].score | 0.6571210622787476 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q5571762 |
| concepts[2].display_name | Extracellular |
| concepts[3].id | https://openalex.org/C48349386 |
| concepts[3].level | 2 |
| concepts[3].score | 0.6198596358299255 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q424361 |
| concepts[3].display_name | Reactive oxygen species |
| concepts[4].id | https://openalex.org/C55493867 |
| concepts[4].level | 1 |
| concepts[4].score | 0.509000301361084 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[4].display_name | Biochemistry |
| concepts[5].id | https://openalex.org/C2775838275 |
| concepts[5].level | 3 |
| concepts[5].score | 0.5065723657608032 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q410776 |
| concepts[5].display_name | Superoxide dismutase |
| concepts[6].id | https://openalex.org/C55904794 |
| concepts[6].level | 2 |
| concepts[6].score | 0.4697169363498688 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q82682 |
| concepts[6].display_name | Redox |
| concepts[7].id | https://openalex.org/C95444343 |
| concepts[7].level | 1 |
| concepts[7].score | 0.46145758032798767 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q7141 |
| concepts[7].display_name | Cell biology |
| concepts[8].id | https://openalex.org/C2778979269 |
| concepts[8].level | 3 |
| concepts[8].score | 0.4561348557472229 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q106951292 |
| concepts[8].display_name | Catalase |
| concepts[9].id | https://openalex.org/C12554922 |
| concepts[9].level | 1 |
| concepts[9].score | 0.44980186223983765 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q7100 |
| concepts[9].display_name | Biophysics |
| concepts[10].id | https://openalex.org/C523546767 |
| concepts[10].level | 2 |
| concepts[10].score | 0.44529491662979126 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q10876 |
| concepts[10].display_name | Bacteria |
| concepts[11].id | https://openalex.org/C86803240 |
| concepts[11].level | 0 |
| concepts[11].score | 0.4357392489910126 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[11].display_name | Biology |
| concepts[12].id | https://openalex.org/C544778455 |
| concepts[12].level | 2 |
| concepts[12].score | 0.43525347113609314 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q753 |
| concepts[12].display_name | Copper |
| concepts[13].id | https://openalex.org/C2780795997 |
| concepts[13].level | 3 |
| concepts[13].score | 0.4317750930786133 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q413283 |
| concepts[13].display_name | Superoxide |
| concepts[14].id | https://openalex.org/C103247709 |
| concepts[14].level | 3 |
| concepts[14].score | 0.4305644631385803 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q1069641 |
| concepts[14].display_name | Chemoreceptor |
| concepts[15].id | https://openalex.org/C185592680 |
| concepts[15].level | 0 |
| concepts[15].score | 0.37931394577026367 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[15].display_name | Chemistry |
| concepts[16].id | https://openalex.org/C2776151105 |
| concepts[16].level | 2 |
| concepts[16].score | 0.2920304834842682 |
| concepts[16].wikidata | https://www.wikidata.org/wiki/Q898814 |
| concepts[16].display_name | Oxidative stress |
| concepts[17].id | https://openalex.org/C170493617 |
| concepts[17].level | 2 |
| concepts[17].score | 0.21853110194206238 |
| concepts[17].wikidata | https://www.wikidata.org/wiki/Q208467 |
| concepts[17].display_name | Receptor |
| concepts[18].id | https://openalex.org/C181199279 |
| concepts[18].level | 2 |
| concepts[18].score | 0.15096762776374817 |
| concepts[18].wikidata | https://www.wikidata.org/wiki/Q8047 |
| concepts[18].display_name | Enzyme |
| concepts[19].id | https://openalex.org/C179104552 |
| concepts[19].level | 1 |
| concepts[19].score | 0.08198320865631104 |
| concepts[19].wikidata | https://www.wikidata.org/wiki/Q11165 |
| concepts[19].display_name | Inorganic chemistry |
| concepts[20].id | https://openalex.org/C54355233 |
| concepts[20].level | 1 |
| concepts[20].score | 0.0 |
| concepts[20].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[20].display_name | Genetics |
| concepts[21].id | https://openalex.org/C178790620 |
| concepts[21].level | 1 |
| concepts[21].score | 0.0 |
| concepts[21].wikidata | https://www.wikidata.org/wiki/Q11351 |
| concepts[21].display_name | Organic chemistry |
| keywords[0].id | https://openalex.org/keywords/chemotaxis |
| keywords[0].score | 0.9638805389404297 |
| keywords[0].display_name | Chemotaxis |
| keywords[1].id | https://openalex.org/keywords/cytoplasm |
| keywords[1].score | 0.6708698272705078 |
| keywords[1].display_name | Cytoplasm |
| keywords[2].id | https://openalex.org/keywords/extracellular |
| keywords[2].score | 0.6571210622787476 |
| keywords[2].display_name | Extracellular |
| keywords[3].id | https://openalex.org/keywords/reactive-oxygen-species |
| keywords[3].score | 0.6198596358299255 |
| keywords[3].display_name | Reactive oxygen species |
| keywords[4].id | https://openalex.org/keywords/biochemistry |
| keywords[4].score | 0.509000301361084 |
| keywords[4].display_name | Biochemistry |
| keywords[5].id | https://openalex.org/keywords/superoxide-dismutase |
| keywords[5].score | 0.5065723657608032 |
| keywords[5].display_name | Superoxide dismutase |
| keywords[6].id | https://openalex.org/keywords/redox |
| keywords[6].score | 0.4697169363498688 |
| keywords[6].display_name | Redox |
| keywords[7].id | https://openalex.org/keywords/cell-biology |
| keywords[7].score | 0.46145758032798767 |
| keywords[7].display_name | Cell biology |
| keywords[8].id | https://openalex.org/keywords/catalase |
| keywords[8].score | 0.4561348557472229 |
| keywords[8].display_name | Catalase |
| keywords[9].id | https://openalex.org/keywords/biophysics |
| keywords[9].score | 0.44980186223983765 |
| keywords[9].display_name | Biophysics |
| keywords[10].id | https://openalex.org/keywords/bacteria |
| keywords[10].score | 0.44529491662979126 |
| keywords[10].display_name | Bacteria |
| keywords[11].id | https://openalex.org/keywords/biology |
| keywords[11].score | 0.4357392489910126 |
| keywords[11].display_name | Biology |
| keywords[12].id | https://openalex.org/keywords/copper |
| keywords[12].score | 0.43525347113609314 |
| keywords[12].display_name | Copper |
| keywords[13].id | https://openalex.org/keywords/superoxide |
| keywords[13].score | 0.4317750930786133 |
| keywords[13].display_name | Superoxide |
| keywords[14].id | https://openalex.org/keywords/chemoreceptor |
| keywords[14].score | 0.4305644631385803 |
| keywords[14].display_name | Chemoreceptor |
| keywords[15].id | https://openalex.org/keywords/chemistry |
| keywords[15].score | 0.37931394577026367 |
| keywords[15].display_name | Chemistry |
| keywords[16].id | https://openalex.org/keywords/oxidative-stress |
| keywords[16].score | 0.2920304834842682 |
| keywords[16].display_name | Oxidative stress |
| keywords[17].id | https://openalex.org/keywords/receptor |
| keywords[17].score | 0.21853110194206238 |
| keywords[17].display_name | Receptor |
| keywords[18].id | https://openalex.org/keywords/enzyme |
| keywords[18].score | 0.15096762776374817 |
| keywords[18].display_name | Enzyme |
| keywords[19].id | https://openalex.org/keywords/inorganic-chemistry |
| keywords[19].score | 0.08198320865631104 |
| keywords[19].display_name | Inorganic chemistry |
| language | en |
| locations[0].id | doi:10.1101/2022.06.29.497744 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S4306402567 |
| locations[0].source.issn | |
| locations[0].source.type | repository |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | |
| locations[0].source.is_core | False |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| locations[0].source.host_organization | https://openalex.org/I2750212522 |
| locations[0].source.host_organization_name | Cold Spring Harbor Laboratory |
| locations[0].source.host_organization_lineage | https://openalex.org/I2750212522 |
| locations[0].license | |
| locations[0].pdf_url | https://www.biorxiv.org/content/biorxiv/early/2022/09/16/2022.06.29.497744.full.pdf |
| locations[0].version | acceptedVersion |
| locations[0].raw_type | posted-content |
| locations[0].license_id | |
| locations[0].is_accepted | True |
| locations[0].is_published | False |
| locations[0].raw_source_name | |
| locations[0].landing_page_url | https://doi.org/10.1101/2022.06.29.497744 |
| indexed_in | crossref |
| authorships[0].author.id | https://openalex.org/A5040904374 |
| authorships[0].author.orcid | |
| authorships[0].author.display_name | Gwennaëlle Louis |
| authorships[0].countries | BE |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I149768937 |
| authorships[0].affiliations[0].raw_affiliation_string | Research Unit in Biology of Microorganisms (URBM), Department of Biology, Namur Research Institute for Life Sciences (NARILIS), University of Namur, Namur, Belgium |
| authorships[0].institutions[0].id | https://openalex.org/I149768937 |
| authorships[0].institutions[0].ror | https://ror.org/03d1maw17 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I149768937 |
| authorships[0].institutions[0].country_code | BE |
| authorships[0].institutions[0].display_name | University of Namur |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Gwennaëlle Louis |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Research Unit in Biology of Microorganisms (URBM), Department of Biology, Namur Research Institute for Life Sciences (NARILIS), University of Namur, Namur, Belgium |
| authorships[1].author.id | https://openalex.org/A5085773124 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Pauline Cherry |
| authorships[1].countries | BE |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I149768937 |
| authorships[1].affiliations[0].raw_affiliation_string | Research Unit in Biology of Microorganisms (URBM), Department of Biology, Namur Research Institute for Life Sciences (NARILIS), University of Namur, Namur, Belgium |
| authorships[1].institutions[0].id | https://openalex.org/I149768937 |
| authorships[1].institutions[0].ror | https://ror.org/03d1maw17 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I149768937 |
| authorships[1].institutions[0].country_code | BE |
| authorships[1].institutions[0].display_name | University of Namur |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Pauline Cherry |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Research Unit in Biology of Microorganisms (URBM), Department of Biology, Namur Research Institute for Life Sciences (NARILIS), University of Namur, Namur, Belgium |
| authorships[2].author.id | https://openalex.org/A5004240078 |
| authorships[2].author.orcid | https://orcid.org/0000-0001-8208-3310 |
| authorships[2].author.display_name | Catherine Michaux |
| authorships[2].countries | BE |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I149768937 |
| authorships[2].affiliations[0].raw_affiliation_string | Laboratoire de Chimie Physique des Biomolécules, Namur Research Institute for Life Sciences (NARILIS) and Namur Institute of Structured Matter (NISM), University of Namur, Rue de Bruxelles, 61, 5000 Namur, Belgium |
| authorships[2].institutions[0].id | https://openalex.org/I149768937 |
| authorships[2].institutions[0].ror | https://ror.org/03d1maw17 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I149768937 |
| authorships[2].institutions[0].country_code | BE |
| authorships[2].institutions[0].display_name | University of Namur |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Catherine Michaux |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Laboratoire de Chimie Physique des Biomolécules, Namur Research Institute for Life Sciences (NARILIS) and Namur Institute of Structured Matter (NISM), University of Namur, Rue de Bruxelles, 61, 5000 Namur, Belgium |
| authorships[3].author.id | https://openalex.org/A5024132307 |
| authorships[3].author.orcid | https://orcid.org/0000-0001-5143-0105 |
| authorships[3].author.display_name | Sophie Rahuel-Clermont |
| authorships[3].countries | FR |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I4210152866, https://openalex.org/I90183372, https://openalex.org/I1294671590 |
| authorships[3].affiliations[0].raw_affiliation_string | Université de Lorraine, CNRS, IMoPA, F-54000 Nancy, France |
| authorships[3].institutions[0].id | https://openalex.org/I1294671590 |
| authorships[3].institutions[0].ror | https://ror.org/02feahw73 |
| authorships[3].institutions[0].type | government |
| authorships[3].institutions[0].lineage | https://openalex.org/I1294671590 |
| authorships[3].institutions[0].country_code | FR |
| authorships[3].institutions[0].display_name | Centre National de la Recherche Scientifique |
| authorships[3].institutions[1].id | https://openalex.org/I4210152866 |
| authorships[3].institutions[1].ror | https://ror.org/04yc2e502 |
| authorships[3].institutions[1].type | facility |
| authorships[3].institutions[1].lineage | https://openalex.org/I1294671590, https://openalex.org/I1294671590, https://openalex.org/I4210095849, https://openalex.org/I4210100260, https://openalex.org/I4210152866, https://openalex.org/I90183372 |
| authorships[3].institutions[1].country_code | FR |
| authorships[3].institutions[1].display_name | Ingénierie Moléculaire et Physiopathologie Articulaire |
| authorships[3].institutions[2].id | https://openalex.org/I90183372 |
| authorships[3].institutions[2].ror | https://ror.org/04vfs2w97 |
| authorships[3].institutions[2].type | education |
| authorships[3].institutions[2].lineage | https://openalex.org/I90183372 |
| authorships[3].institutions[2].country_code | FR |
| authorships[3].institutions[2].display_name | Université de Lorraine |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Sophie Rahuel-Clermont |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Université de Lorraine, CNRS, IMoPA, F-54000 Nancy, France |
| authorships[4].author.id | https://openalex.org/A5050278423 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-3902-542X |
| authorships[4].author.display_name | Marc Dieu |
| authorships[4].countries | BE |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I149768937 |
| authorships[4].affiliations[0].raw_affiliation_string | MaSUN, Mass Spectrometry Facility, University of Namur, Namur, Belgium |
| authorships[4].institutions[0].id | https://openalex.org/I149768937 |
| authorships[4].institutions[0].ror | https://ror.org/03d1maw17 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I149768937 |
| authorships[4].institutions[0].country_code | BE |
| authorships[4].institutions[0].display_name | University of Namur |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Marc Dieu |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | MaSUN, Mass Spectrometry Facility, University of Namur, Namur, Belgium |
| authorships[5].author.id | https://openalex.org/A5064875796 |
| authorships[5].author.orcid | |
| authorships[5].author.display_name | Françoise Tilquin |
| authorships[5].countries | BE |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I149768937 |
| authorships[5].affiliations[0].raw_affiliation_string | Research Unit in Biology of Microorganisms (URBM), Department of Biology, Namur Research Institute for Life Sciences (NARILIS), University of Namur, Namur, Belgium |
| authorships[5].institutions[0].id | https://openalex.org/I149768937 |
| authorships[5].institutions[0].ror | https://ror.org/03d1maw17 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I149768937 |
| authorships[5].institutions[0].country_code | BE |
| authorships[5].institutions[0].display_name | University of Namur |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Françoise Tilquin |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Research Unit in Biology of Microorganisms (URBM), Department of Biology, Namur Research Institute for Life Sciences (NARILIS), University of Namur, Namur, Belgium |
| authorships[6].author.id | https://openalex.org/A5044630298 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-1909-572X |
| authorships[6].author.display_name | Laurens Maertens |
| authorships[6].countries | BE |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I4210114391 |
| authorships[6].affiliations[0].raw_affiliation_string | Microbiology Unit, Interdisciplinary Biosciences, Belgian Nuclear Research Centre (SCK CEN), 2400 Mol, Belgium |
| authorships[6].affiliations[1].institution_ids | https://openalex.org/I149768937 |
| authorships[6].affiliations[1].raw_affiliation_string | Research Unit in Biology of Microorganisms (URBM), Department of Biology, Namur Research Institute for Life Sciences (NARILIS), University of Namur, Namur, Belgium |
| authorships[6].institutions[0].id | https://openalex.org/I4210114391 |
| authorships[6].institutions[0].ror | https://ror.org/020xs5r81 |
| authorships[6].institutions[0].type | facility |
| authorships[6].institutions[0].lineage | https://openalex.org/I4210114391 |
| authorships[6].institutions[0].country_code | BE |
| authorships[6].institutions[0].display_name | Belgian Nuclear Research Centre |
| authorships[6].institutions[1].id | https://openalex.org/I149768937 |
| authorships[6].institutions[1].ror | https://ror.org/03d1maw17 |
| authorships[6].institutions[1].type | education |
| authorships[6].institutions[1].lineage | https://openalex.org/I149768937 |
| authorships[6].institutions[1].country_code | BE |
| authorships[6].institutions[1].display_name | University of Namur |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Laurens Maertens |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Microbiology Unit, Interdisciplinary Biosciences, Belgian Nuclear Research Centre (SCK CEN), 2400 Mol, Belgium, Research Unit in Biology of Microorganisms (URBM), Department of Biology, Namur Research Institute for Life Sciences (NARILIS), University of Namur, Namur, Belgium |
| authorships[7].author.id | https://openalex.org/A5057332959 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-7459-496X |
| authorships[7].author.display_name | Rob Van Houdt |
| authorships[7].countries | BE |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I4210114391 |
| authorships[7].affiliations[0].raw_affiliation_string | Microbiology Unit, Interdisciplinary Biosciences, Belgian Nuclear Research Centre (SCK CEN), 2400 Mol, Belgium |
| authorships[7].institutions[0].id | https://openalex.org/I4210114391 |
| authorships[7].institutions[0].ror | https://ror.org/020xs5r81 |
| authorships[7].institutions[0].type | facility |
| authorships[7].institutions[0].lineage | https://openalex.org/I4210114391 |
| authorships[7].institutions[0].country_code | BE |
| authorships[7].institutions[0].display_name | Belgian Nuclear Research Centre |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Rob Van Houdt |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Microbiology Unit, Interdisciplinary Biosciences, Belgian Nuclear Research Centre (SCK CEN), 2400 Mol, Belgium |
| authorships[8].author.id | https://openalex.org/A5034814853 |
| authorships[8].author.orcid | https://orcid.org/0000-0003-4144-3353 |
| authorships[8].author.display_name | Patricia Renard |
| authorships[8].countries | BE |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I149768937 |
| authorships[8].affiliations[0].raw_affiliation_string | MaSUN, Mass Spectrometry Facility, University of Namur, Namur, Belgium |
| authorships[8].institutions[0].id | https://openalex.org/I149768937 |
| authorships[8].institutions[0].ror | https://ror.org/03d1maw17 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I149768937 |
| authorships[8].institutions[0].country_code | BE |
| authorships[8].institutions[0].display_name | University of Namur |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Patricia Renard |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | MaSUN, Mass Spectrometry Facility, University of Namur, Namur, Belgium |
| authorships[9].author.id | https://openalex.org/A5111426118 |
| authorships[9].author.orcid | |
| authorships[9].author.display_name | Éric A. Perpète |
| authorships[9].countries | BE |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I149768937 |
| authorships[9].affiliations[0].raw_affiliation_string | Laboratoire de Chimie Physique des Biomolécules, Namur Research Institute for Life Sciences (NARILIS) and Namur Institute of Structured Matter (NISM), University of Namur, Rue de Bruxelles, 61, 5000 Namur, Belgium |
| authorships[9].institutions[0].id | https://openalex.org/I149768937 |
| authorships[9].institutions[0].ror | https://ror.org/03d1maw17 |
| authorships[9].institutions[0].type | education |
| authorships[9].institutions[0].lineage | https://openalex.org/I149768937 |
| authorships[9].institutions[0].country_code | BE |
| authorships[9].institutions[0].display_name | University of Namur |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Eric Perpete |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Laboratoire de Chimie Physique des Biomolécules, Namur Research Institute for Life Sciences (NARILIS) and Namur Institute of Structured Matter (NISM), University of Namur, Rue de Bruxelles, 61, 5000 Namur, Belgium |
| authorships[10].author.id | https://openalex.org/A5108598972 |
| authorships[10].author.orcid | https://orcid.org/0000-0002-0221-6580 |
| authorships[10].author.display_name | Jean‐Yves Matroule |
| authorships[10].countries | BE |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I149768937 |
| authorships[10].affiliations[0].raw_affiliation_string | Research Unit in Biology of Microorganisms (URBM), Department of Biology, Namur Research Institute for Life Sciences (NARILIS), University of Namur, Namur, Belgium |
| authorships[10].institutions[0].id | https://openalex.org/I149768937 |
| authorships[10].institutions[0].ror | https://ror.org/03d1maw17 |
| authorships[10].institutions[0].type | education |
| authorships[10].institutions[0].lineage | https://openalex.org/I149768937 |
| authorships[10].institutions[0].country_code | BE |
| authorships[10].institutions[0].display_name | University of Namur |
| authorships[10].author_position | last |
| authorships[10].raw_author_name | Jean-Yves Matroule |
| authorships[10].is_corresponding | True |
| authorships[10].raw_affiliation_strings | Research Unit in Biology of Microorganisms (URBM), Department of Biology, Namur Research Institute for Life Sciences (NARILIS), University of Namur, Namur, Belgium |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.biorxiv.org/content/biorxiv/early/2022/09/16/2022.06.29.497744.full.pdf |
| open_access.oa_status | green |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | A cytoplasmic chemoreceptor and Reactive Oxygen Species mediate bacterial chemotaxis to copper |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10915 |
| primary_topic.field.id | https://openalex.org/fields/29 |
| primary_topic.field.display_name | Nursing |
| primary_topic.score | 0.9976000189781189 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2916 |
| primary_topic.subfield.display_name | Nutrition and Dietetics |
| primary_topic.display_name | Trace Elements in Health |
| related_works | https://openalex.org/W1596865785, https://openalex.org/W2085357479, https://openalex.org/W2156804656, https://openalex.org/W2074324989, https://openalex.org/W2081917043, https://openalex.org/W2348520005, https://openalex.org/W4386887434, https://openalex.org/W4378783558, https://openalex.org/W1953847668, https://openalex.org/W1647427496 |
| cited_by_count | 0 |
| locations_count | 1 |
| best_oa_location.id | doi:10.1101/2022.06.29.497744 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4306402567 |
| best_oa_location.source.issn | |
| best_oa_location.source.type | repository |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | |
| best_oa_location.source.is_core | False |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| best_oa_location.source.host_organization | https://openalex.org/I2750212522 |
| best_oa_location.source.host_organization_name | Cold Spring Harbor Laboratory |
| best_oa_location.source.host_organization_lineage | https://openalex.org/I2750212522 |
| best_oa_location.license | |
| best_oa_location.pdf_url | https://www.biorxiv.org/content/biorxiv/early/2022/09/16/2022.06.29.497744.full.pdf |
| best_oa_location.version | acceptedVersion |
| best_oa_location.raw_type | posted-content |
| best_oa_location.license_id | |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | False |
| best_oa_location.raw_source_name | |
| best_oa_location.landing_page_url | https://doi.org/10.1101/2022.06.29.497744 |
| primary_location.id | doi:10.1101/2022.06.29.497744 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S4306402567 |
| primary_location.source.issn | |
| primary_location.source.type | repository |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | |
| primary_location.source.is_core | False |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| primary_location.source.host_organization | https://openalex.org/I2750212522 |
| primary_location.source.host_organization_name | Cold Spring Harbor Laboratory |
| primary_location.source.host_organization_lineage | https://openalex.org/I2750212522 |
| primary_location.license | |
| primary_location.pdf_url | https://www.biorxiv.org/content/biorxiv/early/2022/09/16/2022.06.29.497744.full.pdf |
| primary_location.version | acceptedVersion |
| primary_location.raw_type | posted-content |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | False |
| primary_location.raw_source_name | |
| primary_location.landing_page_url | https://doi.org/10.1101/2022.06.29.497744 |
| publication_date | 2022-06-29 |
| publication_year | 2022 |
| referenced_works | https://openalex.org/W2064441783, https://openalex.org/W2805617375, https://openalex.org/W2038234011, https://openalex.org/W2023527025, https://openalex.org/W1940238873, https://openalex.org/W2021933010, https://openalex.org/W2025570065, https://openalex.org/W4283837136, https://openalex.org/W2074279517, https://openalex.org/W2097951502, https://openalex.org/W3020494352, https://openalex.org/W2461980614, https://openalex.org/W1963894537, https://openalex.org/W2370363004, https://openalex.org/W2765751461, https://openalex.org/W2945367020, https://openalex.org/W2010835651, https://openalex.org/W1968997545, https://openalex.org/W2144518030, https://openalex.org/W2135086075, https://openalex.org/W2082873640, https://openalex.org/W1489286950, https://openalex.org/W2029476353, https://openalex.org/W2128747388, https://openalex.org/W2152770371, https://openalex.org/W4205192056, https://openalex.org/W2119872597, https://openalex.org/W3177828909, https://openalex.org/W3211795435, https://openalex.org/W2159794836, https://openalex.org/W1980099457, https://openalex.org/W2228168283, https://openalex.org/W3165291968, https://openalex.org/W1999259053, https://openalex.org/W2955177827, https://openalex.org/W2148158936, https://openalex.org/W2177092266, https://openalex.org/W1977559935, https://openalex.org/W1993225645, https://openalex.org/W2606713195, https://openalex.org/W2064562224, https://openalex.org/W2096046927, https://openalex.org/W2104977809, https://openalex.org/W4244066891, https://openalex.org/W1946826587, https://openalex.org/W2125376264, https://openalex.org/W1998049513, https://openalex.org/W2467964007, https://openalex.org/W2952907530, https://openalex.org/W2135078307, https://openalex.org/W4206950245 |
| referenced_works_count | 51 |
| abstract_inverted_index.a | 3, 27, 32, 82, 144, 187, 197, 211 |
| abstract_inverted_index.75 | 154 |
| abstract_inverted_index.99 | 157 |
| abstract_inverted_index.Cu | 36, 69, 77, 119, 133, 138, 167, 170, 201 |
| abstract_inverted_index.In | 147 |
| abstract_inverted_index.We | 20, 129 |
| abstract_inverted_index.be | 88 |
| abstract_inverted_index.by | 7, 90 |
| abstract_inverted_index.in | 17, 101, 166, 176, 186, 214 |
| abstract_inverted_index.is | 2 |
| abstract_inverted_index.of | 57, 74, 98, 124, 200 |
| abstract_inverted_index.on | 39, 196 |
| abstract_inverted_index.to | 13, 31, 47, 127 |
| abstract_inverted_index.we | 64, 149, 173 |
| abstract_inverted_index.Cu. | 128 |
| abstract_inverted_index.ROS | 51, 59, 99, 115 |
| abstract_inverted_index.The | 96 |
| abstract_inverted_index.and | 9, 50, 80, 93, 155, 169, 180 |
| abstract_inverted_index.are | 163 |
| abstract_inverted_index.but | 109 |
| abstract_inverted_index.can | 25, 87, 209 |
| abstract_inverted_index.has | 43 |
| abstract_inverted_index.key | 164, 212 |
| abstract_inverted_index.low | 141 |
| abstract_inverted_index.not | 104 |
| abstract_inverted_index.our | 191 |
| abstract_inverted_index.the | 54, 67, 75, 102, 122, 132, 152, 159, 205 |
| abstract_inverted_index.McpR | 160, 184 |
| abstract_inverted_index.also | 110, 130 |
| abstract_inverted_index.been | 44 |
| abstract_inverted_index.both | 178 |
| abstract_inverted_index.cell | 41 |
| abstract_inverted_index.from | 117 |
| abstract_inverted_index.ions | 37, 70, 78, 120, 139, 182 |
| abstract_inverted_index.only | 105 |
| abstract_inverted_index.play | 210 |
| abstract_inverted_index.role | 56, 213 |
| abstract_inverted_index.that | 23, 66, 114, 151, 175, 204 |
| abstract_inverted_index.used | 6 |
| abstract_inverted_index.with | 140 |
| abstract_inverted_index.Cu(I) | 179 |
| abstract_inverted_index.Here, | 63 |
| abstract_inverted_index.McpR, | 135 |
| abstract_inverted_index.binds | 137 |
| abstract_inverted_index.found | 65 |
| abstract_inverted_index.redox | 207 |
| abstract_inverted_index.study | 192 |
| abstract_inverted_index.their | 15 |
| abstract_inverted_index.vitro | 177 |
| abstract_inverted_index.which | 86, 136 |
| abstract_inverted_index.Cu(II) | 181 |
| abstract_inverted_index.copper | 33 |
| abstract_inverted_index.domain | 162 |
| abstract_inverted_index.events | 49 |
| abstract_inverted_index.growth | 108 |
| abstract_inverted_index.labile | 145 |
| abstract_inverted_index.linked | 46 |
| abstract_inverted_index.living | 11 |
| abstract_inverted_index.mainly | 45 |
| abstract_inverted_index.sensor | 161 |
| abstract_inverted_index.showed | 22 |
| abstract_inverted_index.status | 208 |
| abstract_inverted_index.within | 158 |
| abstract_inverted_index.content | 71 |
| abstract_inverted_index.control | 123, 199 |
| abstract_inverted_index.derived | 116 |
| abstract_inverted_index.fitness | 16 |
| abstract_inverted_index.impedes | 111 |
| abstract_inverted_index.largely | 61 |
| abstract_inverted_index.manner. | 189 |
| abstract_inverted_index.mediate | 121 |
| abstract_inverted_index.mirrors | 72 |
| abstract_inverted_index.precise | 55 |
| abstract_inverted_index.remains | 60 |
| abstract_inverted_index.stress, | 85 |
| abstract_inverted_index.trigger | 26 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.Finally, | 172 |
| abstract_inverted_index.Overall, | 190 |
| abstract_inverted_index.although | 53 |
| abstract_inverted_index.bacteria | 24 |
| abstract_inverted_index.catalase | 94 |
| abstract_inverted_index.cellular | 206 |
| abstract_inverted_index.cysteine | 153 |
| abstract_inverted_index.debated. | 62 |
| abstract_inverted_index.distinct | 188 |
| abstract_inverted_index.improves | 106 |
| abstract_inverted_index.insights | 195 |
| abstract_inverted_index.maintain | 14 |
| abstract_inverted_index.modulate | 183 |
| abstract_inverted_index.negative | 28 |
| abstract_inverted_index.provides | 193 |
| abstract_inverted_index.residues | 165 |
| abstract_inverted_index.response | 30 |
| abstract_inverted_index.strategy | 5 |
| abstract_inverted_index.toxicity | 38 |
| abstract_inverted_index.triggers | 81 |
| abstract_inverted_index.(Cu)-rich | 34 |
| abstract_inverted_index.abrogated | 89 |
| abstract_inverted_index.addition, | 148 |
| abstract_inverted_index.affinity, | 142 |
| abstract_inverted_index.bacterial | 40, 107, 125, 215 |
| abstract_inverted_index.cytoplasm | 103 |
| abstract_inverted_index.dismutase | 92 |
| abstract_inverted_index.histidine | 156 |
| abstract_inverted_index.organisms | 12 |
| abstract_inverted_index.oxidative | 84 |
| abstract_inverted_index.stressful | 18 |
| abstract_inverted_index.Chemotaxis | 1 |
| abstract_inverted_index.chemotaxis | 126, 168 |
| abstract_inverted_index.discovered | 174 |
| abstract_inverted_index.identified | 131 |
| abstract_inverted_index.indicating | 113, 203 |
| abstract_inverted_index.inhibition | 97 |
| abstract_inverted_index.physiology | 42 |
| abstract_inverted_index.previously | 21 |
| abstract_inverted_index.production | 100 |
| abstract_inverted_index.suggesting | 143 |
| abstract_inverted_index.superoxide | 91 |
| abstract_inverted_index.variations | 73 |
| abstract_inverted_index.widespread | 4 |
| abstract_inverted_index.chemotactic | 29 |
| abstract_inverted_index.chemotaxis, | 202 |
| abstract_inverted_index.chemotaxis. | 216 |
| abstract_inverted_index.cytoplasmic | 68, 118 |
| abstract_inverted_index.demonstrate | 150 |
| abstract_inverted_index.mechanistic | 194 |
| abstract_inverted_index.production, | 52 |
| abstract_inverted_index.redox-based | 198 |
| abstract_inverted_index.unicellular | 8 |
| abstract_inverted_index.Cu-generated | 58 |
| abstract_inverted_index.conformation | 185 |
| abstract_inverted_index.environment. | 35 |
| abstract_inverted_index.interaction. | 146 |
| abstract_inverted_index.chemoreceptor | 134 |
| abstract_inverted_index.concentration | 79 |
| abstract_inverted_index.coordination. | 171 |
| abstract_inverted_index.environments. | 19 |
| abstract_inverted_index.extracellular | 76 |
| abstract_inverted_index.multicellular | 10 |
| abstract_inverted_index.Cu-chemotaxis, | 112 |
| abstract_inverted_index.dose-dependent | 83 |
| abstract_inverted_index.mismetallation | 48 |
| abstract_inverted_index.overexpression. | 95 |
| cited_by_percentile_year | |
| corresponding_author_ids | https://openalex.org/A5108598972 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 11 |
| corresponding_institution_ids | https://openalex.org/I149768937 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/15 |
| sustainable_development_goals[0].score | 0.5799999833106995 |
| sustainable_development_goals[0].display_name | Life in Land |
| citation_normalized_percentile.value | 0.08474343 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |